hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09809.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RBMXL3 | RNA-binding motif protein, X-linked-like-3 | 2 | UniProt NCBI |
| CBARP | Voltage-dependent calcium channel beta subunit-associated regulatory protein | 5 | UniProt NCBI |
| CACNB2 | Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2) (Lambert-Eaton myasthenic syndrome antigen B) (MYSB) | 5 | UniProt NCBI |
| CACNB1 | Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1) | 5 | UniProt NCBI |
| CACNB3 | Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-112308 | 1.09182472013e-07 | 0.6 | CACNB2 CACNB1 CACNB3 | Presynaptic depolarization and calcium channel opening |
| REAC:R-HSA-419037 | 9.10580767182e-06 | 0.6 | CACNB2 CACNB1 CACNB3 | NCAM1 interactions |
| REAC:R-HSA-375165 | 3.5683276241e-05 | 0.6 | CACNB2 CACNB1 CACNB3 | NCAM signaling for neurite out-growth |
| WP:WP2118 | 3.90305291366e-05 | 0.6 | CACNB2 CACNB1 CACNB3 | Arrhythmogenic right ventricular cardiomyopathy |
| KEGG:05412 | 4.64569454207e-05 | 0.6 | CACNB2 CACNB1 CACNB3 | Arrhythmogenic right ventricular cardiomyopathy |
| KEGG:04260 | 5.52628114904e-05 | 0.6 | CACNB2 CACNB1 CACNB3 | Cardiac muscle contraction |
| KEGG:05414 | 6.51136022216e-05 | 0.6 | CACNB2 CACNB1 CACNB3 | Dilated cardiomyopathy |
| KEGG:05410 | 6.51136022216e-05 | 0.6 | CACNB2 CACNB1 CACNB3 | Hypertrophic cardiomyopathy |
| GO:1990454 | 8.06911104389e-05 | 0.6 | CACNB2 CACNB1 CACNB3 | L-type voltage-gated calcium channel complex |
| KEGG:04921 | 0.000246155766644 | 0.6 | CACNB2 CACNB1 CACNB3 | Oxytocin signaling pathway |
| KEGG:04261 | 0.0002524957978 | 0.6 | CACNB2 CACNB1 CACNB3 | Adrenergic signaling in cardiomyocytes |
| GO:0061577 | 0.000349481973524 | 0.6 | CACNB2 CACNB1 CACNB3 | calcium ion transmembrane transport via high voltage-gated calcium channel |
| GO:0008331 | 0.000349481973524 | 0.6 | CACNB2 CACNB1 CACNB3 | high voltage-gated calcium channel activity |
| GO:1903169 | 0.00043484599868 | 0.8 | CACNB2 CACNB3 CBARP CACNB1 | regulation of calcium ion transmembrane transport |
| REAC:R-HSA-5576893 | 0.000683310775372 | 0.4 | CACNB2 CACNB1 | Phase 2 - plateau phase |
| GO:1901385 | 0.000929874009882 | 0.6 | CACNB2 CBARP CACNB3 | regulation of voltage-gated calcium channel activity |
| GO:0007528 | 0.00147736290187 | 0.6 | CACNB2 CACNB1 CACNB3 | neuromuscular junction development |
| WP:WP382 | 0.00157746248845 | 0.6 | CACNB2 CACNB1 CACNB3 | MAPK signaling pathway |
| GO:0051924 | 0.00188884895508 | 0.8 | CACNB2 CACNB3 CBARP CACNB1 | regulation of calcium ion transport |
| KEGG:04010 | 0.00215031496116 | 0.6 | CACNB2 CACNB1 CACNB3 | MAPK signaling pathway |
| REAC:R-HSA-400042 | 0.00350190276731 | 0.4 | CACNB2 CACNB3 | Adrenaline,noradrenaline inhibits insulin secretion |
| REAC:R-HSA-5576892 | 0.00418294558639 | 0.4 | CACNB2 CACNB1 | Phase 0 - rapid depolarisation |
| REAC:R-HSA-112315 | 0.0041994817849 | 0.6 | CACNB2 CACNB1 CACNB3 | Transmission across Chemical Synapses |
| GO:0005245 | 0.00430818612204 | 0.6 | CACNB2 CACNB1 CACNB3 | voltage-gated calcium channel activity |
| GO:0030315 | 0.00475337188383 | 0.6 | CACNB2 CACNB1 CACNB3 | T-tubule |
| GO:0005891 | 0.00522817157061 | 0.6 | CACNB2 CACNB1 CACNB3 | voltage-gated calcium channel complex |
| GO:1904062 | 0.00563530898302 | 0.8 | CACNB2 CACNB3 CBARP CACNB1 | regulation of monoatomic cation transmembrane transport |
| GO:0070588 | 0.00563530898302 | 0.8 | CACNB2 CACNB3 CBARP CACNB1 | calcium ion transmembrane transport |
| GO:0034765 | 0.00825090824596 | 0.8 | CACNB2 CACNB3 CBARP CACNB1 | regulation of monoatomic ion transmembrane transport |
| WP:WP5356 | 0.00931707261303 | 0.4 | CACNB2 CACNB1 | Affected pathways in Duchenne muscular dystrophy |
| GO:0010959 | 0.0130363720333 | 0.8 | CACNB2 CACNB3 CBARP CACNB1 | regulation of metal ion transport |
| REAC:R-HSA-112316 | 0.0132169246876 | 0.6 | CACNB2 CACNB1 CACNB3 | Neuronal System |
| GO:0006816 | 0.0175068921761 | 0.8 | CACNB2 CACNB3 CBARP CACNB1 | calcium ion transport |
| GO:0034704 | 0.019918492568 | 0.6 | CACNB2 CACNB1 CACNB3 | calcium channel complex |
| GO:0043269 | 0.0233977310013 | 0.8 | CACNB2 CACNB3 CBARP CACNB1 | regulation of monoatomic ion transport |
| GO:1901019 | 0.0237169649094 | 0.6 | CACNB2 CBARP CACNB3 | regulation of calcium ion transmembrane transporter activity |
| GO:1901843 | 0.0280843539964 | 0.4 | CACNB2 CACNB3 | positive regulation of high voltage-gated calcium channel activity |
| GO:0034762 | 0.0302165890257 | 0.8 | CACNB2 CACNB3 CBARP CACNB1 | regulation of transmembrane transport |
| REAC:R-HSA-422356 | 0.0313469851718 | 0.4 | CACNB2 CACNB3 | Regulation of insulin secretion |
| WP:WP536 | 0.0360146352745 | 0.4 | CACNB1 CACNB3 | Calcium regulation in cardiac cells |
| GO:0042383 | 0.0417184596383 | 0.6 | CACNB2 CACNB1 CACNB3 | sarcolemma |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CACNB3 | CACNB2 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CACNB3 | CACNB1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CBARP | CACNB3 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RBMXL3 | CACNB1 | 0.998 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CACNB2 | CACNB1 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CBARP | CACNB1 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CACNB3 | RBMXL3 | 0.904 | bioplex3_WMM WMM_only | |
| CBARP | CACNB2 | 0.754 | 0.09 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| CBARP | RBMXL3 | 0.478 | bioplex3_WMM WMM_only | |
| CACNB2 | RBMXL3 | 0.214 | bioplex3_WMM WMM_only |
Related Complexes