hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09780.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CENPS | Centromere protein S (CENP-S) (Apoptosis-inducing TAF9-like domain-containing protein 1) (FANCM-associated histone fold protein 1) (FANCM-interacting histone fold protein 1) (Fanconi anemia-associated polypeptide of 16 kDa) | 5 | UniProt NCBI |
| FANCM | Fanconi anemia group M protein (Protein FACM) (EC 3.6.4.13) (ATP-dependent RNA helicase FANCM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog) | 5 | UniProt NCBI |
| CFAP68 | Cilia- and flagella-associated protein 68 | 5 | UniProt NCBI |
| CENPX | Centromere protein X (CENP-X) (FANCM-associated histone fold protein 2) (FANCM-interacting histone fold protein 2) (Fanconi anemia-associated polypeptide of 10 kDa) (Retinoic acid-inducible gene D9 protein homolog) (Stimulated by retinoic acid gene 13 protein homolog) | 5 | UniProt NCBI |
| FAAP24 | Fanconi anemia core complex-associated protein 24 (Fanconi anemia-associated protein of 24 kDa) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0071821 | 1.31563155046e-10 | 0.8 | CENPX FAAP24 CENPS FANCM | FANCM-MHF complex |
| REAC:R-HSA-6783310 | 2.23277738459e-08 | 0.8 | CENPX FAAP24 CENPS FANCM | Fanconi Anemia Pathway |
| KEGG:03460 | 2.69964987601e-08 | 0.8 | CENPX FAAP24 CENPS FANCM | Fanconi anemia pathway |
| GO:0043240 | 6.50952358374e-08 | 0.8 | CENPX FAAP24 CENPS FANCM | Fanconi anaemia nuclear complex |
| WP:WP4946 | 1.05784593025e-06 | 0.8 | CENPX FAAP24 CENPS FANCM | DNA repair pathways full network |
| GO:0036297 | 5.37501604002e-06 | 0.8 | CENPX FAAP24 CENPS FANCM | interstrand cross-link repair |
| CORUM:6145 | 1.36501667663e-05 | 0.4 | CENPS CENPX | CENP-S-X complex |
| CORUM:6146 | 8.18785830799e-05 | 0.4 | CENPS CENPX | CENP-T-W-S-X heterotetramer complex |
| GO:0000712 | 0.000115261178119 | 0.6 | CENPX CENPS FANCM | resolution of meiotic recombination intermediates |
| REAC:R-HSA-73894 | 0.000150476434856 | 0.8 | CENPX FAAP24 CENPS FANCM | DNA Repair |
| CORUM:6884 | 0.000490935356523 | 0.4 | FANCM FAAP24 | Fanconi anemia FAAP100 complex |
| GO:0007131 | 0.00875197805683 | 0.6 | CENPX CENPS FANCM | reciprocal meiotic recombination |
| GO:0140527 | 0.00875197805683 | 0.6 | CENPX CENPS FANCM | reciprocal homologous recombination |
| GO:0031297 | 0.0135806930791 | 0.6 | CENPX CENPS FANCM | replication fork processing |
| GO:0035825 | 0.0155155487472 | 0.6 | CENPX CENPS FANCM | homologous recombination |
| GO:0045005 | 0.0211358171848 | 0.6 | CENPX CENPS FANCM | DNA-templated DNA replication maintenance of fidelity |
| REAC:R-HSA-606279 | 0.0275944536635 | 0.4 | CENPS CENPX | Deposition of new CENPA-containing nucleosomes at the centromere |
| REAC:R-HSA-774815 | 0.0275944536635 | 0.4 | CENPS CENPX | Nucleosome assembly |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CENPS | FANCM | 0.999 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| FANCM | FAAP24 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CENPX | CENPS | 0.998 | 0.186 | hein_WMM bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| CFAP68 | CENPS | 0.988 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| CENPX | FAAP24 | 0.982 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CENPS | FAAP24 | 0.922 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| CENPX | FANCM | 0.786 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes