hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_09723.1

Complex Portal: CPX-16468

Confidence: Moderate High

Genename	Protein Name	Uniprot Annotation Score	Links
LDB1	LIM domain-binding protein 1 (LDB-1) (Carboxyl-terminal LIM domain-binding protein 2) (CLIM-2) (LIM domain-binding factor CLIM2) (hLdb1) (Nuclear LIM interactor)	5	UniProt NCBI
FAM107A	Actin-associated protein FAM107A (Down-regulated in renal cell carcinoma 1) (Protein TU3A)	5	UniProt NCBI
SSBP2	Single-stranded DNA-binding protein 2 (Sequence-specific single-stranded-DNA-binding protein 2)	4	UniProt NCBI
LHX4	LIM/homeobox protein Lhx4 (LIM homeobox protein 4)	5	UniProt NCBI
LHX1	LIM/homeobox protein Lhx1 (LIM homeobox protein 1) (Homeobox protein Lim-1) (hLim-1)	5	UniProt NCBI
LMO4	LIM domain transcription factor LMO4 (Breast tumor autoantigen) (LIM domain only protein 4) (LMO-4)	5	UniProt NCBI
LMX1B	LIM homeobox transcription factor 1-beta (LIM/homeobox protein 1.2) (LMX-1.2) (LIM/homeobox protein LMX1B)	5	UniProt NCBI
IDI2	Isopentenyl-diphosphate delta-isomerase 2 (EC 5.3.3.2) (Isopentenyl pyrophosphate isomerase 2) (IPP isomerase 2) (IPPI2)	5	UniProt NCBI
SSBP4	Single-stranded DNA-binding protein 4	3	UniProt NCBI
ISL2	Insulin gene enhancer protein ISL-2 (Islet-2)	4	UniProt NCBI
LHX3	LIM/homeobox protein Lhx3 (LIM homeobox protein 3)	5	UniProt NCBI
LHX6	LIM/homeobox protein Lhx6 (LIM homeobox protein 6) (LIM/homeobox protein Lhx6.1)	5	UniProt NCBI
LMO3	LIM domain only protein 3 (LMO-3) (Neuronal-specific transcription factor DAT1) (Rhombotin-3)	5	UniProt NCBI
ISL1	Insulin gene enhancer protein ISL-1 (Islet-1)	5	UniProt NCBI
LHX2	LIM/homeobox protein Lhx2 (Homeobox protein LH-2) (LIM homeobox protein 2)	5	UniProt NCBI
LHX9	LIM/homeobox protein Lhx9 (LIM homeobox protein 9)	5	UniProt NCBI
LMO1	Rhombotin-1 (Cysteine-rich protein TTG-1) (LIM domain only protein 1) (LMO-1) (T-cell translocation protein 1)	5	UniProt NCBI
SSBP3	Single-stranded DNA-binding protein 3 (Sequence-specific single-stranded-DNA-binding protein)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-9010553	7.06006721508e-06	0.352941176471	LDB1 LHX3 LHX9 LHX4 ISL1 LHX2	Regulation of expression of SLITs and ROBOs
REAC:R-HSA-376176	2.86697378511e-05	0.352941176471	LDB1 LHX3 LHX9 LHX4 ISL1 LHX2	Signaling by ROBO receptors
GO:0006357	5.95663991185e-05	0.764705882353	SSBP3 LHX9 ISL2 LHX2 LMX1B SSBP2 LHX3 LDB1 ISL1 LHX4 LHX1 LHX6 SSBP4	regulation of transcription by RNA polymerase II
GO:0030182	7.05672762289e-05	0.588235294118	LHX9 ISL2 LMX1B ISL1 LHX3 LDB1 LHX1 LHX4 LHX6 LHX2	neuron differentiation
GO:0045893	0.000104595586888	0.647058823529	SSBP3 ISL2 LHX2 LMX1B SSBP2 LHX3 LDB1 LHX4 LHX1 ISL1 SSBP4	positive regulation of DNA-templated transcription
GO:1902680	0.000107813126176	0.647058823529	SSBP3 ISL2 LHX2 LMX1B SSBP2 LHX3 LDB1 LHX4 LHX1 ISL1 SSBP4	positive regulation of RNA biosynthetic process
GO:0006366	0.000116131587736	0.764705882353	SSBP3 LHX9 ISL2 LHX2 LMX1B SSBP2 LHX3 LDB1 ISL1 LHX4 LHX1 LHX6 SSBP4	transcription by RNA polymerase II
GO:0048699	0.00012090079649	0.588235294118	LHX9 ISL2 LMX1B ISL1 LHX3 LDB1 LHX1 LHX4 LHX6 LHX2	generation of neurons
CORUM:2214	0.000326093232852	0.117647058824	LMO4 LDB1	LMO4-BRCA1-CTIP-LDB1 complex
GO:0051254	0.000350501062038	0.647058823529	SSBP3 ISL2 LHX2 LMX1B SSBP2 LHX3 LDB1 LHX4 LHX1 ISL1 SSBP4	positive regulation of RNA metabolic process
GO:0022008	0.000448152303313	0.588235294118	LHX9 ISL2 LMX1B ISL1 LHX3 LDB1 LHX1 LHX4 LHX6 LHX2	neurogenesis
GO:0000785	0.00102387073305	0.588235294118	LHX9 ISL2 LMX1B ISL1 LHX3 LDB1 LHX1 LHX4 LHX6 LHX2	chromatin
GO:0007399	0.00115355128391	0.647058823529	LHX1 LHX9 ISL2 LMX1B ISL1 LHX3 LDB1 LMO4 LHX4 LHX6 LHX2	nervous system development
GO:0045935	0.00141585817562	0.647058823529	SSBP3 ISL2 LHX2 LMX1B SSBP2 LHX3 LDB1 LHX4 LHX1 ISL1 SSBP4	positive regulation of nucleobase-containing compound metabolic process
GO:0032993	0.00180081252918	0.588235294118	LHX9 ISL2 LMX1B ISL1 LHX3 LDB1 LHX1 LHX4 LHX6 LHX2	protein-DNA complex
GO:0045944	0.00223816727233	0.529411764706	SSBP3 ISL2 LMX1B SSBP2 LHX3 SSBP4 LHX4 ISL1 LDB1	positive regulation of transcription by RNA polymerase II
GO:0006355	0.00236483376833	0.764705882353	SSBP3 LHX9 ISL2 LHX2 LMX1B SSBP2 LHX3 LDB1 ISL1 LHX4 LHX1 LHX6 SSBP4	regulation of DNA-templated transcription
GO:2001141	0.00254798328536	0.764705882353	SSBP3 LHX9 ISL2 LHX2 LMX1B SSBP2 LHX3 LDB1 ISL1 LHX4 LHX1 LHX6 SSBP4	regulation of RNA biosynthetic process
REAC:R-HSA-422475	0.00365297118293	0.352941176471	LDB1 LHX3 LHX9 LHX4 ISL1 LHX2	Axon guidance
GO:0006351	0.00423921000044	0.764705882353	SSBP3 LHX9 ISL2 LHX2 LMX1B SSBP2 LHX3 LDB1 ISL1 LHX4 LHX1 LHX6 SSBP4	DNA-templated transcription
REAC:R-HSA-9675108	0.00450311568434	0.352941176471	LDB1 LHX3 LHX9 LHX4 ISL1 LHX2	Nervous system development
GO:0032774	0.00483430999548	0.764705882353	SSBP3 LHX9 ISL2 LHX2 LMX1B SSBP2 LHX3 LDB1 ISL1 LHX4 LHX1 LHX6 SSBP4	RNA biosynthetic process
GO:0000981	0.00738489542992	0.529411764706	LHX1 ISL2 LMX1B LHX3 LHX2 LHX6 LHX4 ISL1 LHX9	DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0009893	0.00767879216834	0.764705882353	ISL2 FAM107A SSBP3 LMO4 LHX2 SSBP2 LMX1B LHX3 LDB1 LHX4 LHX1 ISL1 SSBP4	positive regulation of metabolic process
GO:0051173	0.00896509764874	0.705882352941	FAM107A SSBP3 ISL2 LHX2 LMX1B SSBP2 LHX3 LDB1 LHX4 LHX1 ISL1 SSBP4	positive regulation of nitrogen compound metabolic process
WP:WP2064	0.00915030248182	0.176470588235	LHX1 ISL1 LHX2	Neural crest differentiation
GO:0051252	0.00934229575476	0.764705882353	SSBP3 LHX9 ISL2 LHX2 LMX1B SSBP2 LHX3 LDB1 ISL1 LHX4 LHX1 LHX6 SSBP4	regulation of RNA metabolic process
GO:0003700	0.0125758974792	0.529411764706	LHX1 ISL2 LMX1B LHX3 LHX2 LHX6 LHX4 ISL1 LHX9	DNA-binding transcription factor activity
GO:0010557	0.0134060656379	0.647058823529	SSBP3 ISL2 LHX2 LMX1B SSBP2 LHX3 LDB1 LHX4 LHX1 ISL1 SSBP4	positive regulation of macromolecule biosynthetic process
GO:0031328	0.0181816089592	0.647058823529	SSBP3 ISL2 LHX2 LMX1B SSBP2 LHX3 LDB1 LHX4 LHX1 ISL1 SSBP4	positive regulation of cellular biosynthetic process
GO:0009891	0.0194172181	0.647058823529	SSBP3 ISL2 LHX2 LMX1B SSBP2 LHX3 LDB1 LHX4 LHX1 ISL1 SSBP4	positive regulation of biosynthetic process
GO:0000976	0.0194982068955	0.529411764706	LHX1 ISL2 LMX1B LHX3 LHX2 LHX6 LHX4 ISL1 LHX9	transcription cis-regulatory region binding
GO:0001067	0.0196686651866	0.529411764706	LHX1 ISL2 LMX1B LHX3 LHX2 LHX6 LHX4 ISL1 LHX9	transcription regulatory region nucleic acid binding
HP:0031218	0.0207069091434	0.117647058824	LHX4 LHX3	Inappropriate antidiuretic hormone secretion
HP:0000839	0.0207069091434	0.117647058824	LHX4 LHX3	Pituitary dwarfism
GO:0140110	0.0219577131744	0.588235294118	LHX1 LMO3 ISL2 LMX1B LHX3 LHX2 LHX6 LHX4 ISL1 LHX9	transcription regulator activity
GO:0034654	0.022424383566	0.764705882353	SSBP3 LHX9 ISL2 LHX2 LMX1B SSBP2 LHX3 LDB1 ISL1 LHX4 LHX1 LHX6 SSBP4	nucleobase-containing compound biosynthetic process
GO:0031325	0.0257477184958	0.705882352941	ISL2 SSBP3 LMO4 LHX2 LMX1B SSBP2 LHX3 LDB1 LHX4 LHX1 ISL1 SSBP4	positive regulation of cellular metabolic process
GO:0018130	0.0279859642755	0.764705882353	SSBP3 LHX9 ISL2 LHX2 LMX1B SSBP2 LHX3 LDB1 ISL1 LHX4 LHX1 LHX6 SSBP4	heterocycle biosynthetic process
GO:0019438	0.0283492307145	0.764705882353	SSBP3 LHX9 ISL2 LHX2 LMX1B SSBP2 LHX3 LDB1 ISL1 LHX4 LHX1 LHX6 SSBP4	aromatic compound biosynthetic process
GO:0019219	0.0284712701129	0.764705882353	SSBP3 LHX9 ISL2 LHX2 LMX1B SSBP2 LHX3 LDB1 ISL1 LHX4 LHX1 LHX6 SSBP4	regulation of nucleobase-containing compound metabolic process
GO:1990837	0.0290633756618	0.529411764706	LHX1 ISL2 LMX1B LHX3 LHX2 LHX6 LHX4 ISL1 LHX9	sequence-specific double-stranded DNA binding
GO:0005694	0.0320102634687	0.588235294118	LHX9 ISL2 LMX1B ISL1 LHX3 LDB1 LHX1 LHX4 LHX6 LHX2	chromosome
GO:0010604	0.0360670387828	0.705882352941	FAM107A SSBP3 ISL2 LHX2 LMX1B SSBP2 LHX3 LDB1 LHX4 LHX1 ISL1 SSBP4	positive regulation of macromolecule metabolic process
HP:0031219	0.038600021268	0.117647058824	LHX4 LHX3	Reduced radioactive iodine uptake
HP:0031221	0.038600021268	0.117647058824	LHX4 LHX3	Abnormal radioactive iodine uptake test result
GO:1901362	0.0402702656883	0.764705882353	SSBP3 LHX9 ISL2 LHX2 LMX1B SSBP2 LHX3 LDB1 ISL1 LHX4 LHX1 LHX6 SSBP4	organic cyclic compound biosynthetic process
HP:0031098	0.0495946438232	0.117647058824	LHX4 LHX3	Decreased thyroid-stimulating hormone level
CORUM:3181	0.0497089104684	0.0588235294118	LMO4	LMO4-CREB complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
LMO4	SSBP4	1.0	0.054
LMO4	SSBP3	1.0	0.0933333333333
SSBP2	LMO4	1.0	0.076
LMX1B	SSBP4	1.0
SSBP4	ISL2	1.0
LDB1	SSBP4	1.0
LDB1	SSBP3	1.0
SSBP2	LMX1B	1.0
ISL2	SSBP3	1.0		mutually_exclusive (Q8TAP4)
SSBP2	SSBP3	1.0	0.098
SSBP2	SSBP4	1.0	0.088
SSBP4	ISL1	0.999
SSBP2	ISL2	0.999		mutually_exclusive (Q8TAP4)
LDB1	SSBP2	0.999
SSBP4	LMO1	0.999
ISL1	SSBP3	0.999
LMX1B	SSBP3	0.999
SSBP4	SSBP3	0.999	0.154
LDB1	LMX1B	0.999
LHX2	SSBP3	0.999
SSBP2	ISL1	0.998
LHX6	SSBP4	0.998
LMX1B	ISL2	0.998
LDB1	ISL2	0.998
LHX6	SSBP3	0.998
LMO3	SSBP4	0.998
LHX6	LDB1	0.998
LMO3	LDB1	0.997
LDB1	LMO1	0.997
LMO1	SSBP3	0.997
LHX6	LMX1B	0.997
SSBP2	LMO1	0.997
LMO3	SSBP2	0.996		structurally_consistent (dimer)
LMO3	SSBP3	0.996		structurally_consistent (dimer)
LHX4	SSBP4	0.995
LHX3	SSBP3	0.994
LDB1	LMO4	0.994
LMO4	LMX1B	0.993
LMO4	ISL2	0.993		structurally_consistent (dimer)
LDB1	LHX4	0.992
LDB1	ISL1	0.992
ISL2	ISL1	0.992
LMO3	LMX1B	0.991
LHX4	SSBP3	0.988
LMO4	LMO1	0.987
FAM107A	LMO3	0.984
LMO4	ISL1	0.984
LHX3	LDB1	0.984
LHX1	SSBP4	0.984
LMX1B	ISL1	0.983
SSBP4	LHX9	0.982
IDI2	SSBP3	0.977
LMO3	LHX4	0.976
ISL2	LMO1	0.975
SSBP4	LHX2	0.975
LMO3	ISL2	0.974		structurally_consistent (dimer)
LMO4	IDI2	0.974
LHX9	SSBP3	0.973
LDB1	LHX9	0.972
SSBP2	IDI2	0.972
LHX1	SSBP3	0.969
IDI2	SSBP4	0.963
LHX6	SSBP2	0.961
LDB1	IDI2	0.961
LHX3	ISL2	0.956
SSBP2	LHX4	0.94
LMX1B	LMO1	0.934
LHX3	SSBP4	0.924
LHX3	SSBP2	0.916
LMO3	ISL1	0.905
LMX1B	IDI2	0.904
LHX2	LMO1	0.892
LMO4	LHX2	0.855
ISL2	LHX2	0.838
LMX1B	LHX2	0.838
ISL1	LHX2	0.826
SSBP2	LHX2	0.803
LDB1	LHX2	0.791
LHX4	ISL1	0.778
LHX4	ISL2	0.773		structurally_consistent (dimer)
ISL1	LMO1	0.73
LHX1	LMO4	0.575
LHX4	LMX1B	0.569
LHX1	LHX2	0.465
IDI2	ISL2	0.402
LHX1	LMX1B	0.4
LHX1	ISL2	0.4
LHX4	LMO4	0.4		structurally_consistent (Q96A47)
SSBP2	LHX1	0.4
LDB1	LHX1	0.4
LHX4	LHX1	0.396
LHX1	ISL1	0.367
LHX1	LMO1	0.333
LHX4	LMO1	0.164
LHX4	LHX2	0.146
FAM107A	LHX4	0.113
FAM107A	ISL1	0.095
FAM107A	LDB1	0.076
FAM107A	SSBP4	0.076
FAM107A	SSBP2	0.076
FAM107A	ISL2	0.076
FAM107A	SSBP3	0.076
FAM107A	LMX1B	0.042

Related Complexes

Genename	Complexes
LDB1	huMAP3_02691.1 huMAP3_09723.1 huMAP3_13541.1
FAM107A	huMAP3_01733.1 huMAP3_04791.1 huMAP3_09723.1 huMAP3_11447.1 huMAP3_11518.1 huMAP3_11671.1 huMAP3_11722.1 huMAP3_12164.1 huMAP3_12217.1 huMAP3_13238.1 huMAP3_14279.1 huMAP3_14991.1
SSBP2	huMAP3_02691.1 huMAP3_09723.1 huMAP3_13541.1
LHX4	huMAP3_02691.1 huMAP3_09723.1 huMAP3_13541.1
LHX1	huMAP3_02691.1 huMAP3_09723.1 huMAP3_13541.1
LMO4	huMAP3_02691.1 huMAP3_09723.1 huMAP3_13541.1
LMX1B	huMAP3_02691.1 huMAP3_09723.1 huMAP3_13541.1
IDI2	huMAP3_02691.1 huMAP3_09723.1 huMAP3_13541.1
SSBP4	huMAP3_02691.1 huMAP3_09723.1 huMAP3_13541.1
ISL2	huMAP3_02691.1 huMAP3_09723.1 huMAP3_13541.1
LHX3	huMAP3_01557.1 huMAP3_02691.1 huMAP3_06128.1 huMAP3_09723.1 huMAP3_13541.1
LHX6	huMAP3_01166.1 huMAP3_01950.1 huMAP3_02691.1 huMAP3_05656.1 huMAP3_09723.1 huMAP3_09856.1
LMO3	huMAP3_01733.1 huMAP3_04791.1 huMAP3_09723.1 huMAP3_11722.1 huMAP3_13541.1 huMAP3_14094.1 huMAP3_14991.1
ISL1	huMAP3_02691.1 huMAP3_09723.1 huMAP3_13541.1
LHX2	huMAP3_02691.1 huMAP3_09723.1 huMAP3_13541.1
LHX9	huMAP3_02691.1 huMAP3_09723.1 huMAP3_13541.1
LMO1	huMAP3_02691.1 huMAP3_03114.1 huMAP3_09723.1 huMAP3_11722.1 huMAP3_13541.1 huMAP3_14006.1 huMAP3_14094.1
SSBP3	huMAP3_02691.1 huMAP3_09723.1 huMAP3_13541.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_09723.1

Complex Portal: CPX-16468