hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09836.1
Complex Portal: CPX-13178
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PDAP1 | 28 kDa heat- and acid-stable phosphoprotein (PDGF-associated protein) (PAP) (PDGFA-associated protein 1) (PAP1) | 4 | UniProt NCBI |
| RTRAF | RNA transcription, translation and transport factor protein (CLE7 homolog) (CLE) (hCLE) | 5 | UniProt NCBI |
| IFI16 | Gamma-interferon-inducible protein 16 (Ifi-16) (Interferon-inducible myeloid differentiation transcriptional activator) | 5 | UniProt NCBI |
| DEK | Protein DEK | 5 | UniProt NCBI |
| NEMF | Ribosome quality control complex subunit NEMF (Antigen NY-CO-1) (Nuclear export mediator factor) (Serologically defined colon cancer antigen 1) | 5 | UniProt NCBI |
| RTCB | RNA-splicing ligase RtcB homolog (EC 6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase) | 5 | UniProt NCBI |
| DDX1 | ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB) | 5 | UniProt NCBI |
| GTPBP1 | GTP-binding protein 1 (G-protein 1) (GP-1) (GP1) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6301 | 9.81744484776e-08 | 0.375 | RTRAF RTCB DDX1 | tRNA Splicing Ligase Complex |
| GO:0072669 | 0.000301045822538 | 0.375 | RTRAF RTCB DDX1 | tRNA-splicing ligase complex |
| GO:0003723 | 0.000348124406106 | 1.0 | GTPBP1 DDX1 DEK IFI16 NEMF PDAP1 RTRAF RTCB | RNA binding |
| REAC:R-HSA-6784531 | 0.000592943247076 | 0.375 | RTRAF RTCB DDX1 | tRNA processing in the nucleus |
| GO:0006388 | 0.000886327111509 | 0.375 | RTRAF RTCB DDX1 | tRNA splicing, via endonucleolytic cleavage and ligation |
| GO:0000394 | 0.00118146610329 | 0.375 | RTRAF RTCB DDX1 | RNA splicing, via endonucleolytic cleavage and ligation |
| HPA:0340461 | 0.00158311763429 | 1.0 | GTPBP1 DDX1 DEK IFI16 NEMF PDAP1 RTRAF RTCB | ovary; ovarian stroma cells[>=Low] |
| HPA:0160251 | 0.00186218249003 | 1.0 | GTPBP1 DDX1 DEK IFI16 NEMF PDAP1 RTRAF RTCB | endometrium 1; cells in endometrial stroma[>=Low] |
| HPA:0530721 | 0.00299238762926 | 1.0 | GTPBP1 DDX1 DEK IFI16 NEMF PDAP1 RTRAF RTCB | spleen; cells in white pulp[>=Low] |
| REAC:R-HSA-72306 | 0.00350506047164 | 0.375 | RTRAF RTCB DDX1 | tRNA processing |
| HPA:0170252 | 0.00517551495788 | 0.75 | GTPBP1 DDX1 DEK IFI16 NEMF RTRAF | endometrium 2; cells in endometrial stroma[>=Medium] |
| HPA:0030071 | 0.00574478196768 | 1.0 | GTPBP1 DDX1 DEK IFI16 NEMF PDAP1 RTRAF RTCB | appendix; lymphoid tissue[>=Low] |
| HPA:0270352 | 0.00650854733563 | 0.875 | GTPBP1 DDX1 DEK IFI16 NEMF PDAP1 RTRAF | kidney; cells in glomeruli[>=Medium] |
| HPA:0490692 | 0.00688674603574 | 0.875 | GTPBP1 DDX1 DEK NEMF PDAP1 RTRAF RTCB | smooth muscle; smooth muscle cells[>=Medium] |
| HPA:0310431 | 0.0101376364563 | 1.0 | GTPBP1 DDX1 DEK IFI16 NEMF PDAP1 RTRAF RTCB | lymph node; germinal center cells[>=Low] |
| HPA:0270351 | 0.0107594052781 | 1.0 | GTPBP1 DDX1 DEK IFI16 NEMF PDAP1 RTRAF RTCB | kidney; cells in glomeruli[>=Low] |
| HPA:0340462 | 0.0109830778194 | 0.75 | DEK IFI16 DDX1 PDAP1 RTRAF RTCB | ovary; ovarian stroma cells[>=Medium] |
| HPA:0460671 | 0.0139657476636 | 1.0 | GTPBP1 DDX1 DEK IFI16 NEMF PDAP1 RTRAF RTCB | skin 1; melanocytes[>=Low] |
| HPA:0170251 | 0.0169899383154 | 0.875 | GTPBP1 NEMF DEK IFI16 DDX1 RTRAF RTCB | endometrium 2; cells in endometrial stroma[>=Low] |
| HPA:0340000 | 0.017002949903 | 1.0 | GTPBP1 DDX1 DEK IFI16 NEMF PDAP1 RTRAF RTCB | ovary |
| HPA:0130201 | 0.0223904412067 | 1.0 | GTPBP1 DDX1 DEK IFI16 NEMF PDAP1 RTRAF RTCB | colon; endothelial cells[>=Low] |
| HPA:0440342 | 0.0241638804332 | 0.875 | GTPBP1 DDX1 DEK NEMF PDAP1 RTRAF RTCB | skeletal muscle; myocytes[>=Medium] |
| HPA:0180052 | 0.024892450361 | 1.0 | GTPBP1 DDX1 DEK IFI16 NEMF PDAP1 RTRAF RTCB | epididymis; glandular cells[>=Medium] |
| HPA:0050092 | 0.0271872872672 | 0.875 | GTPBP1 DDX1 DEK NEMF PDAP1 RTRAF RTCB | breast; myoepithelial cells[>=Medium] |
| HPA:0530000 | 0.0305463975712 | 1.0 | GTPBP1 DDX1 DEK IFI16 NEMF PDAP1 RTRAF RTCB | spleen |
| HPA:0600431 | 0.0361943099766 | 1.0 | GTPBP1 DDX1 DEK IFI16 NEMF PDAP1 RTRAF RTCB | tonsil; germinal center cells[>=Low] |
| HPA:0310442 | 0.0366220502371 | 0.875 | GTPBP1 DDX1 DEK IFI16 NEMF PDAP1 RTRAF | lymph node; non-germinal center cells[>=Medium] |
| HPA:0610832 | 0.0370714569997 | 1.0 | GTPBP1 DDX1 DEK IFI16 NEMF PDAP1 RTRAF RTCB | urinary bladder; urothelial cells[>=Medium] |
| HPA:0620221 | 0.0379671479571 | 1.0 | GTPBP1 DDX1 DEK IFI16 NEMF PDAP1 RTRAF RTCB | vagina; squamous epithelial cells[>=Low] |
| HPA:0620000 | 0.0379671479571 | 1.0 | GTPBP1 DDX1 DEK IFI16 NEMF PDAP1 RTRAF RTCB | vagina |
| HPA:0310441 | 0.0380804298284 | 1.0 | GTPBP1 DDX1 DEK IFI16 NEMF PDAP1 RTRAF RTCB | lymph node; non-germinal center cells[>=Low] |
| HPA:0630052 | 0.0408273538891 | 0.875 | GTPBP1 DDX1 DEK NEMF PDAP1 RTRAF RTCB | cervix; glandular cells[>=Medium] |
| HPA:0600441 | 0.0408291020219 | 1.0 | GTPBP1 DDX1 DEK IFI16 NEMF PDAP1 RTRAF RTCB | tonsil; non-germinal center cells[>=Low] |
| HPA:0351183 | 0.0437717975659 | 0.5 | PDAP1 RTCB DDX1 RTRAF | pancreas; pancreatic endocrine cells[High] |
| HPA:0100122 | 0.0458743073551 | 0.75 | DDX1 DEK NEMF PDAP1 RTRAF RTCB | cerebral cortex; glial cells[>=Medium] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| DDX1 | RTCB | 1.0 | 0.978 |
structurally_consistent (dimer)
|
hein_WMM youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| RTRAF | DDX1 | 1.0 | 0.97 |
mutually_exclusive (Q9Y3I0)
|
hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| RTRAF | RTCB | 0.996 | 0.92 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| RTRAF | IFI16 | 0.991 | 0.196 | hein_WMM bioplex3_HEK293 bioplex3_WMM WMM_only | |
| RTRAF | GTPBP1 | 0.99 | 0.192 | hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| RTRAF | NEMF | 0.978 | 0.136 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| PDAP1 | RTRAF | 0.977 | 0.12 | hein_WMM bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM treiber_WMM WMM_only | |
| DEK | RTRAF | 0.976 | 0.13 | hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| NEMF | DDX1 | 0.974 | 0.138 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| NEMF | RTCB | 0.973 | 0.162 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| DEK | RTCB | 0.97 | 0.118 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only treiber_WMM | |
| PDAP1 | NEMF | 0.964 | 0.098 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| IFI16 | RTCB | 0.895 | 0.388 | hein_WMM bioplex3_HEK293 bioplex3_WMM treiber_WMM WMM_only | |
| DEK | NEMF | 0.883 | 0.062 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| DDX1 | IFI16 | 0.857 | 0.338 | hein_WMM bioplex3_HEK293 bioplex3_WMM treiber_WMM WMM_only | |
| PDAP1 | IFI16 | 0.851 | 0.136 | hein_WMM bioplex3_HEK293 WMM_only | |
| GTPBP1 | RTCB | 0.756 | 0.154 | hein_WMM youn () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM treiber_WMM WMM_only | |
| DDX1 | GTPBP1 | 0.708 | 0.094 | hein_WMM youn () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM treiber_WMM WMM_only | |
| PDAP1 | DEK | 0.679 | 0.156 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| DEK | DDX1 | 0.673 | 0.208 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| DEK | IFI16 | 0.522 | 0.328666666667 | hein_WMM bioplex3_HEK293 WMM_only | |
| PDAP1 | RTCB | 0.498 | 0.08 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| NEMF | GTPBP1 | 0.492 | 0.086 | hein_WMM youn () bioplex_WMM Guru bioplex3_WMM youn_WMM fraction | |
| PDAP1 | DDX1 | 0.268 | 0.074 | hein_WMM youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| NEMF | IFI16 | 0.048 | 0.184 | hein_WMM WMM_only | |
| DEK | GTPBP1 | 0.044 | 0.054 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| PDAP1 | GTPBP1 | 0.018 | 0.076 | youn () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction | |
| IFI16 | GTPBP1 | 0.012 | 0.084 | WMM_only treiber_WMM |
Related Complexes