hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09736.1
Complex Portal: CPX-18767
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GPR137 | Integral membrane protein GPR137 (Transmembrane 7 superfamily member 1-like 1 protein) | 5 | UniProt NCBI |
| GOLM2 | Protein GOLM2 (Cancer susceptibility candidate gene 4 protein) (CASC4) (Golgi membrane protein 2) | 4 | UniProt NCBI |
| DPEP1 | Dipeptidase 1 (EC 3.4.13.19) (Beta-lactamase) (EC 3.5.2.6) (Dehydropeptidase-I) (Microsomal dipeptidase) (Renal dipeptidase) (hRDP) | 5 | UniProt NCBI |
| STEAP3 | Metalloreductase STEAP3 (EC 1.16.1.-) (Dudulin-2) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6) (hTSAP6) (pHyde) (hpHyde) | 5 | UniProt NCBI |
| GBA2 | Non-lysosomal glucosylceramidase (NLGase) (EC 3.2.1.45) (Beta-glucocerebrosidase 2) (Beta-glucosidase 2) (Bile acid beta-glucosidase GBA2) (Bile acid glucosyl transferase GBA2) (Cholesterol glucosyltransferase GBA2) (EC 2.4.1.-) (Cholesteryl-beta-glucosidase GBA2) (EC 3.2.1.-) (Glucosylceramidase 2) (Non-lysosomal cholesterol glycosyltransferase) (Non-lysosomal galactosylceramidase) (EC 3.2.1.46) (Non-lysosomal glycosylceramidase) | 5 | UniProt NCBI |
| CYB561 | Transmembrane ascorbate-dependent reductase CYB561 (EC 7.2.1.-) (Cytochrome b-561) (Cytochrome b561) | 5 | UniProt NCBI |
| TMEM258 | Transmembrane protein 258 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258) (Oligosaccharyl transferase subunit TMEM258) | 5 | UniProt NCBI |
| STEAP2 | Metalloreductase STEAP2 (EC 1.16.1.-) (Prostate cancer-associated protein 1) (Protein up-regulated in metastatic prostate cancer) (PUMPCn) (Six-transmembrane epithelial antigen of prostate 2) (SixTransMembrane protein of prostate 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-917977 | 0.0143201223364 | 0.285714285714 | STEAP2 STEAP3 | Transferrin endocytosis and recycling |
| WP:WP3286 | 0.0166893818359 | 0.285714285714 | STEAP2 STEAP3 | Copper homeostasis |
| GO:0000293 | 0.0294899169624 | 0.285714285714 | STEAP2 STEAP3 | ferric-chelate reductase activity |
| GO:0008823 | 0.0294899169624 | 0.285714285714 | STEAP2 STEAP3 | cupric reductase activity |
| GO:0052851 | 0.0294899169624 | 0.285714285714 | STEAP2 STEAP3 | ferric-chelate reductase (NADPH) activity |
| REAC:R-HSA-917937 | 0.0499595563988 | 0.285714285714 | STEAP2 STEAP3 | Iron uptake and transport |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| DPEP1 | CYB561 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| GBA2 | DPEP1 | 0.995 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| DPEP1 | GOLM2 | 0.994 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| GPR137 | DPEP1 | 0.992 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| TMEM258 | DPEP1 | 0.99 | 0.082 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| STEAP3 | DPEP1 | 0.984 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| STEAP2 | DPEP1 | 0.955 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| GBA2 | CYB561 | 0.717 | 0.12 | bioplex3_WMM WMM_only | |
| GBA2 | GOLM2 | 0.401 | 0.096 | bioplex3_WMM WMM_only | |
| CYB561 | GOLM2 | 0.388 | 0.052 | bioplex3_WMM WMM_only | |
| STEAP3 | STEAP2 | 0.282 | bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only | ||
| STEAP3 | GPR137 | 0.23 | bioplex_WMM bioplex3_WMM WMM_only | ||
| GBA2 | GPR137 | 0.214 | bioplex3_WMM WMM_only | ||
| GPR137 | CYB561 | 0.214 | bioplex3_WMM WMM_only | ||
| TMEM258 | GPR137 | 0.172 | bioplex_WMM bioplex3_WMM WMM_only | ||
| STEAP2 | GPR137 | 0.172 | bioplex_WMM bioplex3_WMM WMM_only | ||
| TMEM258 | STEAP2 | 0.164 | bioplex_WMM bioplex3_WMM WMM_only | ||
| TMEM258 | STEAP3 | 0.16 | 0.016 | bioplex_WMM bioplex3_WMM WMM_only | |
| GPR137 | GOLM2 | 0.106 | bioplex3_WMM WMM_only | ||
| STEAP3 | GOLM2 | 0.093 | 0.054 | bioplex3_WMM WMM_only | |
| GBA2 | TMEM258 | 0.055 | 0.046 | bioplex3_WMM WMM_only | |
| TMEM258 | CYB561 | 0.055 | 0.102 | bioplex3_WMM WMM_only | |
| STEAP2 | CYB561 | 0.046 | bioplex3_WMM WMM_only | ||
| GBA2 | STEAP2 | 0.046 | bioplex3_WMM WMM_only | ||
| STEAP3 | CYB561 | 0.042 | 0.05 | bioplex3_WMM WMM_only | |
| TMEM258 | GOLM2 | 0.042 | 0.032 | bioplex3_WMM WMM_only | |
| STEAP2 | GOLM2 | 0.042 | bioplex3_WMM WMM_only | ||
| GBA2 | STEAP3 | 0.021 | 0.074 | bioplex3_WMM gupta_WMM WMM_only |
Related Complexes