hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09739.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| H2BC26 | Histone H2B type 3-B (H2B type 12) (H2B-clustered histone 26) (H2B.U histone 1) | 5 | UniProt NCBI |
| CFDP1 | Craniofacial development protein 1 (Bucentaur) | 4 | UniProt NCBI |
| RBP1 | Retinol-binding protein 1 (Cellular retinol-binding protein) (CRBP) (Cellular retinol-binding protein I) (CRBP-I) | 5 | UniProt NCBI |
| LZTS3 | Leucine zipper putative tumor suppressor 3 (ProSAP-interacting protein 1) (ProSAPiP1) | 4 | UniProt NCBI |
| H2BC13 | Histone H2B type 1-L (Histone H2B.c) (H2B/c) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HPA:0500703 | 0.00297460874017 | 0.6 | H2BC26 CFDP1 H2BC13 | soft tissue 1; peripheral nerve[High] |
| HPA:0050013 | 0.00605918446772 | 0.6 | H2BC26 CFDP1 H2BC13 | breast; adipocytes[High] |
| REAC:R-HSA-171306 | 0.0117954816348 | 0.4 | H2BC26 H2BC13 | Packaging Of Telomere Ends |
| REAC:R-HSA-110330 | 0.0136499247655 | 0.4 | H2BC26 H2BC13 | Recognition and association of DNA glycosylase with site containing an affected purine |
| REAC:R-HSA-110331 | 0.0136499247655 | 0.4 | H2BC26 H2BC13 | Cleavage of the damaged purine |
| REAC:R-HSA-73927 | 0.0136499247655 | 0.4 | H2BC26 H2BC13 | Depurination |
| REAC:R-HSA-110328 | 0.0163316506439 | 0.4 | H2BC26 H2BC13 | Recognition and association of DNA glycosylase with site containing an affected pyrimidine |
| REAC:R-HSA-110329 | 0.0163316506439 | 0.4 | H2BC26 H2BC13 | Cleavage of the damaged pyrimidine |
| REAC:R-HSA-73928 | 0.0163316506439 | 0.4 | H2BC26 H2BC13 | Depyrimidination |
| REAC:R-HSA-73929 | 0.0170393864121 | 0.4 | H2BC26 H2BC13 | Base-Excision Repair, AP Site Formation |
| REAC:R-HSA-73728 | 0.0192520251047 | 0.4 | H2BC26 H2BC13 | RNA Polymerase I Promoter Opening |
| HPA:0010013 | 0.0195929727386 | 0.6 | H2BC26 CFDP1 H2BC13 | adipose tissue; adipocytes[High] |
| REAC:R-HSA-5334118 | 0.0200193611976 | 0.4 | H2BC26 H2BC13 | DNA methylation |
| REAC:R-HSA-5625886 | 0.0215986811086 | 0.4 | H2BC26 H2BC13 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
| REAC:R-HSA-9670095 | 0.0224106525753 | 0.4 | H2BC26 H2BC13 | Inhibition of DNA recombination at telomere |
| REAC:R-HSA-427359 | 0.0232374901507 | 0.4 | H2BC26 H2BC13 | SIRT1 negatively regulates rRNA expression |
| REAC:R-HSA-68616 | 0.0240791876622 | 0.4 | H2BC26 H2BC13 | Assembly of the ORC complex at the origin of replication |
| KEGG:05322 | 0.0258857078716 | 0.4 | H2BC26 H2BC13 | Systemic lupus erythematosus |
| REAC:R-HSA-2299718 | 0.0266933781073 | 0.4 | H2BC26 H2BC13 | Condensation of Prophase Chromosomes |
| REAC:R-HSA-9710421 | 0.0275944536635 | 0.4 | H2BC26 H2BC13 | Defective pyroptosis |
| REAC:R-HSA-212300 | 0.0275944536635 | 0.4 | H2BC26 H2BC13 | PRC2 methylates histones and DNA |
| REAC:R-HSA-774815 | 0.0275944536635 | 0.4 | H2BC26 H2BC13 | Nucleosome assembly |
| REAC:R-HSA-606279 | 0.0275944536635 | 0.4 | H2BC26 H2BC13 | Deposition of new CENPA-containing nucleosomes at the centromere |
| REAC:R-HSA-5693571 | 0.0275944536635 | 0.4 | H2BC26 H2BC13 | Nonhomologous End-Joining (NHEJ) |
| REAC:R-HSA-1221632 | 0.0285103583123 | 0.4 | H2BC26 H2BC13 | Meiotic synapsis |
| HPA:0510653 | 0.0290892096992 | 0.6 | H2BC26 CFDP1 H2BC13 | soft tissue 2; fibroblasts[High] |
| REAC:R-HSA-427389 | 0.0303866302294 | 0.4 | H2BC26 H2BC13 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression |
| REAC:R-HSA-2559586 | 0.0333121022189 | 0.4 | H2BC26 H2BC13 | DNA Damage/Telomere Stress Induced Senescence |
| REAC:R-HSA-5693565 | 0.0374197925333 | 0.4 | H2BC26 H2BC13 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks |
| REAC:R-HSA-9616222 | 0.0374197925333 | 0.4 | H2BC26 H2BC13 | Transcriptional regulation of granulopoiesis |
| REAC:R-HSA-5693606 | 0.0384836492499 | 0.4 | H2BC26 H2BC13 | DNA Double Strand Break Response |
| REAC:R-HSA-912446 | 0.0384836492499 | 0.4 | H2BC26 H2BC13 | Meiotic recombination |
| REAC:R-HSA-1912408 | 0.0428866281036 | 0.4 | H2BC26 H2BC13 | Pre-NOTCH Transcription and Translation |
| REAC:R-HSA-73884 | 0.0428866281036 | 0.4 | H2BC26 H2BC13 | Base Excision Repair |
| REAC:R-HSA-201722 | 0.0440242300692 | 0.4 | H2BC26 H2BC13 | Formation of the beta-catenin:TCF transactivating complex |
| REAC:R-HSA-5250924 | 0.0451765626421 | 0.4 | H2BC26 H2BC13 | B-WICH complex positively regulates rRNA expression |
| REAC:R-HSA-73772 | 0.0463436196778 | 0.4 | H2BC26 H2BC13 | RNA Polymerase I Promoter Escape |
| REAC:R-HSA-3214815 | 0.0475253950332 | 0.4 | H2BC26 H2BC13 | HDACs deacetylate histones |
| REAC:R-HSA-8936459 | 0.0475253950332 | 0.4 | H2BC26 H2BC13 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function |
| REAC:R-HSA-5625740 | 0.0487218825663 | 0.4 | H2BC26 H2BC13 | RHO GTPases activate PKNs |
| KEGG:05034 | 0.0491193697999 | 0.4 | H2BC26 H2BC13 | Alcoholism |
| KEGG:04613 | 0.0491193697999 | 0.4 | H2BC26 H2BC13 | Neutrophil extracellular trap formation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| H2BC26 | CFDP1 | 0.995 | 0.214820512821 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| LZTS3 | H2BC26 | 0.988 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| H2BC13 | H2BC26 | 0.971 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| H2BC26 | RBP1 | 0.951 | 0.092 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| H2BC13 | CFDP1 | 0.297 | bioplex_WMM bioplex3_WMM WMM_only | |
| RBP1 | CFDP1 | 0.076 | 0.024 | bioplex3_WMM WMM_only |
| H2BC13 | RBP1 | 0.076 | bioplex3_WMM WMM_only |
Related Complexes