hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09722.1
Complex Portal: CPX-13924
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| WTAP | Pre-mRNA-splicing regulator WTAP (Female-lethal(2)D homolog) (hFL(2)D) (WT1-associated protein) (Wilms tumor 1-associating protein) | 5 | UniProt NCBI |
| VIRMA | Protein virilizer homolog | 5 | UniProt NCBI |
| CBLL1 | E3 ubiquitin-protein ligase Hakai (EC 2.3.2.27) (Casitas B-lineage lymphoma-transforming sequence-like protein 1) (c-Cbl-like protein 1) (RING finger protein 188) (RING-type E3 ubiquitin transferase Hakai) | 5 | UniProt NCBI |
| ZC3H13 | Zinc finger CCCH domain-containing protein 13 | 5 | UniProt NCBI |
| CBLL2 | E3 ubiquitin-protein ligase CBLL2 (EC 2.3.2.27) (Cbl proto-oncogene-like protein 2) (RING-type E3 ubiquitin transferase ZNF645) (Zinc finger protein 645) (c-Cbl-like protein 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0036396 | 9.20740386965e-09 | 0.8 | CBLL1 ZC3H13 WTAP VIRMA | RNA N6-methyladenosine methyltransferase complex |
| GO:0045293 | 9.40213012535e-08 | 0.8 | CBLL1 ZC3H13 WTAP VIRMA | mRNA editing complex |
| GO:0080009 | 3.12897432326e-07 | 0.8 | CBLL1 ZC3H13 WTAP VIRMA | mRNA methylation |
| GO:0016556 | 2.69021579342e-06 | 0.8 | CBLL1 ZC3H13 WTAP VIRMA | mRNA modification |
| CORUM:929 | 1.67158430686e-05 | 0.6 | ZC3H13 WTAP VIRMA | CEN complex |
| GO:0001510 | 0.000186904603412 | 0.8 | CBLL1 ZC3H13 WTAP VIRMA | RNA methylation |
| GO:0034708 | 0.000349949920328 | 0.8 | CBLL1 ZC3H13 WTAP VIRMA | methyltransferase complex |
| GO:0043414 | 0.00139398670092 | 0.8 | CBLL1 ZC3H13 WTAP VIRMA | macromolecule methylation |
| GO:0032259 | 0.00162736464815 | 0.8 | CBLL1 ZC3H13 WTAP VIRMA | methylation |
| GO:0009451 | 0.00294018150071 | 0.8 | CBLL1 ZC3H13 WTAP VIRMA | RNA modification |
| GO:0016607 | 0.0400283267175 | 0.8 | CBLL1 ZC3H13 WTAP VIRMA | nuclear speck |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| WTAP | VIRMA | 1.0 | 0.606 |
structurally_consistent (dimer)
|
hein_WMM youn () bioplex_WMM Guru bioplex3_WMM youn_WMM Malo fraction |
| CBLL2 | VIRMA | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| WTAP | CBLL2 | 0.999 |
structurally_consistent (Q69YN4)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CBLL2 | ZC3H13 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| VIRMA | ZC3H13 | 0.999 | 0.294 | bioplex_WMM Guru bioplex3_WMM youn_WMM Malo fraction | |
| WTAP | ZC3H13 | 0.995 | 0.242 | bioplex_WMM Guru bioplex3_WMM youn_WMM Malo fraction | |
| CBLL1 | VIRMA | 0.987 | 0.1 |
structurally_consistent (dimer)
|
youn () youn_WMM Malo fraction |
| WTAP | CBLL1 | 0.868 | 0.594 |
structurally_consistent (Q69YN4)
|
youn_WMM Malo fraction |
| CBLL1 | ZC3H13 | 0.423 | 0.286 | hein_WMM WMM_only |
Related Complexes