hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09830.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TOP2B | DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme) | 5 | UniProt NCBI |
| NOL9 | Polynucleotide 5'-hydroxyl-kinase NOL9 (EC 2.7.1.78) (Nucleolar protein 9) | 5 | UniProt NCBI |
| LAS1L | Ribosomal biogenesis protein LAS1L (Endoribonuclease LAS1L) (EC 3.1.-.-) (Protein LAS1 homolog) | 5 | UniProt NCBI |
| SENP3 | Sentrin-specific protease 3 (EC 3.4.22.-) (SUMO-1-specific protease 3) (Sentrin/SUMO-specific protease SENP3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6855 | 1.40299620761e-08 | 0.75 | NOL9 SENP3 LAS1L | LAS1L-PELP1-TEX10-WDR18-NOL9-SENP3 complex |
| CORUM:6854 | 5.12488211613e-05 | 0.5 | LAS1L SENP3 | 5FMC (Friends of Methylated Chtop) complex |
| REAC:R-HSA-6791226 | 0.00132908901162 | 0.75 | NOL9 SENP3 LAS1L | Major pathway of rRNA processing in the nucleolus and cytosol |
| REAC:R-HSA-8868773 | 0.00156371199708 | 0.75 | NOL9 SENP3 LAS1L | rRNA processing in the nucleus and cytosol |
| CORUM:5386 | 0.00166239650991 | 0.5 | LAS1L SENP3 | MLL1-WDR5 complex |
| REAC:R-HSA-72312 | 0.00182434362823 | 0.75 | NOL9 SENP3 LAS1L | rRNA processing |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NOL9 | LAS1L | 1.0 | 0.976 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| SENP3 | NOL9 | 1.0 | 0.392 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| SENP3 | LAS1L | 0.999 | 0.586 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM treiber_WMM WMM_only |
| SENP3 | TOP2B | 0.989 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| LAS1L | TOP2B | 0.966 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only treiber_WMM | |
| NOL9 | TOP2B | 0.173 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only treiber_WMM |
Related Complexes