hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_09832.1

Complex Portal: CPX-17221

Confidence: Moderate High

Genename	Protein Name	Uniprot Annotation Score	Links
APOC3	Apolipoprotein C-III (Apo-CIII) (ApoC-III) (Apolipoprotein C3)	5	UniProt NCBI
C5	Complement C5 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4) [Cleaved into: Complement C5 beta chain; Complement C5 alpha chain; C5a anaphylatoxin; Complement C5 alpha' chain]	5	UniProt NCBI
F2	Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain]	5	UniProt NCBI
MATN2	Matrilin-2	5	UniProt NCBI
UBE2U	Ubiquitin-conjugating enzyme E2 U (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme U) (Ubiquitin carrier protein U) (Ubiquitin-protein ligase U)	5	UniProt NCBI
TTR	Transthyretin (ATTR) (Prealbumin) (TBPA)	5	UniProt NCBI
THBS4	Thrombospondin-4	5	UniProt NCBI
ADSS1	Adenylosuccinate synthetase isozyme 1 (AMPSase 1) (AdSS 1) (EC 6.3.4.4) (Adenylosuccinate synthetase, basic isozyme) (Adenylosuccinate synthetase, muscle isozyme) (M-type adenylosuccinate synthetase) (Adenylosuccinate synthetase-like 1) (AdSSL1) (IMP--aspartate ligase 1)	5	UniProt NCBI
APCS	Serum amyloid P-component (SAP) (9.5S alpha-1-glycoprotein) [Cleaved into: Serum amyloid P-component(1-203)]	5	UniProt NCBI
SAA2	Serum amyloid A-2 protein (SAA2) [Cleaved into: Amyloid A2 protein (AA2)]	5	UniProt NCBI
RBP4	Retinol-binding protein 4 (Plasma retinol-binding protein) (PRBP) (RBP) [Cleaved into: Plasma retinol-binding protein(1-182); Plasma retinol-binding protein(1-181); Plasma retinol-binding protein(1-179); Plasma retinol-binding protein(1-176)]	5	UniProt NCBI
SERPINA6	Corticosteroid-binding globulin (CBG) (Serpin A6) (Transcortin)	5	UniProt NCBI
CFB	Complement factor B (EC 3.4.21.47) (C3/C5 convertase) (Glycine-rich beta glycoprotein) (GBG) (PBF2) (Properdin factor B) [Cleaved into: Complement factor B Ba fragment; Complement factor B Bb fragment]	5	UniProt NCBI
PLG	Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B]	5	UniProt NCBI
C4BPA	C4b-binding protein alpha chain (C4bp) (Proline-rich protein) (PRP)	5	UniProt NCBI
ITIH4	Inter-alpha-trypsin inhibitor heavy chain H4 (ITI heavy chain H4) (ITI-HC4) (Inter-alpha-inhibitor heavy chain 4) (Inter-alpha-trypsin inhibitor family heavy chain-related protein) (IHRP) (Plasma kallikrein sensitive glycoprotein 120) (Gp120) (PK-120) [Cleaved into: 70 kDa inter-alpha-trypsin inhibitor heavy chain H4; 35 kDa inter-alpha-trypsin inhibitor heavy chain H4]	5	UniProt NCBI
SAA4	Serum amyloid A-4 protein (Constitutively expressed serum amyloid A protein) (C-SAA)	4	UniProt NCBI
