hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_09726.1

Complex Portal: CPX-18746

Confidence: Moderate High

Genename	Protein Name	Uniprot Annotation Score	Links
PRKCZ	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)	5	UniProt NCBI
PARD6G	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D)	5	UniProt NCBI
LLGL1	Lethal(2) giant larvae protein homolog 1 (LLGL) (DLG4) (Hugl-1) (Human homolog to the D-lgl gene protein)	5	UniProt NCBI
LLGL2	LLGL scribble cell polarity complex component 2 (HGL) (Lethal(2) giant larvae protein homolog 2)	5	UniProt NCBI
RGL1	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1)	4	UniProt NCBI
PARD3	Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha)	5	UniProt NCBI
ZNF3	Zinc finger protein 3 (Zinc finger protein HF.12) (Zinc finger protein HZF3.1) (Zinc finger protein KOX25)	5	UniProt NCBI
PRKCI	Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota)	5	UniProt NCBI
PTPN21	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1)	5	UniProt NCBI
PARD6B	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B)	5	UniProt NCBI
PARD6A	Partitioning defective 6 homolog alpha (PAR-6) (PAR-6 alpha) (PAR-6A) (PAR6C) (Tax interaction protein 40) (TIP-40)	5	UniProt NCBI
BEGAIN	Brain-enriched guanylate kinase-associated protein	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0120157	1.70843062971e-15	0.545454545455	PARD6A PARD3 PARD6G PARD6B PRKCZ PRKCI	PAR polarity complex
GO:0045197	7.78708912689e-15	0.727272727273	PARD3 LLGL1 PARD6A PARD6B PARD6G LLGL2 PRKCI PRKCZ	establishment or maintenance of epithelial cell apical/basal polarity
GO:0061245	1.52061640976e-14	0.727272727273	PARD3 LLGL1 PARD6A PARD6B PARD6G LLGL2 PRKCI PRKCZ	establishment or maintenance of bipolar cell polarity
GO:0035088	1.52061640976e-14	0.727272727273	PARD3 LLGL1 PARD6A PARD6B PARD6G LLGL2 PRKCI PRKCZ	establishment or maintenance of apical/basal cell polarity
KEGG:04530	4.48555818586e-13	0.727272727273	PARD3 LLGL1 PARD6A PARD6B PARD6G LLGL2 PRKCI PRKCZ	Tight junction
KEGG:04390	6.70361678139e-13	0.727272727273	PARD3 LLGL1 PARD6A PARD6B PARD6G LLGL2 PRKCI PRKCZ	Hippo signaling pathway
WP:WP5090	8.24696632009e-12	0.636363636364	PARD3 PARD6A PARD6G LLGL2 PRKCZ PARD6B PRKCI	Complement system in neuronal development and plasticity
REAC:R-HSA-420029	6.45070920371e-11	0.454545454545	PARD3 PARD6B PARD6G PARD6A PRKCI	Tight junction interactions
KEGG:05165	1.94722470723e-10	0.727272727273	PARD3 LLGL1 PARD6A PARD6B PARD6G LLGL2 PRKCI PRKCZ	Human papillomavirus infection
GO:0007163	1.12947164598e-09	0.727272727273	PARD3 LLGL1 PARD6A PARD6B PARD6G LLGL2 PRKCI PRKCZ	establishment or maintenance of cell polarity
CORUM:956	2.10621603952e-08	0.272727272727	PARD3 PARD6B PRKCI	PAR-3-PAR-6B-PRKCI complex
CORUM:959	2.10621603952e-08	0.272727272727	PRKCI LLGL1 PARD6B	LLGL1-PAR-6B-PRKCI complex
CORUM:955	2.10621603952e-08	0.272727272727	PRKCI LLGL2 PARD6B	LLGL2-PAR-6B-PRKCI complex
REAC:R-HSA-421270	2.59760249778e-08	0.454545454545	PARD3 PARD6B PARD6G PARD6A PRKCI	Cell-cell junction organization
KEGG:04015	4.40640883844e-08	0.545454545455	PARD6A PARD3 PARD6G PARD6B PRKCZ PRKCI	Rap1 signaling pathway
CORUM:7444	8.42140472852e-08	0.272727272727	PARD3 PARD6A PRKCI	HOOK2-PAR3-Par6alpha-PKCiota complex
CORUM:905	2.10448665621e-07	0.272727272727	PARD3 PARD6A PRKCI	KIF3A/B-PAR-3-aPKC-PAR-6 complex
GO:0070160	2.19828511676e-07	0.545454545455	PARD6A PARD3 PARD6G PARD6B PRKCZ PRKCI	tight junction
GO:0005911	2.49960880022e-07	0.727272727273	PARD3 LLGL1 PARD6A PARD6B PARD6G LLGL2 PRKCI PRKCZ	cell-cell junction
REAC:R-HSA-446728	2.94732951953e-07	0.454545454545	PARD3 PARD6B PARD6G PARD6A PRKCI	Cell junction organization
KEGG:04144	3.22103907307e-07	0.545454545455	PARD6A PARD3 PARD6G PARD6B PRKCZ PRKCI	Endocytosis
REAC:R-HSA-1500931	1.82452134465e-06	0.454545454545	PARD3 PARD6B PARD6G PARD6A PRKCI	Cell-Cell communication
KEGG:04360	2.72357950308e-06	0.454545454545	PRKCZ PARD6B PARD6G PARD6A PARD3	Axon guidance
GO:1902554	8.12227009488e-06	0.545454545455	PARD6A PARD3 PARD6G PARD6B PRKCZ PRKCI	serine/threonine protein kinase complex
GO:1902911	1.75230249588e-05	0.545454545455	PARD6A PARD3 PARD6G PARD6B PRKCZ PRKCI	protein kinase complex
REAC:R-HSA-2173791	3.7205851709e-05	0.272727272727	PRKCZ PARD6A PARD3	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
GO:0005938	5.7440277882e-05	0.545454545455	PARD3 LLGL1 PARD6A PARD6G LLGL2 PARD6B	cell cortex
GO:0070161	6.84576801172e-05	0.727272727273	PARD3 LLGL1 PARD6A PARD6B PARD6G LLGL2 PRKCI PRKCZ	anchoring junction
CORUM:831	0.000102551658964	0.181818181818	PARD3 PARD6A	PAR-6-PAR-3-VE-cadherin complex, endothelial
CORUM:847	0.000102551658964	0.181818181818	PARD3 PRKCI	RICH1-PAR3-aPKC polarity complex
CORUM:7300	0.000102551658964	0.181818181818	PRKCI PARD6A	PARD3B-PARD6A-PRKCI complex
CORUM:918	0.000102551658964	0.181818181818	PARD3 PARD6A	PAR3-PAR6-PALS1 complex
CORUM:5535	0.000102551658964	0.181818181818	PARD3 PARD6A	PLCB3-PARD3-PARD6A complex
CORUM:5534	0.000102551658964	0.181818181818	PARD3 PARD6A	PLCB1-PARD3-PARD6A complex
WP:WP5381	0.00026373584261	0.363636363636	PARD3 PARD6B LLGL1 PRKCI	Smith Magenis and Potocki Lupski syndrome copy number variation
GO:0030054	0.000279661714549	0.818181818182	PARD3 LLGL1 PARD6A PARD6B PARD6G LLGL2 PRKCI PRKCZ BEGAIN	cell junction
GO:0061695	0.000916859101547	0.545454545455	PARD6A PARD3 PARD6G PARD6B PRKCZ PRKCI	transferase complex, transferring phosphorus-containing groups
REAC:R-HSA-170834	0.00841445831967	0.272727272727	PRKCZ PARD6A PARD3	Signaling by TGF-beta Receptor Complex
REAC:R-HSA-9006936	0.0160674755621	0.272727272727	PRKCZ PARD6A PARD3	Signaling by TGFB family members
WP:WP5283	0.0280261977151	0.181818181818	PRKCZ PRKCI	Chronic hyperglycemia impairment of neuron function
GO:0000226	0.0285893467678	0.545454545455	PARD3 LLGL1 PARD6A PARD6G LLGL2 PARD6B	microtubule cytoskeleton organization
GO:0030010	0.0328160426431	0.363636363636	PRKCZ PARD3 LLGL1 LLGL2	establishment of cell polarity

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
PRKCI	PARD6B	1.0	0.106	structurally_consistent (dimer)
PARD6B	LLGL2	1.0	0.184
LLGL1	PARD6B	1.0	0.12
PRKCZ	PARD6B	1.0	0.168	structurally_consistent (dimer)
PRKCI	LLGL2	1.0	0.048
PARD6A	LLGL2	1.0
PRKCI	LLGL1	0.999	0.108
PARD6G	LLGL2	0.999
PRKCI	PRKCZ	0.999	0.336	mutually_exclusive (Q9BYG5)
PARD6A	PRKCZ	0.999		structurally_consistent (dimer)
PARD6G	PRKCZ	0.999		structurally_consistent (dimer)
PARD3	PARD6B	0.998	0.116
PARD6G	PARD6B	0.998
PRKCZ	LLGL2	0.998	0.124
LLGL1	LLGL2	0.997	0.0501219512195
PRKCZ	LLGL1	0.997	0.094	structurally_consistent (dimer)
PRKCI	PARD6G	0.995
PRKCZ	BEGAIN	0.993
PTPN21	PARD6B	0.991	0.158	mutually_exclusive (Q9NPB6)
PARD3	LLGL2	0.986	0.03
PARD3	PRKCI	0.983	0.068
ZNF3	LLGL1	0.978	0.082
ZNF3	PARD6B	0.962	0.096
PRKCI	PARD6A	0.959
PARD6A	PARD6B	0.957		structurally_consistent (dimer)
ZNF3	PRKCI	0.952	0.098
LLGL2	RGL1	0.951
PARD6A	BEGAIN	0.902
PARD3	PRKCZ	0.893	0.14
PARD6G	PARD6A	0.887		mutually_exclusive (Q05513)
PARD3	LLGL1	0.864	0.034
PARD6A	LLGL1	0.862		mutually_exclusive (Q05513)
PARD6G	LLGL1	0.815
PARD6G	BEGAIN	0.676
PARD6A	RGL1	0.572
PRKCZ	RGL1	0.502
BEGAIN	PARD6B	0.455
ZNF3	LLGL2	0.446	0.054
BEGAIN	LLGL2	0.401
PTPN21	PRKCZ	0.357	0.148
PARD3	PTPN21	0.357	0.062
PARD6G	RGL1	0.35
BEGAIN	LLGL1	0.349
PRKCI	BEGAIN	0.343
PARD6B	RGL1	0.333
PTPN21	PRKCI	0.324	0.104
PTPN21	LLGL1	0.217	0.056
PTPN21	LLGL2	0.215	0.09
ZNF3	PARD6A	0.192
PRKCI	RGL1	0.164
PARD3	PARD6G	0.07
PARD3	PARD6A	0.063
ZNF3	PARD6G	0.055
LLGL1	RGL1	0.052
PARD3	ZNF3	0.049	0.064
PTPN21	PARD6G	0.046
ZNF3	PRKCZ	0.013	0.158

Related Complexes

Genename	Complexes
PRKCZ	huMAP3_02982.1 huMAP3_05806.1 huMAP3_07433.1 huMAP3_08694.1 huMAP3_09726.1 huMAP3_10212.1 huMAP3_12987.1
PARD6G	huMAP3_01634.1 huMAP3_01836.1 huMAP3_03400.1 huMAP3_05806.1 huMAP3_07433.1 huMAP3_09726.1 huMAP3_10212.1 huMAP3_12987.1 huMAP3_14802.1
LLGL1	huMAP3_03400.1 huMAP3_05806.1 huMAP3_07433.1 huMAP3_09726.1 huMAP3_10212.1 huMAP3_12987.1
LLGL2	huMAP3_03500.1 huMAP3_05836.1 huMAP3_09726.1 huMAP3_10212.1 huMAP3_12987.1
RGL1	huMAP3_03500.1 huMAP3_09726.1 huMAP3_10212.1 huMAP3_11897.1 huMAP3_12987.1 huMAP3_14124.1
PARD3	huMAP3_00531.1 huMAP3_03400.1 huMAP3_05806.1 huMAP3_06269.1 huMAP3_07838.1 huMAP3_09641.1 huMAP3_09726.1 huMAP3_09810.1 huMAP3_10212.1 huMAP3_10898.1 huMAP3_12987.1 huMAP3_14118.1
ZNF3	huMAP3_01206.1 huMAP3_05806.1 huMAP3_07433.1 huMAP3_08235.1 huMAP3_09726.1 huMAP3_10212.1 huMAP3_12987.1
PRKCI	huMAP3_01206.1 huMAP3_05806.1 huMAP3_07433.1 huMAP3_08235.1 huMAP3_09726.1 huMAP3_10212.1 huMAP3_12987.1
PTPN21	huMAP3_00803.1 huMAP3_02230.1 huMAP3_03367.1 huMAP3_03400.1 huMAP3_05769.1 huMAP3_09726.1 huMAP3_09949.1 huMAP3_10212.1 huMAP3_10383.1 huMAP3_11656.1 huMAP3_12615.1 huMAP3_12987.1 huMAP3_13342.1
PARD6B	huMAP3_03400.1 huMAP3_05806.1 huMAP3_05836.1 huMAP3_07433.1 huMAP3_09726.1 huMAP3_10212.1 huMAP3_12987.1
PARD6A	huMAP3_02982.1 huMAP3_05806.1 huMAP3_07433.1 huMAP3_08235.1 huMAP3_09726.1 huMAP3_10212.1 huMAP3_12987.1
BEGAIN	huMAP3_02982.1 huMAP3_03502.1 huMAP3_04756.1 huMAP3_08345.1 huMAP3_08694.1 huMAP3_09726.1 huMAP3_10212.1 huMAP3_10798.1 huMAP3_12987.1 huMAP3_13335.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_09726.1

Complex Portal: CPX-18746