hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_09823.1

Confidence: Moderate High

Genename	Protein Name	Uniprot Annotation Score	Links
PIP4K2A	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-Phosphate 4-Kinase) (PI5P4Kalpha) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(4)P-5-kinase B isoform) (PtdIns(4)P-5-kinase C isoform) (PtdIns(5)P-4-kinase isoform 2-alpha)	5	UniProt NCBI
MEX3B	RNA-binding protein MEX3B (RING finger and KH domain-containing protein 3) (RING finger protein 195)	5	UniProt NCBI
PIP4K2B	Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (PtdIns(5)P-4-kinase isoform 2-beta)	5	UniProt NCBI
AFF3	AF4/FMR2 family member 3 (Lymphoid nuclear protein related to AF4) (Protein LAF-4)	5	UniProt NCBI
MEX3C	RNA-binding E3 ubiquitin-protein ligase MEX3C (EC 2.3.2.27) (RING finger and KH domain-containing protein 2) (RING finger protein 194) (RING-type E3 ubiquitin transferase MEX3C)	5	UniProt NCBI
PNISR	Arginine/serine-rich protein PNISR (PNN-interacting serine/arginine-rich protein) (SR-related protein) (SR-rich protein) (Serine/arginine-rich-splicing regulatory protein 130) (SRrp130) (Splicing factor, arginine/serine-rich 130) (Splicing factor, arginine/serine-rich 18)	5	UniProt NCBI
PIP4K2C	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC 2.7.1.149) (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) (PI(5)P 4-kinase type II gamma) (PIP4KII-gamma)	5	UniProt NCBI
AHCYL1	S-adenosylhomocysteine hydrolase-like protein 1 (DC-expressed AHCY-like molecule) (IP(3)Rs binding protein released with IP(3)) (IRBIT) (Putative adenosylhomocysteinase 2) (S-adenosyl-L-homocysteine hydrolase 2) (AdoHcyase 2)	5	UniProt NCBI
NOS1AP	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C-terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein)	5	UniProt NCBI
LENG8	Leukocyte receptor cluster member 8	5	UniProt NCBI
PLCD3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-3) (Phospholipase C-delta-3) (PLC-delta-3)	5	UniProt NCBI
GRM3	Metabotropic glutamate receptor 3 (mGluR3)	5	UniProt NCBI
TCOF1	Treacle protein (Treacher Collins syndrome protein)	5	UniProt NCBI
DIP2C	Disco-interacting protein 2 homolog C (DIP2 homolog C)	3	UniProt NCBI
UBE2H	Ubiquitin-conjugating enzyme E2 H (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme H) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme H) (UbcH2) (Ubiquitin carrier protein H) (Ubiquitin-conjugating enzyme E2-20K) (Ubiquitin-protein ligase H)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-8847453	1.04689056608e-06	0.2	PIP4K2A PIP4K2C PIP4K2B	Synthesis of PIPs in the nucleus
WP:WP5411	8.73137052731e-06	0.266666666667	PIP4K2A PIP4K2C PLCD3 PIP4K2B	Phosphatidyl inositol phosphate pathway
WP:WP4971	8.73137052731e-06	0.266666666667	PIP4K2A PIP4K2C PLCD3 PIP4K2B	Phosphoinositides metabolism