ITIH1	Inter-alpha-trypsin inhibitor heavy chain H1 (ITI heavy chain H1) (ITI-HC1) (Inter-alpha-inhibitor heavy chain 1) (Inter-alpha-trypsin inhibitor complex component III) (Serum-derived hyaluronan-associated protein) (SHAP)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:04610	8.36387187519e-07	0.294117647059	PLG F2 C4BPA C5 CFB	Complement and coagulation cascades
WP:WP2806	2.38150368507e-06	0.294117647059	PLG CFB C4BPA C5 APCS	Complement system
WP:WP1533	1.5505225967e-05	0.235294117647	PLG F2 SAA4 SAA2	Vitamin B12 metabolism
REAC:R-HSA-977606	3.98513404194e-05	0.235294117647	F2 C4BPA C5 CFB	Regulation of Complement cascade
WP:WP176	4.68091886874e-05	0.235294117647	PLG F2 SAA4 SAA2	Folate metabolism
GO:0072562	5.1335541262e-05	0.352941176471	PLG CFB F2 C4BPA ITIH4 APCS	blood microparticle
CORUM:6821	5.44233315652e-05	0.117647058824	TTR RBP4	TTR-RBP complex
REAC:R-HSA-166658	7.6189180398e-05	0.235294117647	F2 C4BPA C5 CFB	Complement cascade
WP:WP15	0.000110741434116	0.235294117647	PLG F2 SAA4 SAA2	Selenium micronutrient network
GO:0070062	0.000131422543434	0.764705882353	PLG TTR SAA2 RBP4 ITIH4 C5 F2 SAA4 SERPINA6 APOC3 CFB THBS4 APCS	extracellular exosome
GO:1903561	0.000147535942481	0.764705882353	PLG TTR SAA2 RBP4 ITIH4 C5 F2 SAA4 SERPINA6 APOC3 CFB THBS4 APCS	extracellular vesicle
GO:0065010	0.000148537899903	0.764705882353	PLG TTR SAA2 RBP4 ITIH4 C5 F2 SAA4 SERPINA6 APOC3 CFB THBS4 APCS	extracellular membrane-bounded organelle
GO:0043230	0.000148537899903	0.764705882353	PLG TTR SAA2 RBP4 ITIH4 C5 F2 SAA4 SERPINA6 APOC3 CFB THBS4 APCS	extracellular organelle
GO:0005615	0.000460927370639	0.823529411765	PLG TTR SAA2 RBP4 ITIH4 C5 F2 SAA4 SERPINA6 APOC3 CFB THBS4 APCS C4BPA	extracellular space
GO:0062023	0.00119464925601	0.411764705882	PLG MATN2 ITIH4 F2 THBS4 APOC3 APCS	collagen-containing extracellular matrix
KEGG:05150	0.00158622893373	0.176470588235	CFB C5 PLG	Staphylococcus aureus infection
GO:0005576	0.00169920930817	0.823529411765	PLG TTR SAA2 RBP4 ITIH4 C5 F2 SAA4 SERPINA6 APOC3 CFB THBS4 APCS C4BPA	extracellular region
WP:WP4927	0.00216481322863	0.117647058824	F2 PLG	COVID 19 thrombosis and anticoagulation
WP:WP558	0.00233372025386	0.176470588235	PLG F2 CFB	Complement and coagulation cascades
REAC:R-HSA-975634	0.00405691277329	0.176470588235	APOC3 RBP4 TTR	Retinoid metabolism and transport
GO:0031012	0.00483194398063	0.411764705882	PLG MATN2 ITIH4 F2 THBS4 APOC3 APCS	extracellular matrix
GO:0030312	0.00483194398063	0.411764705882	PLG MATN2 ITIH4 F2 THBS4 APOC3 APCS	external encapsulating structure
REAC:R-HSA-6806667	0.00505652633168	0.176470588235	APOC3 RBP4 TTR	Metabolism of fat-soluble vitamins
WP:WP5104	0.00518489458152	0.117647058824	CFB C5	Acquired partial lipodystrophy Barraquer Simons syndrome
REAC:R-HSA-174577	0.00859750008678	0.117647058824	CFB C5	Activation of C3 and C5
REAC:R-HSA-9675143	0.014718410425	0.117647058824	TTR RBP4	Diseases of the neuronal system
REAC:R-HSA-2474795	0.014718410425	0.117647058824	TTR RBP4	Diseases associated with visual transduction
REAC:R-HSA-2453864	0.014718410425	0.117647058824	TTR RBP4	Retinoid cycle disease events
WP:WP5090	0.0158582466184	0.176470588235	CFB C5 C4BPA	Complement system in neuronal development and plasticity
WP:WP545	0.019480441964	0.117647058824	CFB C5	Complement activation
HP:0005381	0.0207069091434	0.117647058824	CFB C5	Recurrent meningococcal disease
WP:WP272	0.0219005077051	0.117647058824	F2 PLG	Blood clotting cascade
HP:0005430	0.0289698372489	0.117647058824	CFB C5	Recurrent Neisserial infections
REAC:R-HSA-2187338	0.030396175383	0.176470588235	APOC3 RBP4 TTR	Visual phototransduction

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
UBE2U	SAA4	0.999
UBE2U	RBP4	0.998
C5	UBE2U	0.998
UBE2U	SERPINA6	0.998
UBE2U	SAA2	0.997
UBE2U	ITIH1	0.997
MATN2	ADSS1	0.997	0.088
F2	UBE2U	0.997
APOC3	UBE2U	0.995
UBE2U	CFB	0.995
UBE2U	APCS	0.993
UBE2U	TTR	0.993
UBE2U	ITIH4	0.993
MATN2	APCS	0.992	0.09
UBE2U	C4BPA	0.991
MATN2	CFB	0.989	0.218
THBS4	MATN2	0.988
UBE2U	PLG	0.986
ITIH1	MATN2	0.982	0.08
MATN2	TTR	0.98	0.09
MATN2	PLG	0.977	0.168
APOC3	MATN2	0.974	0.216
MATN2	ITIH4	0.973	0.181555555556
ITIH1	APCS	0.905	0.404
SAA2	SAA4	0.902
ITIH1	PLG	0.851	0.56
APOC3	CFB	0.829	0.34
ITIH1	C4BPA	0.828	0.272
C4BPA	ITIH4	0.828	0.254
APCS	ITIH4	0.828	0.498
PLG	APCS	0.817	0.398
TTR	APCS	0.781	0.688	structurally_consistent (dimer)
CFB	ITIH4	0.77	0.418
C4BPA	APCS	0.77	0.23	structurally_consistent (dimer)
RBP4	SAA4	0.768
C4BPA	TTR	0.766	0.298	structurally_consistent (P02743)
C4BPA	PLG	0.766	0.346
F2	PLG	0.753	0.436
APOC3	ITIH4	0.75	0.319
TTR	ITIH4	0.746	0.382
ITIH1	TTR	0.746	0.384
ITIH1	ITIH4	0.746	0.58
CFB	APCS	0.746	0.408
ITIH1	CFB	0.744	0.506
SAA2	RBP4	0.73
SAA2	SERPINA6	0.703
F2	SAA4	0.688
PLG	ITIH4	0.676	0.556
APOC3	SAA4	0.656
TTR	PLG	0.655	0.342	mutually_exclusive (P01009)
APOC3	ITIH1	0.649	0.338
APOC3	APCS	0.649	0.38
SERPINA6	CFB	0.634	0.532
SERPINA6	ITIH1	0.634	0.406
SERPINA6	ITIH4	0.634	0.418
SERPINA6	C4BPA	0.634	0.366
SAA4	C4BPA	0.633
SAA4	CFB	0.633
SAA4	ITIH1	0.633
SAA4	ITIH4	0.633
C5	SERPINA6	0.633	0.424
APOC3	TTR	0.628	0.35
PLG	CFB	0.621	0.338
SERPINA6	SAA4	0.616
C5	SAA4	0.616
TTR	CFB	0.616	0.51
C4BPA	CFB	0.613	0.186
APOC3	PLG	0.598	0.436
C5	C4BPA	0.534	0.236
C5	ITIH1	0.534	0.468
C5	CFB	0.511	0.356
APOC3	SAA2	0.474
C5	SAA2	0.468
F2	SAA2	0.468
C5	ITIH4	0.455	0.433
APOC3	ADSS1	0.452	0.09
SAA4	APCS	0.445
C5	APCS	0.438	0.516
SAA2	C4BPA	0.418
SAA2	ITIH1	0.418
C5	TTR	0.404	0.42
F2	ITIH4	0.404	0.494
F2	SERPINA6	0.396	0.6374375
SAA2	APCS	0.396
RBP4	SERPINA6	0.388	0.324
F2	CFB	0.384	0.326
F2	ITIH1	0.384	0.53
F2	C4BPA	0.384	0.32
F2	APCS	0.384	0.436528409091
SAA2	CFB	0.378
SAA4	TTR	0.378
SAA2	ITIH4	0.378
F2	TTR	0.372	0.52
APOC3	SERPINA6	0.37
F2	C5	0.366	0.474
C5	PLG	0.362	0.314
RBP4	C4BPA	0.356	0.222
F2	RBP4	0.356	0.362
RBP4	ITIH1	0.356	0.574
C5	RBP4	0.356	0.382
RBP4	TTR	0.346	0.232
APOC3	RBP4	0.343	0.22
F2	APOC3	0.335	0.6
APOC3	C5	0.335	0.404
RBP4	APCS	0.334	0.218
SAA2	TTR	0.334
RBP4	CFB	0.334	0.148
RBP4	ITIH4	0.315	0.417
APOC3	C4BPA	0.314	0.328
ADSS1	APCS	0.269
ITIH1	ADSS1	0.269	0.038
ADSS1	CFB	0.255	0.066
ADSS1	ITIH4	0.255	0.042
ADSS1	TTR	0.22
SAA4	PLG	0.22
SAA2	PLG	0.22
SERPINA6	APCS	0.219	0.348
THBS4	ADSS1	0.214
SERPINA6	TTR	0.188	0.498
ADSS1	PLG	0.188	0.07
SERPINA6	PLG	0.188	0.352
RBP4	PLG	0.157	0.282
APOC3	THBS4	0.092
THBS4	CFB	0.055
ITIH1	THBS4	0.055
THBS4	APCS	0.055
THBS4	ITIH4	0.046
THBS4	TTR	0.043
THBS4	PLG	0.042

Related Complexes

Genename	Complexes
APOC3	huMAP3_00178.1 huMAP3_00961.1 huMAP3_04159.1 huMAP3_06018.1 huMAP3_06190.1 huMAP3_06724.1 huMAP3_07064.1 huMAP3_07541.1 huMAP3_07603.1 huMAP3_07701.1 huMAP3_08395.1 huMAP3_08796.1 huMAP3_09273.1 huMAP3_09391.1 huMAP3_09531.1 huMAP3_09832.1 huMAP3_10004.1 huMAP3_10101.1 huMAP3_10426.1 huMAP3_10678.1 huMAP3_15040.1
C5	huMAP3_00178.1 huMAP3_02811.1 huMAP3_05922.1 huMAP3_06499.1 huMAP3_07119.1 huMAP3_07376.1 huMAP3_07541.1 huMAP3_08224.1 huMAP3_08395.1 huMAP3_08796.1 huMAP3_09434.1 huMAP3_09531.1 huMAP3_09832.1 huMAP3_10101.1 huMAP3_10678.1
F2	huMAP3_00074.1 huMAP3_07541.1 huMAP3_07701.1 huMAP3_08218.1 huMAP3_08395.1 huMAP3_08796.1 huMAP3_09273.1 huMAP3_09531.1 huMAP3_09832.1 huMAP3_10101.1 huMAP3_10678.1
MATN2	huMAP3_00961.1 huMAP3_06018.1 huMAP3_06190.1 huMAP3_06724.1 huMAP3_07064.1 huMAP3_07541.1 huMAP3_07603.1 huMAP3_07647.1 huMAP3_07701.1 huMAP3_08395.1 huMAP3_09273.1 huMAP3_09391.1 huMAP3_09531.1 huMAP3_09832.1 huMAP3_10101.1 huMAP3_10426.1 huMAP3_10678.1 huMAP3_11307.1 huMAP3_15040.1
UBE2U	huMAP3_00178.1 huMAP3_03086.1 huMAP3_03402.1 huMAP3_05943.1 huMAP3_07119.1 huMAP3_07541.1 huMAP3_07611.1 huMAP3_07701.1 huMAP3_08395.1 huMAP3_08796.1 huMAP3_09273.1 huMAP3_09531.1 huMAP3_09832.1 huMAP3_10101.1 huMAP3_10678.1 huMAP3_14322.1 huMAP3_15040.1
TTR	huMAP3_05735.1 huMAP3_08218.1 huMAP3_08796.1 huMAP3_09273.1 huMAP3_09531.1 huMAP3_09832.1 huMAP3_10101.1 huMAP3_10501.1 huMAP3_10678.1 huMAP3_15040.1
THBS4	huMAP3_00961.1 huMAP3_02211.1 huMAP3_06018.1 huMAP3_06190.1 huMAP3_06724.1 huMAP3_07064.1 huMAP3_07505.1 huMAP3_07603.1 huMAP3_07647.1 huMAP3_08051.1 huMAP3_09391.1 huMAP3_09832.1 huMAP3_10426.1 huMAP3_11307.1 huMAP3_12316.1 huMAP3_15040.1
ADSS1	huMAP3_03131.1 huMAP3_05178.1 huMAP3_06018.1 huMAP3_06190.1 huMAP3_06724.1 huMAP3_07064.1 huMAP3_07603.1 huMAP3_07647.1 huMAP3_09391.1 huMAP3_09832.1 huMAP3_11307.1 huMAP3_12694.1 huMAP3_15040.1
APCS	huMAP3_07064.1 huMAP3_07541.1 huMAP3_07701.1 huMAP3_08049.1 huMAP3_08395.1 huMAP3_08796.1 huMAP3_09273.1 huMAP3_09531.1 huMAP3_09832.1 huMAP3_09846.1 huMAP3_10101.1 huMAP3_15040.1
SAA2	huMAP3_00178.1 huMAP3_03402.1 huMAP3_05943.1 huMAP3_07119.1 huMAP3_07541.1 huMAP3_07701.1 huMAP3_08395.1 huMAP3_08796.1 huMAP3_09273.1 huMAP3_09531.1 huMAP3_09832.1 huMAP3_10101.1 huMAP3_13054.1 huMAP3_14041.1 huMAP3_14322.1 huMAP3_14675.1
RBP4	huMAP3_00178.1 huMAP3_05943.1 huMAP3_07119.1 huMAP3_08796.1 huMAP3_09832.1 huMAP3_13398.1 huMAP3_14155.1 huMAP3_15072.1
SERPINA6	huMAP3_00178.1 huMAP3_05943.1 huMAP3_08796.1 huMAP3_09832.1 huMAP3_14295.1
CFB	huMAP3_06724.1 huMAP3_07701.1 huMAP3_08395.1 huMAP3_08796.1 huMAP3_09273.1 huMAP3_09531.1 huMAP3_09832.1 huMAP3_10101.1 huMAP3_10678.1 huMAP3_15040.1
PLG	huMAP3_06190.1 huMAP3_07701.1 huMAP3_08395.1 huMAP3_08796.1 huMAP3_09273.1 huMAP3_09531.1 huMAP3_09832.1 huMAP3_10101.1 huMAP3_10678.1 huMAP3_13521.1 huMAP3_15040.1
C4BPA	huMAP3_02768.1 huMAP3_02811.1 huMAP3_03086.1 huMAP3_06454.1 huMAP3_07376.1 huMAP3_07541.1 huMAP3_07701.1 huMAP3_08139.1 huMAP3_08395.1 huMAP3_08796.1 huMAP3_09273.1 huMAP3_09531.1 huMAP3_09832.1 huMAP3_10101.1 huMAP3_10678.1 huMAP3_15040.1
ITIH4	huMAP3_08796.1 huMAP3_09434.1 huMAP3_09531.1 huMAP3_09832.1 huMAP3_10101.1 huMAP3_10678.1 huMAP3_15040.1
SAA4	huMAP3_00178.1 huMAP3_03402.1 huMAP3_05943.1 huMAP3_07119.1 huMAP3_07541.1 huMAP3_07701.1 huMAP3_08395.1 huMAP3_08796.1 huMAP3_09273.1 huMAP3_09531.1 huMAP3_09832.1 huMAP3_10101.1 huMAP3_14295.1
ITIH1	huMAP3_00178.1 huMAP3_00961.1 huMAP3_02811.1 huMAP3_06018.1 huMAP3_06190.1 huMAP3_06724.1 huMAP3_07064.1 huMAP3_07541.1 huMAP3_07603.1 huMAP3_07701.1 huMAP3_08395.1 huMAP3_08796.1 huMAP3_09273.1 huMAP3_09391.1 huMAP3_09531.1 huMAP3_09832.1 huMAP3_10101.1 huMAP3_10426.1 huMAP3_10678.1 huMAP3_15040.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_09832.1

Complex Portal: CPX-17221