hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_09779.1

Complex Portal: CPX-12010

Confidence: Moderate High

Genename	Protein Name	Uniprot Annotation Score	Links
COPS5	COP9 signalosome complex subunit 5 (SGN5) (Signalosome subunit 5) (EC 3.4.-.-) (Jun activation domain-binding protein 1)	5	UniProt NCBI
COPS7B	COP9 signalosome complex subunit 7b (SGN7b) (Signalosome subunit 7b) (JAB1-containing signalosome subunit 7b)	5	UniProt NCBI
RBX1	E3 ubiquitin-protein ligase RBX1 (EC 2.3.2.27) (EC 2.3.2.32) (E3 ubiquitin-protein transferase RBX1) (Protein ZYP) (RING finger protein 75) (RING-box protein 1) (Rbx1) (Regulator of cullins 1) (ROC1) [Cleaved into: E3 ubiquitin-protein ligase RBX1, N-terminally processed (E3 ubiquitin-protein transferase RBX1, N-terminally processed)]	5	UniProt NCBI
KLHL13	Kelch-like protein 13 (BTB and kelch domain-containing protein 2)	5	UniProt NCBI
COPS7A	COP9 signalosome complex subunit 7a (SGN7a) (Signalosome subunit 7a) (Dermal papilla-derived protein 10) (JAB1-containing signalosome subunit 7a)	5	UniProt NCBI
LRR1	Leucine-rich repeat protein 1 (4-1BB-mediated-signaling molecule) (4-1BBlrr) (LRR-repeat protein 1) (LRR-1) (Peptidylprolyl isomerase-like 5)	5	UniProt NCBI
GPS1	COP9 signalosome complex subunit 1 (SGN1) (Signalosome subunit 1) (G protein pathway suppressor 1) (GPS-1) (JAB1-containing signalosome subunit 1) (Protein MFH)	5	UniProt NCBI
COPS6	COP9 signalosome complex subunit 6 (SGN6) (Signalosome subunit 6) (JAB1-containing signalosome subunit 6) (MOV34 homolog) (Vpr-interacting protein) (hVIP)	5	UniProt NCBI
DCAF4	DDB1- and CUL4-associated factor 4 (WD repeat-containing protein 21A)	5	UniProt NCBI
BTBD2	BTB/POZ domain-containing protein 2	5	UniProt NCBI
DDA1	DET1- and DDB1-associated protein 1 (Placenta cross-immune reaction antigen 1) (PCIA-1)	5	UniProt NCBI
CRBN	Protein cereblon	5	UniProt NCBI
COPS8	COP9 signalosome complex subunit 8 (SGN8) (Signalosome subunit 8) (COP9 homolog) (hCOP9) (JAB1-containing signalosome subunit 8)	5	UniProt NCBI
KLHDC3	Kelch domain-containing protein 3 (Testis intracellular mediator protein)	5	UniProt NCBI
CUL2	Cullin-2 (CUL-2)	5	UniProt NCBI
FEM1C	Protein fem-1 homolog C (FEM1c) (FEM1-gamma)	5	UniProt NCBI
NEDD8	NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8) (Ubiquitin-like protein Nedd8)	5	UniProt NCBI
COPS3	COP9 signalosome complex subunit 3 (SGN3) (Signalosome subunit 3) (JAB1-containing signalosome subunit 3)	5	UniProt NCBI
DDB2	DNA damage-binding protein 2 (DDB p48 subunit) (DDBb) (Damage-specific DNA-binding protein 2) (UV-damaged DNA-binding protein 2) (UV-DDB 2)	5	UniProt NCBI
FEM1B	Protein fem-1 homolog B (FEM1b) (FEM1-beta) (Fem-1-like death receptor-binding protein alpha) (Fem-1-like in apoptotic pathway protein alpha) (F1A-alpha)	5	UniProt NCBI
CUL3	Cullin-3 (CUL-3)	5	UniProt NCBI
COPS4	COP9 signalosome complex subunit 4 (SGN4) (Signalosome subunit 4) (JAB1-containing signalosome subunit 4)	5	UniProt NCBI
DCAF1	DDB1- and CUL4-associated factor 1 (HIV-1 Vpr-binding protein) (VprBP) (Serine/threonine-protein kinase VPRBP) (EC 2.7.11.1) (Vpr-interacting protein)	5	UniProt NCBI
DCAF8L2	DDB1- and CUL4-associated factor 8-like protein 2 (WD repeat-containing protein 42C)	2	UniProt NCBI
DCAF16	DDB1- and CUL4-associated factor 16	4	UniProt NCBI
DCAF6	DDB1- and CUL4-associated factor 6 (Androgen receptor complex-associated protein) (ARCAP) (IQ motif and WD repeat-containing protein 1) (Nuclear receptor interaction protein) (NRIP)	5	UniProt NCBI
APPBP2	Amyloid protein-binding protein 2 (Amyloid beta precursor protein-binding protein 2) (APP-BP2) (Protein interacting with APP tail 1)	5	UniProt NCBI
ERCC8	DNA excision repair protein ERCC-8 (Cockayne syndrome WD repeat protein CSA)	5	UniProt NCBI
ANKRD39	Ankyrin repeat domain-containing protein 39	2	UniProt NCBI
CUL4B	Cullin-4B (CUL-4B)	5	UniProt NCBI
DDB1	DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe)	5	UniProt NCBI
BRWD3	Bromodomain and WD repeat-containing protein 3	5	UniProt NCBI
BTBD1	BTB/POZ domain-containing protein 1 (Hepatitis C virus NS5A-transactivated protein 8) (HCV NS5A-transactivated protein 8)	5	UniProt NCBI
KLHL24	Kelch-like protein 24 (Kainate receptor-interacting protein for GluR6) (KRIP6) (Protein DRE1)	5	UniProt NCBI
COPS9	COP9 signalosome complex subunit 9 (CSN acidic protein) (CSNAP) (Myeloma-overexpressed gene 2 protein)	5	UniProt NCBI
FBXO17	F-box only protein 17 (F-box only protein 26)	5	UniProt NCBI
COPS2	COP9 signalosome complex subunit 2 (SGN2) (Signalosome subunit 2) (Alien homolog) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (TR-interacting protein 15) (TRIP-15)	5	UniProt NCBI
KCTD20	BTB/POZ domain-containing protein KCTD20 (Potassium channel tetramerization domain containing 20)	3	UniProt NCBI
CUL4A	Cullin-4A (CUL-4A)	5	UniProt NCBI
BTBD10	BTB/POZ domain-containing protein 10 (Glucose metabolism-related protein 1)	4	UniProt NCBI
KLHL18	Kelch-like protein 18	4	UniProt NCBI
DTL	Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein)	5	UniProt NCBI
KLHL42	Kelch-like protein 42 (Cullin-3-binding protein 9) (Ctb9) (Kelch domain-containing protein 5)	5	UniProt NCBI
DCAF11	DDB1- and CUL4-associated factor 11 (WD repeat-containing protein 23)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-8951664	1.16764301977e-44	0.704545454545	COPS8 FEM1C RBX1 DCAF11 NEDD8 COPS4 DCAF6 CUL4B FEM1B ERCC8 COPS5 DCAF4 LRR1 COPS7B KLHL13 GPS1 CUL3 DDA1 CUL2 BTBD1 FBXO17 COPS2 DDB2 CUL4A COPS6 COPS3 DCAF16 DTL DDB1 KLHL42 COPS7A	Neddylation
GO:0031461	3.50006050692e-33	0.568181818182	FEM1C RBX1 APPBP2 FBXO17 KLHDC3 DCAF6 CUL4B FEM1B DDB1 DCAF1 DCAF4 KLHL24 CUL3 CUL2 DCAF16 DDA1 KLHL13 DDB2 CUL4A CRBN DTL DCAF8L2 ERCC8 KLHL42 DCAF11	cullin-RING ubiquitin ligase complex
CORUM:727	2.17189292125e-29	0.272727272727	COPS8 CUL4A RBX1 COPS5 COPS7A ERCC8 COPS6 COPS3 DDB1 COPS2 GPS1 COPS4	CSA complex
CORUM:726	2.17189292125e-29	0.272727272727	COPS8 DDB2 CUL4A RBX1 COPS5 COPS7A COPS6 COPS3 DDB1 COPS2 GPS1 COPS4	DDB2 complex
CORUM:728	2.17189292125e-29	0.272727272727	COPS8 CUL4A RBX1 COPS5 COPS7A ERCC8 COPS6 COPS3 DDB1 COPS2 GPS1 COPS4	CSA-POLIIa complex
GO:0000151	1.64448963567e-27	0.568181818182	FEM1C RBX1 APPBP2 FBXO17 KLHDC3 DCAF6 CUL4B FEM1B DDB1 DCAF1 DCAF4 KLHL24 CUL3 CUL2 DCAF16 DDA1 KLHL13 DDB2 CUL4A CRBN DTL DCAF8L2 ERCC8 KLHL42 DCAF11	ubiquitin ligase complex
GO:0080008	2.73433839228e-25	0.340909090909	DDB1 DDA1 RBX1 DCAF11 DCAF1 DCAF4 CRBN CUL4A DTL DCAF8L2 DCAF6 DCAF16 ERCC8 DDB2 CUL4B	Cul4-RING E3 ubiquitin ligase complex
REAC:R-HSA-5696394	1.60502236282e-24	0.318181818182	COPS8 DDB2 CUL4B RBX1 COPS5 COPS7A CUL4A COPS7B COPS6 COPS3 DDB1 COPS2 GPS1 COPS4	DNA Damage Recognition in GG-NER
REAC:R-HSA-6781823	2.85827142777e-22	0.318181818182	COPS8 CUL4B RBX1 COPS5 COPS7A ERCC8 CUL4A COPS7B COPS6 COPS3 DDB1 COPS2 GPS1 COPS4	Formation of TC-NER Pre-Incision Complex
REAC:R-HSA-597592	2.17925576792e-21	0.704545454545	COPS8 FEM1C RBX1 DCAF11 NEDD8 COPS4 DCAF6 CUL4B FEM1B ERCC8 COPS5 DCAF4 LRR1 COPS7B KLHL13 GPS1 CUL3 DDA1 CUL2 BTBD1 FBXO17 COPS2 DDB2 CUL4A COPS6 COPS3 DCAF16 DTL DDB1 KLHL42 COPS7A	Post-translational protein modification