REAC:R-HSA-6811555	2.19170770572e-05	0.2	PIP4K2A PIP4K2C PIP4K2B	PI5P Regulates TP53 Acetylation
KEGG:00562	2.672611706e-05	0.266666666667	PIP4K2A PIP4K2C PLCD3 PIP4K2B	Inositol phosphate metabolism
GO:0016309	4.37346186898e-05	0.2	PIP4K2A PIP4K2C PIP4K2B	1-phosphatidylinositol-5-phosphate 4-kinase activity
GO:1902633	4.37346186898e-05	0.2	PIP4K2A PIP4K2C PIP4K2B	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process
GO:1902635	4.37346186898e-05	0.2	PIP4K2A PIP4K2C PIP4K2B	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process
KEGG:04070	7.89688402514e-05	0.266666666667	PIP4K2A PIP4K2C PLCD3 PIP4K2B	Phosphatidylinositol signaling system
REAC:R-HSA-6804758	0.00104570459746	0.2	PIP4K2A PIP4K2C PIP4K2B	Regulation of TP53 Activity through Acetylation
GO:0016308	0.00244160521127	0.2	PIP4K2A PIP4K2C PIP4K2B	1-phosphatidylinositol-4-phosphate 5-kinase activity
REAC:R-HSA-1660499	0.00413284350139	0.2	PIP4K2A PIP4K2C PIP4K2B	Synthesis of PIPs at the plasma membrane
REAC:R-HSA-1483255	0.0149683930725	0.2	PIP4K2A PIP4K2C PIP4K2B	PI Metabolism
REAC:R-HSA-6811558	0.0162494145878	0.2	PIP4K2A PIP4K2C PIP4K2B	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
REAC:R-HSA-199418	0.0212950102388	0.2	PIP4K2A PIP4K2C PIP4K2B	Negative regulation of the PI3K/AKT network
GO:2000786	0.0294840968368	0.2	PIP4K2A PIP4K2C PIP4K2B	positive regulation of autophagosome assembly
WP:WP51	0.0307164567268	0.2	PIP4K2A PIP4K2C PIP4K2B	Regulation of actin cytoskeleton
REAC:R-HSA-9006925	0.0368897361677	0.266666666667	PIP4K2A PIP4K2C AHCYL1 PIP4K2B	Intracellular signaling by second messengers
CORUM:6371	0.0498224659463	0.0666666666667	GRM3	mGluR3-mGluR8 complex

Edges

Protein 1	Protein 2	Score	ProteomeHD
PIP4K2B	PIP4K2C	1.0	0.014
PIP4K2A	PIP4K2C	1.0	0.0883043478261
PIP4K2A	PIP4K2B	1.0	0.318
PIP4K2A	PLCD3	0.999	0.068
PIP4K2A	NOS1AP	0.997	0.074
PLCD3	PIP4K2C	0.994	0.15
TCOF1	PIP4K2C	0.991	0.056
PIP4K2A	PNISR	0.99	0.024
PIP4K2A	DIP2C	0.99	0.106
PIP4K2A	TCOF1	0.984	0.11
PIP4K2A	GRM3	0.983
PIP4K2C	NOS1AP	0.982	0.098
PIP4K2A	MEX3B	0.978	0.098
PIP4K2A	AHCYL1	0.974	0.048
PIP4K2B	NOS1AP	0.971	0.042
PIP4K2A	LENG8	0.968	0.092
PIP4K2A	UBE2H	0.964	0.048
PIP4K2A	AFF3	0.963
PIP4K2A	MEX3C	0.96	0.106
AHCYL1	PLCD3	0.951	0.082
PIP4K2B	PLCD3	0.95	0.068
PLCD3	NOS1AP	0.948	0.18
PLCD3	TCOF1	0.908	0.028
PLCD3	PNISR	0.902	0.066
PIP4K2C	DIP2C	0.87	0.094
PLCD3	DIP2C	0.851	0.138
PLCD3	LENG8	0.729	0.194
DIP2C	LENG8	0.687	0.098
UBE2H	DIP2C	0.674	0.066
MEX3B	GRM3	0.572
GRM3	AFF3	0.572
GRM3	MEX3C	0.572
MEX3B	NOS1AP	0.557	0.128
GRM3	DIP2C	0.557
PIP4K2B	AHCYL1	0.552	0.042
PIP4K2C	UBE2H	0.54	0.018
PNISR	GRM3	0.502
PIP4K2C	MEX3B	0.473	0.17
PLCD3	UBE2H	0.417	0.09
TCOF1	PNISR	0.4	0.204
AHCYL1	PIP4K2C	0.347	0.046
MEX3B	DIP2C	0.333	0.098
PIP4K2B	GRM3	0.333
PNISR	DIP2C	0.333	0.104
AFF3	DIP2C	0.333
MEX3C	DIP2C	0.333	0.094
TCOF1	NOS1AP	0.304	0.084
MEX3B	AFF3	0.303
AFF3	MEX3C	0.303
UBE2H	GRM3	0.302
AHCYL1	MEX3B	0.276	0.178
AHCYL1	MEX3C	0.276	0.132
MEX3B	MEX3C	0.265	0.226
PIP4K2B	DIP2C	0.265	0.04
PIP4K2B	TCOF1	0.26	0.044
PIP4K2C	MEX3C	0.244	0.08
UBE2H	NOS1AP	0.241	0.076
AHCYL1	DIP2C	0.241	0.1792
NOS1AP	DIP2C	0.23	0.138
TCOF1	GRM3	0.225
PIP4K2B	MEX3C	0.213	0.098
PIP4K2B	AFF3	0.213
PIP4K2B	MEX3B	0.213	0.068
PIP4K2B	UBE2H	0.212	0.046
UBE2H	PNISR	0.204	0.04
AHCYL1	AFF3	0.2
PLCD3	MEX3C	0.193	0.072
PLCD3	MEX3B	0.193	0.116
PLCD3	AFF3	0.193
AHCYL1	NOS1AP	0.191	0.16
MEX3B	UBE2H	0.188	0.068
UBE2H	MEX3C	0.188	0.142
UBE2H	AFF3	0.188
TCOF1	DIP2C	0.188	0.092
AHCYL1	GRM3	0.18
MEX3B	PNISR	0.172	0.088
PNISR	AFF3	0.172
PNISR	MEX3C	0.172	0.076
TCOF1	AFF3	0.17
AFF3	LENG8	0.168
PNISR	NOS1AP	0.167	0.114
MEX3B	LENG8	0.166	0.19
GRM3	LENG8	0.165
UBE2H	LENG8	0.157	0.062
AHCYL1	UBE2H	0.151	0.08
PIP4K2C	GRM3	0.143
PLCD3	GRM3	0.142
MEX3C	NOS1AP	0.14	0.096
AFF3	NOS1AP	0.14
TCOF1	UBE2H	0.136	0.054
TCOF1	MEX3C	0.136	0.104
PIP4K2C	AFF3	0.134
GRM3	NOS1AP	0.123
TCOF1	LENG8	0.11	0.172
AHCYL1	PNISR	0.088	0.032
MEX3C	LENG8	0.087	0.068
PIP4K2B	PNISR	0.082	0.022
PIP4K2C	PNISR	0.075	0.054
AHCYL1	TCOF1	0.059	0.09
PNISR	LENG8	0.038	0.134
NOS1AP	LENG8	0.035	0.114
TCOF1	MEX3B	0.031	0.096
PIP4K2B	LENG8	0.018	0.036
AHCYL1	LENG8	0.016	0.062
PIP4K2C	LENG8	0.009	0.048

Related Complexes

Genename	Complexes
PIP4K2A	huMAP3_00550.1 huMAP3_00708.1 huMAP3_02291.1 huMAP3_02922.1 huMAP3_03481.1 huMAP3_05647.1 huMAP3_06847.1 huMAP3_07416.1 huMAP3_08199.1 huMAP3_08289.1 huMAP3_08432.1 huMAP3_08874.1 huMAP3_08914.1 huMAP3_09163.1 huMAP3_09657.1 huMAP3_09823.1 huMAP3_10366.1 huMAP3_10611.1 huMAP3_10883.1 huMAP3_10957.1 huMAP3_11931.1 huMAP3_12214.1 huMAP3_12350.1 huMAP3_13786.1 huMAP3_13857.1 huMAP3_14693.1
MEX3B	huMAP3_01974.1 huMAP3_03481.1 huMAP3_05647.1 huMAP3_06171.1 huMAP3_08199.1 huMAP3_08289.1 huMAP3_08432.1 huMAP3_08874.1 huMAP3_09163.1 huMAP3_09657.1 huMAP3_09823.1 huMAP3_10957.1 huMAP3_12269.1 huMAP3_15202.1
PIP4K2B	huMAP3_00550.1 huMAP3_00708.1 huMAP3_02291.1 huMAP3_03481.1 huMAP3_04301.1 huMAP3_06847.1 huMAP3_07416.1 huMAP3_07859.1 huMAP3_08199.1 huMAP3_08289.1 huMAP3_08432.1 huMAP3_08874.1 huMAP3_08914.1 huMAP3_09163.1 huMAP3_09657.1 huMAP3_09823.1 huMAP3_10366.1 huMAP3_10611.1 huMAP3_10753.1 huMAP3_10883.1 huMAP3_10957.1 huMAP3_11931.1 huMAP3_12214.1 huMAP3_12350.1 huMAP3_13786.1 huMAP3_13857.1
AFF3	huMAP3_02922.1 huMAP3_03741.1 huMAP3_08199.1 huMAP3_08432.1 huMAP3_08616.1 huMAP3_08874.1 huMAP3_09163.1 huMAP3_09823.1 huMAP3_11931.1 huMAP3_12214.1 huMAP3_12350.1 huMAP3_12618.1 huMAP3_13608.1 huMAP3_13857.1 huMAP3_13924.1 huMAP3_14008.1 huMAP3_14061.1 huMAP3_14693.1
MEX3C	huMAP3_03481.1 huMAP3_04419.1 huMAP3_05647.1 huMAP3_07288.1 huMAP3_07979.1 huMAP3_08199.1 huMAP3_08289.1 huMAP3_08432.1 huMAP3_08874.1 huMAP3_09163.1 huMAP3_09657.1 huMAP3_09823.1 huMAP3_10957.1 huMAP3_12214.1 huMAP3_12350.1 huMAP3_13857.1 huMAP3_14640.1 huMAP3_14693.1
