hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_09784.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TSSK6 | Testis-specific serine/threonine-protein kinase 6 (TSK-6) (TSSK-6) (Testis-specific kinase 6) (EC 2.7.11.1) (Cancer/testis antigen 72) (CT72) (Serine/threonine-protein kinase SSTK) (Small serine/threonine kinase) | 5 | UniProt NCBI |
| MAP3K14 | Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa-beta-inducing kinase) (HsNIK) (Serine/threonine-protein kinase NIK) | 5 | UniProt NCBI |
| CDK11A | Cyclin-dependent kinase 11A (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 2) (Cell division protein kinase 11A) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L2) | 5 | UniProt NCBI |
| FKBP5 | Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase) | 5 | UniProt NCBI |
| CDC37 | Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed] | 5 | UniProt NCBI |
| CDK15 | Cyclin-dependent kinase 15 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein) (Cell division protein kinase 15) (Serine/threonine-protein kinase ALS2CR7) (Serine/threonine-protein kinase PFTAIRE-2) | 5 | UniProt NCBI |
| STK11 | Serine/threonine-protein kinase STK11 (EC 2.7.11.1) (Liver kinase B1) (LKB1) (hLKB1) (Renal carcinoma antigen NY-REN-19) | 5 | UniProt NCBI |
| IKBKG | NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier) | 5 | UniProt NCBI |
| CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16) | 5 | UniProt NCBI |
| IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1) | 5 | UniProt NCBI |
| A6NIL8 | None | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5266 | 4.25355132415e-12 | 0.5 | MAP3K14 CHUK IKBKB CDC37 IKBKG | TNF-alpha/NF-kappa B signaling complex 6 |
| CORUM:5194 | 1.69065897579e-09 | 0.4 | MAP3K14 IKBKB CHUK IKBKG | TNF-alpha/NF-kappa B signaling complex (SEC16A, CHUK, IKBKB, NFKB2, REL, IKBKG, MAP3K14, RELA, FBXW7, USP2) |
| WP:WP3849 | 5.37011148829e-09 | 0.4 | MAP3K14 IKBKB CHUK IKBKG | MAPK and NFkB signaling pathways inhibited by Yersinia YopJ |
| CORUM:5844 | 1.68385473419e-08 | 0.3 | IKBKG CHUK IKBKB | I-kappa-B kinase complex |
| CORUM:2100 | 1.68385473419e-08 | 0.3 | MAP3K14 CHUK IKBKB | CHUK-IKBKB-MAP3K14 complex |
| CORUM:2121 | 1.68385473419e-08 | 0.3 | IKBKG CHUK IKBKB | I-kappa-B kinase complex |
| REAC:R-HSA-5603027 | 5.57217629429e-08 | 0.3 | IKBKG CHUK IKBKB | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) |
| REAC:R-HSA-5602636 | 5.57217629429e-08 | 0.3 | IKBKG CHUK IKBKB | IKBKB deficiency causes SCID |
| CORUM:2118 | 6.73299894294e-08 | 0.3 | IKBKG CHUK IKBKB | CHUK-ERC1-IKBKB-IKBKG |
| WP:WP262 | 7.90978508109e-08 | 0.4 | MAP3K14 IKBKB CHUK IKBKG | Ebstein Barr virus LMP1 signaling |
| WP:WP231 | 1.34818870607e-07 | 0.5 | MAP3K14 CHUK IKBKB CDC37 IKBKG | TNF alpha signaling pathway |
| CORUM:5285 | 1.68264493604e-07 | 0.3 | CHUK FKBP5 CDC37 | TNF-alpha/NF-kappa B signaling complex 9 |
| CORUM:2727 | 1.68264493604e-07 | 0.3 | IKBKG CHUK IKBKB | SRC-3 complex |
| CORUM:2105 | 1.68264493604e-07 | 0.3 | MAP3K14 CHUK IKBKB | IkappaB kinase complex (IKBKB, CHUK, IKBKAP, NFKBIA, RELA, MAP3K14) |
| WP:WP4479 | 7.93551702481e-07 | 0.3 | IKBKG CHUK IKBKB | Supression of HMGB1 mediated inflammation by THBD |
| WP:WP2795 | 1.20237378466e-06 | 0.4 | MAP3K14 IKBKB CHUK IKBKG | Cardiac hypertrophic response |
| WP:WP4480 | 1.26922647876e-06 | 0.3 | IKBKG CHUK IKBKB | Altered glycosylation of MUC1 in tumor microenvironment |
| WP:WP4562 | 1.26922647876e-06 | 0.3 | IKBKG CHUK IKBKB | Canonical NF kB pathway |
| WP:WP288 | 1.90315557518e-06 | 0.3 | IKBKG CHUK IKBKB | Nod like receptor NLR signaling pathway |
| REAC:R-HSA-5603029 | 1.94746021672e-06 | 0.3 | IKBKG CHUK IKBKB | IkBA variant leads to EDA-ID |
| CORUM:5286 | 2.01554870026e-06 | 0.3 | IKBKG CDC37 CHUK | TNF-alpha/NF-kappa B signaling complex 10 |
| WP:WP195 | 2.086092221e-06 | 0.4 | MAP3K14 IKBKB CHUK IKBKG | IL 1 signaling pathway |
| WP:WP3863 | 2.27077497663e-06 | 0.4 | MAP3K14 IKBKB CHUK IKBKG | T cell antigen receptor TCR pathway during Staphylococcus aureus infection |
| WP:WP5072 | 3.13421326296e-06 | 0.4 | MAP3K14 IKBKB CHUK IKBKG | Modulators of TCR signaling and T cell activation |
| KEGG:04920 | 3.2509227435e-06 | 0.4 | STK11 IKBKB CHUK IKBKG | Adipocytokine signaling pathway |
| KEGG:05120 | 3.2509227435e-06 | 0.4 | MAP3K14 IKBKB CHUK IKBKG | Epithelial cell signaling in Helicobacter pylori infection |
| WP:WP1434 | 3.73565492855e-06 | 0.3 | MAP3K14 CHUK IKBKB | Osteopontin signaling |
| WP:WP69 | 5.57090892881e-06 | 0.4 | MAP3K14 IKBKB CHUK IKBKG | T cell receptor signaling pathway |
| CORUM:6344 | 6.10504685098e-06 | 0.3 | IKBKG CHUK IKBKB | TNF-R1-associated signaling complex |
| GO:1902911 | 8.02952519765e-06 | 0.6 | STK11 IKBKB CDK11A TSSK6 IKBKG CHUK | protein kinase complex |
| KEGG:04064 | 8.58346845042e-06 | 0.4 | MAP3K14 IKBKB CHUK IKBKG | NF-kappa B signaling pathway |
| REAC:R-HSA-933543 | 9.16769422079e-06 | 0.3 | IKBKG CHUK IKBKB | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 |
| WP:WP1544 | 9.20443491165e-06 | 0.4 | MAP3K14 IKBKB CHUK IKBKG | MicroRNAs in cardiomyocyte hypertrophy |
| KEGG:04625 | 1.09707081303e-05 | 0.4 | MAP3K14 IKBKB CHUK IKBKG | C-type lectin receptor signaling pathway |
| REAC:R-HSA-937039 | 1.58792502117e-05 | 0.3 | IKBKG CHUK IKBKB | IRAK1 recruits IKK complex |
| REAC:R-HSA-975144 | 1.58792502117e-05 | 0.3 | IKBKG CHUK IKBKB | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation |
| GO:0004674 | 1.6244887329e-05 | 0.7 | MAP3K14 CDK15 STK11 IKBKB CDK11A TSSK6 CHUK | protein serine/threonine kinase activity |
| KEGG:04668 | 1.719231916e-05 | 0.4 | MAP3K14 IKBKB CHUK IKBKG | TNF signaling pathway |
| WP:WP4961 | 1.84280815715e-05 | 0.3 | IKBKG CHUK IKBKB | STING pathway in Kawasaki like disease and COVID 19 |
| REAC:R-HSA-5684264 | 2.02026912702e-05 | 0.3 | IKBKG CHUK IKBKB | MAP3K8 (TPL2)-dependent MAPK1/3 activation |
| KEGG:04660 | 2.38135824192e-05 | 0.4 | MAP3K14 IKBKB CHUK IKBKG | T cell receptor signaling pathway |
| WP:WP4482 | 2.57266083477e-05 | 0.3 | IKBKG CHUK IKBKB | Vitamin D in inflammatory diseases |
| WP:WP712 | 2.57266083477e-05 | 0.3 | IKBKG CHUK IKBKB | Estrogen signaling pathway |
| CORUM:5233 | 2.57548629133e-05 | 0.3 | IKBKG CHUK IKBKB | TNF-alpha/NF-kappa B signaling complex 5 |
| KEGG:01523 | 2.99521863906e-05 | 0.3 | IKBKG CHUK IKBKB | Antifolate resistance |
| CORUM:2101 | 3.07577115383e-05 | 0.2 | CHUK IKBKB | IKKA-IKKB complex |
| CORUM:5828 | 3.07577115383e-05 | 0.2 | IKBKG IKBKB | IKBKG-IKBKB complex |
| CORUM:5829 | 3.07577115383e-05 | 0.2 | IKBKG CHUK | IKBKG-CHUK complex |
| CORUM:2104 | 3.07577115383e-05 | 0.2 | MAP3K14 IKBKB | IKKB-NIK complex |
| CORUM:6152 | 3.07577115383e-05 | 0.2 | IKBKG CHUK | IKBKG-CHUK complex |
| REAC:R-HSA-1810476 | 3.10587251411e-05 | 0.3 | IKBKG CHUK IKBKB | RIP-mediated NFkB activation via ZBP1 |
| REAC:R-HSA-9758274 | 3.10587251411e-05 | 0.3 | IKBKG CHUK IKBKB | Regulation of NF-kappa B signaling |
| KEGG:04151 | 3.24513023441e-05 | 0.5 | STK11 CHUK IKBKB CDC37 IKBKG | PI3K-Akt signaling pathway |
| KEGG:04380 | 3.70889874115e-05 | 0.4 | MAP3K14 IKBKB CHUK IKBKG | Osteoclast differentiation |
| KEGG:04210 | 4.39971863747e-05 | 0.4 | MAP3K14 IKBKB CHUK IKBKG | Apoptosis |
| REAC:R-HSA-1606322 | 4.52244707165e-05 | 0.3 | IKBKG CHUK IKBKB | ZBP1(DAI) mediated induction of type I IFNs |
| WP:WP4172 | 4.85700243388e-05 | 0.5 | STK11 CHUK IKBKB CDC37 IKBKG | PI3K Akt signaling pathway |
| KEGG:04936 | 5.01795914e-05 | 0.4 | MAP3K14 IKBKB CHUK IKBKG | Alcoholic liver disease |
| WP:WP3851 | 5.18113283391e-05 | 0.3 | IKBKG CHUK IKBKB | TLR4 signaling and tolerance |
| REAC:R-HSA-168927 | 5.36847545384e-05 | 0.3 | IKBKG CHUK IKBKB | TICAM1, RIP1-mediated IKK complex recruitment |
| WP:WP5113 | 5.85482698541e-05 | 0.3 | IKBKG CHUK IKBKB | Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway |
| WP:WP1433 | 5.85482698541e-05 | 0.3 | IKBKG CHUK IKBKB | Nucleotide binding oligomerization domain NOD pathway |
| REAC:R-HSA-937041 | 6.31358311141e-05 | 0.3 | IKBKG CHUK IKBKB | IKK complex recruitment mediated by RIP1 |
| WP:WP3858 | 6.5843121313e-05 | 0.3 | IKBKG CHUK IKBKB | Toll like receptor signaling related to MyD88 |
| REAC:R-HSA-5607764 | 6.63043144043e-05 | 0.4 | MAP3K14 IKBKB CHUK IKBKG | CLEC7A (Dectin-1) signaling |
| REAC:R-HSA-933542 | 7.36319907643e-05 | 0.3 | IKBKG CHUK IKBKB | TRAF6 mediated NF-kB activation |
| WP:WP4481 | 7.37177804475e-05 | 0.3 | IKBKG CHUK IKBKB | Resistin as a regulator of inflammation |
| WP:WP2112 | 7.37177804475e-05 | 0.3 | MAP3K14 IKBKB IKBKG | IL 17 signaling pathway |
| WP:WP4880 | 8.21941130224e-05 | 0.3 | IKBKG CHUK IKBKB | Host pathogen interaction of human coronaviruses interferon induction |
| WP:WP4496 | 9.1293952863e-05 | 0.3 | MAP3K14 CHUK IKBKB | Signal transduction through IL1R |
| WP:WP4329 | 0.000101039101881 | 0.3 | IKBKG CHUK IKBKB | miRNA role in immune response in sepsis |
| GO:0004672 | 0.000118657922416 | 0.7 | MAP3K14 CDK15 STK11 IKBKB CDK11A TSSK6 CHUK | protein kinase activity |
| WP:WP4136 | 0.000122552375685 | 0.3 | IKBKG CHUK IKBKB | Fibrin complement receptor 3 signaling pathway |
| WP:WP2036 | 0.000160205320908 | 0.3 | MAP3K14 CHUK IKBKB | TNF related weak inducer of apoptosis TWEAK signaling pathway |
| REAC:R-HSA-5602358 | 0.000161586017522 | 0.3 | IKBKG CHUK IKBKB | Diseases associated with the TLR signaling cascade |
| REAC:R-HSA-5260271 | 0.000161586017522 | 0.3 | IKBKG CHUK IKBKB | Diseases of Immune System |
| REAC:R-HSA-5621481 | 0.000211058966522 | 0.4 | MAP3K14 IKBKB CHUK IKBKG | C-type lectin receptors (CLRs) |
| KEGG:05169 | 0.000222091335709 | 0.4 | MAP3K14 IKBKB CHUK IKBKG | Epstein-Barr virus infection |
| GO:0008385 | 0.0002304395259 | 0.3 | IKBKG CHUK IKBKB | IkappaB kinase complex |
| REAC:R-HSA-168638 | 0.000273513409135 | 0.3 | IKBKG CHUK IKBKB | NOD1/2 Signaling Pathway |
| REAC:R-HSA-5357956 | 0.000273513409135 | 0.3 | IKBKG CHUK IKBKB | TNFR1-induced NF-kappa-B signaling pathway |
| WP:WP2637 | 0.000276207454893 | 0.3 | MAP3K14 CHUK IKBKB | Interleukin 1 IL 1 structural pathway |
| CORUM:5234 | 0.000307240465423 | 0.2 | CDC37 IKBKB | IKBKB-CDC37-KIAA1967-HSP90AB1-HSP90AA1 complex |
| CORUM:2055 | 0.000307240465423 | 0.2 | CHUK IKBKB | CASP8-CHUK-IKBKB-MALT1-BCL10 complex |
| KEGG:05166 | 0.000324224430663 | 0.4 | MAP3K14 IKBKB CHUK IKBKG | Human T-cell leukemia virus 1 infection |
| WP:WP2018 | 0.000339381389295 | 0.3 | IKBKG CHUK IKBKB | RANKL RANK signaling pathway |
| KEGG:05208 | 0.000350976864595 | 0.4 | MAP3K14 IKBKB CHUK IKBKG | Chemical carcinogenesis - reactive oxygen species |
| KEGG:05221 | 0.000370085777234 | 0.3 | IKBKG CHUK IKBKB | Acute myeloid leukemia |
| REAC:R-HSA-445989 | 0.000393160884162 | 0.3 | IKBKG CHUK IKBKB | TAK1-dependent IKK and NF-kappa-B activation |
| GO:0061695 | 0.000423454860605 | 0.6 | STK11 IKBKB CDK11A TSSK6 IKBKG CHUK | transferase complex, transferring phosphorus-containing groups |
| CORUM:5269 | 0.000460692494101 | 0.2 | FKBP5 CDC37 | TNF-alpha/NF-kappa B signaling complex 8 |
| GO:0016773 | 0.000462052987205 | 0.7 | MAP3K14 CDK15 STK11 IKBKB CDK11A TSSK6 CHUK | phosphotransferase activity, alcohol group as acceptor |
| KEGG:04622 | 0.000496184652725 | 0.3 | IKBKG CHUK IKBKB | RIG-I-like receptor signaling pathway |
| GO:1902554 | 0.000535311189474 | 0.5 | STK11 CHUK IKBKB CDK11A IKBKG | serine/threonine protein kinase complex |
| WP:WP3865 | 0.000552952277359 | 0.3 | IKBKG CHUK IKBKB | Novel intracellular components of RIG I like receptor pathway |
| KEGG:04662 | 0.000568680046045 | 0.3 | IKBKG CHUK IKBKB | B cell receptor signaling pathway |
| KEGG:04623 | 0.000620702678883 | 0.3 | IKBKG CHUK IKBKB | Cytosolic DNA-sensing pathway |
| WP:WP382 | 0.000672700526913 | 0.4 | MAP3K14 IKBKB CHUK IKBKG | MAPK signaling pathway |
| KEGG:05212 | 0.000675777425028 | 0.3 | IKBKG CHUK IKBKB | Pancreatic cancer |
| WP:WP5293 | 0.000723415702349 | 0.3 | IKBKG CHUK IKBKB | Acute myeloid leukemia |
| REAC:R-HSA-5357905 | 0.000727178991453 | 0.3 | IKBKG CHUK IKBKB | Regulation of TNFR1 signaling |
| KEGG:04010 | 0.000728772187137 | 0.4 | MAP3K14 IKBKB CHUK IKBKG | MAPK signaling pathway |
| KEGG:04658 | 0.000733988186241 | 0.3 | IKBKG CHUK IKBKB | Th1 and Th2 cell differentiation |
| KEGG:05220 | 0.000733988186241 | 0.3 | IKBKG CHUK IKBKB | Chronic myeloid leukemia |
| GO:0016301 | 0.000752700953995 | 0.7 | MAP3K14 CDK15 STK11 IKBKB CDK11A TSSK6 CHUK | kinase activity |
| KEGG:04657 | 0.000827367271254 | 0.3 | IKBKG CHUK IKBKB | IL-17 signaling pathway |
| REAC:R-HSA-168643 | 0.000832877998849 | 0.3 | IKBKG CHUK IKBKB | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| CORUM:5268 | 0.000859331699025 | 0.2 | FKBP5 CDC37 | TNF-alpha/NF-kappa B signaling complex 7 |
| WP:WP3303 | 0.00088240868124 | 0.3 | IKBKG CHUK IKBKB | RAC1 PAK1 p38 MMP2 pathway |
| KEGG:05235 | 0.000928271799762 | 0.3 | IKBKG CHUK IKBKB | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| GO:1990459 | 0.000966803032193 | 0.3 | IKBKG CHUK IKBKB | transferrin receptor binding |
| WP:WP4655 | 0.000969904252276 | 0.3 | IKBKG CHUK IKBKB | Cytosolic DNA sensing pathway |
| WP:WP2034 | 0.00111161276717 | 0.3 | IKBKG CHUK IKBKB | Leptin signaling pathway |
| KEGG:05222 | 0.00115377586402 | 0.3 | IKBKG CHUK IKBKB | Small cell lung cancer |
| KEGG:04620 | 0.00119455170155 | 0.3 | IKBKG CHUK IKBKB | Toll-like receptor signaling pathway |
| KEGG:05142 | 0.00123626686132 | 0.3 | IKBKG CHUK IKBKB | Chagas disease |
| REAC:R-HSA-75893 | 0.0012820759141 | 0.3 | IKBKG CHUK IKBKB | TNF signaling |
| KEGG:05215 | 0.0013225560495 | 0.3 | IKBKG CHUK IKBKB | Prostate cancer |
| KEGG:04659 | 0.0013225560495 | 0.3 | IKBKG CHUK IKBKB | Th17 cell differentiation |
| KEGG:05145 | 0.00136715049003 | 0.3 | IKBKG CHUK IKBKB | Toxoplasmosis |
| WP:WP254 | 0.00137707513928 | 0.3 | IKBKG CHUK IKBKB | Apoptosis |
| CORUM:5193 | 0.00138006084651 | 0.2 | IKBKG CHUK | TNF-alpha/NF-kappa B signaling complex (CHUK, KPNA3, NFKB2, NFKBIB, REL, IKBKG, NFKB1, NFKBIE, RELB, NFKBIA, RELA, TNIP2) |
| CORUM:5230 | 0.00138006084651 | 0.2 | IKBKG CHUK | CHUK-NFKB2-REL-IKBKG-SPAG9-NFKB1-NFKBIE-COPB2-TNIP1-NFKBIA-RELA-TNIP2 complex |
| WP:WP5098 | 0.00143474462389 | 0.3 | IKBKG CHUK IKBKB | T cell activation SARS CoV 2 |
| REAC:R-HSA-450294 | 0.00151544399962 | 0.3 | IKBKG CHUK IKBKB | MAP kinase activation |
| WP:WP3932 | 0.00154367635208 | 0.4 | STK11 IKBKB CDC37 IKBKG | Focal adhesion PI3K Akt mTOR signaling pathway |
| WP:WP23 | 0.00155482417707 | 0.3 | IKBKG CHUK IKBKB | B cell receptor signaling pathway |
| REAC:R-HSA-1834949 | 0.00177533901832 | 0.3 | IKBKG CHUK IKBKB | Cytosolic sensors of pathogen-associated DNA |
| WP:WP4263 | 0.00188362598587 | 0.3 | IKBKG CHUK IKBKB | Pancreatic adenocarcinoma pathway |
| WP:WP75 | 0.00202701355416 | 0.3 | IKBKG CHUK IKBKB | Toll like receptor signaling pathway |
| REAC:R-HSA-448424 | 0.00206314708251 | 0.3 | IKBKG CHUK IKBKB | Interleukin-17 signaling |
| REAC:R-HSA-1169091 | 0.0023802481167 | 0.3 | IKBKG CHUK IKBKB | Activation of NF-kappaB in B cells |
| WP:WP4658 | 0.00249995876317 | 0.3 | IKBKG CHUK IKBKB | Small cell lung cancer |
| KEGG:04068 | 0.00261407475108 | 0.3 | STK11 CHUK IKBKB | FoxO signaling pathway |
| KEGG:05135 | 0.00275465046999 | 0.3 | IKBKG CHUK IKBKB | Yersinia infection |
| CORUM:5232 | 0.00278671748515 | 0.2 | IKBKG CHUK | TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I) |
| GO:0016772 | 0.00282565151127 | 0.7 | MAP3K14 CDK15 STK11 IKBKB CDK11A TSSK6 CHUK | transferase activity, transferring phosphorus-containing groups |
| KEGG:05418 | 0.00290010582105 | 0.3 | IKBKG CHUK IKBKB | Fluid shear stress and atherosclerosis |
| KEGG:05162 | 0.00344875538076 | 0.3 | IKBKG CHUK IKBKB | Measles |
| REAC:R-HSA-1168372 | 0.00352101579197 | 0.3 | IKBKG CHUK IKBKB | Downstream signaling events of B Cell Receptor (BCR) |
| REAC:R-HSA-2871837 | 0.00366640411985 | 0.3 | IKBKG CHUK IKBKB | FCERI mediated NF-kB activation |
| REAC:R-HSA-168928 | 0.00366640411985 | 0.3 | IKBKG CHUK IKBKB | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| KEGG:05160 | 0.00406147233016 | 0.3 | IKBKG CHUK IKBKB | Hepatitis C |
| REAC:R-HSA-975871 | 0.0047964327539 | 0.3 | IKBKG CHUK IKBKB | MyD88 cascade initiated on plasma membrane |
| REAC:R-HSA-168176 | 0.0047964327539 | 0.3 | IKBKG CHUK IKBKB | Toll Like Receptor 5 (TLR5) Cascade |
| REAC:R-HSA-168142 | 0.0047964327539 | 0.3 | IKBKG CHUK IKBKB | Toll Like Receptor 10 (TLR10) Cascade |
| KEGG:04062 | 0.00484440033129 | 0.3 | IKBKG CHUK IKBKB | Chemokine signaling pathway |
| REAC:R-HSA-975138 | 0.00515688962472 | 0.3 | IKBKG CHUK IKBKB | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| REAC:R-HSA-975155 | 0.00534363091831 | 0.3 | IKBKG CHUK IKBKB | MyD88 dependent cascade initiated on endosome |
| REAC:R-HSA-168181 | 0.00534363091831 | 0.3 | IKBKG CHUK IKBKB | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| REAC:R-HSA-1236974 | 0.00534363091831 | 0.3 | IKBKG CHUK IKBKB | ER-Phagosome pathway |
| KEGG:05164 | 0.00538057649313 | 0.3 | IKBKG CHUK IKBKB | Influenza A |
| KEGG:04621 | 0.00560546698078 | 0.3 | IKBKG CHUK IKBKB | NOD-like receptor signaling pathway |
| KEGG:04150 | 0.00583642418014 | 0.3 | STK11 CHUK IKBKB | mTOR signaling pathway |
| KEGG:05161 | 0.00583642418014 | 0.3 | IKBKG CHUK IKBKB | Hepatitis B |
| REAC:R-HSA-168138 | 0.00613516450091 | 0.3 | IKBKG CHUK IKBKB | Toll Like Receptor 9 (TLR9) Cascade |
| REAC:R-HSA-202424 | 0.00613516450091 | 0.3 | IKBKG CHUK IKBKB | Downstream TCR signaling |
| WP:WP3929 | 0.00626678489164 | 0.3 | IKBKG CHUK IKBKB | Chemokine signaling pathway |
| REAC:R-HSA-168164 | 0.00655835959712 | 0.3 | IKBKG CHUK IKBKB | Toll Like Receptor 3 (TLR3) Cascade |
| WP:WP2380 | 0.00658064183178 | 0.3 | IKBKG CHUK IKBKB | Brain derived neurotrophic factor BDNF signaling pathway |
| WP:WP4630 | 0.00658064183178 | 0.3 | IKBKG CHUK IKBKB | Measles virus infection |
| REAC:R-HSA-166166 | 0.00700036206772 | 0.3 | IKBKG CHUK IKBKB | MyD88-independent TLR4 cascade |
| REAC:R-HSA-937061 | 0.00700036206772 | 0.3 | IKBKG CHUK IKBKB | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-166058 | 0.00746156180307 | 0.3 | IKBKG CHUK IKBKB | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| REAC:R-HSA-168188 | 0.00746156180307 | 0.3 | IKBKG CHUK IKBKB | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-983705 | 0.00769948216088 | 0.3 | IKBKG CHUK IKBKB | Signaling by the B Cell Receptor (BCR) |
| REAC:R-HSA-181438 | 0.00794234750558 | 0.3 | IKBKG CHUK IKBKB | Toll Like Receptor 2 (TLR2) Cascade |
| REAC:R-HSA-168179 | 0.00794234750558 | 0.3 | IKBKG CHUK IKBKB | Toll Like Receptor TLR1:TLR2 Cascade |
| KEGG:05130 | 0.00805498557194 | 0.3 | IKBKG CHUK IKBKB | Pathogenic Escherichia coli infection |
| REAC:R-HSA-1236975 | 0.00819020623966 | 0.3 | IKBKG CHUK IKBKB | Antigen processing-Cross presentation |
| REAC:R-HSA-9020702 | 0.00844310669164 | 0.3 | IKBKG CHUK IKBKB | Interleukin-1 signaling |
| KEGG:05167 | 0.00849596419776 | 0.3 | IKBKG CHUK IKBKB | Kaposi sarcoma-associated herpesvirus infection |
| WP:WP4666 | 0.00907021898379 | 0.3 | IKBKG CHUK IKBKB | Hepatitis B infection |
| REAC:R-HSA-202403 | 0.01035862204 | 0.3 | IKBKG CHUK IKBKB | TCR signaling |
| KEGG:05417 | 0.0104169791335 | 0.3 | IKBKG CHUK IKBKB | Lipid and atherosclerosis |
| KEGG:04014 | 0.0111149849555 | 0.3 | IKBKG CHUK IKBKB | Ras signaling pathway |
| WP:WP4223 | 0.0111813805009 | 0.3 | IKBKG CHUK IKBKB | Ras signaling |
| REAC:R-HSA-2454202 | 0.0118886569504 | 0.3 | IKBKG CHUK IKBKB | Fc epsilon receptor (FCERI) signaling |
| REAC:R-HSA-9705671 | 0.0122114640727 | 0.3 | IKBKG CHUK IKBKB | SARS-CoV-2 activates/modulates innate and adaptive immune responses |
| KEGG:05163 | 0.0126008892131 | 0.3 | IKBKG CHUK IKBKB | Human cytomegalovirus infection |
| KEGG:05170 | 0.0127952251481 | 0.3 | IKBKG CHUK IKBKB | Human immunodeficiency virus 1 infection |
| KEGG:05171 | 0.0146325667892 | 0.3 | IKBKG CHUK IKBKB | Coronavirus disease - COVID-19 |
| REAC:R-HSA-166016 | 0.0161495944471 | 0.3 | IKBKG CHUK IKBKB | Toll Like Receptor 4 (TLR4) Cascade |
| REAC:R-HSA-73887 | 0.0177651546753 | 0.3 | IKBKG CHUK IKBKB | Death Receptor Signaling |
| WP:WP3617 | 0.0178579187559 | 0.2 | CHUK IKBKB | Photodynamic therapy induced NF kB survival signaling |
| REAC:R-HSA-446652 | 0.0186112177015 | 0.3 | IKBKG CHUK IKBKB | Interleukin-1 family signaling |
| KEGG:05132 | 0.0198241007008 | 0.3 | IKBKG CHUK IKBKB | Salmonella infection |
| KEGG:05131 | 0.0206126143711 | 0.3 | IKBKG CHUK IKBKB | Shigellosis |
| GO:0008384 | 0.0210690324038 | 0.2 | CHUK IKBKB | IkappaB kinase activity |
| REAC:R-HSA-168898 | 0.0247610923631 | 0.3 | IKBKG CHUK IKBKB | Toll-like Receptor Cascades |
| WP:WP2332 | 0.0287758668954 | 0.2 | CHUK IKBKB | Interleukin 11 signaling pathway |
| WP:WP3878 | 0.0335282776025 | 0.2 | STK11 IKBKG | ATM signaling in development and disease |
| KEGG:05165 | 0.0438405134702 | 0.3 | IKBKG CHUK IKBKB | Human papillomavirus infection |
| WP:WP395 | 0.0441033585523 | 0.2 | CHUK IKBKB | IL 4 signaling pathway |
| CORUM:2123 | 0.0499436884912 | 0.1 | IKBKG | IKBKG homodimer complex |
| CORUM:5827 | 0.0499436884912 | 0.1 | IKBKG | IKBKG homotetramer complex |
| CORUM:5730 | 0.0499436884912 | 0.1 | IKBKG | IKBKG homotrimer complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| IKBKG | IKBKB | 1.0 | 0.29 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| CHUK | IKBKG | 0.999 | 0.176 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| CHUK | IKBKB | 0.998 | 0.07 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | |
| CDC37 | CHUK | 0.998 | 0.25 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| CDC37 | IKBKB | 0.997 | 0.21 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 | |
| CDK11A | FKBP5 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 | ||
| CDK11A | CDC37 | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM | ||
| FKBP5 | CDK15 | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| CDC37 | IKBKG | 0.991 | 0.22 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 | |
| CDC37 | STK11 | 0.991 | 0.139 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TSSK6 | CDC37 | 0.986 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TSSK6 | FKBP5 | 0.983 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| FKBP5 | CDC37 | 0.975 | 0.16 | bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM bioplex3_HCT116 fraction boldt_WMM | |
| FKBP5 | STK11 | 0.974 | 0.236 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| FKBP5 | IKBKB | 0.969 | 0.16 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MAP3K14 | IKBKG | 0.969 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| MAP3K14 | IKBKB | 0.961 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| FKBP5 | CHUK | 0.958 | 0.126 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CDC37 | CDK15 | 0.957 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| A6NIL8 | CDC37 | 0.952 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| FKBP5 | IKBKG | 0.914 | 0.118 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CHUK | MAP3K14 | 0.901 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| A6NIL8 | CDK15 | 0.871 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| A6NIL8 | CHUK | 0.843 | bioplex3_WMM WMM_only | ||
| A6NIL8 | IKBKB | 0.762 | bioplex3_WMM WMM_only | ||
| A6NIL8 | IKBKG | 0.709 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| A6NIL8 | STK11 | 0.703 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| FKBP5 | A6NIL8 | 0.664 | bioplex_WMM bioplex3_WMM WMM_only | ||
| CDC37 | MAP3K14 | 0.551 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| CDK11A | CHUK | 0.512 | bioplex3_WMM WMM_only | ||
| CDK11A | IKBKG | 0.464 | bioplex3_WMM WMM_only | ||
| STK11 | IKBKB | 0.356 | 0.206 | bioplex3_WMM WMM_only | |
| CDK11A | IKBKB | 0.227 | bioplex3_WMM youn_WMM WMM_only | ||
| CDK11A | STK11 | 0.22 | bioplex3_WMM WMM_only | ||
| STK11 | IKBKG | 0.157 | 0.164 | bioplex3_WMM WMM_only | |
| STK11 | CHUK | 0.147 | 0.18 | bioplex3_WMM WMM_only | |
| CDK11A | A6NIL8 | 0.13 | bioplex3_WMM WMM_only |
Related Complexes