hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09717.1
Complex Portal: CPX-16226
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LETM2 | LETM1 domain-containing protein LETM2, mitochondrial (LETM1 and EF-hand domain-containing protein 2) (Leucine zipper-EF-hand-containing transmembrane protein 1-like) | 3 | UniProt NCBI |
| DYNLT2B | Dynein light chain Tctex-type protein 2B (Tctex1 domain-containing protein 2) | 5 | UniProt NCBI |
| DYNC2I1 | Cytoplasmic dynein 2 intermediate chain 1 (Dynein 2 intermediate chain 1) (WD repeat-containing protein 60) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0010454 | 0.000126523416231 | 0.666666666667 | DYNC2I1 DYNLT2B | Acetabular spurs |
| CORUM:6236 | 0.000225453649047 | 0.666666666667 | DYNC2I1 DYNLT2B | Dynein-2 complex, cytoplasmic |
| WP:WP4532 | 0.000397139561296 | 0.666666666667 | DYNC2I1 DYNLT2B | Intraflagellar transport proteins binding to dynein |
| HP:0000895 | 0.00115089028102 | 0.666666666667 | DYNC2I1 DYNLT2B | Lateral clavicle hook |
| WP:WP4906 | 0.00180332266367 | 0.666666666667 | DYNC2I1 DYNLT2B | 3q29 copy number variation syndrome |
| WP:WP5234 | 0.00321742070882 | 0.666666666667 | DYNC2I1 DYNLT2B | Bardet Biedl syndrome |
| GO:0031021 | 0.00421361424067 | 0.666666666667 | DYNC2I1 DYNLT2B | interphase microtubule organizing center |
| WP:WP4536 | 0.00536035090333 | 0.666666666667 | DYNC2I1 DYNLT2B | Genes related to primary cilium development based on CRISPR |
| REAC:R-HSA-5620924 | 0.00867409880878 | 0.666666666667 | DYNC2I1 DYNLT2B | Intraflagellar transport |
| WP:WP4803 | 0.0135986549013 | 0.666666666667 | DYNC2I1 DYNLT2B | Ciliopathies |
| HP:0000773 | 0.0194392651505 | 0.666666666667 | DYNC2I1 DYNLT2B | Short ribs |
| WP:WP4352 | 0.0243888015773 | 0.666666666667 | DYNC2I1 DYNLT2B | Ciliary landscape |
| HP:0001830 | 0.024644630388 | 0.666666666667 | DYNC2I1 DYNLT2B | Postaxial foot polydactyly |
| HP:0003170 | 0.0359423574679 | 0.666666666667 | DYNC2I1 DYNLT2B | Abnormal acetabulum morphology |
| HP:0001162 | 0.0408514331117 | 0.666666666667 | DYNC2I1 DYNLT2B | Postaxial hand polydactyly |
| HP:0010322 | 0.0408514331117 | 0.666666666667 | DYNC2I1 DYNLT2B | Abnormal fifth toe morphology |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| DYNC2I1 | DYNLT2B | 1.0 |
mutually_exclusive (Q96FJ2)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM | |
| LETM2 | DYNLT2B | 0.982 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes