hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09730.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PFKM | ATP-dependent 6-phosphofructokinase, muscle type (ATP-PFK) (PFK-M) (EC 2.7.1.11) (6-phosphofructokinase type A) (Phosphofructo-1-kinase isozyme A) (PFK-A) (Phosphohexokinase) | 5 | UniProt NCBI |
| NUBP2 | Cytosolic Fe-S cluster assembly factor NUBP2 (Nucleotide-binding protein 2) (NBP 2) | 5 | UniProt NCBI |
| IRAK1 | Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1) | 5 | UniProt NCBI |
| HK2 | Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Hexokinase-B) (Muscle form hexokinase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00052 | 0.000813386863776 | 0.5 | HK2 PFKM | Galactose metabolism |
| KEGG:00051 | 0.0014030052018 | 0.5 | HK2 PFKM | Fructose and mannose metabolism |
| WP:WP534 | 0.002190823719 | 0.5 | HK2 PFKM | Glycolysis and gluconeogenesis |
| KEGG:00010 | 0.00471711368352 | 0.5 | HK2 PFKM | Glycolysis / Gluconeogenesis |
| KEGG:05230 | 0.00551283411821 | 0.5 | HK2 PFKM | Central carbon metabolism in cancer |
| WP:WP4018 | 0.00703973989842 | 0.5 | HK2 PFKM | Clear cell renal cell carcinoma pathways |
| WP:WP5355 | 0.0092628309276 | 0.5 | HK2 PFKM | Metabolic Epileptic Disorders |
| KEGG:04066 | 0.0120599434394 | 0.5 | HK2 PFKM | HIF-1 signaling pathway |
| KEGG:01200 | 0.0133093129958 | 0.5 | HK2 PFKM | Carbon metabolism |
| REAC:R-HSA-70171 | 0.0212029570934 | 0.5 | HK2 PFKM | Glycolysis |
| REAC:R-HSA-70326 | 0.0313666733646 | 0.5 | HK2 PFKM | Glucose metabolism |
| CORUM:1944 | 0.049938562206 | 0.25 | IRAK1 | IRAK1-IRAK2 complex |
| CORUM:1945 | 0.049938562206 | 0.25 | IRAK1 | IRAK1-IRAK3 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NUBP2 | IRAK1 | 0.988 | 0.128 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM WMM_only |
| NUBP2 | PFKM | 0.963 | 0.12 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| NUBP2 | HK2 | 0.962 | 0.04 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| IRAK1 | HK2 | 0.956 | 0.076 | bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only |
| IRAK1 | PFKM | 0.672 | 0.124 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| HK2 | PFKM | 0.527 | 0.066 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only treiber_WMM |
Related Complexes