hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09716.1
Complex Portal: CPX-10782
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PRIM1 | DNA primase small subunit (EC 2.7.7.102) (DNA primase 49 kDa subunit) (p49) | 5 | UniProt NCBI |
| PRR12 | Proline-rich protein 12 | 4 | UniProt NCBI |
| POLA1 | DNA polymerase alpha catalytic subunit (EC 2.7.7.7) (DNA polymerase alpha catalytic subunit p180) | 5 | UniProt NCBI |
| NLGN4Y | Neuroligin-4, Y-linked (Neuroligin Y) | 5 | UniProt NCBI |
| C15orf39 | Uncharacterized protein C15orf39 | 3 | UniProt NCBI |
| PRIM2 | DNA primase large subunit (DNA primase 58 kDa subunit) (p58) | 5 | UniProt NCBI |
| POLA2 | DNA polymerase alpha subunit B (DNA polymerase alpha 70 kDa subunit) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1100 | 1.92263483365e-12 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | DNA polymerase alpha-primase complex |
| CORUM:1107 | 2.4205307311e-10 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | DNA synthesome core complex |
| REAC:R-HSA-68952 | 2.49703862656e-10 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | DNA replication initiation |
| CORUM:1098 | 4.033555059e-10 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | DNA synthesome complex (13 subunits) |
| CORUM:1108 | 1.37265258548e-09 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | DNA synthesome complex (15 subunits) |
| CORUM:1111 | 1.92139781673e-09 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | DNA synthesome complex (17 subunits) |
| CORUM:1099 | 1.92139781673e-09 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | DNA synthesome complex (17 subunits) |
| REAC:R-HSA-174430 | 2.5484518932e-09 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | Telomere C-strand synthesis initiation |
| REAC:R-HSA-113501 | 2.5484518932e-09 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| REAC:R-HSA-69166 | 3.56724633417e-09 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | Removal of the Flap Intermediate |
| REAC:R-HSA-69109 | 3.56724633417e-09 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | Leading Strand Synthesis |
| REAC:R-HSA-69091 | 3.56724633417e-09 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | Polymerase switching |
| GO:0005658 | 4.60395405777e-09 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | alpha DNA polymerase:primase complex |
| GO:0006269 | 4.60395405777e-09 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | DNA replication, synthesis of RNA primer |
| REAC:R-HSA-69183 | 4.86362738832e-09 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | Processive synthesis on the lagging strand |
| REAC:R-HSA-69186 | 1.72490220596e-08 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | Lagging Strand Synthesis |
| REAC:R-HSA-113510 | 2.60340792443e-08 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | E2F mediated regulation of DNA replication |
| REAC:R-HSA-174411 | 5.31720535121e-08 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | Polymerase switching on the C-strand of the telomere |
| KEGG:03030 | 5.63292822889e-08 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | DNA replication |
| REAC:R-HSA-69190 | 1.277713074e-07 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | DNA strand elongation |
| REAC:R-HSA-68962 | 1.4537101986e-07 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | Activation of the pre-replicative complex |
| REAC:R-HSA-174417 | 1.64726720638e-07 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | Telomere C-strand (Lagging Strand) Synthesis |
| WP:WP466 | 1.85577872789e-07 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | DNA replication |
| REAC:R-HSA-180786 | 8.85160190125e-07 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | Extension of Telomeres |
| REAC:R-HSA-9710421 | 1.84539860471e-06 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | Defective pyroptosis |
| GO:0042575 | 4.45024769139e-06 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | DNA polymerase complex |
| GO:0043601 | 6.71679244503e-06 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | nuclear replisome |
| REAC:R-HSA-9645723 | 9.40454269709e-06 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | Diseases of programmed cell death |
| GO:0030894 | 9.75381672605e-06 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | replisome |
| REAC:R-HSA-157579 | 1.37774573413e-05 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | Telomere Maintenance |
| REAC:R-HSA-69239 | 2.78128949887e-05 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | Synthesis of DNA |
| GO:0006270 | 3.29649973093e-05 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | DNA replication initiation |
| REAC:R-HSA-73886 | 3.61497405074e-05 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | Chromosome Maintenance |
| REAC:R-HSA-69206 | 3.97128087888e-05 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | G1/S Transition |
| REAC:R-HSA-69002 | 6.5097378491e-05 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | DNA Replication Pre-Initiation |
| REAC:R-HSA-453279 | 6.5097378491e-05 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | Mitotic G1 phase and G1/S transition |
| GO:0043596 | 7.53137668044e-05 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | nuclear replication fork |
| REAC:R-HSA-69242 | 8.92028515313e-05 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | S Phase |
| REAC:R-HSA-69306 | 0.000128038705621 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | DNA Replication |
| WP:WP45 | 0.0002507595765 | 0.428571428571 | POLA2 PRIM1 PRIM2 | G1 to S cell cycle control |
| CORUM:1003 | 0.000573957048441 | 0.285714285714 | POLA1 POLA2 | RC complex (Replication competent complex) |
| GO:0005657 | 0.000617288463902 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | replication fork |
| GO:0055029 | 0.002536243155 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | nuclear DNA-directed RNA polymerase complex |
| GO:0000428 | 0.0026497943547 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | DNA-directed RNA polymerase complex |
| GO:0030880 | 0.00301333997974 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | RNA polymerase complex |
| REAC:R-HSA-69278 | 0.0103191476058 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | Cell Cycle, Mitotic |
| GO:0006261 | 0.0142054380156 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | DNA-templated DNA replication |
| REAC:R-HSA-1640170 | 0.0231929958906 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | Cell Cycle |
| GO:0000228 | 0.0322799316792 | 0.571428571429 | POLA1 POLA2 PRIM1 PRIM2 | nuclear chromosome |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PRIM1 | POLA2 | 0.999 | 0.81 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM fraction | |
| PRIM1 | PRIM2 | 0.999 | 0.922 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | |
| PRIM1 | NLGN4Y | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| NLGN4Y | PRIM2 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| PRIM1 | POLA1 | 0.994 | 0.818 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM fraction | |
| POLA1 | POLA2 | 0.979 | 0.84 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction | |
| C15orf39 | POLA2 | 0.971 | 0.054 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| PRIM1 | C15orf39 | 0.969 | 0.078 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| POLA1 | PRIM2 | 0.969 | 0.838 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| PRIM2 | POLA2 | 0.966 | 0.872 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| PRR12 | PRIM1 | 0.951 | 0.1 | hein_WMM bioplex3_WMM WMM_only | |
| POLA1 | C15orf39 | 0.928 | 0.09 | hein_WMM bioplex3_WMM WMM_only | |
| C15orf39 | PRIM2 | 0.925 | 0.104 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| PRR12 | C15orf39 | 0.882 | 0.166 | hein_WMM bioplex3_WMM WMM_only | |
| PRR12 | POLA2 | 0.881 | 0.062 | hein_WMM bioplex3_WMM youn_WMM WMM_only | |
| PRR12 | POLA1 | 0.879 | 0.048 | hein_WMM bioplex3_WMM youn_WMM WMM_only | |
| PRR12 | PRIM2 | 0.78 | 0.038 | hein_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes