hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_09787.1

Complex Portal: CPX-20172

Confidence: Moderate High

Genename	Protein Name	Uniprot Annotation Score	Links
CASC3	Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein) (MLN 51) (Protein barentsz) (Btz)	5	UniProt NCBI
MAGOH	Protein mago nashi homolog	5	UniProt NCBI
PYM1	Partner of Y14 and mago (PYM homolog 1 exon junction complex-associated factor) (Protein wibg homolog)	5	UniProt NCBI
MAGOHB	Protein mago nashi homolog 2	5	UniProt NCBI
VANGL2	Vang-like protein 2 (Loop-tail protein 1 homolog) (Strabismus 1) (Van Gogh-like protein 2)	5	UniProt NCBI
PNN	Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Desmosome-associated protein) (Domain-rich serine protein) (DRS protein) (DRSP) (Melanoma metastasis clone A protein) (Nuclear protein SDK3) (SR-like protein)	5	UniProt NCBI
RBM8A	RNA-binding protein 8A (Binder of OVCA1-1) (BOV-1) (RNA-binding motif protein 8A) (RNA-binding protein Y14) (Ribonucleoprotein RBM8A)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0035145	1.00249058106e-12	0.857142857143	CASC3 MAGOHB MAGOH PNN PYM1 RBM8A	exon-exon junction complex
CORUM:755	9.61159511016e-12	0.571428571429	CASC3 PYM1 RBM8A MAGOH	Exon junction complex (EIF4A3, MLN51, UPF3B, MAGOH, Y14, PYM)
KEGG:03015	1.79208409668e-11	0.857142857143	CASC3 MAGOHB MAGOH PNN PYM1 RBM8A	mRNA surveillance pathway
KEGG:03013	3.40528566192e-11	0.857142857143	CASC3 MAGOHB MAGOH PNN PYM1 RBM8A	Nucleocytoplasmic transport
CORUM:744	2.80877722849e-08	0.428571428571	CASC3 RBM8A MAGOH	Exon junction complex (EIF4A3, MLN51, MAGOH, Y14)
CORUM:769	2.80877722849e-08	0.428571428571	CASC3 RBM8A MAGOH	Exon junction complex (EIF4A3, MLN51, MAGOH, Y14)
CORUM:754	2.80877722849e-08	0.428571428571	CASC3 RBM8A MAGOH	Exon junction complex (EIF4A3, MLN51, UPF3B, MAGOH, Y14)
CORUM:740	2.80877722849e-08	0.428571428571	CASC3 RBM8A MAGOH	Exon junction complex (EIF4A3, MLN51, MAGOH, Y14)
GO:0000184	4.47351531807e-08	0.714285714286	RBM8A CASC3 PYM1 MAGOHB MAGOH	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:2000622	3.03561565333e-07	0.571428571429	RBM8A CASC3 MAGOHB MAGOH	regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
REAC:R-HSA-72187	1.20724098212e-06	0.571428571429	RBM8A CASC3 MAGOHB MAGOH	mRNA 3'-end processing
REAC:R-HSA-72163	1.86345710026e-06	0.714285714286	RBM8A CASC3 PNN MAGOHB MAGOH	mRNA Splicing - Major Pathway
REAC:R-HSA-73856	2.10571370059e-06	0.571428571429	RBM8A CASC3 MAGOHB MAGOH	RNA Polymerase II Transcription Termination
REAC:R-HSA-72172	2.21331432852e-06	0.714285714286	RBM8A CASC3 PNN MAGOHB MAGOH	mRNA Splicing
REAC:R-HSA-159236	3.23754553505e-06	0.571428571429	RBM8A CASC3 MAGOHB MAGOH	Transport of Mature mRNA derived from an Intron-Containing Transcript
GO:1990501	3.36420143768e-06	0.428571428571	MAGOH MAGOHB RBM8A	exon-exon junction subcomplex mago-y14
GO:1903503	3.36420143768e-06	0.428571428571	MAGOH MAGOHB RBM8A	ATPase inhibitor complex
REAC:R-HSA-72202	5.2974479806e-06	0.571428571429	RBM8A CASC3 MAGOHB MAGOH	Transport of Mature Transcript to Cytoplasm
REAC:R-HSA-72203	8.81576662769e-06	0.714285714286	RBM8A CASC3 PNN MAGOHB MAGOH	Processing of Capped Intron-Containing Pre-mRNA
CORUM:773	2.05265451394e-05	0.285714285714	MAGOH RBM8A	Y14-Magoh complex
CORUM:763	2.05265451394e-05	0.285714285714	MAGOH RBM8A	Y14-Magoh complex
REAC:R-HSA-927802	2.3391410089e-05	0.571428571429	RBM8A CASC3 MAGOHB MAGOH	Nonsense-Mediated Decay (NMD)
REAC:R-HSA-975957	2.3391410089e-05	0.571428571429	RBM8A CASC3 MAGOHB MAGOH	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
GO:0000956	2.50587434005e-05	0.714285714286	RBM8A CASC3 PYM1 MAGOHB MAGOH	nuclear-transcribed mRNA catabolic process
CORUM:1293	6.1565588648e-05	0.285714285714	MAGOH RBM8A	IPO13-RBM8A-MAGOH complex
REAC:R-HSA-9010553	0.000106027951568	0.571428571429	RBM8A CASC3 MAGOHB MAGOH	Regulation of expression of SLITs and ROBOs
GO:0005681	0.000206894724857	0.714285714286	RBM8A CASC3 PNN MAGOHB MAGOH	spliceosomal complex
REAC:R-HSA-376176	0.000271661382471	0.571428571429	RBM8A CASC3 MAGOHB MAGOH	Signaling by ROBO receptors
CORUM:6742	0.000307617328197	0.285714285714	MAGOH RBM8A	SMG1-UPF2-Y14-MAGOH-UPF3B-EIF4A3 complex
CORUM:785	0.000430566012817	0.285714285714	MAGOH RBM8A	Exon junction complex
GO:0006402	0.000505306533655	0.714285714286	RBM8A CASC3 PYM1 MAGOHB MAGOH	mRNA catabolic process
CORUM:1181	0.000506001725363	0.428571428571	MAGOH RBM8A PNN	C complex spliceosome
GO:0006406	0.000657005257405	0.571428571429	RBM8A CASC3 MAGOHB MAGOH	mRNA export from nucleus
GO:0071006	0.000738757615619	0.428571428571	CASC3 MAGOHB RBM8A	U2-type catalytic step 1 spliceosome
GO:0071012	0.000738757615619	0.428571428571	CASC3 MAGOHB RBM8A	catalytic step 1 spliceosome
REAC:R-HSA-8953854	0.000832722936992	0.714285714286	RBM8A CASC3 PNN MAGOHB MAGOH	Metabolism of RNA
GO:0051028	0.000936913630871	0.571428571429	RBM8A CASC3 MAGOHB MAGOH	mRNA transport
GO:0016071	0.000979013104412	0.857142857143	CASC3 MAGOHB MAGOH PNN PYM1 RBM8A	mRNA metabolic process
KEGG:03040	0.00108816732534	0.428571428571	MAGOH MAGOHB RBM8A	Spliceosome
GO:0006401	0.00138041909589	0.714285714286	RBM8A CASC3 PYM1 MAGOHB MAGOH	RNA catabolic process
GO:0006405	0.0018400127105	0.571428571429	RBM8A CASC3 MAGOHB MAGOH	RNA export from nucleus
GO:0000377	0.00196089960599	0.714285714286	RBM8A CASC3 PNN MAGOHB MAGOH	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
GO:0000398	0.00196089960599	0.714285714286	RBM8A CASC3 PNN MAGOHB MAGOH	mRNA splicing, via spliceosome
GO:0071013	0.00202210317171	0.571428571429	RBM8A MAGOH MAGOHB PNN	catalytic step 2 spliceosome
GO:0000375	0.00211304872099	0.714285714286	RBM8A CASC3 PNN MAGOHB MAGOH	RNA splicing, via transesterification reactions
GO:0050657	0.004672681336	0.571428571429	RBM8A CASC3 MAGOHB MAGOH	nucleic acid transport
GO:0050658	0.004672681336	0.571428571429	RBM8A CASC3 MAGOHB MAGOH	RNA transport
GO:0051236	0.00522474919744	0.571428571429	RBM8A CASC3 MAGOHB MAGOH	establishment of RNA localization
GO:0006397	0.00621145030352	0.714285714286	RBM8A CASC3 PNN MAGOHB MAGOH	mRNA processing
REAC:R-HSA-422475	0.00732241318188	0.571428571429	RBM8A CASC3 MAGOHB MAGOH	Axon guidance
REAC:R-HSA-9675108	0.00845717716544	0.571428571429	RBM8A CASC3 MAGOHB MAGOH	Nervous system development
GO:0008380	0.00965864313965	0.714285714286	RBM8A CASC3 PNN MAGOHB MAGOH	RNA splicing
GO:0034655	0.0134243874038	0.714285714286	RBM8A CASC3 PYM1 MAGOHB MAGOH	nucleobase-containing compound catabolic process
GO:0006403	0.0138047299997	0.571428571429	RBM8A CASC3 MAGOHB MAGOH	RNA localization
GO:0051168	0.0146147722157	0.571428571429	RBM8A CASC3 MAGOHB MAGOH	nuclear export
GO:0015931	0.0177319694674	0.571428571429	RBM8A CASC3 MAGOHB MAGOH	nucleobase-containing compound transport
GO:0046700	0.0189413068412	0.714285714286	RBM8A CASC3 PYM1 MAGOHB MAGOH	heterocycle catabolic process
GO:0044270	0.019167277252	0.714285714286	RBM8A CASC3 PYM1 MAGOHB MAGOH	cellular nitrogen compound catabolic process
GO:0061013	0.0197221628961	0.571428571429	RBM8A CASC3 MAGOHB MAGOH	regulation of mRNA catabolic process
GO:0019439	0.0203295403983	0.714285714286	RBM8A CASC3 PYM1 MAGOHB MAGOH	aromatic compound catabolic process
WP:WP5362	0.0207233783056	0.285714285714	MAGOH PYM1	TAR syndrome
GO:1901361	0.024430774758	0.714285714286	RBM8A CASC3 PYM1 MAGOHB MAGOH	organic cyclic compound catabolic process

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
MAGOH	RBM8A	1.0		structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM treiber_WMM
PNN	RBM8A	0.999	0.874	mutually_exclusive (P38919)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM treiber_WMM
MAGOH	PYM1	0.997		structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116
RBM8A	PYM1	0.996	0.096	mutually_exclusive (Q96A72)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM
MAGOH	MAGOHB	0.994			hein_WMM bioplex3_WMM hein () gupta_WMM
MAGOH	CASC3	0.993			hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM
PNN	CASC3	0.991	0.652	mutually_exclusive (P38919)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM
PYM1	CASC3	0.989	0.104		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116
RBM8A	MAGOHB	0.983	0.946	mutually_exclusive (Q96J01) structurally_consistent (dimer)	hein_WMM bioplex3_WMM hein () gupta_WMM
MAGOH	PNN	0.982			hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM treiber_WMM
RBM8A	CASC3	0.982	0.706		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein ()
PNN	MAGOHB	0.97	0.766		hein_WMM bioplex3_WMM WMM_only
PNN	VANGL2	0.953	0.168		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM
PYM1	MAGOHB	0.854	0.1	mutually_exclusive (P38919) structurally_consistent (dimer)	hein_WMM bioplex3_WMM hein ()
MAGOHB	CASC3	0.139	0.518		hein_WMM bioplex3_WMM WMM_only
PNN	PYM1	0.117	0.098	mutually_exclusive (P38919)	hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
MAGOH	VANGL2	0.093			bioplex_WMM bioplex3_WMM WMM_only
RBM8A	VANGL2	0.056	0.076		bioplex_WMM bioplex3_WMM WMM_only
CASC3	VANGL2	0.025	0.12		bioplex_WMM bioplex3_WMM WMM_only
PYM1	VANGL2	0.01			youn_WMM WMM_only

Related Complexes

Genename	Complexes
CASC3	huMAP3_05846.1 huMAP3_06975.1 huMAP3_07737.1 huMAP3_07904.1 huMAP3_08627.1 huMAP3_09095.1 huMAP3_09621.1 huMAP3_09787.1 huMAP3_09943.1 huMAP3_10114.1 huMAP3_10564.1 huMAP3_10789.1 huMAP3_11032.1 huMAP3_11073.1
MAGOH	huMAP3_00837.1 huMAP3_04073.1 huMAP3_06443.1 huMAP3_07098.1 huMAP3_07208.1 huMAP3_07561.1 huMAP3_07904.1 huMAP3_08344.1 huMAP3_09621.1 huMAP3_09787.1 huMAP3_09905.1 huMAP3_09943.1 huMAP3_10564.1 huMAP3_10789.1 huMAP3_11073.1
PYM1	huMAP3_01288.1 huMAP3_02598.1 huMAP3_04073.1 huMAP3_05708.1 huMAP3_06443.1 huMAP3_07208.1 huMAP3_07733.1 huMAP3_07904.1 huMAP3_08627.1 huMAP3_09787.1 huMAP3_10789.1 huMAP3_11073.1
MAGOHB	huMAP3_01312.1 huMAP3_04073.1 huMAP3_06443.1 huMAP3_06799.1 huMAP3_07674.1 huMAP3_07904.1 huMAP3_08082.1 huMAP3_08344.1 huMAP3_09149.1 huMAP3_09621.1 huMAP3_09787.1 huMAP3_09905.1 huMAP3_10789.1 huMAP3_11073.1
VANGL2	huMAP3_08082.1 huMAP3_09181.1 huMAP3_09787.1
PNN	huMAP3_00837.1 huMAP3_01312.1 huMAP3_05740.1 huMAP3_06391.1 huMAP3_06799.1 huMAP3_07098.1 huMAP3_07267.1 huMAP3_07561.1 huMAP3_07674.1 huMAP3_08082.1 huMAP3_08302.1 huMAP3_08344.1 huMAP3_09226.1 huMAP3_09621.1 huMAP3_09787.1 huMAP3_09905.1 huMAP3_09943.1 huMAP3_10250.1 huMAP3_10564.1 huMAP3_10789.1 huMAP3_11073.1
RBM8A	huMAP3_00837.1 huMAP3_01288.1 huMAP3_03123.1 huMAP3_06443.1 huMAP3_07098.1 huMAP3_07561.1 huMAP3_07904.1 huMAP3_08344.1 huMAP3_09149.1 huMAP3_09621.1 huMAP3_09787.1 huMAP3_09943.1 huMAP3_10564.1 huMAP3_10789.1 huMAP3_11073.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_09787.1

Complex Portal: CPX-20172