hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09796.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PLEKHH3 | Pleckstrin homology domain-containing family H member 3 (PH domain-containing family H member 3) | 3 | UniProt NCBI |
| PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (EC 3.1.4.11) (PLC-154) (Phosphoinositide phospholipase C-beta-1) (Phospholipase C-I) (PLC-I) (Phospholipase C-beta-1) (PLC-beta-1) | 5 | UniProt NCBI |
| SLITRK3 | SLIT and NTRK-like protein 3 | 5 | UniProt NCBI |
| PTGER3 | Prostaglandin E2 receptor EP3 subtype (PGE receptor EP3 subtype) (PGE2 receptor EP3 subtype) (PGE2-R) (Prostanoid EP3 receptor) | 5 | UniProt NCBI |
| RHBDF2 | Inactive rhomboid protein 2 (iRhom2) (Rhomboid 5 homolog 2) (Rhomboid family member 2) (Rhomboid veinlet-like protein 5) (Rhomboid veinlet-like protein 6) | 5 | UniProt NCBI |
| ERBB2 | Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04020 | 0.00161563805052 | 0.5 | PTGER3 PLCB1 ERBB2 | Calcium signaling pathway |
| WP:WP5122 | 0.0023190863075 | 0.333333333333 | PTGER3 PLCB1 | Prostaglandin and leukotriene metabolism in senescence |
| WP:WP5321 | 0.00301015088032 | 0.333333333333 | PTGER3 PLCB1 | Prostaglandin and leukotriene metabolism in senescence |
| KEGG:05200 | 0.0272817161758 | 0.5 | PTGER3 PLCB1 ERBB2 | Pathways in cancer |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RHBDF2 | PTGER3 | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PLCB1 | PTGER3 | 0.99 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ERBB2 | PTGER3 | 0.986 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SLITRK3 | ERBB2 | 0.983 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PLEKHH3 | PTGER3 | 0.973 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RHBDF2 | SLITRK3 | 0.963 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RHBDF2 | ERBB2 | 0.962 | 0.072 | bioplex_WMM bioplex3_WMM WMM_only |
| PLEKHH3 | RHBDF2 | 0.961 | 0.076 | bioplex_WMM bioplex3_WMM WMM_only |
| PLEKHH3 | ERBB2 | 0.939 | 0.132 | bioplex_WMM bioplex3_WMM WMM_only |
| PLEKHH3 | SLITRK3 | 0.884 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PLCB1 | SLITRK3 | 0.864 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| PLCB1 | RHBDF2 | 0.435 | 0.074 | bioplex_WMM bioplex3_WMM WMM_only |
| PLEKHH3 | PLCB1 | 0.342 | 0.102 | bioplex_WMM bioplex3_WMM WMM_only |
| PLCB1 | ERBB2 | 0.342 | 0.136 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes