hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_09727.1
Complex Portal: CPX-21353
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DOC2A | Double C2-like domain-containing protein alpha (Doc2) (Doc2-alpha) | 5 | UniProt NCBI |
| TTC21B | Tetratricopeptide repeat protein 21B (TPR repeat protein 21B) (Intraflagellar transport 139 homolog) | 5 | UniProt NCBI |
| RPH3A | Rabphilin-3A (Exophilin-1) | 5 | UniProt NCBI |
| DOC2B | Double C2-like domain-containing protein beta (Doc2-beta) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0061669 | 7.68841921772e-06 | 0.75 | DOC2B DOC2A RPH3A | spontaneous neurotransmitter secretion |
| GO:0098814 | 4.61210427592e-05 | 0.75 | DOC2B DOC2A RPH3A | spontaneous synaptic transmission |
| GO:0017158 | 0.000591522022343 | 0.75 | DOC2B DOC2A RPH3A | regulation of calcium ion-dependent exocytosis |
| GO:0017156 | 0.0025122894873 | 0.75 | DOC2B DOC2A RPH3A | calcium-ion regulated exocytosis |
| GO:0098850 | 0.0028092043205 | 0.5 | DOC2A RPH3A | extrinsic component of synaptic vesicle membrane |
| GO:1903305 | 0.0183580179548 | 0.75 | DOC2B DOC2A RPH3A | regulation of regulated secretory pathway |
| GO:0007269 | 0.0378152735667 | 0.75 | DOC2B DOC2A RPH3A | neurotransmitter secretion |
| GO:0099643 | 0.0378152735667 | 0.75 | DOC2B DOC2A RPH3A | signal release from synapse |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| DOC2A | DOC2B | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RPH3A | DOC2B | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| DOC2A | TTC21B | 0.977 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| DOC2B | TTC21B | 0.961 |
structurally_consistent (Q14183)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| DOC2A | RPH3A | 0.078 | bioplex3_WMM WMM_only |
Related Complexes