hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09793.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CCNI | Cyclin-I | 4 | UniProt NCBI |
| CABLES1 | CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1) | 5 | UniProt NCBI |
| CDK5 | Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) | 5 | UniProt NCBI |
| CNPPD1 | Protein CNPPD1 (Cyclin Pas1/PHO80 domain-containing protein 1) | 3 | UniProt NCBI |
| CDK5R1 | Cyclin-dependent kinase 5 activator 1 (CDK5 activator 1) (Cyclin-dependent kinase 5 regulatory subunit 1) (TPKII regulatory subunit) [Cleaved into: Cyclin-dependent kinase 5 activator 1, p35 (p35); Cyclin-dependent kinase 5 activator 1, p25 (p25) (Tau protein kinase II 23 kDa subunit) (p23)] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0000307 | 4.47449753489e-05 | 0.8 | CDK5 CDK5R1 CCNI CNPPD1 | cyclin-dependent protein kinase holoenzyme complex |
| REAC:R-HSA-9032845 | 0.000151950811602 | 0.4 | CDK5 CDK5R1 | Activated NTRK2 signals through CDK5 |
| GO:1902554 | 0.00130803575944 | 0.8 | CDK5 CDK5R1 CCNI CNPPD1 | serine/threonine protein kinase complex |
| REAC:R-HSA-399956 | 0.001593300657 | 0.4 | CDK5 CDK5R1 | CRMPs in Sema3A signaling |
| GO:1902911 | 0.00218060317198 | 0.8 | CDK5 CDK5R1 CCNI CNPPD1 | protein kinase complex |
| REAC:R-HSA-9006115 | 0.00232071308473 | 0.4 | CDK5 CDK5R1 | Signaling by NTRK2 (TRKB) |
| REAC:R-HSA-9768919 | 0.00232071308473 | 0.4 | CDK5 CDK5R1 | NPAS4 regulates expression of target genes |
| REAC:R-HSA-8863678 | 0.00318398402781 | 0.4 | CDK5 CDK5R1 | Neurodegenerative Diseases |
| REAC:R-HSA-8862803 | 0.00318398402781 | 0.4 | CDK5 CDK5R1 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
| KEGG:05030 | 0.00370756607295 | 0.4 | CDK5 CDK5R1 | Cocaine addiction |
| REAC:R-HSA-9734009 | 0.00418294558639 | 0.4 | CDK5 CDK5R1 | Defective Intrinsic Pathway for Apoptosis |
| GO:0016533 | 0.00468200720083 | 0.4 | CDK5 CDK5R1 | protein kinase 5 complex |
| WP:WP3878 | 0.00479747871248 | 0.4 | CDK5 CDK5R1 | ATM signaling in development and disease |
| REAC:R-HSA-9634815 | 0.00572567861867 | 0.4 | CDK5 CDK5R1 | Transcriptional Regulation by NPAS4 |
| REAC:R-HSA-9031628 | 0.00750894366662 | 0.4 | CDK5 CDK5R1 | NGF-stimulated transcription |
| GO:0016538 | 0.0109904490822 | 0.6 | CNPPD1 CCNI CDK5R1 | cyclin-dependent protein serine/threonine kinase regulator activity |
| REAC:R-HSA-198725 | 0.0215986811086 | 0.4 | CDK5 CDK5R1 | Nuclear Events (kinase and transcription factor activation) |
| REAC:R-HSA-373755 | 0.0258071378099 | 0.4 | CDK5 CDK5R1 | Semaphorin interactions |
| GO:0061695 | 0.0306592465565 | 0.8 | CDK5 CDK5R1 CCNI CNPPD1 | transferase complex, transferring phosphorus-containing groups |
| WP:WP2380 | 0.0434056741534 | 0.4 | CDK5 CDK5R1 | Brain derived neurotrophic factor BDNF signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CDK5 | CDK5R1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CDK5 | CCNI | 0.993 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CNPPD1 | CDK5 | 0.992 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CABLES1 | CDK5 | 0.987 | 0.086 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| CABLES1 | CDK5R1 | 0.146 | bioplex3_WMM WMM_only |
Related Complexes