PNISR	huMAP3_02291.1 huMAP3_02922.1 huMAP3_03481.1 huMAP3_05647.1 huMAP3_06847.1 huMAP3_08199.1 huMAP3_08289.1 huMAP3_08432.1 huMAP3_08874.1 huMAP3_08914.1 huMAP3_09163.1 huMAP3_09657.1 huMAP3_09823.1 huMAP3_10611.1 huMAP3_10957.1 huMAP3_11931.1 huMAP3_12028.1 huMAP3_12214.1 huMAP3_12350.1 huMAP3_13857.1 huMAP3_13971.1
PIP4K2C	huMAP3_01275.1 huMAP3_04301.1 huMAP3_05601.1 huMAP3_05855.1 huMAP3_07416.1 huMAP3_07859.1 huMAP3_08199.1 huMAP3_08289.1 huMAP3_08432.1 huMAP3_08874.1 huMAP3_08914.1 huMAP3_09163.1 huMAP3_09657.1 huMAP3_09823.1 huMAP3_10366.1 huMAP3_10611.1 huMAP3_10753.1 huMAP3_10883.1 huMAP3_10957.1 huMAP3_11931.1 huMAP3_12214.1 huMAP3_12350.1 huMAP3_13786.1 huMAP3_13857.1
AHCYL1	huMAP3_00550.1 huMAP3_02291.1 huMAP3_03410.1 huMAP3_03481.1 huMAP3_06847.1 huMAP3_07110.1 huMAP3_08199.1 huMAP3_08289.1 huMAP3_08432.1 huMAP3_08739.1 huMAP3_08874.1 huMAP3_09163.1 huMAP3_09280.1 huMAP3_09657.1 huMAP3_09823.1 huMAP3_10366.1 huMAP3_10611.1 huMAP3_10844.1 huMAP3_10957.1 huMAP3_13428.1 huMAP3_13742.1 huMAP3_14337.1
NOS1AP	huMAP3_03481.1 huMAP3_04394.1 huMAP3_06573.1 huMAP3_06847.1 huMAP3_06938.1 huMAP3_07124.1 huMAP3_08199.1 huMAP3_08432.1 huMAP3_08493.1 huMAP3_08874.1 huMAP3_08914.1 huMAP3_09163.1 huMAP3_09303.1 huMAP3_09607.1 huMAP3_09823.1 huMAP3_10250.1 huMAP3_10469.1 huMAP3_10611.1 huMAP3_10753.1 huMAP3_10883.1 huMAP3_10957.1 huMAP3_11931.1 huMAP3_12350.1 huMAP3_13786.1
LENG8	huMAP3_08199.1 huMAP3_08432.1 huMAP3_08874.1 huMAP3_09163.1 huMAP3_09823.1
PLCD3	huMAP3_00550.1 huMAP3_02291.1 huMAP3_03481.1 huMAP3_04301.1 huMAP3_06847.1 huMAP3_08199.1 huMAP3_08289.1 huMAP3_08432.1 huMAP3_08739.1 huMAP3_08874.1 huMAP3_09163.1 huMAP3_09657.1 huMAP3_09823.1 huMAP3_10366.1 huMAP3_10611.1 huMAP3_10753.1 huMAP3_10957.1 huMAP3_11931.1 huMAP3_12214.1 huMAP3_12350.1
GRM3	huMAP3_02291.1 huMAP3_02922.1 huMAP3_03481.1 huMAP3_05647.1 huMAP3_06847.1 huMAP3_08199.1 huMAP3_08289.1 huMAP3_08432.1 huMAP3_08874.1 huMAP3_08914.1 huMAP3_09163.1 huMAP3_09657.1 huMAP3_09823.1 huMAP3_10611.1 huMAP3_10957.1 huMAP3_12214.1 huMAP3_12350.1 huMAP3_13786.1 huMAP3_13857.1 huMAP3_14693.1
TCOF1	huMAP3_01275.1 huMAP3_03799.1 huMAP3_06847.1 huMAP3_07286.1 huMAP3_09163.1 huMAP3_09447.1 huMAP3_09823.1 huMAP3_10819.1 huMAP3_10957.1 huMAP3_11931.1 huMAP3_13072.1
DIP2C	huMAP3_03481.1 huMAP3_05647.1 huMAP3_08199.1 huMAP3_08289.1 huMAP3_08432.1 huMAP3_08831.1 huMAP3_08874.1 huMAP3_09163.1 huMAP3_09657.1 huMAP3_09823.1 huMAP3_10957.1 huMAP3_11633.1 huMAP3_11729.1
UBE2H	huMAP3_02047.1 huMAP3_04962.1 huMAP3_06961.1 huMAP3_08199.1 huMAP3_09823.1 huMAP3_10466.1 huMAP3_10903.1 huMAP3_10931.1 huMAP3_12752.1 huMAP3_14309.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_09823.1