hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09719.1
Complex Portal: CPX-18251
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| FBXO9 | F-box only protein 9 (Cross-immune reaction antigen 1) (Renal carcinoma antigen NY-REN-57) | 5 | UniProt NCBI |
| KDM2A | Lysine-specific demethylase 2A (EC 1.14.11.27) (CXXC-type zinc finger protein 8) (F-box and leucine-rich repeat protein 11) (F-box protein FBL7) (F-box protein Lilina) (F-box/LRR-repeat protein 11) (JmjC domain-containing histone demethylation protein 1A) ([Histone-H3]-lysine-36 demethylase 1A) | 5 | UniProt NCBI |
| FBXL16 | F-box/LRR-repeat protein 16 (F-box and leucine-rich repeat protein 16) | 4 | UniProt NCBI |
| FBXW9 | F-box/WD repeat-containing protein 9 (F-box and WD-40 domain-containing protein 9) | 3 | UniProt NCBI |
| FBXL15 | F-box/LRR-repeat protein 15 (F-box only protein 37) | 5 | UniProt NCBI |
| FBXL8 | F-box/LRR-repeat protein 8 (F-box and leucine-rich repeat protein 8) (F-box protein FBL8) | 3 | UniProt NCBI |
| KDM2B | Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B) | 5 | UniProt NCBI |
| FBXL18 | F-box/LRR-repeat protein 18 (F-box and leucine-rich repeat protein 18) | 4 | UniProt NCBI |
| EEF2 | Elongation factor 2 (EF-2) (EC 3.6.5.-) | 5 | UniProt NCBI |
| FBXO31 | F-box only protein 31 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0031146 | 1.18517073386e-09 | 0.666666666667 | FBXL8 FBXO9 FBXL18 FBXO31 FBXL16 FBXL15 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
| REAC:R-HSA-8951664 | 1.55222285173e-09 | 0.777777777778 | FBXW9 FBXL8 FBXO9 FBXL18 FBXO31 FBXL16 FBXL15 | Neddylation |
| REAC:R-HSA-983168 | 7.63393696818e-09 | 0.777777777778 | FBXW9 FBXL8 FBXO9 FBXL18 FBXO31 FBXL16 FBXL15 | Antigen processing: Ubiquitination & Proteasome degradation |
| GO:0019005 | 8.92743918497e-09 | 0.666666666667 | FBXL8 FBXO9 FBXL18 FBXO31 FBXL16 FBXL15 | SCF ubiquitin ligase complex |
| REAC:R-HSA-983169 | 3.21523862361e-08 | 0.777777777778 | FBXW9 FBXL8 FBXO9 FBXL18 FBXO31 FBXL16 FBXL15 | Class I MHC mediated antigen processing & presentation |
| REAC:R-HSA-1280218 | 3.05180298279e-06 | 0.777777777778 | FBXW9 FBXL8 FBXO9 FBXL18 FBXO31 FBXL16 FBXL15 | Adaptive Immune System |
| GO:0031461 | 8.92754588756e-06 | 0.666666666667 | FBXL8 FBXO9 FBXL18 FBXO31 FBXL16 FBXL15 | cullin-RING ubiquitin ligase complex |
| GO:0000151 | 0.000179732815089 | 0.666666666667 | FBXL8 FBXO9 FBXL18 FBXO31 FBXL16 FBXL15 | ubiquitin ligase complex |
| REAC:R-HSA-597592 | 0.000218137300916 | 0.777777777778 | FBXW9 FBXL8 FBXO9 FBXL18 FBXO31 FBXL16 FBXL15 | Post-translational protein modification |
| GO:0043161 | 0.000530475383283 | 0.666666666667 | FBXL8 FBXO9 FBXL18 FBXO31 FBXL16 FBXL15 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| REAC:R-HSA-168256 | 0.00186369688073 | 0.777777777778 | FBXW9 FBXL8 FBXO9 FBXL18 FBXO31 FBXL16 FBXL15 | Immune System |
| REAC:R-HSA-392499 | 0.00202692701529 | 0.777777777778 | FBXW9 FBXL8 FBXO9 FBXL18 FBXO31 FBXL16 FBXL15 | Metabolism of proteins |
| GO:0010498 | 0.00221420903646 | 0.666666666667 | FBXL8 FBXO9 FBXL18 FBXO31 FBXL16 FBXL15 | proteasomal protein catabolic process |
| GO:0006511 | 0.00537628237252 | 0.666666666667 | FBXL8 FBXO9 FBXL18 FBXO31 FBXL16 FBXL15 | ubiquitin-dependent protein catabolic process |
| GO:0019941 | 0.00591809375688 | 0.666666666667 | FBXL8 FBXO9 FBXL18 FBXO31 FBXL16 FBXL15 | modification-dependent protein catabolic process |
