hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_09760.1

Complex Portal: CPX-21317

Confidence: Moderate High

Genename	Protein Name	Uniprot Annotation Score	Links
GYG1	Glycogenin-1 (GN-1) (GN1) (EC 2.4.1.186)	5	UniProt NCBI
GYG2	Glycogenin-2 (GN-2) (GN2) (EC 2.4.1.186)	5	UniProt NCBI
PPP1R3B	Protein phosphatase 1 regulatory subunit 3B (Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL) (Protein phosphatase 1 regulatory subunit 4) (PP1 subunit R4) (Protein phosphatase 1 subunit GL) (PTG)	4	UniProt NCBI
PYGM	Glycogen phosphorylase, muscle form (EC 2.4.1.1) (Myophosphorylase)	5	UniProt NCBI
PPP1R3F	Protein phosphatase 1 regulatory subunit 3F (R3F)	5	UniProt NCBI
PPP1R3C	Protein phosphatase 1 regulatory subunit 3C (Protein phosphatase 1 regulatory subunit 5) (PP1 subunit R5) (Protein targeting to glycogen) (PTG)	5	UniProt NCBI
NANOS1	Nanos homolog 1 (NOS-1) (EC_Rep1a)	5	UniProt NCBI
STBD1	Starch-binding domain-containing protein 1 (Genethonin-1) (Glycophagy cargo receptor STBD1)	5	UniProt NCBI
GYS2	Glycogen [starch] synthase, liver (EC 2.4.1.11) (Glycogen synthase 2)	5	UniProt NCBI
GYS1	Glycogen [starch] synthase, muscle (EC 2.4.1.11) (Glycogen synthase 1)	5	UniProt NCBI
PYGB	Glycogen phosphorylase, brain form (EC 2.4.1.1)	5	UniProt NCBI
PYGL	Glycogen phosphorylase, liver form (EC 2.4.1.1)	5	UniProt NCBI
AGL	Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC 2.4.1.25) (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC 3.2.1.33) (Dextrin 6-alpha-D-glucosidase)]	5	UniProt NCBI
GBE1	1,4-alpha-glucan-branching enzyme (EC 2.4.1.18) (Brancher enzyme) (Glycogen-branching enzyme)	5	UniProt NCBI
PPP1R3D	Protein phosphatase 1 regulatory subunit 3D (Protein phosphatase 1 regulatory subunit 6) (PP1 subunit R6) (Protein phosphatase 1-binding subunit R6)	4	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0005977	3.74729960963e-23	0.916666666667	PPP1R3C GYG1 GBE1 PPP1R3B GYG2 AGL PPP1R3F PPP1R3D PYGL STBD1 GYS2	glycogen metabolic process
GO:0044042	3.74729960963e-23	0.916666666667	PPP1R3C GYG1 GBE1 PPP1R3B GYG2 AGL PPP1R3F PPP1R3D PYGL STBD1 GYS2	glucan metabolic process
GO:0006112	2.22894503304e-22	0.916666666667	PPP1R3C GYG1 GBE1 PPP1R3B GYG2 AGL PPP1R3F PPP1R3D PYGL STBD1 GYS2	energy reserve metabolic process
GO:0005976	1.54192646189e-21	0.916666666667	PPP1R3C GYG1 GBE1 PPP1R3B GYG2 AGL PPP1R3F PPP1R3D PYGL STBD1 GYS2	polysaccharide metabolic process
REAC:R-HSA-8982491	2.62624002277e-15	0.583333333333	PPP1R3C PYGL GBE1 AGL GYG2 GYS2 GYG1	Glycogen metabolism
