hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_09839.1

Complex Portal: CPX-17569

Confidence: Moderate High

Genename	Protein Name	Uniprot Annotation Score	Links
EXOC6B	Exocyst complex component 6B (Exocyst complex component Sec15B) (SEC15-like protein 2)	5	UniProt NCBI
EXOC1	Exocyst complex component 1 (Exocyst complex component Sec3)	5	UniProt NCBI
EXOC2	Exocyst complex component 2 (Exocyst complex component Sec5)	5	UniProt NCBI
EXOC7	Exocyst complex component 7 (Exocyst complex component Exo70)	5	UniProt NCBI
EXOC8	Exocyst complex component 8 (Exocyst complex 84 kDa subunit)	5	UniProt NCBI
KRT86	Keratin, type II cuticular Hb6 (Hair keratin K2.11) (Keratin-86) (K86) (Type II hair keratin Hb6) (Type-II keratin Kb26)	5	UniProt NCBI
PRR30	Proline-rich protein 30	2	UniProt NCBI
EXOC4	Exocyst complex component 4 (Exocyst complex component Sec8)	5	UniProt NCBI
EXOC5	Exocyst complex component 5 (Exocyst complex component Sec10) (hSec10)	5	UniProt NCBI
IL1R2	Interleukin-1 receptor type 2 (IL-1R-2) (IL-1RT-2) (IL-1RT2) (CD121 antigen-like family member B) (CDw121b) (IL-1 type II receptor) (Interleukin-1 receptor beta) (IL-1R-beta) (Interleukin-1 receptor type II) (CD antigen CD121b) [Cleaved into: Interleukin-1 receptor type 2, membrane form (mIL-1R2) (mIL-1RII); Interleukin-1 receptor type 2, soluble form (sIL-1R2) (sIL-1RII)]	5	UniProt NCBI
EXOC3	Exocyst complex component 3 (Exocyst complex component Sec6)	5	UniProt NCBI
EXOC6	Exocyst complex component 6 (Exocyst complex component Sec15A) (SEC15-like protein 1)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0090522	1.31533480551e-25	0.75	EXOC8 EXOC6 EXOC1 EXOC7 EXOC3 EXOC4 EXOC5 EXOC6B EXOC2	vesicle tethering involved in exocytosis
CORUM:6167	5.84339887594e-25	0.666666666667	EXOC8 EXOC6 EXOC7 EXOC3 EXOC4 EXOC5 EXOC1 EXOC2	Exocyst complex
CORUM:89	5.84339887594e-25	0.666666666667	EXOC8 EXOC6 EXOC7 EXOC3 EXOC4 EXOC5 EXOC1 EXOC2	Exocyst Sec6/8 complex
GO:0000145	2.63086698588e-22	0.75	EXOC8 EXOC6 EXOC1 EXOC7 EXOC3 EXOC4 EXOC5 EXOC6B EXOC2	exocyst
REAC:R-HSA-5620916	1.13951342981e-19	0.666666666667	EXOC8 EXOC6 EXOC7 EXOC3 EXOC4 EXOC5 EXOC1 EXOC2	VxPx cargo-targeting to cilium
REAC:R-HSA-264876	5.29526466882e-19	0.666666666667	EXOC8 EXOC6 EXOC7 EXOC3 EXOC4 EXOC5 EXOC1 EXOC2	Insulin processing
GO:0099022	1.87457297413e-18	0.75	EXOC8 EXOC6 EXOC1 EXOC7 EXOC3 EXOC4 EXOC5 EXOC6B EXOC2	vesicle tethering
GO:0006904	9.24267762689e-18	0.75	EXOC8 EXOC6 EXOC1 EXOC7 EXOC3 EXOC4 EXOC5 EXOC6B EXOC2	vesicle docking involved in exocytosis
GO:0090148	4.58098422836e-17	0.75	EXOC8 EXOC6 EXOC1 EXOC7 EXOC3 EXOC4 EXOC5 EXOC6B EXOC2	membrane fission
REAC:R-HSA-5620920	6.74879540162e-16	0.666666666667	EXOC8 EXOC6 EXOC7 EXOC3 EXOC4 EXOC5 EXOC1 EXOC2	Cargo trafficking to the periciliary membrane
GO:0140029	6.93683908117e-16	0.75	EXOC8 EXOC6 EXOC1 EXOC7 EXOC3 EXOC4 EXOC5 EXOC6B EXOC2	exocytic process
GO:0048278	6.93683908117e-16	0.75	EXOC8 EXOC6 EXOC1 EXOC7 EXOC3 EXOC4 EXOC5 EXOC6B EXOC2	vesicle docking
GO:0006903	1.17286689142e-15	0.75	EXOC8 EXOC6 EXOC1 EXOC7 EXOC3 EXOC4 EXOC5 EXOC6B EXOC2	vesicle targeting
GO:0099023	2.25916574346e-15	0.75	EXOC8 EXOC6 EXOC1 EXOC7 EXOC3 EXOC4 EXOC5 EXOC6B EXOC2	vesicle tethering complex
GO:0140056	6.41153786124e-15	0.75	EXOC8 EXOC6 EXOC1 EXOC7 EXOC3 EXOC4 EXOC5 EXOC6B EXOC2	organelle localization by membrane tethering
REAC:R-HSA-2980736	1.47828855014e-14	0.666666666667	EXOC8 EXOC6 EXOC7 EXOC3 EXOC4 EXOC5 EXOC1 EXOC2	Peptide hormone metabolism
GO:0022406	2.09536980114e-14	0.75	EXOC8 EXOC6 EXOC1 EXOC7 EXOC3 EXOC4 EXOC5 EXOC6B EXOC2	membrane docking
REAC:R-HSA-1445148	2.15050592347e-14	0.666666666667	EXOC8 EXOC6 EXOC7 EXOC3 EXOC4 EXOC5 EXOC1 EXOC2	Translocation of SLC2A4 (GLUT4) to the plasma membrane
GO:0000281	3.01040555653e-14	0.75	EXOC8 EXOC6 EXOC1 EXOC7 EXOC3 EXOC4 EXOC5 EXOC6B EXOC2	mitotic cytokinesis
WP:WP5366	1.4565074906e-13	0.666666666667	EXOC8 EXOC6 EXOC7 EXOC3 EXOC4 EXOC5 EXOC1 EXOC2	NF1 copy number variation syndrome
GO:0061640	2.96116641521e-13	0.75	EXOC8 EXOC6 EXOC1 EXOC7 EXOC3 EXOC4 EXOC5 EXOC6B EXOC2	cytoskeleton-dependent cytokinesis
WP:WP4352	5.21373706103e-13	0.75	EXOC8 EXOC6 EXOC1 EXOC7 EXOC3 EXOC4 EXOC5 EXOC6B EXOC2	Ciliary landscape
GO:0000910	1.71551062013e-11	0.75	EXOC8 EXOC6 EXOC1 EXOC7 EXOC3 EXOC4 EXOC5 EXOC6B EXOC2	cytokinesis
GO:0051650	3.01686682315e-11	0.75	EXOC8 EXOC6 EXOC1 EXOC7 EXOC3 EXOC4 EXOC5 EXOC6B EXOC2	establishment of vesicle localization
GO:0051648	4.1643663285e-11	0.75	EXOC8 EXOC6 EXOC1 EXOC7 EXOC3 EXOC4 EXOC5 EXOC6B EXOC2	vesicle localization
GO:0005938	4.1643663285e-11	0.75	EXOC8 EXOC6 EXOC1 EXOC7 EXOC3 EXOC4 EXOC5 EXOC6B EXOC2	cell cortex
REAC:R-HSA-5617833	8.67855027065e-11	0.666666666667	EXOC8 EXOC6 EXOC7 EXOC3 EXOC4 EXOC5 EXOC1 EXOC2	Cilium Assembly
GO:0006893	2.45050735925e-10	0.583333333333	EXOC8 EXOC6 EXOC1 EXOC4 EXOC5 EXOC6B EXOC2	Golgi to plasma membrane transport
GO:0006887	4.3760367863e-10	0.75	EXOC8 EXOC6 EXOC1 EXOC7 EXOC3 EXOC4 EXOC5 EXOC6B EXOC2	exocytosis
GO:0051301	6.76194985768e-10	0.75	EXOC8 EXOC6 EXOC1 EXOC7 EXOC3 EXOC4 EXOC5 EXOC6B EXOC2	cell division
REAC:R-HSA-1852241	1.78971078533e-09	0.666666666667	EXOC8 EXOC6 EXOC7 EXOC3 EXOC4 EXOC5 EXOC1 EXOC2	Organelle biogenesis and maintenance
GO:0006892	1.5102469393e-08	0.583333333333	EXOC8 EXOC6 EXOC1 EXOC4 EXOC5 EXOC6B EXOC2	post-Golgi vesicle-mediated transport
CORUM:6169	2.5725558439e-08	0.25	EXOC7 EXOC6 EXOC5	Exocyst EXOC5-EXOC6-EXOC7 subcomplex
GO:0051656	3.70916622557e-08	0.75	EXOC8 EXOC6 EXOC1 EXOC7 EXOC3 EXOC4 EXOC5 EXOC6B EXOC2	establishment of organelle localization
GO:0098876	1.35211465895e-07	0.583333333333	EXOC8 EXOC6 EXOC1 EXOC4 EXOC5 EXOC6B EXOC2	vesicle-mediated transport to the plasma membrane
GO:0032940	3.01000185221e-07	0.75	EXOC8 EXOC6 EXOC1 EXOC7 EXOC3 EXOC4 EXOC5 EXOC6B EXOC2	secretion by cell
GO:0051640	3.37936712334e-07	0.75	EXOC8 EXOC6 EXOC1 EXOC7 EXOC3 EXOC4 EXOC5 EXOC6B EXOC2	organelle localization
REAC:R-HSA-199991	6.22841230648e-07	0.666666666667	EXOC8 EXOC6 EXOC7 EXOC3 EXOC4 EXOC5 EXOC1 EXOC2	Membrane Trafficking
GO:0046903	6.92497358902e-07	0.75	EXOC8 EXOC6 EXOC1 EXOC7 EXOC3 EXOC4 EXOC5 EXOC6B EXOC2	secretion
GO:0140352	7.17352773118e-07	0.75	EXOC8 EXOC6 EXOC1 EXOC7 EXOC3 EXOC4 EXOC5 EXOC6B EXOC2	export from cell
REAC:R-HSA-5653656	9.56782809885e-07	0.666666666667	EXOC8 EXOC6 EXOC7 EXOC3 EXOC4 EXOC5 EXOC1 EXOC2	Vesicle-mediated transport
GO:0061024	1.79676865542e-06	0.75	EXOC8 EXOC6 EXOC1 EXOC7 EXOC3 EXOC4 EXOC5 EXOC6B EXOC2	membrane organization
GO:1903047	2.98651463536e-06	0.75	EXOC8 EXOC6 EXOC1 EXOC7 EXOC3 EXOC4 EXOC5 EXOC6B EXOC2	mitotic cell cycle process
GO:0000278	1.62634231933e-05	0.75	EXOC8 EXOC6 EXOC1 EXOC7 EXOC3 EXOC4 EXOC5 EXOC6B EXOC2	mitotic cell cycle
GO:0048193	2.48744975219e-05	0.583333333333	EXOC8 EXOC6 EXOC1 EXOC4 EXOC5 EXOC6B EXOC2	Golgi vesicle transport
CORUM:6168	3.75927585468e-05	0.166666666667	EXOC5 EXOC6	Exocyst EXOC5-EXOC6 subcomplex
GO:0022402	0.000242088014925	0.75	EXOC8 EXOC6 EXOC1 EXOC7 EXOC3 EXOC4 EXOC5 EXOC6B EXOC2	cell cycle process
GO:0016192	0.000660666889787	0.75	EXOC8 EXOC6 EXOC1 EXOC7 EXOC3 EXOC4 EXOC5 EXOC6B EXOC2	vesicle-mediated transport
KEGG:05132	0.00125499904514	0.333333333333	EXOC7 EXOC5 EXOC2 EXOC4	Salmonella infection
GO:0007049	0.00215586789473	0.75	EXOC8 EXOC6 EXOC1 EXOC7 EXOC3 EXOC4 EXOC5 EXOC6B EXOC2	cell cycle
GO:0051668	0.00271618387292	0.583333333333	EXOC8 EXOC6 EXOC1 EXOC4 EXOC5 EXOC6B EXOC2	localization within membrane
REAC:R-HSA-392499	0.0029832414005	0.666666666667	EXOC8 EXOC6 EXOC7 EXOC3 EXOC4 EXOC5 EXOC1 EXOC2	Metabolism of proteins