| GO:0043632 | 0.00673624890584 | 0.666666666667 | FBXL8 FBXO9 FBXL18 FBXO31 FBXL16 FBXL15 | modification-dependent macromolecule catabolic process |
| GO:0051603 | 0.0183571145865 | 0.666666666667 | FBXL8 FBXO9 FBXL18 FBXO31 FBXL16 FBXL15 | proteolysis involved in protein catabolic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| FBXO9 | EEF2 | 0.998 | 0.252 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM | |
| FBXL15 | FBXL16 | 0.981 |
mutually_exclusive (P63208)
|
hein_WMM bioplex3_WMM WMM_only | |
| FBXL8 | FBXL15 | 0.981 | 0.06 |
mutually_exclusive (P63208)
|
hein_WMM bioplex3_WMM WMM_only |
| FBXL15 | FBXO31 | 0.98 | hein_WMM bioplex3_WMM WMM_only | ||
| FBXL8 | FBXO9 | 0.978 | 0.13 |
mutually_exclusive (P63208)
|
hein_WMM bioplex3_WMM WMM_only |
| FBXL8 | FBXO31 | 0.976 | hein_WMM bioplex3_WMM WMM_only | ||
| FBXL15 | FBXO9 | 0.974 | 0.066 |
mutually_exclusive (P63208)
|
hein_WMM bioplex3_WMM WMM_only |
| FBXO31 | FBXO9 | 0.969 |
mutually_exclusive (P63208)
|
hein_WMM bioplex3_WMM WMM_only | |
| FBXL8 | KDM2A | 0.961 | 0.036 |
mutually_exclusive (P63208)
|
hein_WMM bioplex3_WMM WMM_only |
| FBXL8 | FBXL16 | 0.959 |
mutually_exclusive (P63208)
|
hein_WMM bioplex3_WMM WMM_only | |
| KDM2B | FBXL15 | 0.959 | 0.142 |
mutually_exclusive (P63208)
|
hein_WMM bioplex3_WMM WMM_only |
| FBXL16 | FBXO9 | 0.959 |
mutually_exclusive (P63208)
|
hein_WMM bioplex3_WMM WMM_only | |
| KDM2B | FBXW9 | 0.956 | 0.114 |
mutually_exclusive (P63208)
|
hein_WMM bioplex3_WMM WMM_only |
| FBXL8 | KDM2B | 0.954 | 0.056 |
mutually_exclusive (P63208)
|
hein_WMM bioplex3_WMM WMM_only |
| FBXL8 | FBXW9 | 0.952 | 0.054 | hein_WMM bioplex3_WMM WMM_only | |
| KDM2B | FBXO9 | 0.95 | 0.076 |
mutually_exclusive (P63208)
|
hein_WMM bioplex3_WMM WMM_only |
| FBXL16 | FBXW9 | 0.944 |
mutually_exclusive (P63208)
|
hein_WMM bioplex3_WMM WMM_only | |
| FBXL15 | FBXW9 | 0.943 | 0.104 |
mutually_exclusive (P63208)
|
hein_WMM bioplex3_WMM WMM_only |
| FBXO31 | KDM2A | 0.932 |
mutually_exclusive (P63208)
|
hein_WMM bioplex3_WMM WMM_only | |
| KDM2B | KDM2A | 0.931 | 0.104 |
mutually_exclusive (P63208)
|
hein_WMM bioplex3_WMM WMM_only |
| FBXW9 | FBXO9 | 0.93 | 0.088 |
mutually_exclusive (P63208)
|
hein_WMM bioplex3_WMM WMM_only |
| FBXO31 | FBXW9 | 0.915 | hein_WMM bioplex3_WMM WMM_only | ||
| KDM2B | FBXO31 | 0.913 |
mutually_exclusive (P63208)
|
hein_WMM bioplex3_WMM WMM_only | |
| FBXO31 | FBXL16 | 0.909 |
mutually_exclusive (P63208)
|
hein_WMM bioplex3_WMM WMM_only | |
| FBXL15 | KDM2A | 0.909 | 0.094 |
mutually_exclusive (P63208)
|
hein_WMM bioplex3_WMM WMM_only |
| KDM2A | FBXO9 | 0.909 | 0.064 |
mutually_exclusive (P63208)
|
hein_WMM bioplex3_WMM WMM_only |
| KDM2B | FBXL16 | 0.892 |
mutually_exclusive (P63208)
|
hein_WMM bioplex3_WMM WMM_only | |
| FBXW9 | KDM2A | 0.88 | 0.04 |
mutually_exclusive (P63208)
|
hein_WMM bioplex3_WMM WMM_only |
| FBXL8 | EEF2 | 0.688 | 0.218 | bioplex3_WMM WMM_only | |
| FBXO31 | EEF2 | 0.688 | bioplex3_WMM WMM_only | ||
| FBXL16 | KDM2A | 0.674 |
mutually_exclusive (P63208)
|
hein_WMM bioplex3_WMM WMM_only | |
| KDM2B | EEF2 | 0.471 | 0.266714285714 | bioplex3_WMM gupta_WMM WMM_only | |
| KDM2A | EEF2 | 0.395 | 0.144 | bioplex3_WMM WMM_only | |
| FBXW9 | EEF2 | 0.3 | 0.124 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| FBXL15 | EEF2 | 0.076 | 0.184714285714 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 | |
| FBXL16 | EEF2 | 0.028 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 |
Related Complexes