hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09821.1
Complex Portal: CPX-2498
Confidence: Moderate High  
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DFFB | DNA fragmentation factor subunit beta (EC 3.-.-.-) (Caspase-activated deoxyribonuclease) (CAD) (Caspase-activated DNase) (Caspase-activated nuclease) (CPAN) (DNA fragmentation factor 40 kDa subunit) (DFF-40) | 5 | UniProt   NCBI |
| DFFA | DNA fragmentation factor subunit alpha (DNA fragmentation factor 45 kDa subunit) (DFF-45) (Inhibitor of CAD) (ICAD) | 5 | UniProt   NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
|   REAC:R-HSA-140342 | 0.000133283416666 | 1.0 | DFFB DFFA | Apoptosis induced DNA fragmentation |
|   WP:WP314 | 0.000299222823835 | 1.0 | DFFB DFFA | Fas ligand pathway and stress induction of heat shock proteins |
|   GO:1902511 | 0.000468200720083 | 1.0 | DFFB DFFA | negative regulation of apoptotic DNA fragmentation |
|   GO:1903625 | 0.000468200720083 | 1.0 | DFFB DFFA | negative regulation of DNA catabolic process |
|   WP:WP4298 | 0.00105770799037 | 1.0 | DFFB DFFA | Acute viral myocarditis |
|   WP:WP254 | 0.00111857408398 | 1.0 | DFFB DFFA | Apoptosis |
|   KEGG:04210 | 0.00116074761854 | 1.0 | DFFB DFFA | Apoptosis |
|   WP:WP1772 | 0.00127818796583 | 1.0 | DFFB DFFA | Apoptosis modulation and signaling |
|   REAC:R-HSA-75153 | 0.0020095038205 | 1.0 | DFFB DFFA | Apoptotic execution phase |
|   GO:1902510 | 0.00468200720083 | 1.0 | DFFB DFFA | regulation of apoptotic DNA fragmentation |
|   GO:1903624 | 0.00468200720083 | 1.0 | DFFB DFFA | regulation of DNA catabolic process |
|   REAC:R-HSA-109581 | 0.0234014921954 | 1.0 | DFFB DFFA | Apoptosis |
|   GO:0006309 | 0.0257510396046 | 1.0 | DFFB DFFA | apoptotic DNA fragmentation |
|   REAC:R-HSA-5357801 | 0.0319897287616 | 1.0 | DFFB DFFA | Programmed Cell Death |
|   GO:0030262 | 0.0426062655276 | 1.0 | DFFB DFFA | apoptotic nuclear changes |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
|  DFFA |  DFFB | 1.0 | 0.172           |          | bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116     |
Related Complexes
| Genename | Complexes |
|---|---|
| DFFB | huMAP3_09821.1 huMAP3_10577.1 huMAP3_11108.1 huMAP3_12631.1 huMAP3_15196.1 |
| DFFA | huMAP3_00023.1 huMAP3_09821.1 huMAP3_09999.1 huMAP3_10577.1 huMAP3_12631.1 huMAP3_15196.1 |