hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_09742.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MFSD10 | Major facilitator superfamily domain-containing protein 10 (Tetracycline transporter-like protein) | 5 | UniProt NCBI |
| CYP2C9 | Cytochrome P450 2C9 (EC 1.14.14.1) ((R)-limonene 6-monooxygenase) (EC 1.14.14.53) ((S)-limonene 6-monooxygenase) (EC 1.14.14.51) ((S)-limonene 7-monooxygenase) (EC 1.14.14.52) (CYPIIC9) (Cholesterol 25-hydroxylase) (Cytochrome P-450MP) (Cytochrome P450 MP-4) (Cytochrome P450 MP-8) (Cytochrome P450 PB-1) (S-mephenytoin 4-hydroxylase) | 5 | UniProt NCBI |
| TOMM40 | Mitochondrial import receptor subunit TOM40 homolog (Protein Haymaker) (Translocase of outer membrane 40 kDa subunit homolog) (p38.5) | 5 | UniProt NCBI |
| CYP2C19 | Cytochrome P450 2C19 (EC 1.14.14.1) ((R)-limonene 6-monooxygenase) (EC 1.14.14.53) ((S)-limonene 6-monooxygenase) (EC 1.14.14.51) ((S)-limonene 7-monooxygenase) (EC 1.14.14.52) (CYPIIC17) (CYPIIC19) (Cytochrome P450-11A) (Cytochrome P450-254C) (Fenbendazole monooxygenase (4'-hydroxylating)) (EC 1.14.14.75) (Mephenytoin 4-hydroxylase) | 5 | UniProt NCBI |
| CYP2C18 | Cytochrome P450 2C18 (EC 1.14.14.1) (CYPIIC18) (Cytochrome P450-6b/29c) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP2491 | 1.53201365097e-05 | 0.5 | CYP2C18 CYP2C19 | Diclofenac metabolic pathway |
| REAC:R-HSA-211981 | 0.00214930898727 | 0.5 | CYP2C18 CYP2C19 | Xenobiotics |
| WP:WP43 | 0.002190823719 | 0.5 | CYP2C18 CYP2C19 | Oxidation by cytochrome P450 |
| KEGG:05204 | 0.0034402616107 | 0.5 | CYP2C18 CYP2C19 | Chemical carcinogenesis - DNA adducts |
| KEGG:04726 | 0.00867836513934 | 0.5 | CYP2C18 CYP2C19 | Serotonergic synapse |
| REAC:R-HSA-211897 | 0.0101102645678 | 0.5 | CYP2C18 CYP2C19 | Cytochrome P450 - arranged by substrate type |
| WP:WP702 | 0.0228199530946 | 0.5 | CYP2C18 CYP2C19 | Metapathway biotransformation Phase I and II |
| REAC:R-HSA-211945 | 0.0297941212351 | 0.5 | CYP2C18 CYP2C19 | Phase I - Functionalization of compounds |
| CORUM:3092 | 0.049938562206 | 0.25 | TOMM40 | APP-TOM40 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CYP2C9 | CYP2C18 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CYP2C9 | CYP2C19 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MFSD10 | CYP2C18 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CYP2C9 | TOMM40 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CYP2C19 | CYP2C18 | 0.985 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| CYP2C9 | MFSD10 | 0.902 | bioplex3_WMM WMM_only | |
| CYP2C19 | TOMM40 | 0.273 | bioplex_WMM bioplex3_WMM WMM_only | |
| CYP2C18 | TOMM40 | 0.243 | bioplex_WMM bioplex3_WMM WMM_only | |
| MFSD10 | TOMM40 | 0.003 | 0.05 | gupta_WMM WMM_only |
Related Complexes