hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_09817.1

Confidence: Moderate High

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Genename	Protein Name	Uniprot Annotation Score	Links
DHPS	Deoxyhypusine synthase (DHS) (EC 2.5.1.46)	5	UniProt NCBI
MAPK1	Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)	5	UniProt NCBI
MAPK3	Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associated protein 2 kinase) (p44-ERK1)	5	UniProt NCBI
PTPRR	Receptor-type tyrosine-protein phosphatase R (R-PTP-R) (EC 3.1.3.48) (Ch-1PTPase) (NC-PTPCOM1) (Protein-tyrosine phosphatase PCPTP1)	5	UniProt NCBI
RPS6KA1	Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1)	5	UniProt NCBI
RPS6KA2	Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3)	5	UniProt NCBI
RPS6KA3	Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2)	5	UniProt NCBI

Showing 1 to 7 of 7 entries

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Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-444257	5.07705636973e-11	0.666666666667	RPS6KA1 MAPK3 RPS6KA3 RPS6KA2	RSK activation
REAC:R-HSA-881907	2.63746755285e-09	0.666666666667	RPS6KA1 MAPK3 RPS6KA3 RPS6KA2	Gastrin-CREB signalling pathway via PKC and MAPK
REAC:R-HSA-198753	8.66845929073e-09	0.666666666667	RPS6KA1 MAPK3 RPS6KA3 RPS6KA2	ERK/MAPK targets
REAC:R-HSA-442742	1.05936223437e-08	0.666666666667	RPS6KA1 MAPK3 RPS6KA3 RPS6KA2	CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
WP:WP4877	1.54744482581e-08	0.666666666667	RPS6KA1 MAPK3 RPS6KA3 RPS6KA2	Host pathogen interaction of human coronaviruses MAPK signaling
REAC:R-HSA-450282	3.96532736613e-08	0.666666666667	RPS6KA1 MAPK3 RPS6KA3 RPS6KA2	MAPK targets/ Nuclear events mediated by MAP kinases
KEGG:04720	1.28507720159e-07	0.666666666667	RPS6KA1 MAPK3 RPS6KA3 RPS6KA2	Long-term potentiation
REAC:R-HSA-199920	2.47215416054e-07	0.5	RPS6KA1 RPS6KA2 RPS6KA3	CREB phosphorylation
KEGG:04010	3.73730923895e-07	0.833333333333	RPS6KA1 RPS6KA3 PTPRR RPS6KA2 MAPK3	MAPK signaling pathway
REAC:R-HSA-198725	4.56391388507e-07	0.666666666667	RPS6KA1 MAPK3 RPS6KA3 RPS6KA2	Nuclear Events (kinase and transcription factor activation)

Showing 1 to 10 of 78 entries

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Protein 1	Protein 2	Score	ProteomeHD	Evidence
RPS6KA3	RPS6KA2	0.999		bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only
MAPK1	MAPK3	0.999	0.446	bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM
RPS6KA3	RPS6KA1	0.998	0.154	bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
DHPS	MAPK1	0.998	0.024	bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only
MAPK1	RPS6KA3	0.996	0.164	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
RPS6KA1	RPS6KA2	0.992		bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only
DHPS	MAPK3	0.985	0.022	hein_WMM bioplex_WMM bioplex3_WMM hein ()
MAPK1	PTPRR	0.977		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
MAPK1	RPS6KA1	0.975	0.124	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 fraction
MAPK3	RPS6KA2	0.959		bioplex3_HEK293 bioplex3_WMM WMM_only

Showing 1 to 10 of 17 entries

Related Complexes

Genename	Complexes
RPS6KA1	huMAP3_03542.1 huMAP3_08875.1 huMAP3_09817.1 huMAP3_11291.1 huMAP3_13282.1 huMAP3_13479.1 huMAP3_14916.1
MAPK1	huMAP3_02651.1 huMAP3_02744.1 huMAP3_04858.1 huMAP3_08949.1 huMAP3_09817.1 huMAP3_10404.1 huMAP3_11291.1 huMAP3_13355.1 huMAP3_13479.1 huMAP3_14916.1
PTPRR	huMAP3_02651.1 huMAP3_02744.1 huMAP3_04858.1 huMAP3_08949.1 huMAP3_09817.1 huMAP3_10404.1 huMAP3_11291.1 huMAP3_12424.1 huMAP3_13355.1 huMAP3_14916.1
MAPK3	huMAP3_04858.1 huMAP3_06471.1 huMAP3_08949.1 huMAP3_09817.1 huMAP3_10404.1 huMAP3_13355.1 huMAP3_13479.1 huMAP3_14916.1
RPS6KA2	huMAP3_08875.1 huMAP3_08949.1 huMAP3_09817.1 huMAP3_11291.1 huMAP3_13282.1 huMAP3_13479.1 huMAP3_14916.1
DHPS	huMAP3_01869.1 huMAP3_02651.1 huMAP3_06471.1 huMAP3_08949.1 huMAP3_09817.1 huMAP3_10404.1 huMAP3_12783.1 huMAP3_13479.1
RPS6KA3	huMAP3_03542.1 huMAP3_08875.1 huMAP3_09817.1 huMAP3_11291.1 huMAP3_13355.1 huMAP3_13479.1 huMAP3_14916.1