hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09835.1
Complex Portal: CPX-13119
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NEK9 | Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8) | 5 | UniProt NCBI |
| CDC42EP1 | Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55) | 5 | UniProt NCBI |
| TUBB4B | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | 5 | UniProt NCBI |
| EML1 | Echinoderm microtubule-associated protein-like 1 (EMAP-1) (HuEMAP-1) | 5 | UniProt NCBI |
| EML4 | Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120) | 5 | UniProt NCBI |
| EML2 | Echinoderm microtubule-associated protein-like 2 (EMAP-2) (HuEMAP-2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9648025 | 0.00162692918042 | 0.5 | NEK9 EML4 TUBB4B | EML4 and NUDC in mitotic spindle formation |
| REAC:R-HSA-68877 | 0.00834875761735 | 0.5 | NEK9 EML4 TUBB4B | Mitotic Prometaphase |
| GO:0072686 | 0.00994765941928 | 0.666666666667 | TUBB4B EML2 EML4 EML1 | mitotic spindle |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| EML4 | EML1 | 1.0 | 0.088 |
mutually_exclusive (Q13509)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| EML1 | EML2 | 0.997 | hein_WMM bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| EML4 | EML2 | 0.99 |
mutually_exclusive (Q9BVA1)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| NEK9 | EML4 | 0.988 | 0.064 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM hein () gupta_WMM boldt_WMM | |
| TUBB4B | NEK9 | 0.988 | 0.146 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 boldt_WMM | |
| TUBB4B | EML2 | 0.986 |
structurally_consistent (Q3ZCM7)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TUBB4B | CDC42EP1 | 0.983 | 0.215445631678 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only | |
| NEK9 | EML1 | 0.983 | 0.072 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 gupta_WMM | |
| NEK9 | EML2 | 0.981 | hein_WMM bioplex_WMM bioplex3_WMM hein () | ||
| TUBB4B | EML4 | 0.976 | 0.216 |
mutually_exclusive (Q13509)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 boldt_WMM WMM_only |
| TUBB4B | EML1 | 0.834 | 0.104590909091 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CDC42EP1 | EML2 | 0.497 | bioplex_WMM bioplex3_WMM WMM_only | ||
| CDC42EP1 | EML1 | 0.115 | 0.06 | bioplex_WMM bioplex3_WMM WMM_only | |
| CDC42EP1 | EML4 | 0.014 | 0.15 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| CDC42EP1 | NEK9 | 0.012 | 0.092 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
Related Complexes