GO:0032446	7.96507272728e-21	0.590909090909	COPS8 DTL RBX1 NEDD8 COPS4 COPS9 CUL4B DDB1 COPS5 KLHL24 COPS7B KLHL13 KLHL18 GPS1 CUL3 DDA1 CUL2 COPS6 DDB2 CUL4A COPS2 COPS3 CRBN ERCC8 KLHL42 COPS7A	protein modification by small protein conjugation
GO:0043687	1.74158052178e-20	0.613636363636	COPS8 DTL RBX1 NEDD8 COPS5 COPS9 CUL4B DDB1 DCAF1 KLHL24 COPS7B KLHL13 KLHL18 GPS1 CUL3 DDA1 CUL2 COPS2 DDB2 COPS4 CUL4A COPS6 COPS3 CRBN ERCC8 KLHL42 COPS7A	post-translational protein modification
GO:0045116	9.00999354246e-20	0.272727272727	COPS8 RBX1 NEDD8 COPS5 COPS7A COPS9 COPS7B COPS6 COPS3 COPS2 GPS1 COPS4	protein neddylation
GO:0070647	1.0143841866e-19	0.590909090909	COPS8 DTL RBX1 NEDD8 COPS4 COPS9 CUL4B DDB1 COPS5 KLHL24 COPS7B KLHL13 KLHL18 GPS1 CUL3 DDA1 CUL2 COPS6 DDB2 CUL4A COPS2 COPS3 CRBN ERCC8 KLHL42 COPS7A	protein modification by small protein conjugation or removal
REAC:R-HSA-6781827	1.29346789732e-19	0.318181818182	COPS8 CUL4B RBX1 COPS5 COPS7A ERCC8 CUL4A COPS7B COPS6 COPS3 DDB1 COPS2 GPS1 COPS4	Transcription-Coupled Nucleotide Excision Repair (TC-NER)
REAC:R-HSA-5696398	2.62847732399e-19	0.340909090909	COPS8 DDB2 CUL4B RBX1 COPS5 COPS7A ERCC8 CUL4A COPS7B COPS6 COPS3 DDB1 COPS2 GPS1 COPS4	Nucleotide Excision Repair
REAC:R-HSA-5696399	4.02581796303e-19	0.318181818182	COPS8 DDB2 CUL4B RBX1 COPS5 COPS7A CUL4A COPS7B COPS6 COPS3 DDB1 COPS2 GPS1 COPS4	Global Genome Nucleotide Excision Repair (GG-NER)
CORUM:2174	6.99102280732e-19	0.181818181818	COPS8 COPS7A COPS6 COPS5 COPS3 COPS2 GPS1 COPS4	COP9 signalosome complex
GO:0000338	4.22940881219e-18	0.204545454545	COPS8 COPS6 COPS5 COPS7A COPS7B COPS2 COPS3 GPS1 COPS4	protein deneddylation
CORUM:2179	6.27813662457e-18	0.181818181818	COPS8 COPS7A COPS6 COPS5 COPS3 COPS2 GPS1 COPS4	CNS-P53 complex
REAC:R-HSA-392499	3.85155944418e-17	0.704545454545	COPS8 FEM1C RBX1 DCAF11 NEDD8 COPS4 DCAF6 CUL4B FEM1B ERCC8 COPS5 DCAF4 LRR1 COPS7B KLHL13 GPS1 CUL3 DDA1 CUL2 BTBD1 FBXO17 COPS2 DDB2 CUL4A COPS6 COPS3 DCAF16 DTL DDB1 KLHL42 COPS7A	Metabolism of proteins
GO:2000434	9.20535035921e-17	0.227272727273	COPS8 COPS6 COPS5 COPS7A COPS9 COPS7B COPS2 COPS3 GPS1 COPS4	regulation of protein neddylation
GO:1990234	2.5612616164e-16	0.568181818182	FEM1C RBX1 APPBP2 FBXO17 KLHDC3 DCAF6 CUL4B FEM1B DDB1 DCAF1 DCAF4 KLHL24 CUL3 CUL2 DCAF16 DDA1 KLHL13 DDB2 CUL4A CRBN DTL DCAF8L2 ERCC8 KLHL42 DCAF11	transferase complex
GO:0008180	2.92067757068e-16	0.25	COPS8 COPS6 COPS5 COPS7A COPS9 COPS7B DCAF1 COPS3 COPS2 GPS1 COPS4	COP9 signalosome
GO:0140535	1.03790010139e-15	0.568181818182	FEM1C RBX1 APPBP2 FBXO17 KLHDC3 DCAF6 CUL4B FEM1B DDB1 DCAF1 DCAF4 KLHL24 CUL3 CUL2 DCAF16 DDA1 KLHL13 DDB2 CUL4A CRBN DTL DCAF8L2 ERCC8 KLHL42 DCAF11	intracellular protein-containing complex
REAC:R-HSA-73894	7.92591826714e-14	0.363636363636	COPS8 DDB2 CUL4B RBX1 COPS5 COPS7A ERCC8 CUL4A DTL COPS7B COPS6 COPS3 DDB1 COPS2 GPS1 COPS4	DNA Repair
GO:0031464	5.09701456873e-13	0.181818181818	CUL4B RBX1 DDB1 CRBN DTL ERCC8 DDB2 CUL4A	Cul4A-RING E3 ubiquitin ligase complex
CORUM:1162	3.97513842408e-11	0.113636363636	RBX1 CUL4A DDB2 DDB1 CUL4B	Ubiquitin E3 ligase (DDB1, DDB2, CUL4A, CUL4B, RBX1)
CORUM:6482	3.97513842408e-11	0.113636363636	DDB1 DTL COPS2 GPS1 CUL4B	CUL4B-DDB1-DTL-CSN complex
GO:0043161	4.31179397877e-11	0.363636363636	FEM1B FEM1C KLHL42 KLHDC3 APPBP2 FBXO17 CRBN CUL4A DTL CUL3 CUL2 RBX1 DDB1 ERCC8 DCAF11 DDA1	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006511	5.015602607e-11	0.409090909091	FEM1B FEM1C KLHL42 KLHDC3 DTL NEDD8 COPS3 CRBN CUL4A APPBP2 CUL3 CUL2 RBX1 DDB1 ERCC8 DCAF11 FBXO17 DDA1	ubiquitin-dependent protein catabolic process
REAC:R-HSA-8856825	5.37297796165e-11	0.227272727273	COPS8 COPS6 NEDD8 COPS5 COPS7A COPS7B COPS2 COPS3 GPS1 COPS4	Cargo recognition for clathrin-mediated endocytosis
GO:0019941	6.65039569186e-11	0.409090909091	FEM1B FEM1C KLHL42 KLHDC3 DTL NEDD8 COPS3 CRBN CUL4A APPBP2 CUL3 CUL2 RBX1 DDB1 ERCC8 DCAF11 FBXO17 DDA1	modification-dependent protein catabolic process
GO:0010498	8.55553773662e-11	0.386363636364	FEM1B FEM1C KLHL42 KLHDC3 APPBP2 FBXO17 CRBN CUL4A DTL CUL3 CUL2 RBX1 DDB1 CUL4B ERCC8 DCAF11 DDA1	proteasomal protein catabolic process
GO:0043632	9.72590975297e-11	0.409090909091	FEM1B FEM1C KLHL42 KLHDC3 DTL NEDD8 COPS3 CRBN CUL4A APPBP2 CUL3 CUL2 RBX1 DDB1 ERCC8 DCAF11 FBXO17 DDA1	modification-dependent macromolecule catabolic process
GO:0051603	1.03734461609e-10	0.431818181818	FEM1B FEM1C KLHL42 KLHDC3 DTL NEDD8 COPS3 CRBN CUL4A APPBP2 CUL3 CUL2 RBX1 DDB1 CUL4B ERCC8 DCAF11 FBXO17 DDA1	proteolysis involved in protein catabolic process
GO:0030163	5.00891760525e-10	0.454545454545	FEM1B FEM1C KLHL42 KLHDC3 DTL DCAF1 NEDD8 COPS3 CRBN CUL4A APPBP2 CUL3 CUL2 RBX1 DDB1 CUL4B ERCC8 DCAF11 FBXO17 DDA1	protein catabolic process
REAC:R-HSA-8856828	1.99011202361e-09	0.227272727273	COPS8 COPS6 NEDD8 COPS5 COPS7A COPS7B COPS2 COPS3 GPS1 COPS4	Clathrin-mediated endocytosis
CORUM:2715	2.21125486114e-09	0.113636363636	RBX1 CUL3 GPS1 CUL2 COPS8	Ubiquitin E3 ligase (CSN1, CSN8, HRT1, SKP1, SKP2, CUL1, CUL2, CUL3)
GO:1902494	2.47896571721e-09	0.568181818182	FEM1C RBX1 APPBP2 FBXO17 KLHDC3 DCAF6 CUL4B FEM1B DDB1 DCAF1 DCAF4 KLHL24 CUL3 CUL2 DCAF16 DDA1 KLHL13 DDB2 CUL4A CRBN DTL DCAF8L2 ERCC8 KLHL42 DCAF11	catalytic complex
GO:0031465	9.77884052323e-09	0.113636363636	RBX1 DTL DDB2 DDB1 CUL4B	Cul4B-RING E3 ubiquitin ligase complex
GO:1903320	1.06216262421e-08	0.272727272727	COPS8 RBX1 COPS5 COPS2 COPS7A COPS9 COPS7B COPS6 COPS3 COPS4 GPS1 CUL3	regulation of protein modification by small protein conjugation or removal
GO:0140627	1.19260547778e-08	0.136363636364	FEM1B CUL4A RBX1 CUL2 KLHDC3 FEM1C	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
GO:1901873	1.28390024766e-08	0.272727272727	COPS8 RBX1 COPS5 COPS2 COPS7A COPS9 COPS7B COPS6 COPS3 COPS4 GPS1 CUL3	regulation of post-translational protein modification
KEGG:04120	1.30810909956e-08	0.204545454545	CUL4B RBX1 DDB1 KLHL13 CUL3 CUL2 ERCC8 DDB2 CUL4A	Ubiquitin mediated proteolysis
CORUM:6875	1.45201868786e-08	0.0909090909091	RBX1 CUL4A DDB1 CRBN	CRBN-DDB1-CUL4A-RBX1 E3 ubiquitin ligase
GO:0036211	2.87159709099e-08	0.613636363636	COPS8 DTL RBX1 NEDD8 COPS5 COPS9 CUL4B DDB1 DCAF1 KLHL24 COPS7B KLHL13 KLHL18 GPS1 CUL3 DDA1 CUL2 COPS2 DDB2 COPS4 CUL4A COPS6 COPS3 CRBN ERCC8 KLHL42 COPS7A	protein modification process
GO:0019538	3.91090186031e-08	0.75	COPS8 FEM1C RBX1 NEDD8 COPS5 COPS9 KLHDC3 CUL4B FEM1B ERCC8 DCAF1 KLHL24 COPS7B KLHL13 KLHL18 GPS1 CUL3 DDA1 CUL2 APPBP2 FBXO17 COPS2 DDB2 COPS4 CUL4A COPS6 COPS3 DCAF11 CRBN DTL DDB1 KLHL42 COPS7A	protein metabolic process
GO:0009057	1.85016025328e-07	0.454545454545	FEM1B FEM1C KLHL42 KLHDC3 DTL DCAF1 NEDD8 COPS3 CRBN CUL4A APPBP2 CUL3 CUL2 RBX1 DDB1 CUL4B ERCC8 DCAF11 FBXO17 DDA1	macromolecule catabolic process
GO:0070646	2.04141155948e-07	0.204545454545	COPS8 COPS6 COPS5 COPS7A COPS7B COPS2 COPS3 GPS1 COPS4	protein modification by small protein removal
GO:1901565	2.12808199253e-07	0.454545454545	FEM1B FEM1C KLHL42 KLHDC3 DTL DCAF1 NEDD8 COPS3 CRBN CUL4A APPBP2 CUL3 CUL2 RBX1 DDB1 CUL4B ERCC8 DCAF11 FBXO17 DDA1	organonitrogen compound catabolic process
GO:0043412	2.12898622772e-07	0.613636363636	COPS8 DTL RBX1 NEDD8 COPS5 COPS9 CUL4B DDB1 DCAF1 KLHL24 COPS7B KLHL13 KLHL18 GPS1 CUL3 DDA1 CUL2 COPS2 DDB2 COPS4 CUL4A COPS6 COPS3 CRBN ERCC8 KLHL42 COPS7A	macromolecule modification
WP:WP5114	2.53448374656e-07	0.159090909091	CUL4B RBX1 DDB1 DDB2 ERCC8 GPS1 CUL4A	Nucleotide excision repair in xeroderma pigmentosum
WP:WP4753	3.88653844539e-07	0.136363636364	CUL4B RBX1 ERCC8 DDB1 DDB2 CUL4A	Nucleotide excision repair
GO:0016567	6.20493946561e-07	0.340909090909	DDA1 KLHL42 KLHL24 RBX1 ERCC8 CRBN KLHL13 CUL4A DTL CUL3 CUL2 DDB1 KLHL18 DDB2 CUL4B	protein ubiquitination
WP:WP5381	1.01901972272e-06	0.181818181818	COPS8 COPS7A COPS6 COPS5 COPS3 COPS2 GPS1 COPS4	Smith Magenis and Potocki Lupski syndrome copy number variation
KEGG:03420	1.22015436473e-06	0.136363636364	CUL4B RBX1 ERCC8 DDB1 DDB2 CUL4A	Nucleotide excision repair
WP:WP4352	1.28326206013e-06	0.204545454545	COPS8 COPS6 DCAF11 COPS5 COPS3 COPS7B COPS2 COPS7A COPS4	Ciliary landscape
GO:0031462	1.36984619836e-06	0.136363636364	FEM1B FEM1C RBX1 APPBP2 CUL2 KLHDC3	Cul2-RING ubiquitin ligase complex
GO:0005654	1.42773883266e-06	0.727272727273	COPS8 FEM1C BTBD1 RBX1 DCAF11 NEDD8 COPS5 COPS9 DCAF6 CUL4B FEM1B ERCC8 DCAF1 DCAF4 BTBD10 CUL3 KLHDC3 DCAF16 COPS7B DDA1 CUL2 APPBP2 COPS2 DDB2 COPS4 CUL4A COPS6 COPS3 GPS1 DTL DDB1 COPS7A	nucleoplasm
GO:0032991	2.08399152771e-06	0.818181818182	COPS8 FEM1C RBX1 DCAF11 APPBP2 COPS5 COPS9 KLHDC3 DCAF6 CUL4B FEM1B ERCC8 DCAF1 DCAF4 KLHL24 COPS7B KLHL13 DCAF16 CUL3 DDA1 CUL2 BTBD1 FBXO17 COPS2 DDB2 COPS4 CUL4A COPS6 COPS3 GPS1 CRBN DTL DCAF8L2 DDB1 KLHL42 COPS7A	protein-containing complex
GO:0006508	2.16745979811e-06	0.431818181818	FEM1B FEM1C KLHL42 KLHDC3 DTL NEDD8 COPS3 CRBN CUL4A APPBP2 CUL3 CUL2 RBX1 DDB1 CUL4B ERCC8 DCAF11 FBXO17 DDA1	proteolysis
CORUM:2722	5.17485294316e-06	0.0681818181818	RBX1 CUL4A DDB1	Ubiquitin E3 ligase (DDB1, CUL4A, RBX1)
CORUM:6486	5.17485294316e-06	0.0681818181818	DDB1 CUL4A DTL	CUL4A-DDB1-DTL complex
CORUM:391	5.17485294316e-06	0.0681818181818	RBX1 CUL4A DDB1	Ubiquitin E3 ligase (DDB1, CUL4A, RBX1)
CORUM:7525	5.17485294316e-06	0.0681818181818	RBX1 CUL3 KLHL24	Ubiquitin E3 ligase (CUL3, KLHL24, RBX1)
GO:0031981	8.80000713559e-06	0.727272727273	COPS8 FEM1C BTBD1 RBX1 DCAF11 NEDD8 COPS5 COPS9 DCAF6 CUL4B FEM1B ERCC8 DCAF1 DCAF4 BTBD10 CUL3 KLHDC3 DCAF16 COPS7B DDA1 CUL2 APPBP2 COPS2 DDB2 COPS4 CUL4A COPS6 COPS3 GPS1 DTL DDB1 COPS7A	nuclear lumen
REAC:R-HSA-110314	9.21736720737e-06	0.113636363636	RBX1 CUL4A DTL CUL4B DDB1	Recognition of DNA damage by PCNA-containing replication complex
GO:1901564	1.43602584358e-05	0.75	COPS8 FEM1C RBX1 NEDD8 COPS5 COPS9 KLHDC3 CUL4B FEM1B ERCC8 DCAF1 KLHL24 COPS7B KLHL13 KLHL18 GPS1 CUL3 DDA1 CUL2 APPBP2 FBXO17 COPS2 DDB2 COPS4 CUL4A COPS6 COPS3 DCAF11 CRBN DTL DDB1 KLHL42 COPS7A	organonitrogen compound metabolic process
CORUM:2172	2.0655851212e-05	0.0681818181818	RBX1 CUL4A DDB1	Ubiquitin E3 ligase (CDT1, DDB1, CUL4A, RBX1)
CORUM:7523	2.0655851212e-05	0.0681818181818	RBX1 CUL3 KLHL13	Ubiquitin E3 ligase (CUL3, KLHL9, KLHL13, RBX1)
REAC:R-HSA-983168	4.47707319361e-05	0.204545454545	RBX1 DCAF1 BTBD1 LRR1 KLHL13 CUL3 CUL2 KLHL42 FBXO17	Antigen processing: Ubiquitination & Proteasome degradation
REAC:R-HSA-5696400	4.7298705299e-05	0.113636363636	RBX1 CUL4A DDB2 DDB1 CUL4B	Dual Incision in GG-NER
CORUM:1214	5.15309651367e-05	0.0681818181818	RBX1 CUL4A DDB1	Ubiquitin E3 ligase (DET1, DDB1, CUL4A, RBX1, COP1)
GO:0160072	5.33450584461e-05	0.0909090909091	CUL2 CUL4A CUL3 DDB1	ubiquitin ligase complex scaffold activity
REAC:R-HSA-5696395	5.35710125226e-05	0.113636363636	RBX1 CUL4A DDB2 DDB1 CUL4B	Formation of Incision Complex in GG-NER
REAC:R-HSA-73893	9.55307355674e-05	0.113636363636	RBX1 CUL4A DTL CUL4B DDB1	DNA Damage Bypass
CORUM:1211	0.000102845080442	0.0681818181818	RBX1 CUL4B DDB1	Ubiquitin E3 ligase (AHR, ARNT, DDB1, TBL3, CUL4B, RBX1)
GO:0009411	0.000105683493408	0.181818181818	CUL4B RBX1 ERCC8 DTL COPS9 DDB1 DDB2 CUL4A	response to UV
GO:1901575	0.000118861045599	0.454545454545	FEM1B FEM1C KLHL42 KLHDC3 DTL DCAF1 NEDD8 COPS3 CRBN CUL4A APPBP2 CUL3 CUL2 RBX1 DDB1 CUL4B ERCC8 DCAF11 FBXO17 DDA1	organic substance catabolic process
WP:WP4946	0.000137752884949	0.136363636364	CUL4B RBX1 ERCC8 DDB1 DDB2 CUL4A	DNA repair pathways full network
GO:0009416	0.000166173743296	0.204545454545	CUL4B RBX1 COPS3 DTL COPS9 ERCC8 DDB1 DDB2 CUL4A	response to light stimulus
REAC:R-HSA-9013422	0.000212164942375	0.0909090909091	COPS2 COPS4 GPS1 CUL3	RHOBTB1 GTPase cycle
REAC:R-HSA-983169	0.000251279325975	0.204545454545	RBX1 DCAF1 BTBD1 LRR1 KLHL13 CUL3 CUL2 KLHL42 FBXO17	Class I MHC mediated antigen processing & presentation
REAC:R-HSA-6782210	0.000422424523006	0.113636363636	RBX1 CUL4A CUL4B DDB1 ERCC8	Gap-filling DNA repair synthesis and ligation in TC-NER
REAC:R-HSA-6782135	0.000457204260941	0.113636363636	RBX1 CUL4A CUL4B DDB1 ERCC8	Dual incision in TC-NER
REAC:R-HSA-9706574	0.0012219912783	0.0909090909091	COPS2 COPS4 GPS1 CUL3	RHOBTB GTPase Cycle
CORUM:7533	0.00180047919187	0.0454545454545	KLHL42 CUL3	Ubiquitin E3 ligase (CUL3, KLHL42)
CORUM:790	0.00180047919187	0.0454545454545	DDB1 DDB2	DDB complex
REAC:R-HSA-199991	0.00206273428421	0.227272727273	COPS8 COPS6 NEDD8 COPS5 COPS7A COPS7B COPS2 COPS3 GPS1 COPS4	Membrane Trafficking
GO:0004842	0.00279021283568	0.227272727273	CUL4A RBX1 FBXO17 KLHL13 CUL3 CUL2 ERCC8 KLHL42 DDB2 DTL	ubiquitin-protein transferase activity
GO:0009314	0.00289506432382	0.204545454545	CUL4B RBX1 COPS3 DTL COPS9 ERCC8 DDB1 DDB2 CUL4A	response to radiation
GO:0031974	0.00313394140547	0.727272727273	COPS8 FEM1C BTBD1 RBX1 DCAF11 NEDD8 COPS5 COPS9 DCAF6 CUL4B FEM1B ERCC8 DCAF1 DCAF4 BTBD10 CUL3 KLHDC3 DCAF16 COPS7B DDA1 CUL2 APPBP2 COPS2 DDB2 COPS4 CUL4A COPS6 COPS3 GPS1 DTL DDB1 COPS7A	membrane-enclosed lumen
GO:0043233	0.00313394140547	0.727272727273	COPS8 FEM1C BTBD1 RBX1 DCAF11 NEDD8 COPS5 COPS9 DCAF6 CUL4B FEM1B ERCC8 DCAF1 DCAF4 BTBD10 CUL3 KLHDC3 DCAF16 COPS7B DDA1 CUL2 APPBP2 COPS2 DDB2 COPS4 CUL4A COPS6 COPS3 GPS1 DTL DDB1 COPS7A	organelle lumen
GO:0070013	0.00313394140547	0.727272727273	COPS8 FEM1C BTBD1 RBX1 DCAF11 NEDD8 COPS5 COPS9 DCAF6 CUL4B FEM1B ERCC8 DCAF1 DCAF4 BTBD10 CUL3 KLHDC3 DCAF16 COPS7B DDA1 CUL2 APPBP2 COPS2 DDB2 COPS4 CUL4A COPS6 COPS3 GPS1 DTL DDB1 COPS7A	intracellular organelle lumen
REAC:R-HSA-5653656	0.00332725415699	0.227272727273	COPS8 COPS6 NEDD8 COPS5 COPS7A COPS7B COPS2 COPS3 GPS1 COPS4	Vesicle-mediated transport
GO:0034644	0.00450566790572	0.136363636364	CUL4A RBX1 COPS9 DDB1 DDB2 CUL4B	cellular response to UV
GO:0031463	0.00521970471796	0.113636363636	RBX1 KLHL42 CUL3 KLHL24 KLHL13	Cul3-RING ubiquitin ligase complex
GO:0009056	0.00527536957019	0.454545454545	FEM1B FEM1C KLHL42 KLHDC3 DTL DCAF1 NEDD8 COPS3 CRBN CUL4A APPBP2 CUL3 CUL2 RBX1 DDB1 CUL4B ERCC8 DCAF11 FBXO17 DDA1	catabolic process
CORUM:6492	0.00539108786971	0.0454545454545	DDB1 CUL4A	CUL4A-DDB1-WDR5B complex
CORUM:6493	0.00539108786971	0.0454545454545	DDB1 CUL4A	CUL4A-DDB1-WDR57 complex
CORUM:6494	0.00539108786971	0.0454545454545	DDB1 CUL4A	CUL4A-DDB1-WDR61 complex
CORUM:6553	0.00539108786971	0.0454545454545	DDB1 CUL4B	CUL4B-DDB1-TLE3 complex
CORUM:6550	0.00539108786971	0.0454545454545	DDB1 CUL4A	CUL4B-DDB1-TLE1 complex
CORUM:6491	0.00539108786971	0.0454545454545	DDB1 CUL4A	CUL4A-DDB1-RBBP5 complex
CORUM:7368	0.00539108786971	0.0454545454545	RBX1 CUL3	Ubiquitin E3 ligase (CUL3, KEAP1, RBX1)
CORUM:7517	0.00539108786971	0.0454545454545	RBX1 CUL3	Ubiquitin E3 ligase (CUL3, KLHL7, RBX1)
CORUM:7524	0.00539108786971	0.0454545454545	RBX1 CUL3	Ubiquitin E3 ligase (CUL3, KLHL20, RBX1)
CORUM:6495	0.00539108786971	0.0454545454545	DDB1 CUL4B	CUL4B-DDB1-GRWD1 complex
CORUM:223	0.00539108786971	0.0454545454545	RBX1 CUL4A	CAND1-CUL4A-RBX1 complex
CORUM:224	0.00539108786971	0.0454545454545	RBX1 CUL4B	CAND1-CUL4B-RBX1 complex
CORUM:6488	0.00539108786971	0.0454545454545	DDB1 CUL4A	CUL4A-DDB1-EED complex
CORUM:222	0.00539108786971	0.0454545454545	RBX1 CUL3	CAND1-CUL3-RBX1 complex
CORUM:221	0.00539108786971	0.0454545454545	RBX1 CUL2	CAND1-CUL2-RBX1 complex
CORUM:6489	0.00539108786971	0.0454545454545	DDB1 CUL4A	CUL4A-DDB1-WDR5 complex
CORUM:6490	0.00539108786971	0.0454545454545	DDB1 CUL4B	CUL4B-DDB1-WDR26 complex
CORUM:6487	0.00539108786971	0.0454545454545	DDB1 CUL4B	CUL4B-DDB1-TLE2 complex
GO:0019787	0.00580330930366	0.227272727273	CUL4A RBX1 FBXO17 KLHL13 CUL3 CUL2 ERCC8 KLHL42 DDB2 DTL	ubiquitin-like protein transferase activity
GO:0051246	0.00674959970659	0.409090909091	COPS8 DDA1 RBX1 DCAF1 NEDD8 COPS5 COPS2 COPS7A COPS9 CUL4A DTL COPS7B COPS6 COPS3 DDB1 COPS4 GPS1 CUL3	regulation of protein metabolic process
GO:0005634	0.00731621894197	0.772727272727	COPS8 FEM1C BTBD1 RBX1 DCAF11 NEDD8 COPS5 BRWD3 COPS9 DCAF6 CUL4B FEM1B ERCC8 DCAF1 DCAF4 BTBD10 COPS7B KLHDC3 DCAF16 CUL3 DDA1 CUL2 APPBP2 COPS2 DDB2 COPS4 CUL4A COPS6 COPS3 GPS1 CRBN DTL DDB1 COPS7A	nucleus
GO:0016755	0.00798916517177	0.227272727273	CUL4A RBX1 FBXO17 KLHL13 CUL3 CUL2 ERCC8 KLHL42 DDB2 DTL	aminoacyltransferase activity
CORUM:6902	0.0107615198882	0.0454545454545	RBX1 FBXO17	Ubiquitin E3 ligase (CUL1, FBXO17, RBX1, SKP1)
CORUM:6291	0.0107615198882	0.0454545454545	DDB1 CUL4A	Ubiquitin E3 ligase (DDIT4, DDB1, BTRC, CUL4A)
CORUM:6290	0.0107615198882	0.0454545454545	DDB1 DCAF1	Ubiquitin E3 ligase (DDB1, DYRK2, EDD, VPRBP)
GO:1990756	0.012234818301	0.113636363636	KLHDC3 DCAF1 APPBP2 FEM1C FEM1B	ubiquitin ligase-substrate adaptor activity
GO:0071482	0.0134726263404	0.136363636364	CUL4A RBX1 COPS9 DDB1 DDB2 CUL4B	cellular response to light stimulus
KEGG:05170	0.0176792025562	0.113636363636	RBX1 CUL4A DCAF1 DDB1 CUL4B	Human immunodeficiency virus 1 infection
CORUM:2188	0.0179015125036	0.0454545454545	RBX1 NEDD8	Ubiquitin E3 ligase (CDC34, NEDD8, BTRC, CUL1, SKP1A, RBX1)
CORUM:205	0.0179015125036	0.0454545454545	RBX1 CUL2	Ubiquitin E3 ligase (VHL, TCEB1, TCEB2, CUL2, RBX1)
WP:WP4541	0.0257337245671	0.0909090909091	RBX1 CUL4A DCAF1 DDB1	Hippo Merlin signaling dysregulation
CORUM:7556	0.0268008462152	0.0454545454545	RBX1 CUL2	PRAME complex
WP:WP4860	0.0325195518603	0.0454545454545	RBX1 CUL2	Hijack of ubiquitination by SARS CoV 2
GO:0097602	0.0363278199722	0.0909090909091	BTBD1 RBX1 DDB1 KLHL13	cullin family protein binding
GO:0140767	0.0398200071987	0.113636363636	KLHDC3 DCAF1 APPBP2 FEM1C FEM1B	enzyme-substrate adaptor activity
REAC:R-HSA-1280218	0.0463520103715	0.204545454545	RBX1 DCAF1 BTBD1 LRR1 KLHL13 CUL3 CUL2 KLHL42 FBXO17	Adaptive Immune System

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
COPS7B	COPS6	1.0	0.764
COPS3	DDB2	1.0	0.114	mutually_exclusive (Q9H9Q2)
CUL4A	DDB2	1.0	0.234	structurally_consistent (Q16531)
COPS8	COPS6	1.0	0.844
COPS7B	COPS2	1.0	0.668	structurally_consistent (dimer)
GPS1	COPS8	1.0	0.52	structurally_consistent (dimer)
COPS3	COPS6	1.0	0.884	structurally_consistent (Q96EF6) structurally_consistent (dimer)
GPS1	COPS6	1.0	0.948	structurally_consistent (Q9BT78)
BTBD1	COPS4	1.0	0.168
COPS5	COPS2	1.0	0.958
COPS8	DDB2	1.0	0.062	mutually_exclusive (Q9H9Q2)
COPS7B	COPS8	1.0	0.534	structurally_consistent (P61201) structurally_consistent (dimer)
LRR1	GPS1	1.0	0.19
COPS8	COPS7A	1.0	0.23
COPS2	COPS6	1.0	0.962
DCAF4	COPS8	1.0	0.086
GPS1	DCAF4	1.0	0.086
CUL4B	DDB2	1.0	0.066	structurally_consistent (Q16531) structurally_consistent (dimer)
DCAF11	COPS7A	1.0	0.076
APPBP2	COPS2	1.0	0.098
CUL3	GPS1	1.0	0.66
COPS3	COPS4	1.0	0.94
GPS1	COPS4	1.0	0.91	structurally_consistent (dimer)
CUL4A	DCAF11	1.0	0.062	structurally_consistent (Q16531)
GPS1	DDB2	1.0	0.21	mutually_exclusive (Q9H9Q2)
COPS9	COPS3	1.0	0.1	structurally_consistent (dimer)
BTBD2	COPS8	1.0	0.06	structurally_consistent (P61201)
BTBD1	BTBD2	1.0	0.13	mixed_interface
LRR1	COPS4	1.0	0.112
COPS7A	COPS6	0.999	0.648
COPS8	COPS2	0.999	0.588	mutually_exclusive (Q53RE8) structurally_consistent (dimer)
COPS5	COPS6	0.999	0.96
COPS5	COPS8	0.999	0.808
DCAF11	COPS8	0.999	0.172
CUL2	KLHDC3	0.999	0.226	structurally_consistent (dimer)
COPS7A	COPS3	0.999	0.462	structurally_consistent (dimer)
GPS1	COPS5	0.999	0.942
BTBD1	COPS7A	0.999	0.136
COPS5	COPS7B	0.999	0.572
BTBD1	COPS8	0.999	0.07
COPS2	COPS3	0.999	0.952	structurally_consistent (dimer)
COPS6	COPS4	0.999	0.982	structurally_consistent (dimer)
GPS1	COPS7A	0.999	0.576	structurally_consistent (Q9BT78) structurally_consistent (dimer)
COPS6	DDB2	0.999	0.1
CUL4A	GPS1	0.999	0.58	structurally_consistent (P61201)
CUL4A	CUL4B	0.999	0.374
BTBD1	COPS6	0.999	0.232
COPS2	COPS4	0.999	0.96	structurally_consistent (Q13618)
DCAF4	COPS5	0.999	0.084
CUL2	GPS1	0.999	0.662	structurally_consistent (P61201)
CUL4B	DCAF11	0.999	0.116	structurally_consistent (Q16531)
GPS1	BTBD2	0.999	0.312	structurally_consistent (P61201)
DCAF4	COPS7A	0.999	0.062
COPS4	DDB2	0.999	0.088
DCAF4	COPS4	0.999	0.1
CUL4B	DCAF4	0.999	0.096	structurally_consistent (Q16531)
BTBD1	GPS1	0.999	0.162
COPS5	COPS3	0.999	0.898
APPBP2	COPS8	0.999	0.132
COPS8	COPS4	0.999	0.892	structurally_consistent (dimer)
CUL3	COPS8	0.999	0.324
FEM1B	COPS6	0.999	0.136
FEM1B	COPS3	0.999	0.102	structurally_consistent (dimer)
CUL4A	DCAF4	0.999	0.17	structurally_consistent (Q16531)
COPS8	COPS3	0.999	0.666	structurally_consistent (dimer)
CUL2	FEM1B	0.999	0.114
DTL	CUL4B	0.999	0.11	mutually_exclusive (P61201)
BTBD1	COPS7B	0.999	0.094
BTBD1	COPS3	0.999	0.094	structurally_consistent (dimer)
CUL4A	COPS7A	0.999	0.394	structurally_consistent (P61201)
COPS9	GPS1	0.999	0.122
COPS7A	COPS4	0.999	0.278	structurally_consistent (dimer)
GPS1	COPS2	0.999	0.914	structurally_consistent (dimer)
FEM1B	COPS8	0.999	0.142
BTBD2	COPS6	0.999	0.288
DDB1	DDA1	0.999	0.2	structurally_consistent (dimer)
DDA1	DCAF1	0.999	0.188
CUL2	COPS4	0.999	0.51
BTBD2	COPS7A	0.999	0.126	structurally_consistent (P61201)
COPS7B	COPS3	0.999	0.412	structurally_consistent (dimer)
DCAF4	DDB2	0.999	0.094	mutually_exclusive (Q16531)
COPS9	COPS2	0.999	0.154	structurally_consistent (Q9UNS2)
COPS7B	COPS4	0.999	0.472	structurally_consistent (dimer)
GPS1	DCAF11	0.999	0.158
CUL3	COPS6	0.999	0.574
CUL2	COPS6	0.999	0.462
DDB1	COPS8	0.999	0.274
CUL4B	COPS8	0.999	0.146	structurally_consistent (P61201)
BTBD2	COPS4	0.999	0.26
DDB1	DDB2	0.999	0.212	structurally_consistent (Q13620) structurally_consistent (dimer)
CUL2	APPBP2	0.999	0.214
DCAF4	COPS2	0.999	0.13
LRR1	DCAF4	0.999	0.106
CUL3	COPS2	0.999	0.536	structurally_consistent (dimer)
GPS1	FEM1B	0.999	0.124
DCAF4	DCAF11	0.999	0.048	mutually_exclusive (Q16531)
FEM1B	COPS2	0.999	0.18
LRR1	COPS6	0.999	0.148
COPS5	DDB2	0.999	0.142
DTL	DDB2	0.999	0.086	mutually_exclusive (Q16531)
CUL4A	DDA1	0.999	0.12
DCAF11	COPS3	0.999	0.076
CUL2	LRR1	0.999	0.18
DTL	CUL4A	0.999	0.242
DTL	DDB1	0.999	0.226	structurally_consistent (dimer)
CUL2	COPS3	0.999	0.626
COPS5	COPS4	0.999	0.964
COPS2	COPS7A	0.999	0.59	structurally_consistent (dimer)
COPS7A	DDB2	0.999	0.07	mutually_exclusive (Q9H9Q2)
GPS1	COPS3	0.999	0.946	structurally_consistent (dimer)
LRR1	COPS8	0.999	0.082
BTBD2	COPS5	0.998	0.506
CUL4B	ERCC8	0.998	0.094	structurally_consistent (Q16531)
LRR1	COPS3	0.998	0.134
DCAF11	DDB2	0.998	0.176	mutually_exclusive (Q16531)
DDB1	GPS1	0.998	0.482
CUL4B	GPS1	0.998	0.116	structurally_consistent (P61201)
GPS1	APPBP2	0.998	0.132
CUL2	COPS2	0.998	0.544	structurally_consistent (dimer)
KLHL42	CUL3	0.998	0.178	structurally_consistent (dimer)
NEDD8	COPS8	0.998	0.21	structurally_consistent (Q9BQ90)
CUL4A	RBX1	0.998	0.878
GPS1	NEDD8	0.998	0.312	structurally_consistent (Q9BT78)
DCAF11	COPS4	0.998	0.134	mutually_exclusive (Q15843)
BTBD1	COPS5	0.998	0.32	structurally_consistent (dimer)
DTL	GPS1	0.998	0.186	structurally_consistent (P61201)
COPS9	COPS5	0.998	0.094
LRR1	COPS2	0.998	0.134
COPS2	DDB2	0.998	0.212	mutually_exclusive (Q13620)
DCAF4	COPS6	0.998	0.104
CUL4A	COPS8	0.998	0.218
CUL3	COPS3	0.998	0.532	structurally_consistent (P61201)
DCAF4	COPS3	0.998	0.082
CUL4B	COPS7A	0.998	0.118	structurally_consistent (P61201)
DCAF11	COPS5	0.998	0.14	mutually_exclusive (Q15843)
DCAF11	COPS2	0.998	0.136
BTBD2	COPS2	0.998	0.174	structurally_consistent (Q13618) structurally_consistent (dimer)
DTL	DCAF4	0.998	0.142	mutually_exclusive (Q16531)
BTBD2	COPS3	0.998	0.136
CUL4B	DDB1	0.998	0.272	structurally_consistent (dimer)
NEDD8	COPS2	0.998	0.38
GPS1	COPS7B	0.998	0.414	structurally_consistent (dimer)
DCAF4	COPS7B	0.998	0.064
DTL	COPS4	0.998	0.264
COPS5	COPS7A	0.998	0.644
CRBN	CUL4B	0.997	0.136	structurally_consistent (Q16531)
DTL	DDA1	0.997	0.14	structurally_consistent (Q16531)
COPS5	FBXO17	0.997	0.118
CUL3	BTBD1	0.997	0.225870002477	mixed_interface
COPS9	COPS8	0.997	0.12
CUL2	DCAF4	0.997	0.206
GPS1	DCAF1	0.997	0.366
DCAF11	COPS7B	0.997	0.134
CUL3	BTBD2	0.997	0.33317571885	mixed_interface
CUL4B	DCAF16	0.997	0.128
FBXO17	COPS7B	0.997	0.054
CUL2	COPS5	0.997	0.64	structurally_consistent (Q9BQ90)
CUL4B	DCAF1	0.997	0.048	structurally_consistent (Q16531)
CUL4B	BTBD2	0.997	0.1
COPS7B	DDB2	0.997	0.084	structurally_consistent (dimer)
CUL2	COPS7B	0.997	0.43	structurally_consistent (P61201)
CUL2	BTBD1	0.997	0.118
COPS7B	APPBP2	0.997	0.136	structurally_consistent (Q9UNS2)
CUL4B	BTBD1	0.996	0.098
DDA1	GPS1	0.996	0.3
FBXO17	COPS2	0.996	0.134
DDA1	DCAF11	0.996	0.096
DTL	COPS8	0.996	0.218	structurally_consistent (P61201)
KLHL18	GPS1	0.996	0.308
NEDD8	KLHDC3	0.996	0.12	structurally_consistent (Q92905) structurally_consistent (dimer)
KLHL13	CUL3	0.996	0.176230769231	structurally_consistent (dimer)
CUL4A	BRWD3	0.996
CUL4B	RBX1	0.996	0.138
KLHL18	COPS6	0.996	0.274
FBXO17	COPS8	0.996	0.082
ERCC8	COPS8	0.996	0.092	structurally_consistent (dimer)
APPBP2	COPS3	0.996	0.066	structurally_consistent (dimer)
CUL4B	COPS9	0.996	0.038
BTBD1	COPS2	0.996	0.132
COPS6	DCAF1	0.995	0.246
LRR1	COPS5	0.995	0.162
BTBD1	DDB2	0.995	0.088
DTL	COPS3	0.995	0.1	structurally_consistent (P61201)
ANKRD39	GPS1	0.995	0.106
ANKRD39	COPS7B	0.995	0.13
CUL4A	DDB1	0.995	0.628	structurally_consistent (dimer)
DDB1	DCAF11	0.995	0.142	structurally_consistent (dimer)
BTBD2	COPS7B	0.994	0.134
NEDD8	COPS3	0.994	0.33	structurally_consistent (Q9BQ90)
DDB1	COPS6	0.994	0.582	structurally_consistent (Q8TEB1)
BTBD1	LRR1	0.994	0.114
KLHL42	GPS1	0.994	0.312
FEM1C	GPS1	0.994
DCAF6	COPS2	0.994	0.126	structurally_consistent (Q13098)
ERCC8	COPS3	0.994	0.294	mutually_exclusive (Q99627)
DCAF6	GPS1	0.994	0.192	structurally_consistent (dimer)
FBXO17	COPS6	0.994	0.146	structurally_consistent (dimer)
DTL	COPS6	0.994	0.288
BTBD2	DDB2	0.994	0.238
CUL4B	DDA1	0.994	0.092	structurally_consistent (Q16531)
CUL3	COPS7A	0.994	0.182
DDA1	COPS6	0.994	0.232
ANKRD39	COPS8	0.994	0.184	structurally_consistent (dimer)
ANKRD39	COPS2	0.993	0.12	structurally_consistent (dimer)
CUL4A	COPS9	0.993	0.066
COPS7B	COPS7A	0.993	0.248	mutually_exclusive (Q9BT78) structurally_consistent (dimer)
COPS9	COPS6	0.993	0.044	structurally_consistent (Q9UNS2)
FBXO17	COPS4	0.993	0.1	structurally_consistent (dimer)
DDA1	COPS8	0.993	0.246
KLHL24	COPS2	0.993		structurally_consistent (Q13618)
COPS9	COPS7B	0.993	0.074	structurally_consistent (Q9UNS2)
COPS9	COPS4	0.993	0.102
ANKRD39	COPS6	0.992	0.256
ANKRD39	COPS4	0.992	0.112	structurally_consistent (dimer)
COPS9	COPS7A	0.992	0.106	structurally_consistent (Q9UNS2)
CUL4B	LRR1	0.992	0.088
CUL4B	COPS7B	0.992	0.062	structurally_consistent (P61201)
NEDD8	COPS6	0.992	0.256	structurally_consistent (Q9BT78)
GPS1	FBXO17	0.992	0.152
KCTD20	COPS6	0.992	0.16
CRBN	COPS8	0.992	0.214153846154	structurally_consistent (dimer)
DTL	COPS2	0.992	0.258	structurally_consistent (dimer)
DDA1	DCAF4	0.992	0.084
CUL3	COPS4	0.991	0.378	structurally_consistent (dimer)
BTBD10	COPS8	0.991	0.064
DDA1	COPS7A	0.991	0.116
DDB1	BRWD3	0.991
DDB1	DCAF4	0.991	0.162	structurally_consistent (dimer)
KCTD20	COPS3	0.991	0.098
KCTD20	COPS4	0.991	0.09	mutually_exclusive (Q13618)
KLHL18	COPS3	0.991	0.228
LRR1	BTBD2	0.991	0.08
LRR1	FEM1B	0.991	0.158
COPS9	APPBP2	0.991	0.104
KLHL24	CUL3	0.991		structurally_consistent (dimer)
COPS9	BTBD2	0.991	0.176
FEM1C	CUL2	0.99
FBXO17	COPS7A	0.99	0.054	structurally_consistent (dimer)
BTBD10	BTBD1	0.99	0.144	mutually_exclusive (Q13618)
ERCC8	GPS1	0.99	0.142
KCTD20	BTBD1	0.99	0.102	mutually_exclusive (Q13618)
CUL4A	COPS7B	0.99	0.25
COPS8	DCAF1	0.99	0.092
COPS2	DCAF1	0.99	0.262
CUL4A	BTBD2	0.99	0.29
FBXO17	COPS3	0.99	0.086	structurally_consistent (dimer)
CUL4B	CUL2	0.989	0.112
CUL4A	FEM1B	0.989	0.108
KCTD20	COPS2	0.989	0.132	structurally_consistent (Q13618)
DDA1	COPS4	0.989	0.212
KCTD20	GPS1	0.989	0.108
CUL4A	BTBD1	0.989	0.232
CUL3	COPS5	0.989	0.684
BRWD3	DDA1	0.989
ANKRD39	COPS7A	0.988	0.206
KLHDC3	COPS2	0.988	0.196
ANKRD39	COPS3	0.988	0.17	structurally_consistent (dimer)
DDA1	DDB2	0.988	0.056
BTBD10	COPS4	0.988	0.147	mutually_exclusive (Q13618)
LRR1	DDB2	0.988	0.138
DCAF11	COPS6	0.987	0.134	structurally_consistent (dimer)
KCTD20	BTBD10	0.987	0.09	mutually_exclusive (Q13618)
KCTD20	CUL3	0.987	0.186	structurally_consistent (dimer)
DTL	COPS5	0.987	0.298
CUL2	COPS9	0.987	0.056
FEM1B	COPS4	0.987	0.118
CUL2	BTBD2	0.987	0.296
KLHL24	BTBD10	0.987		mutually_exclusive (Q13618)
BTBD10	GPS1	0.987	0.128
BTBD10	COPS3	0.987	0.096
DDB1	DCAF1	0.987	0.164	structurally_consistent (dimer)
BTBD1	DCAF11	0.987	0.056
LRR1	COPS7B	0.986	0.082
COPS9	DCAF11	0.986	0.068
BTBD10	KLHL42	0.986	0.1	mutually_exclusive (Q13618)
CUL4A	COPS4	0.986	0.32
FEM1B	COPS7B	0.985	0.084
BTBD1	DCAF4	0.985	0.078
CRBN	CUL4A	0.985	0.228
COPS9	BTBD1	0.985	0.106	structurally_consistent (Q9UNS2)
BTBD10	COPS7A	0.985	0.102
DDA1	COPS2	0.984	0.33
CUL4B	ANKRD39	0.984	0.096	mutually_exclusive (P61201)
CUL3	COPS9	0.984	0.096
KLHL13	GPS1	0.984	0.226
CUL3	RBX1	0.984	0.566	structurally_consistent (dimer)
KLHL42	BTBD1	0.984	0.074	mutually_exclusive (Q13618)
KCTD20	COPS7A	0.984	0.092
DTL	RBX1	0.983	0.19
KLHL24	KLHL42	0.983		mutually_exclusive (Q13618)
BTBD10	COPS2	0.983	0.148	structurally_consistent (Q13618)
BTBD10	COPS6	0.983	0.084
BTBD10	KLHL18	0.983	0.119	mutually_exclusive (Q13618)
KLHL24	KLHL18	0.983		mutually_exclusive (Q13618)
CUL2	COPS8	0.983	0.378
CRBN	DDB1	0.983	0.307	mixed_interface
KCTD20	KLHL18	0.983	0.084	mutually_exclusive (Q13618)
DTL	DCAF1	0.983	0.114	mutually_exclusive (Q16531)
ANKRD39	COPS5	0.983	0.118
COPS9	LRR1	0.983	0.09
DCAF6	COPS8	0.982	0.09	structurally_consistent (Q13098)
RBX1	DDB2	0.982	0.054
NEDD8	COPS7A	0.982	0.212	mutually_exclusive (Q9BT78)
BTBD10	CUL3	0.982	0.166	structurally_consistent (dimer)
CUL4B	FEM1B	0.982	0.146
ERCC8	COPS7A	0.982	0.142
BRWD3	DCAF1	0.982
COPS9	FEM1B	0.981	0.1	structurally_consistent (Q9UNS2)
DDA1	COPS5	0.981	0.268
KCTD20	BTBD2	0.981	0.106	mutually_exclusive (Q13618)
CUL4A	LRR1	0.981	0.294
BTBD10	BTBD2	0.981	0.078	mutually_exclusive (Q13618)
DDB1	COPS3	0.981	0.33
KLHL24	KCTD20	0.981		mutually_exclusive (Q13618)
DCAF16	DCAF6	0.98	0.054
LRR1	COPS7A	0.98	0.0851428571429
COPS9	ERCC8	0.979	0.17
DDB1	COPS2	0.979	0.388
LRR1	DCAF11	0.979	0.106
ANKRD39	NEDD8	0.979	0.138	mutually_exclusive (Q9BT78)
KLHDC3	COPS3	0.979	0.068	structurally_consistent (dimer)
KLHL42	BTBD2	0.979	0.174	mutually_exclusive (Q13618)
KLHL24	COPS8	0.979
CUL2	DDB2	0.978	0.118
BTBD1	FEM1B	0.977	0.158
BTBD1	APPBP2	0.977	0.114
NEDD8	COPS4	0.977	0.306	structurally_consistent (dimer)
COPS9	DDB2	0.977	0.068
KCTD20	COPS8	0.977	0.094
COPS3	DCAF1	0.976	0.158
DTL	COPS7A	0.976	0.106	structurally_consistent (P61201)
FEM1B	COPS5	0.975	0.182
KLHL13	BTBD10	0.975	0.104	mutually_exclusive (Q13618)
KCTD20	KLHL42	0.975	0.11	mutually_exclusive (Q13618)
COPS4	DCAF1	0.973	0.16
FEM1B	APPBP2	0.973	0.186
DCAF16	GPS1	0.973	0.246
ERCC8	DCAF4	0.973	0.112	mutually_exclusive (Q16531)
KLHL18	KLHL42	0.972	0.092	mutually_exclusive (Q13618)
CRBN	COPS2	0.972	0.34	mutually_exclusive (Q99627)
APPBP2	COPS4	0.972	0.09
KLHDC3	COPS6	0.972	0.186
CUL4A	CUL2	0.972	0.516
FEM1B	DCAF4	0.972	0.09
CUL4B	DCAF6	0.972	0.096	structurally_consistent (Q16531)
ERCC8	COPS2	0.971	0.292
ERCC8	COPS5	0.971	0.346
LRR1	APPBP2	0.971	0.096
CUL2	COPS7A	0.971	0.256	structurally_consistent (P61201)
BTBD2	APPBP2	0.97	0.15
COPS5	DCAF1	0.97	0.344
DCAF1	DDB2	0.969	0.076	mutually_exclusive (Q16531)
KLHL18	CUL3	0.969	0.278	structurally_consistent (dimer)
DDB1	RBX1	0.969	0.638
ERCC8	DCAF11	0.969	0.108	mutually_exclusive (Q16531)
ERCC8	COPS4	0.968	0.154	mutually_exclusive (Q99627)
DDB1	COPS7A	0.967	0.114
APPBP2	COPS7A	0.967	0.154	structurally_consistent (Q9UNS2)
DCAF16	DCAF11	0.966	0.074
ERCC8	DDB2	0.966	0.09	mutually_exclusive (Q16531)
KLHL18	COPS4	0.965	0.13	mutually_exclusive (Q13618)
KLHDC3	COPS7A	0.964	0.078	structurally_consistent (Q9UNS2)
CUL4A	DCAF6	0.964	0.154	structurally_consistent (Q16531)
KLHL18	COPS8	0.964	0.114
DDB1	DCAF16	0.962	0.260682464455
COPS8	KLHDC3	0.962	0.108	structurally_consistent (dimer)
DCAF11	APPBP2	0.962	0.068
KLHL42	RBX1	0.961	0.224
KLHL13	KCTD20	0.961	0.168	mutually_exclusive (Q13618)
CUL3	ANKRD39	0.961	0.268
FEM1B	DCAF11	0.96	0.08
DCAF4	BTBD2	0.96	0.068
KCTD20	COPS5	0.959	0.156
DTL	DCAF16	0.959	0.106
FEM1B	DDB2	0.959	0.08
COPS7B	KLHDC3	0.959	0.066	structurally_consistent (Q9UNS2)
CUL4A	APPBP2	0.959	0.16
APPBP2	DDB2	0.958	0.142
APPBP2	KLHDC3	0.957	0.138
DDA1	DCAF6	0.956	0.078
CUL3	NEDD8	0.956	0.276
KLHL18	COPS2	0.956	0.28	structurally_consistent (Q13618)
CUL4B	APPBP2	0.955	0.092
CUL4B	BRWD3	0.955
COPS5	APPBP2	0.955	0.108
KLHL18	COPS9	0.955	0.098
CUL4A	COPS2	0.955	0.724	structurally_consistent (dimer)
COPS9	DCAF4	0.951	0.102
KLHL13	KLHL18	0.951	0.142	mutually_exclusive (Q13618)
COPS7A	DCAF1	0.95	0.064
LRR1	FBXO17	0.95	0.072
RBX1	COPS2	0.949	0.36
DTL	DCAF6	0.947	0.228	mutually_exclusive (Q16531)
FEM1B	COPS7A	0.947	0.124
DDB1	LRR1	0.945	0.114
KLHL42	COPS6	0.945	0.248	structurally_consistent (Q96EF6)
DCAF4	APPBP2	0.944	0.104
KLHL18	BTBD2	0.944	0.098	mutually_exclusive (Q13618)
DDA1	ERCC8	0.944	0.17
KLHL24	COPS6	0.943
DDB1	COPS7B	0.942	0.102	structurally_consistent (Q92466)
COPS5	KLHDC3	0.942	0.278	structurally_consistent (dimer)
BRWD3	RBX1	0.941
DTL	DCAF11	0.941	0.114	mutually_exclusive (Q16531)
RBX1	COPS6	0.94	0.7
ERCC8	COPS6	0.939	0.354
CUL4A	DCAF1	0.939	0.126	structurally_consistent (Q16531)
DCAF6	DCAF11	0.938	0.06	mutually_exclusive (Q16531) structurally_consistent (dimer)
DCAF6	COPS3	0.937	0.102	structurally_consistent (Q13098)
DCAF11	NEDD8	0.936	0.078	structurally_consistent (dimer)
FEM1B	BTBD2	0.936	0.154
RBX1	COPS7A	0.936	0.24	mutually_exclusive (Q9H9Q2)
APPBP2	COPS6	0.936	0.186
DDA1	COPS3	0.935	0.33
DCAF4	FBXO17	0.935	0.094
KLHL13	COPS4	0.935	0.184	mutually_exclusive (Q13618)
COPS9	FBXO17	0.93	0.098
RBX1	DCAF11	0.929	0.234
DCAF11	FBXO17	0.929	0.094
KLHL42	COPS8	0.927	0.092
CUL4A	DCAF16	0.927	0.198
DDB1	COPS4	0.927	0.358
DCAF16	COPS4	0.926	0.34
RBX1	COPS8	0.924	0.214
KLHL18	COPS7B	0.924	0.084
FBXO17	DDB2	0.923	0.098
ANKRD39	FBXO17	0.921	0.08	structurally_consistent (dimer)
CUL4A	NEDD8	0.92	0.22
KLHL18	COPS7A	0.919	0.128
FEM1B	FBXO17	0.917	0.092
DCAF6	DDB2	0.916	0.09	mutually_exclusive (Q16531)
DCAF11	DCAF1	0.916	0.074	mutually_exclusive (Q16531)
DDB1	COPS9	0.916	0.112
DCAF4	DCAF1	0.915	0.114	mutually_exclusive (Q16531)
RBX1	GPS1	0.912	0.58
CUL2	FBXO17	0.912	0.106
DCAF6	COPS7B	0.912	0.072	structurally_consistent (Q13098)
CUL4A	COPS5	0.912	0.562
DCAF16	COPS6	0.911	0.522
DCAF16	DDB2	0.911	0.062
DCAF6	COPS6	0.911	0.19
KLHL18	BTBD1	0.911	0.12	mutually_exclusive (Q13618)
DCAF6	COPS5	0.91	0.174
KLHL42	ANKRD39	0.91	0.122	structurally_consistent (Q96EF6)
KLHL24	COPS3	0.909
DDB1	COPS5	0.906	0.76
FBXO17	APPBP2	0.904	0.098
CUL4B	FBXO17	0.904	0.064
DCAF6	FBXO17	0.902	0.062
CUL3	COPS7B	0.9	0.324
CUL4A	FBXO17	0.898	0.14
CUL2	NEDD8	0.896	0.186	structurally_consistent (Q9BQ90)
KLHL42	COPS3	0.895	0.122	mutually_exclusive (Q9UBW8)
KLHL24	KLHL13	0.894		mutually_exclusive (Q13618)
KLHL24	BTBD2	0.89		mutually_exclusive (Q13618)
BTBD10	COPS5	0.89	0.124
DCAF6	APPBP2	0.889	0.112
DDA1	NEDD8	0.888	0.076
CUL2	DCAF11	0.887	0.086
RBX1	COPS4	0.887	0.75
BTBD1	FBXO17	0.885	0.078
FEM1C	FEM1B	0.884
KLHL24	COPS7A	0.881
KLHL13	BTBD2	0.878	0.108	mutually_exclusive (Q13618)
RBX1	COPS5	0.871	0.538
KLHL24	BTBD1	0.871		mutually_exclusive (Q13618)
DTL	ERCC8	0.869	0.08	mutually_exclusive (Q16531)
CUL4A	COPS6	0.865	0.482
KLHL24	GPS1	0.862
GPS1	KLHDC3	0.856	0.156	mutually_exclusive (Q9UNS2)
KLHL24	COPS4	0.854		mutually_exclusive (Q13618)
CUL4A	COPS3	0.852	0.502	structurally_consistent (P61201)
BTBD2	FBXO17	0.852	0.06
ANKRD39	DDB2	0.851	0.192
RBX1	BTBD2	0.851	0.244	structurally_consistent (Q13618)
DCAF16	DDA1	0.849	0.122
ERCC8	COPS7B	0.848	0.1
RBX1	NEDD8	0.848	0.23
KLHL13	KLHL42	0.847	0.088	mutually_exclusive (Q13618)
KLHL42	COPS4	0.84	0.214
CUL4A	ERCC8	0.835	0.116	structurally_consistent (Q16531)
KLHL13	COPS8	0.835	0.12
RBX1	BTBD1	0.83	0.2078
DDB1	DCAF6	0.829	0.256	mutually_exclusive (Q8TEB1) structurally_consistent (dimer)
FEM1C	NEDD8	0.825
CUL2	DCAF6	0.821	0.2
ERCC8	FEM1B	0.815	0.094
CUL2	ERCC8	0.815	0.136
KLHL24	ANKRD39	0.812
ERCC8	APPBP2	0.81	0.084
KLHL13	BTBD1	0.805	0.112	mutually_exclusive (Q13618)
KLHDC3	COPS4	0.804	0.074
ERCC8	LRR1	0.8	0.074
BTBD2	DCAF11	0.797	0.13
RBX1	FEM1B	0.797	0.220579710145
CRBN	DDB2	0.792	0.094	mutually_exclusive (Q16531)
RBX1	COPS3	0.79	0.68	structurally_consistent (Q96EF6)
RBX1	DDA1	0.785	0.306
CRBN	FBXO17	0.785	0.072
KLHL13	COPS2	0.782	0.182	structurally_consistent (Q13618)
BTBD1	ERCC8	0.781	0.096
RBX1	DCAF1	0.781	0.114
CRBN	CUL2	0.78	0.256
FBXO17	KLHDC3	0.766	0.114
DCAF6	ERCC8	0.764	0.084	mutually_exclusive (Q16531)
RBX1	CUL2	0.763	0.556	structurally_consistent (dimer)
CRBN	KLHDC3	0.76	0.112
CRBN	COPS3	0.758	0.16	mutually_exclusive (Q99627)
KLHL13	COPS7A	0.754	0.16
DCAF4	KLHDC3	0.754	0.081
CRBN	FEM1B	0.752	0.068
CRBN	RBX1	0.75	0.3
FBXO17	DCAF1	0.749	0.05
CRBN	COPS7A	0.745	0.064
DCAF16	COPS3	0.743	0.15
CRBN	LRR1	0.743	0.076
DTL	NEDD8	0.743	0.152
CRBN	DCAF4	0.742	0.09	mutually_exclusive (Q16531)
CUL3	ERCC8	0.736	0.144
KLHL18	COPS5	0.735	0.2984
CUL3	LRR1	0.732	0.248
RBX1	DCAF4	0.731	0.156
ANKRD39	BTBD2	0.73	0.136
FEM1C	APPBP2	0.725
COPS7B	DCAF1	0.725	0.05
ERCC8	BTBD2	0.725	0.154
CRBN	BTBD2	0.725	0.132
KLHL18	DDB2	0.723	0.064
CRBN	BTBD1	0.717	0.114
KLHL18	KLHDC3	0.714	0.126
BTBD10	COPS7B	0.712	0.064
KLHL42	COPS2	0.709	0.308	structurally_consistent (Q13618)
DCAF6	COPS4	0.699	0.152	structurally_consistent (Q13098)
CRBN	APPBP2	0.696	0.136
DCAF6	KLHDC3	0.696	0.07
KLHL18	RBX1	0.694	0.174	structurally_consistent (Q13618)
KLHL42	COPS7A	0.692	0.122	structurally_consistent (Q96EF6) structurally_consistent (dimer)
CRBN	COPS5	0.688	0.278
CRBN	DCAF6	0.688	0.072	mutually_exclusive (Q16531)
KLHL18	FEM1B	0.684	0.178
KLHL13	COPS6	0.68	0.134
DDB1	ERCC8	0.677	0.22	structurally_consistent (dimer)
KLHL18	DDB1	0.676	0.2
CUL3	CRBN	0.671	0.404323076923
CUL2	ANKRD39	0.666	0.108	mutually_exclusive (P61201)
KLHL18	LRR1	0.656	0.092
KLHL24	RBX1	0.654		structurally_consistent (Q13618)
KLHL18	CUL2	0.654	0.118
KLHL13	COPS9	0.646	0.078
KLHL18	CUL4B	0.644	0.114
CRBN	ERCC8	0.641	0.086	mixed_interface
KLHL18	CUL4A	0.641	0.112
KLHL18	DCAF11	0.637	0.088
CRBN	COPS9	0.633	0.076
CRBN	COPS7B	0.628	0.132
KLHDC3	DCAF1	0.628	0.124
CRBN	DCAF11	0.627	0.186	mutually_exclusive (Q16531)
KLHL13	RBX1	0.624	0.238	structurally_consistent (Q13618)
CRBN	GPS1	0.616	0.242	mutually_exclusive (Q99627)
BTBD1	NEDD8	0.613	0.122	mutually_exclusive (Q92905)
CUL3	FBXO17	0.612	0.19	structurally_consistent (Q9P2K6)
CUL4B	COPS4	0.612	0.192
FEM1B	KLHDC3	0.609	0.068
LRR1	KLHDC3	0.607	0.122
KLHL13	COPS3	0.607	0.042
CUL4B	NEDD8	0.601	0.112
KLHL18	APPBP2	0.594	0.118
APPBP2	DCAF1	0.594	0.108
CUL4B	KLHDC3	0.593	0.08
CRBN	DCAF1	0.588	0.114	mutually_exclusive (Q16531)
ERCC8	KLHDC3	0.587	0.134
COPS9	NEDD8	0.587	0.052
KLHL42	DCAF11	0.582	0.08
DTL	BTBD2	0.581	0.17
FEM1C	DCAF4	0.565
KLHL13	APPBP2	0.563	0.11
RBX1	LRR1	0.557	0.24
FEM1C	LRR1	0.553
CUL3	KLHDC3	0.552	0.316
NEDD8	COPS7B	0.55	0.096
LRR1	DCAF1	0.546	0.1
CRBN	DCAF16	0.545	0.13
ERCC8	DCAF1	0.537	0.202	mutually_exclusive (Q16531)
BTBD1	KLHDC3	0.532	0.07
KLHL18	DCAF4	0.532	0.166
CRBN	COPS6	0.53	0.292
NEDD8	COPS5	0.53	0.36	structurally_consistent (dimer)
CUL3	DCAF4	0.525	0.232326300985
DCAF6	LRR1	0.522	0.076
DDB1	APPBP2	0.522	0.188
CUL4A	ANKRD39	0.511	0.154	mutually_exclusive (P61201)
DCAF6	COPS7A	0.511	0.164	structurally_consistent (Q13098)
DCAF6	DCAF4	0.508	0.1	mutually_exclusive (Q16531)
DDB1	FEM1B	0.504	0.246
DCAF16	COPS5	0.504	0.512
KCTD20	RBX1	0.483	0.206	structurally_consistent (Q13618)
CUL4A	KLHDC3	0.481	0.182
KLHL18	ERCC8	0.48	0.124
DTL	CUL2	0.474	0.148
CRBN	COPS4	0.47	0.198	mutually_exclusive (Q99627)
ERCC8	FBXO17	0.47	0.124
KLHL18	FBXO17	0.468	0.1
COPS9	DCAF1	0.468	0.094
KLHL42	FEM1C	0.465
RBX1	DCAF16	0.461	0.274
CUL4B	COPS3	0.455	0.212	structurally_consistent (P61201)
KLHL13	COPS5	0.447	0.314
DTL	BTBD1	0.445	0.146
KLHDC3	DDB2	0.444	0.092
DCAF16	ANKRD39	0.444	0.124
BRWD3	DCAF11	0.443
DCAF16	COPS7B	0.443	0.198
DCAF11	KLHDC3	0.438	0.076
FEM1C	KLHDC3	0.436
FEM1C	COPS4	0.436
DCAF16	ERCC8	0.435	0.084
KLHL13	LRR1	0.434	0.142
CUL2	DCAF1	0.432	0.126
FEM1C	COPS3	0.431
KLHL18	FEM1C	0.431
CUL3	DCAF1	0.429	0.268
KCTD20	NEDD8	0.426	0.102
BTBD10	NEDD8	0.421	0.052
DDB1	FBXO17	0.419	0.18
BTBD2	KLHDC3	0.418	0.094
FEM1C	COPS5	0.414
DTL	LRR1	0.413	0.144
FEM1B	DCAF1	0.412	0.136175
KLHL24	KLHDC3	0.412
BTBD1	DCAF1	0.409	0.116
FEM1C	COPS7B	0.407
FEM1C	COPS2	0.407
KLHL13	DCAF4	0.404	0.096
RBX1	FBXO17	0.403	0.164	structurally_consistent (dimer)
FEM1C	COPS9	0.401
CRBN	ANKRD39	0.397	0.092	mutually_exclusive (Q99627)
ERCC8	ANKRD39	0.389	0.098	mutually_exclusive (Q99627)
DCAF6	DCAF1	0.38	0.102	mutually_exclusive (Q16531)
KLHL18	CRBN	0.37	0.112
DCAF16	COPS7A	0.361	0.162
COPS9	KLHDC3	0.36	0.062	structurally_consistent (Q9UNS2)
BTBD10	RBX1	0.351	0.132	structurally_consistent (Q13618)
RBX1	DCAF6	0.346	0.308579710145
DCAF6	BTBD2	0.345	0.098
BTBD10	ANKRD39	0.333	0.15
COPS9	DCAF6	0.311	0.078
KLHL24	FBXO17	0.31
FEM1C	COPS7A	0.303
NEDD8	DCAF1	0.295	0.066
KLHL13	KLHDC3	0.289	0.164
KLHL42	APPBP2	0.289	0.174
BRWD3	COPS6	0.288
BRWD3	COPS8	0.288
BRWD3	COPS2	0.288
NEDD8	FBXO17	0.288	0.15	structurally_consistent (Q9BT78)
DCAF16	COPS2	0.288	0.358
FEM1C	DCAF11	0.283
DCAF6	FEM1B	0.282	0.14
FEM1C	COPS6	0.275
FEM1C	COPS8	0.269
DDA1	LRR1	0.267	0.126
CUL3	APPBP2	0.26	0.381215189873
DDA1	CUL2	0.257	0.27
KLHL18	DCAF6	0.251	0.086
CUL4B	COPS6	0.247	0.226
KLHL24	CRBN	0.246
LRR1	NEDD8	0.244	0.208
FEM1C	BTBD1	0.244
FEM1C	DCAF6	0.239
DTL	FEM1C	0.237
FEM1C	DDB2	0.234
DCAF6	BTBD1	0.233	0.108
KCTD20	CUL2	0.232	0.146
BTBD10	DDB2	0.232	0.076
RBX1	ERCC8	0.232	0.162
BTBD10	CUL2	0.232	0.096
BTBD10	DCAF11	0.232	0.068
BTBD10	LRR1	0.232	0.112
KCTD20	CUL4B	0.232	0.1
KCTD20	LRR1	0.232	0.106
CUL3	DDB2	0.231	0.256
KLHL24	COPS5	0.23
KLHL42	CRBN	0.229	0.092
DDB1	NEDD8	0.226	0.42	structurally_consistent (Q8TEB1)
BRWD3	GPS1	0.226
BRWD3	COPS3	0.226
KLHL13	DCAF11	0.225	0.072
KLHL42	DDB2	0.222	0.052
DTL	APPBP2	0.219	0.124
KLHL24	CUL2	0.217
DDB1	BTBD1	0.215	0.188
BTBD2	DCAF1	0.215	0.124
KLHL18	ANKRD39	0.213	0.176
KLHL42	COPS7B	0.207	0.04	mutually_exclusive (Q9UBW8)
KLHL24	DCAF11	0.206
KLHL24	COPS7B	0.205
NEDD8	DDB2	0.205	0.096
KLHL42	NEDD8	0.202	0.098
CUL3	FEM1B	0.201	0.246
KLHL42	FEM1B	0.198	0.136
KCTD20	COPS7B	0.196	0.098
KLHL13	COPS7B	0.195	0.038
KLHL42	CUL4B	0.192	0.062
KCTD20	DCAF11	0.192	0.134
BRWD3	ERCC8	0.192
KCTD20	DDB2	0.192	0.13
KCTD20	DCAF4	0.192	0.072
BTBD10	DCAF4	0.192	0.054
BRWD3	NEDD8	0.192
CUL4B	FEM1C	0.188
BRWD3	COPS4	0.186
DCAF16	DCAF1	0.185	0.116666666667
KLHL42	KLHDC3	0.184	0.09
DTL	CRBN	0.18	0.094	mutually_exclusive (Q16531)
KLHL42	COPS5	0.179	0.3
KCTD20	ANKRD39	0.172	0.176
KLHL18	NEDD8	0.171	0.178
DDB1	FEM1C	0.17
CUL4A	FEM1C	0.17
CUL3	CUL2	0.17	0.54
DDB1	BTBD2	0.168	0.166
KLHL42	DCAF6	0.168	0.094
KLHL42	CUL2	0.167	0.148
KLHL13	DDB2	0.166	0.088
DCAF16	FEM1C	0.165
KLHL13	FEM1B	0.162	0.158
DDA1	BTBD2	0.16	0.098
NEDD8	APPBP2	0.155	0.108
KLHL13	FEM1C	0.152
ANKRD39	DCAF11	0.151	0.09
DTL	FEM1B	0.151	0.122
DCAF16	COPS8	0.15	0.308
KLHL42	CUL4A	0.149	0.106
DTL	BRWD3	0.149
BTBD1	ANKRD39	0.146	0.114	structurally_consistent (Q9UNS2)
KCTD20	DCAF1	0.143	0.122
CRBN	FEM1C	0.143
KLHL24	CUL4B	0.139
CUL3	DCAF6	0.138	0.242
KLHL13	ANKRD39	0.135	0.116
KLHL13	CUL2	0.134	0.11
DDA1	COPS7B	0.133	0.246
RBX1	FEM1C	0.131
KLHL24	NEDD8	0.13
KLHL42	COPS9	0.129	0.068
KLHL13	CUL4A	0.129	0.128
CUL3	FEM1C	0.123
KLHL24	DDB2	0.123
BTBD10	DCAF1	0.122	0.098
KLHL42	LRR1	0.119	0.106
KLHL13	CUL4B	0.118	0.086
KLHL24	FEM1B	0.114
KLHL13	DDA1	0.114	0.12
DCAF16	DCAF4	0.114	0.076
FEM1C	ANKRD39	0.113
DCAF4	NEDD8	0.108	0.092
BRWD3	COPS7A	0.108
FEM1B	NEDD8	0.107	0.098
KLHL24	COPS9	0.107
KLHL42	DCAF4	0.107	0.09
DTL	FBXO17	0.103	0.076
ANKRD39	DCAF4	0.102	0.12
DTL	ANKRD39	0.102	0.2
FEM1C	BTBD2	0.101
ERCC8	NEDD8	0.101	0.134
KLHL24	LRR1	0.1
KLHL42	DCAF16	0.099	0.138
KLHL13	DCAF1	0.098	0.142
KLHL18	DCAF1	0.098	0.124
ANKRD39	KLHDC3	0.097	0.128
DCAF16	APPBP2	0.097	0.086
DDB1	ANKRD39	0.094	0.122
RBX1	KLHDC3	0.094	0.168	structurally_consistent (Q13617)
DTL	CUL3	0.094	0.322
DTL	COPS7B	0.09	0.052	structurally_consistent (P61201)
KLHL13	FBXO17	0.088	0.078
KLHL24	DCAF4	0.087
DDA1	FEM1B	0.085	0.142
KLHL13	ERCC8	0.08	0.086
KLHL42	FBXO17	0.079	0.07	structurally_consistent (dimer)
FEM1C	FBXO17	0.078
FEM1C	ERCC8	0.076
ANKRD39	LRR1	0.076	0.12
DDA1	BTBD1	0.076	0.076
DDB1	KLHDC3	0.074	0.17
KLHL13	CRBN	0.073	0.114
KLHL18	DDA1	0.073	0.114
KLHL13	NEDD8	0.072	0.072
KLHL24	APPBP2	0.071
KLHL24	CUL4A	0.069
FEM1C	DCAF1	0.069
BTBD2	NEDD8	0.068	0.146
KLHL42	DDB1	0.068	0.14
ANKRD39	FEM1B	0.064	0.164
KLHL13	DDB1	0.064	0.112
BTBD10	DDA1	0.063	0.084
BRWD3	DDB2	0.063
KCTD20	CUL4A	0.063	0.2225
BTBD10	CUL4B	0.063	0.066
BRWD3	DCAF4	0.063
DTL	KCTD20	0.063	0.24
KLHL24	FEM1C	0.063
ANKRD39	APPBP2	0.062	0.154
CRBN	NEDD8	0.061	0.134
KLHL24	DCAF16	0.061
DCAF16	NEDD8	0.059	0.16
CRBN	DDA1	0.058	0.034
RBX1	COPS7B	0.057	0.226	structurally_consistent (dimer)
DTL	KLHL13	0.057	0.136
DTL	KLHDC3	0.056	0.114
CUL4B	COPS5	0.055	0.252
DCAF16	FEM1B	0.055	0.1
DCAF16	CUL2	0.055	0.15
KLHL18	DCAF16	0.054	0.104
CUL3	DCAF11	0.053	0.225715189873
DCAF16	FBXO17	0.053	0.066
CUL3	BRWD3	0.052
KLHL13	DCAF6	0.052	0.132
DTL	KLHL24	0.051
DTL	KLHL18	0.05	0.128
KLHL24	DCAF1	0.05
DTL	BTBD10	0.049	0.142
KLHL42	ERCC8	0.049	0.13
CUL3	DCAF16	0.049	0.291215189873
BTBD10	CUL4A	0.048	0.082
DCAF16	BTBD2	0.046	0.176
CUL3	CUL4B	0.046	0.228
DCAF6	ANKRD39	0.046	0.138
DCAF6	NEDD8	0.045	0.064	structurally_consistent (Q8TEB1)
DCAF16	LRR1	0.044	0.142
KLHL24	ERCC8	0.044
DDA1	ANKRD39	0.044	0.13
DTL	KLHL42	0.043	0.142
DDA1	FEM1C	0.043
KLHL24	DDB1	0.042
RBX1	APPBP2	0.042	0.142
CUL3	CUL4A	0.039	0.54
DDA1	FBXO17	0.039	0.102
DDA1	COPS9	0.038	0.096
DTL	COPS9	0.038	0.076
DDB1	CUL2	0.036	0.722
DCAF16	BTBD1	0.035	0.106
KCTD20	DDA1	0.035	0.242
KLHL42	DDA1	0.035	0.078
BRWD3	COPS7B	0.034
KLHL13	DCAF16	0.033	0.1
DDA1	APPBP2	0.028	0.066
BRWD3	COPS5	0.028
DDA1	KLHDC3	0.027	0.126
CUL4B	COPS2	0.026	0.188	structurally_consistent (dimer)
DCAF16	COPS9	0.026	0.09
DCAF16	KLHDC3	0.024	0.108
ANKRD39	DCAF1	0.022	0.112
CUL3	DDA1	0.019	0.29
CUL3	DDB1	0.015	0.61
KLHL24	DCAF6	0.01
KLHL42	DCAF1	0.008	0.116
KLHL24	DDA1	0.004

Related Complexes

Genename	Complexes
COPS5	huMAP3_05041.1 huMAP3_07590.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_14528.1
COPS7B	huMAP3_05041.1 huMAP3_05816.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_14528.1
RBX1	huMAP3_02231.1 huMAP3_02953.1 huMAP3_06808.1 huMAP3_08251.1 huMAP3_09283.1 huMAP3_09779.1 huMAP3_10612.1 huMAP3_14528.1
KLHL13	huMAP3_02073.1 huMAP3_07590.1 huMAP3_07744.1 huMAP3_08550.1 huMAP3_09489.1 huMAP3_09779.1 huMAP3_10939.1 huMAP3_13639.1 huMAP3_14528.1
COPS7A	huMAP3_05041.1 huMAP3_05816.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_14528.1
LRR1	huMAP3_03628.1 huMAP3_07590.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_13769.1 huMAP3_14528.1
GPS1	huMAP3_03628.1 huMAP3_07590.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_14528.1
COPS6	huMAP3_05041.1 huMAP3_05816.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_14528.1
DCAF4	huMAP3_03628.1 huMAP3_07590.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_14528.1
BTBD2	huMAP3_03628.1 huMAP3_07590.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_12609.1 huMAP3_14528.1
DDA1	huMAP3_02953.1 huMAP3_05150.1 huMAP3_06808.1 huMAP3_08251.1 huMAP3_09283.1 huMAP3_09779.1 huMAP3_10612.1 huMAP3_14528.1
CRBN	huMAP3_02229.1 huMAP3_02953.1 huMAP3_06808.1 huMAP3_08251.1 huMAP3_09283.1 huMAP3_09779.1 huMAP3_10612.1 huMAP3_14528.1
COPS8	huMAP3_05041.1 huMAP3_05816.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_14528.1
KLHDC3	huMAP3_05041.1 huMAP3_05215.1 huMAP3_05816.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_10626.1 huMAP3_14528.1
CUL2	huMAP3_03490.1 huMAP3_07590.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_12267.1 huMAP3_14528.1
FEM1C	huMAP3_03490.1 huMAP3_03628.1 huMAP3_07590.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_12267.1 huMAP3_13131.1 huMAP3_14528.1
NEDD8	huMAP3_04750.1 huMAP3_05041.1 huMAP3_05816.1 huMAP3_05894.1 huMAP3_08550.1 huMAP3_08919.1 huMAP3_09779.1 huMAP3_09980.1 huMAP3_14528.1
COPS3	huMAP3_05041.1 huMAP3_05816.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_14528.1
DDB2	huMAP3_07590.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_12003.1 huMAP3_14528.1 huMAP3_14584.1
FEM1B	huMAP3_03628.1 huMAP3_07590.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_12267.1 huMAP3_14528.1
CUL3	huMAP3_02073.1 huMAP3_07590.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_12888.1 huMAP3_13639.1 huMAP3_14528.1
COPS4	huMAP3_05041.1 huMAP3_07590.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_14528.1
DCAF1	huMAP3_05150.1 huMAP3_06808.1 huMAP3_07675.1 huMAP3_09779.1
DCAF8L2	huMAP3_00263.1 huMAP3_00860.1 huMAP3_02229.1 huMAP3_02953.1 huMAP3_06808.1 huMAP3_08251.1 huMAP3_09283.1 huMAP3_09779.1 huMAP3_10612.1 huMAP3_11100.1 huMAP3_11271.1 huMAP3_12806.1 huMAP3_13329.1 huMAP3_14528.1
DCAF16	huMAP3_02953.1 huMAP3_03628.1 huMAP3_07590.1 huMAP3_08251.1 huMAP3_08550.1 huMAP3_09283.1 huMAP3_09779.1 huMAP3_10612.1 huMAP3_14528.1 huMAP3_14809.1
DCAF6	huMAP3_03628.1 huMAP3_07590.1 huMAP3_08550.1 huMAP3_09283.1 huMAP3_09779.1 huMAP3_10612.1 huMAP3_12773.1 huMAP3_14528.1
APPBP2	huMAP3_05041.1 huMAP3_07590.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_14528.1
ERCC8	huMAP3_03628.1 huMAP3_07590.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_14528.1
ANKRD39	huMAP3_03628.1 huMAP3_07590.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_14528.1
CUL4B	huMAP3_02229.1 huMAP3_02953.1 huMAP3_06808.1 huMAP3_08251.1 huMAP3_09283.1 huMAP3_09779.1 huMAP3_10612.1 huMAP3_14528.1
DDB1	huMAP3_02229.1 huMAP3_06808.1 huMAP3_08251.1 huMAP3_09283.1 huMAP3_09779.1 huMAP3_10612.1 huMAP3_11271.1 huMAP3_14528.1
BRWD3	huMAP3_02229.1 huMAP3_02953.1 huMAP3_06808.1 huMAP3_08251.1 huMAP3_09283.1 huMAP3_09779.1 huMAP3_10612.1 huMAP3_14528.1
BTBD1	huMAP3_03628.1 huMAP3_07590.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_14528.1
KLHL24	huMAP3_02073.1 huMAP3_07590.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_14528.1
COPS9	huMAP3_03628.1 huMAP3_07590.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_14528.1
FBXO17	huMAP3_05041.1 huMAP3_07590.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_14528.1
COPS2	huMAP3_05041.1 huMAP3_05816.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_14528.1
KCTD20	huMAP3_02073.1 huMAP3_07590.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_14528.1
CUL4A	huMAP3_02229.1 huMAP3_02953.1 huMAP3_06808.1 huMAP3_08251.1 huMAP3_09283.1 huMAP3_09779.1 huMAP3_10612.1 huMAP3_14528.1
BTBD10	huMAP3_02073.1 huMAP3_07590.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_14528.1
KLHL18	huMAP3_02073.1 huMAP3_07590.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_14528.1
DTL	huMAP3_01951.1 huMAP3_06559.1 huMAP3_06808.1 huMAP3_07938.1 huMAP3_09191.1 huMAP3_09779.1 huMAP3_10656.1 huMAP3_14528.1 huMAP3_14584.1
KLHL42	huMAP3_02073.1 huMAP3_07590.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_13416.1 huMAP3_14528.1
DCAF11	huMAP3_03628.1 huMAP3_06836.1 huMAP3_07590.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_14528.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_09779.1

Complex Portal: CPX-12010