GO:0015980	4.82725031379e-15	0.916666666667	PPP1R3C GYG1 GBE1 PPP1R3B GYG2 AGL PPP1R3F PPP1R3D PYGL STBD1 GYS2	energy derivation by oxidation of organic compounds
GO:0005978	5.02277539725e-15	0.666666666667	PPP1R3C GYG1 GBE1 PPP1R3B GYG2 GYS2 PPP1R3D PPP1R3F	glycogen biosynthetic process
GO:0009250	5.02277539725e-15	0.666666666667	PPP1R3C GYG1 GBE1 PPP1R3B GYG2 GYS2 PPP1R3D PPP1R3F	glucan biosynthetic process
GO:0000271	1.49613703603e-13	0.666666666667	PPP1R3C GYG1 GBE1 PPP1R3B GYG2 GYS2 PPP1R3D PPP1R3F	polysaccharide biosynthetic process
GO:0005975	2.0018135111e-13	0.916666666667	PPP1R3C GYG1 GBE1 PPP1R3B GYG2 AGL PPP1R3F PPP1R3D PYGL STBD1 GYS2	carbohydrate metabolic process
GO:0006091	4.74174079421e-13	0.916666666667	PPP1R3C GYG1 GBE1 PPP1R3B GYG2 AGL PPP1R3F PPP1R3D PYGL STBD1 GYS2	generation of precursor metabolites and energy
KEGG:00500	6.24833217471e-13	0.5	GBE1 PYGL AGL GYG2 GYS2 GYG1	Starch and sucrose metabolism
WP:WP500	1.83578634975e-11	0.5	GBE1 PYGL AGL GYG2 GYS2 GYG1	Glycogen synthesis and degradation
WP:WP5173	2.13760071607e-11	0.416666666667	GYS2 GBE1 PYGL GYG1 GYG2	Disorders of galactose metabolism
GO:2001069	4.27717811223e-11	0.416666666667	PPP1R3B PPP1R3D PPP1R3F STBD1 PPP1R3C	glycogen binding
REAC:R-HSA-3322077	7.73151419505e-11	0.416666666667	GYS2 PPP1R3C GBE1 GYG1 GYG2	Glycogen synthesis
REAC:R-HSA-3229121	7.73151419505e-11	0.416666666667	GYS2 PPP1R3C GBE1 GYG1 GYG2	Glycogen storage diseases
GO:0016051	6.66885821131e-10	0.666666666667	PPP1R3C GYG1 GBE1 PPP1R3B GYG2 GYS2 PPP1R3D PPP1R3F	carbohydrate biosynthetic process
GO:0030247	3.28685663218e-09	0.416666666667	PPP1R3B PPP1R3D PPP1R3F STBD1 PPP1R3C	polysaccharide binding
REAC:R-HSA-5663084	5.46835252108e-09	0.416666666667	GYS2 PPP1R3C GBE1 GYG1 GYG2	Diseases of carbohydrate metabolism
KEGG:04910	1.67673786685e-08	0.5	PPP1R3C PYGL PPP1R3B PPP1R3F GYS2 PPP1R3D	Insulin signaling pathway
REAC:R-HSA-70221	5.04132808075e-08	0.333333333333	AGL PYGL GYG1 GYG2	Glycogen breakdown (glycogenolysis)
REAC:R-HSA-71387	9.31192110921e-08	0.583333333333	PPP1R3C PYGL GBE1 AGL GYG2 GYS2 GYG1	Metabolism of carbohydrates
REAC:R-HSA-3878781	1.1492613607e-07	0.25	GBE1 GYG2 GYS2	Glycogen storage disease type IV (GBE1)
KEGG:04931	4.85041715068e-07	0.416666666667	PPP1R3B PYGL PPP1R3D GYS2 PPP1R3C	Insulin resistance
GO:0030246	1.35119105722e-06	0.5	PPP1R3C PYGL PPP1R3B PPP1R3D STBD1 PPP1R3F	carbohydrate binding
GO:0005980	1.6375274005e-06	0.333333333333	AGL PPP1R3B STBD1 PYGL	glycogen catabolic process
