hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_09762.1
Confidence: Moderate High  
ProteinsGenename | Protein Name | Uniprot Annotation Score | Links |
---|---|---|---|
GPC5 | Glypican-5 [Cleaved into: Secreted glypican-5] | 5 | UniProt   NCBI |
HSPG2 | Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) (Perlecan) (PLC) [Cleaved into: Endorepellin; LG3 peptide] | 5 | UniProt   NCBI |
Enrichments
Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
---|---|---|---|---|
  REAC:R-HSA-3656253 | 0.000155497319444 | 1.0 | HSPG2 GPC5 | Defective EXT1 causes exostoses 1, TRPS2 and CHDS |
  REAC:R-HSA-3656237 | 0.000155497319444 | 1.0 | HSPG2 GPC5 | Defective EXT2 causes exostoses 2 |
  REAC:R-HSA-9694614 | 0.00023239159829 | 1.0 | HSPG2 GPC5 | Attachment and Entry |
  REAC:R-HSA-4420332 | 0.000261440548076 | 1.0 | HSPG2 GPC5 | Defective B3GALT6 causes EDSP2 and SEMDJL1 |
  REAC:R-HSA-3560801 | 0.000261440548076 | 1.0 | HSPG2 GPC5 | Defective B3GAT3 causes JDSSDHD |
  REAC:R-HSA-3560783 | 0.000261440548076 | 1.0 | HSPG2 GPC5 | Defective B4GALT7 causes EDS, progeroid type |
  REAC:R-HSA-2024096 | 0.000394723964742 | 1.0 | HSPG2 GPC5 | HS-GAG degradation |
  REAC:R-HSA-1971475 | 0.000471618243588 | 1.0 | HSPG2 GPC5 | A tetrasaccharide linker sequence is required for GAG synthesis |
  REAC:R-HSA-2022928 | 0.000645911942305 | 1.0 | HSPG2 GPC5 | HS-GAG biosynthesis |
  REAC:R-HSA-9772572 | 0.000902226205124 | 1.0 | HSPG2 GPC5 | Early SARS-CoV-2 Infection Events |
  REAC:R-HSA-3560782 | 0.00120125951175 | 1.0 | HSPG2 GPC5 | Diseases associated with glycosaminoglycan metabolism |
  REAC:R-HSA-975634 | 0.00133283416666 | 1.0 | HSPG2 GPC5 | Retinoid metabolism and transport |
  REAC:R-HSA-6806667 | 0.00154301186217 | 1.0 | HSPG2 GPC5 | Metabolism of fat-soluble vitamins |
  REAC:R-HSA-1793185 | 0.00176856841345 | 1.0 | HSPG2 GPC5 | Chondroitin sulfate/dermatan sulfate metabolism |
  REAC:R-HSA-1638091 | 0.00209323314636 | 1.0 | HSPG2 GPC5 | Heparan sulfate/heparin (HS-GAG) metabolism |
  REAC:R-HSA-2187338 | 0.00513141154164 | 1.0 | HSPG2 GPC5 | Visual phototransduction |
  REAC:R-HSA-1630316 | 0.010244026704 | 1.0 | HSPG2 GPC5 | Glycosaminoglycan metabolism |
  REAC:R-HSA-3781865 | 0.0106216630512 | 1.0 | HSPG2 GPC5 | Diseases of glycosylation |
  REAC:R-HSA-196854 | 0.0209254964166 | 1.0 | HSPG2 GPC5 | Metabolism of vitamins and cofactors |
  REAC:R-HSA-5668914 | 0.0297170756313 | 1.0 | HSPG2 GPC5 | Diseases of metabolism |
  REAC:R-HSA-9709957 | 0.0367862229998 | 1.0 | HSPG2 GPC5 | Sensory Perception |
  HP:0032548 | 0.0499436884913 | 0.5 | HSPG2 | Increased placental thickness |
  HP:0006473 | 0.0499436884913 | 0.5 | HSPG2 | Anterior bowing of long bones |
  HP:0100795 | 0.0499436884913 | 0.5 | HSPG2 | Abnormally straight spine |
Edges
Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
---|---|---|---|---|
 GPC5 |  HSPG2 | 0.988 |            | bioplex3_WMM     bioplex3_HCT116     WMM_only     |
Related Complexes
Genename | Complexes |
---|---|
GPC5 | huMAP3_01093.1 huMAP3_06389.1 huMAP3_09762.1 huMAP3_10863.1 huMAP3_13757.1 |
HSPG2 | huMAP3_09762.1 huMAP3_10863.1 huMAP3_11707.1 |