hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09756.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PCGF1 | Polycomb group RING finger protein 1 (Nervous system Polycomb-1) (NSPc1) (RING finger protein 68) | 5 | UniProt NCBI |
| RNF2 | E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3) (Protein DinG) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING finger protein BAP-1) (RING-type E3 ubiquitin transferase RING2) | 5 | UniProt NCBI |
| ACTL8 | Actin-like protein 8 (Cancer/testis antigen 57) (CT57) | 3 | UniProt NCBI |
| BCOR | BCL-6 corepressor (BCoR) | 5 | UniProt NCBI |
| YAF2 | YY1-associated factor 2 | 5 | UniProt NCBI |
| RING1 | E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein) | 5 | UniProt NCBI |
| RYBP | RING1 and YY1-binding protein (Apoptin-associating protein 1) (APAP-1) (Death effector domain-associated factor) (DED-associated factor) (YY1 and E4TF1-associated factor 1) | 5 | UniProt NCBI |
| KDM2B | Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B) | 5 | UniProt NCBI |
| MORC4 | MORC family CW-type zinc finger protein 4 (Zinc finger CW-type coiled-coil domain protein 2) (Zinc finger CW-type domain protein 4) | 5 | UniProt NCBI |
| PCGF6 | Polycomb group RING finger protein 6 (Mel18 and Bmi1-like RING finger) (RING finger protein 134) | 5 | UniProt NCBI |
| PCGF3 | Polycomb group RING finger protein 3 (RING finger protein 3A) | 5 | UniProt NCBI |
| BCORL1 | BCL-6 corepressor-like protein 1 (BCoR-L1) (BCoR-like protein 1) | 5 | UniProt NCBI |
| FBRS | Probable fibrosin-1 | 2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03083 | 3.30661600008e-22 | 0.846153846154 | BCOR RING1 BCORL1 PCGF6 RYBP PCGF3 RNF2 PCGF1 FBRS KDM2B YAF2 | Polycomb repressive complex |
| CORUM:1178 | 4.98887114089e-17 | 0.461538461538 | BCOR RING1 RYBP PCGF1 KDM2B RNF2 | BCOR complex |
| GO:0031519 | 8.10020961894e-11 | 0.538461538462 | RING1 RYBP PCGF3 RNF2 PCGF1 KDM2B PCGF6 | PcG protein complex |
| CORUM:1194 | 1.04225209759e-08 | 0.307692307692 | PCGF6 RING1 RNF2 YAF2 | E2F-6 complex |
| REAC:R-HSA-8953750 | 1.73889898288e-08 | 0.384615384615 | PCGF6 RYBP RING1 RNF2 YAF2 | Transcriptional Regulation by E2F6 |
| GO:0000152 | 4.40994573663e-08 | 0.461538461538 | BCOR RING1 PCGF3 RNF2 PCGF1 PCGF6 | nuclear ubiquitin ligase complex |
| GO:0035102 | 5.03656711926e-08 | 0.384615384615 | PCGF6 RING1 PCGF1 PCGF3 RNF2 | PRC1 complex |
| WP:WP4553 | 1.55901209169e-06 | 0.307692307692 | BCOR KDM2B PCGF1 RNF2 | FBXL10 enhancement of MAP ERK signaling in diffuse large B cell lymphoma |
| REAC:R-HSA-8939243 | 5.9609772212e-06 | 0.307692307692 | RYBP RING1 RNF2 YAF2 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known |
| GO:0006338 | 1.57940436575e-05 | 0.615384615385 | BCOR RING1 PCGF6 RYBP PCGF3 PCGF1 KDM2B RNF2 | chromatin remodeling |
| GO:0006325 | 4.65968938697e-05 | 0.615384615385 | BCOR RING1 PCGF6 RYBP PCGF3 PCGF1 KDM2B RNF2 | chromatin organization |
| GO:0071824 | 0.000148816711032 | 0.615384615385 | BCOR RING1 PCGF6 RYBP PCGF3 PCGF1 KDM2B RNF2 | protein-DNA complex organization |
| CORUM:1462 | 0.000245952888523 | 0.153846153846 | RNF2 RING1 | hPRC1L complex |
| CORUM:116 | 0.00224666054346 | 0.153846153846 | RNF2 RING1 | Polycomb repressive complex 1 (PRC1, hPRC-H) |
| CORUM:115 | 0.00224666054346 | 0.153846153846 | RNF2 RING1 | Polycomb repressive complex 1 (PRC1, hPRC-H) |
| GO:0000151 | 0.00344313411413 | 0.461538461538 | BCOR RING1 PCGF3 RNF2 PCGF1 PCGF6 | ubiquitin ligase complex |
| GO:0045892 | 0.00719226778978 | 0.615384615385 | BCOR RING1 BCORL1 PCGF6 RNF2 PCGF1 KDM2B YAF2 | negative regulation of DNA-templated transcription |
| REAC:R-HSA-8878171 | 0.00744804005262 | 0.307692307692 | RYBP RING1 RNF2 YAF2 | Transcriptional regulation by RUNX1 |
| GO:1902679 | 0.00786271226784 | 0.615384615385 | BCOR RING1 BCORL1 PCGF6 RNF2 PCGF1 KDM2B YAF2 | negative regulation of RNA biosynthetic process |
| KEGG:04550 | 0.00831781661066 | 0.230769230769 | PCGF3 PCGF1 PCGF6 | Signaling pathways regulating pluripotency of stem cells |
| GO:0010605 | 0.0115071246191 | 0.769230769231 | BCOR RING1 BCORL1 PCGF6 RYBP PCGF3 RNF2 PCGF1 KDM2B YAF2 | negative regulation of macromolecule metabolic process |
| GO:0051253 | 0.01676780394 | 0.615384615385 | BCOR RING1 BCORL1 PCGF6 RNF2 PCGF1 KDM2B YAF2 | negative regulation of RNA metabolic process |
| REAC:R-HSA-4655427 | 0.0208176207539 | 0.153846153846 | RNF2 RING1 | SUMOylation of DNA methylation proteins |
| CORUM:929 | 0.0226529521934 | 0.153846153846 | RNF2 RING1 | CEN complex |
| GO:0009892 | 0.0243678820762 | 0.769230769231 | BCOR RING1 BCORL1 PCGF6 RYBP PCGF3 RNF2 PCGF1 KDM2B YAF2 | negative regulation of metabolic process |
| GO:0010558 | 0.0299144383524 | 0.692307692308 | BCOR RING1 BCORL1 PCGF6 PCGF3 RNF2 PCGF1 KDM2B YAF2 | negative regulation of macromolecule biosynthetic process |
| GO:0031327 | 0.03628935718 | 0.692307692308 | BCOR RING1 BCORL1 PCGF6 PCGF3 RNF2 PCGF1 KDM2B YAF2 | negative regulation of cellular biosynthetic process |
| GO:0045934 | 0.0363473892178 | 0.615384615385 | BCOR RING1 BCORL1 PCGF6 RNF2 PCGF1 KDM2B YAF2 | negative regulation of nucleobase-containing compound metabolic process |
| GO:0051172 | 0.0379520000504 | 0.692307692308 | BCOR RING1 BCORL1 PCGF6 RYBP RNF2 PCGF1 KDM2B YAF2 | negative regulation of nitrogen compound metabolic process |
| GO:0009890 | 0.0381644571375 | 0.692307692308 | BCOR RING1 BCORL1 PCGF6 PCGF3 RNF2 PCGF1 KDM2B YAF2 | negative regulation of biosynthetic process |
| GO:0140513 | 0.0478748528772 | 0.615384615385 | BCOR RING1 PCGF6 RYBP PCGF3 PCGF1 KDM2B RNF2 | nuclear protein-containing complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| YAF2 | RNF2 | 1.0 | 0.124 |
| RYBP | PCGF6 | 1.0 | 0.21 |
| RING1 | PCGF6 | 1.0 | 0.244 |
| RNF2 | PCGF6 | 1.0 | 0.064 |
| YAF2 | RING1 | 1.0 | 0.112 |
| RING1 | FBRS | 1.0 | 0.07 |
| YAF2 | PCGF6 | 1.0 | 0.11 |
| RING1 | PCGF1 | 1.0 | 0.104 |
| RYBP | RNF2 | 1.0 | 0.142 |
| YAF2 | FBRS | 1.0 | 0.19 |
| RYBP | FBRS | 1.0 | 0.118 |
| RYBP | RING1 | 1.0 | 0.146 |
| RYBP | PCGF3 | 1.0 | 0.124 |
| KDM2B | PCGF1 | 1.0 | 0.34 |
| YAF2 | PCGF3 | 0.999 | 0.12 |
| RNF2 | PCGF1 | 0.999 | 0.154 |
| BCOR | PCGF1 | 0.999 | 0.228 |
| RNF2 | FBRS | 0.999 | 0.1 |
| RYBP | PCGF1 | 0.999 | 0.096 |
| RYBP | BCOR | 0.999 | 0.148 |
| YAF2 | PCGF1 | 0.999 | 0.128 |
| YAF2 | RYBP | 0.999 | 0.078 |
| RING1 | PCGF3 | 0.998 | 0.08 |
| RNF2 | RING1 | 0.998 | 0.174 |
| KDM2B | RYBP | 0.998 | 0.108 |
| PCGF3 | FBRS | 0.998 | 0.144 |
| RNF2 | PCGF3 | 0.997 | 0.096 |
| BCORL1 | RING1 | 0.997 | 0.066 |
| YAF2 | BCOR | 0.996 | 0.158 |
| BCORL1 | PCGF1 | 0.996 | 0.18 |
| KDM2B | YAF2 | 0.995 | 0.126 |
| MORC4 | RYBP | 0.995 | 0.066 |
| BCORL1 | BCOR | 0.994 | 0.196 |
| FBRS | PCGF6 | 0.993 | 0.142 |
| KDM2B | BCOR | 0.993 | 0.254 |
| RNF2 | BCOR | 0.99 | 0.172 |
| PCGF3 | PCGF1 | 0.988 | 0.174 |
| BCORL1 | RYBP | 0.987 | 0.14 |
| BCORL1 | PCGF6 | 0.986 | 0.126 |
| KDM2B | RING1 | 0.985 | 0.142 |
| BCOR | PCGF6 | 0.982 | 0.172 |
| BCOR | RING1 | 0.982 | 0.166 |
| BCORL1 | YAF2 | 0.982 | 0.098 |
| PCGF1 | PCGF6 | 0.981 | 0.214 |
| KDM2B | RNF2 | 0.979 | 0.15 |
| KDM2B | BCORL1 | 0.967 | 0.18 |
| ACTL8 | PCGF1 | 0.966 | 0.078 |
| MORC4 | PCGF1 | 0.966 | 0.064 |
| FBRS | PCGF1 | 0.964 | 0.178 |
| BCORL1 | RNF2 | 0.952 | 0.11 |
| PCGF3 | PCGF6 | 0.945 | 0.136 |
| BCOR | FBRS | 0.941 | 0.194 |
| KDM2B | FBRS | 0.937 | 0.092 |
| YAF2 | MORC4 | 0.896 | 0.128 |
| ACTL8 | BCOR | 0.866 | 0.17 |
| ACTL8 | RING1 | 0.796 | 0.094 |
| YAF2 | ACTL8 | 0.781 | 0.078 |
| KDM2B | ACTL8 | 0.774 | 0.168 |
| BCORL1 | FBRS | 0.755 | 0.156 |
| KDM2B | MORC4 | 0.651 | 0.08 |
| MORC4 | RING1 | 0.612 | 0.056 |
| BCORL1 | MORC4 | 0.588 | 0.068 |
| KDM2B | PCGF6 | 0.577 | 0.162 |
| MORC4 | BCOR | 0.437 | 0.062 |
| MORC4 | RNF2 | 0.392 | 0.088 |
| MORC4 | FBRS | 0.35 | 0.074 |
| MORC4 | PCGF3 | 0.32 | 0.082 |
| KDM2B | PCGF3 | 0.291 | 0.13 |
| ACTL8 | RNF2 | 0.26 | 0.05 |
| BCOR | PCGF3 | 0.254 | 0.16 |
| MORC4 | PCGF6 | 0.216 | 0.14 |
| BCORL1 | PCGF3 | 0.209 | 0.14 |
| RYBP | ACTL8 | 0.196 | 0.12 |
| BCORL1 | ACTL8 | 0.149 | |
| ACTL8 | FBRS | 0.149 | 0.082 |
| ACTL8 | PCGF6 | 0.021 | 0.076 |
Related Complexes