GO:0009251	1.6375274005e-06	0.333333333333	AGL PPP1R3B STBD1 PYGL	glucan catabolic process
GO:0000272	1.6375274005e-06	0.333333333333	AGL PPP1R3B STBD1 PYGL	polysaccharide catabolic process
WP:WP4861	2.73759922944e-06	0.333333333333	PPP1R3B PPP1R3D PPP1R3F PPP1R3C	Endoplasmic reticulum stress response in coronavirus infection
GO:0008157	1.76932944819e-05	0.333333333333	PPP1R3B PPP1R3D PPP1R3F PPP1R3C	protein phosphatase 1 binding
GO:0000164	2.35807214014e-05	0.333333333333	PPP1R3B PPP1R3D PPP1R3F PPP1R3C	protein phosphatase type 1 complex
GO:0016758	6.11681347493e-05	0.5	GBE1 PYGL AGL GYG2 GYS2 GYG1	hexosyltransferase activity
REAC:R-HSA-5668914	6.50541413997e-05	0.416666666667	GYS2 PPP1R3C GBE1 GYG1 GYG2	Diseases of metabolism
GO:0005979	9.45274067568e-05	0.333333333333	PPP1R3B PPP1R3D PPP1R3F PPP1R3C	regulation of glycogen biosynthetic process
GO:0010962	9.45274067568e-05	0.333333333333	PPP1R3B PPP1R3D PPP1R3F PPP1R3C	regulation of glucan biosynthetic process
REAC:R-HSA-3858516	0.000167941562639	0.166666666667	GYG2 GYS2	Glycogen storage disease type 0 (liver GYS2)
GO:0032885	0.000192851461451	0.333333333333	PPP1R3B PPP1R3D PPP1R3F PPP1R3C	regulation of polysaccharide biosynthetic process
GO:0070873	0.000192851461451	0.333333333333	PPP1R3B PPP1R3D PPP1R3F PPP1R3C	regulation of glycogen metabolic process
GO:0032881	0.000352898456196	0.333333333333	PPP1R3B PPP1R3D PPP1R3F PPP1R3C	regulation of polysaccharide metabolic process
GO:0016757	0.000405723073008	0.5	GBE1 PYGL AGL GYG2 GYS2 GYG1	glycosyltransferase activity
GO:0008287	0.00293970107719	0.333333333333	PPP1R3B PPP1R3D PPP1R3F PPP1R3C	protein serine/threonine phosphatase complex
GO:1903293	0.00293970107719	0.333333333333	PPP1R3B PPP1R3D PPP1R3F PPP1R3C	phosphatase complex
GO:0035251	0.00347628273893	0.25	GYS2 GYG1 GYG2	UDP-glucosyltransferase activity
GO:0043255	0.00502669894203	0.333333333333	PPP1R3B PPP1R3D PPP1R3F PPP1R3C	regulation of carbohydrate biosynthetic process
REAC:R-HSA-3785653	0.00602661540197	0.166666666667	PPP1R3C GYG1	Myoclonic epilepsy of Lafora
WP:000000	0.00700904569998	1.0	PPP1R3C GYG1 GBE1 GYS2 PPP1R3B GYG2 AGL PPP1R3F PPP1R3D PYGL STBD1 NANOS1	WIKIPATHWAYS
KEGG:01100	0.0145002901226	0.5	GBE1 PYGL AGL GYG2 GYS2 GYG1	Metabolic pathways
GO:0046527	0.0171362685288	0.25	GYS2 GYG1 GYG2	glucosyltransferase activity
HPA:0290402	0.0261007380827	0.75	GBE1 GYG1 PPP1R3B PPP1R3F AGL GYS2 PYGL STBD1 NANOS1	liver; hepatocytes[>=Medium]
GO:0008466	0.0309012475255	0.166666666667	GYG1 GYG2	glycogenin glucosyltransferase activity
GO:0043467	0.0433237077809	0.333333333333	PPP1R3B PPP1R3D PPP1R3F PPP1R3C	regulation of generation of precursor metabolites and energy
REAC:R-HSA-1430728	0.047023980482	0.583333333333	PPP1R3C PYGL GBE1 AGL GYG2 GYS2 GYG1	Metabolism

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
STBD1	GYS1	1.0	0.2
STBD1	GYG1	1.0	0.148
STBD1	AGL	1.0	0.216
STBD1	PYGB	0.999	0.185
GYG2	GYG1	0.999		mutually_exclusive (P13807)
GYG2	GYS1	0.999		structurally_consistent (dimer)
PYGB	GYG1	0.999	0.116
PPP1R3B	GYG1	0.999
PPP1R3B	AGL	0.999
PYGB	PYGM	0.998	0.166
PYGB	GYS1	0.998	0.14
PYGB	PYGL	0.998	0.366
PPP1R3B	PPP1R3D	0.998
PPP1R3B	GYS1	0.997
GYG2	STBD1	0.996
PPP1R3B	PYGB	0.996
GYG2	AGL	0.995
STBD1	GYS2	0.994
PPP1R3C	STBD1	0.994
STBD1	PPP1R3D	0.992	0.112
STBD1	PYGM	0.991	0.178
PPP1R3F	STBD1	0.99	0.104
STBD1	PYGL	0.988	0.228
NANOS1	STBD1	0.988
GYG2	GYS2	0.987
PPP1R3B	STBD1	0.986
GYG2	PPP1R3F	0.981
PPP1R3D	GYG1	0.98	0.052
GYS1	GBE1	0.978	0.098	structurally_consistent (dimer)
GYG1	GBE1	0.978	0.048	structurally_consistent (P13807)
PPP1R3D	GYS1	0.977	0.044
PPP1R3C	PPP1R3D	0.973
PPP1R3C	AGL	0.97
AGL	GYS1	0.969	0.126
GYG1	GYS1	0.962	0.044	structurally_consistent (dimer)
GYS2	PYGB	0.957
PPP1R3C	GYS1	0.956		structurally_consistent (dimer)
PPP1R3F	GYS1	0.95	0.06
PPP1R3B	GYS2	0.949
GYG2	PYGB	0.948
PPP1R3C	GYG1	0.947		mutually_exclusive (P13807)
PYGL	GYS1	0.941	0.146
PPP1R3F	GYG1	0.939	0.042
AGL	GBE1	0.933	0.106
PPP1R3F	PPP1R3D	0.925	0.14
PYGB	PPP1R3D	0.909	0.082
AGL	GYG1	0.903	0.068
PYGB	AGL	0.898	0.206
PPP1R3B	PPP1R3F	0.894
GYS2	AGL	0.893
GYS2	GYS1	0.893
AGL	PPP1R3D	0.871	0.078
GYS2	GYG1	0.866
GYS2	PPP1R3D	0.866
PPP1R3F	PYGB	0.865	0.07
GYG1	PYGM	0.859	0.024
PYGL	PYGM	0.846	0.368
PPP1R3F	AGL	0.812	0.05
GYS1	PYGM	0.811	0.126
PPP1R3B	PYGM	0.771
PPP1R3F	GYS2	0.745
PPP1R3B	PYGL	0.729
AGL	PYGM	0.723	0.056
PPP1R3D	PYGM	0.633	0.076
PYGL	GYG1	0.585	0.046
PPP1R3F	PYGL	0.569	0.03
PYGL	PPP1R3D	0.515	0.044
PPP1R3F	PYGM	0.499	0.026
NANOS1	GYG1	0.41
GYS2	PYGM	0.373
PPP1R3C	GYS2	0.268
GYG2	PPP1R3D	0.263
STBD1	GBE1	0.257	0.19
NANOS1	GYS1	0.252
NANOS1	GYS2	0.241
GYS2	PYGL	0.215
NANOS1	AGL	0.215
PYGL	AGL	0.172	0.054
NANOS1	PPP1R3D	0.172
NANOS1	GYG2	0.172
GYG2	PYGM	0.158
NANOS1	PPP1R3F	0.146
NANOS1	PPP1R3B	0.146
PPP1R3B	GYG2	0.133
NANOS1	PYGM	0.123
NANOS1	PYGB	0.119
GYS2	GBE1	0.075
GYG2	PYGL	0.064
NANOS1	PYGL	0.045
PYGL	GBE1	0.023	0.092
PYGB	GBE1	0.009	0.232
GBE1	PYGM	0.005	0.128
PPP1R3C	PYGL	0.005
GYG2	GBE1	0.004		structurally_consistent (P13807)
PPP1R3B	GBE1	0.002

Related Complexes

Genename	Complexes
GYG1	huMAP3_01734.1 huMAP3_06806.1 huMAP3_08342.1 huMAP3_08505.1 huMAP3_09760.1 huMAP3_10227.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_13075.1
GYG2	huMAP3_01396.1 huMAP3_06909.1 huMAP3_08013.1 huMAP3_08093.1 huMAP3_09760.1 huMAP3_10227.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_13075.1
PPP1R3B	huMAP3_01396.1 huMAP3_06806.1 huMAP3_08093.1 huMAP3_08342.1 huMAP3_09760.1 huMAP3_10227.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_13075.1
PYGM	huMAP3_02460.1 huMAP3_07933.1 huMAP3_08093.1 huMAP3_09076.1 huMAP3_09760.1 huMAP3_10799.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_14138.1
PPP1R3F	huMAP3_01396.1 huMAP3_06909.1 huMAP3_08013.1 huMAP3_08093.1 huMAP3_09760.1 huMAP3_10227.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_13075.1
PPP1R3C	huMAP3_01396.1 huMAP3_06909.1 huMAP3_08013.1 huMAP3_08093.1 huMAP3_09760.1 huMAP3_10227.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_13075.1
NANOS1	huMAP3_00933.1 huMAP3_06513.1 huMAP3_06662.1 huMAP3_08093.1 huMAP3_09760.1 huMAP3_10924.1 huMAP3_11777.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_13239.1 huMAP3_13970.1 huMAP3_14335.1 huMAP3_15138.1
STBD1	huMAP3_01396.1 huMAP3_06909.1 huMAP3_08013.1 huMAP3_08093.1 huMAP3_09760.1 huMAP3_10227.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_13075.1
GYS2	huMAP3_01396.1 huMAP3_06909.1 huMAP3_08013.1 huMAP3_08093.1 huMAP3_09760.1 huMAP3_10227.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_13075.1
GYS1	huMAP3_01734.1 huMAP3_06806.1 huMAP3_08342.1 huMAP3_08505.1 huMAP3_09760.1 huMAP3_10227.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_13075.1
PYGB	huMAP3_01396.1 huMAP3_06909.1 huMAP3_08013.1 huMAP3_08093.1 huMAP3_09760.1 huMAP3_10227.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_13075.1
PYGL	huMAP3_01396.1 huMAP3_06909.1 huMAP3_07415.1 huMAP3_08013.1 huMAP3_08093.1 huMAP3_09760.1 huMAP3_10227.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_13075.1
AGL	huMAP3_01396.1 huMAP3_06909.1 huMAP3_08013.1 huMAP3_08093.1 huMAP3_09760.1 huMAP3_10227.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_13075.1
GBE1	huMAP3_01734.1 huMAP3_03670.1 huMAP3_06806.1 huMAP3_08342.1 huMAP3_08505.1 huMAP3_09760.1 huMAP3_10227.1 huMAP3_11694.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_12971.1 huMAP3_13075.1 huMAP3_14066.1 huMAP3_14742.1
PPP1R3D	huMAP3_01396.1 huMAP3_06909.1 huMAP3_08093.1 huMAP3_08342.1 huMAP3_09760.1 huMAP3_10227.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_13075.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_09760.1

Complex Portal: CPX-21317