WP:WP2290	0.00474345148572	0.166666666667	EXOC8 EXOC2	RalA downstream regulated genes
GO:0051649	0.00514237157526	0.75	EXOC8 EXOC6 EXOC1 EXOC7 EXOC3 EXOC4 EXOC5 EXOC6B EXOC2	establishment of localization in cell

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
EXOC6B	EXOC8	1.0	0.46
EXOC7	EXOC8	1.0	0.878	structurally_consistent (dimer)
EXOC8	EXOC6	1.0	0.218	structurally_consistent (Q9UPT5)
EXOC7	EXOC6	1.0	0.102	structurally_consistent (dimer)
EXOC1	EXOC3	1.0	0.82	mutually_exclusive (Q96KP1)
EXOC5	EXOC6	1.0	0.214
EXOC8	EXOC5	1.0	0.736	structurally_consistent (Q96A65) structurally_consistent (dimer)
EXOC2	EXOC3	1.0	0.956	structurally_consistent (dimer)
EXOC4	EXOC3	1.0	0.45
EXOC6B	EXOC5	1.0	0.268	structurally_consistent (dimer)
EXOC1	EXOC2	1.0	0.834	structurally_consistent (dimer)
EXOC7	EXOC3	1.0	0.486
EXOC1	EXOC4	1.0	0.73
EXOC3	EXOC6	1.0	0.154
EXOC5	EXOC3	1.0	0.608
EXOC6B	EXOC7	1.0	0.48
EXOC1	EXOC6	1.0	0.176
EXOC2	EXOC8	1.0	0.512
EXOC1	EXOC8	1.0	0.606
EXOC4	EXOC6	1.0	0.178
EXOC6B	EXOC3	1.0	0.392
EXOC2	EXOC6	1.0	0.09
EXOC8	EXOC4	0.999	0.374	structurally_consistent (dimer)
EXOC1	EXOC7	0.999	0.57
EXOC1	EXOC5	0.999	0.782
EXOC6B	EXOC4	0.999	0.254
EXOC7	EXOC5	0.999	0.802
IL1R2	EXOC6B	0.999		structurally_consistent (O00471)
IL1R2	EXOC8	0.999		structurally_consistent (O00471)
EXOC6B	EXOC2	0.999	0.362
IL1R2	EXOC6	0.999
EXOC8	EXOC3	0.999	0.786
IL1R2	EXOC7	0.998
EXOC6B	EXOC6	0.998	0.016
IL1R2	EXOC1	0.998
IL1R2	EXOC5	0.998		structurally_consistent (dimer)
EXOC6B	EXOC1	0.998	0.374
EXOC2	EXOC5	0.998	0.788
EXOC2	EXOC4	0.998	0.818
IL1R2	EXOC2	0.997
EXOC7	EXOC4	0.997	0.232
IL1R2	EXOC4	0.996
EXOC2	EXOC7	0.996	0.4
IL1R2	EXOC3	0.995
EXOC4	EXOC5	0.991	0.474	structurally_consistent (dimer)
IL1R2	PRR30	0.986
KRT86	EXOC4	0.973	0.056
EXOC1	KRT86	0.027	0.054
EXOC7	KRT86	0.009	0.02
EXOC2	KRT86	0.009	0.024
KRT86	EXOC5	0.009	0.044
EXOC8	KRT86	0.009	0.024
KRT86	EXOC3	0.009	0.012
KRT86	EXOC6	0.009	0.05
EXOC6B	KRT86	0.009	0.016

Related Complexes

Genename	Complexes
EXOC6B	huMAP3_04054.1 huMAP3_07009.1 huMAP3_09839.1 huMAP3_12587.1
EXOC1	huMAP3_04054.1 huMAP3_07009.1 huMAP3_09839.1 huMAP3_12587.1
EXOC2	huMAP3_04054.1 huMAP3_07009.1 huMAP3_09839.1 huMAP3_12587.1
EXOC7	huMAP3_04054.1 huMAP3_07009.1 huMAP3_09839.1 huMAP3_12587.1
EXOC8	huMAP3_04054.1 huMAP3_07009.1 huMAP3_09839.1 huMAP3_12587.1
KRT86	huMAP3_04054.1 huMAP3_06887.1 huMAP3_09839.1 huMAP3_12587.1 huMAP3_14032.1
PRR30	huMAP3_01624.1 huMAP3_02199.1 huMAP3_07009.1 huMAP3_07634.1 huMAP3_08254.1 huMAP3_09839.1 huMAP3_12587.1 huMAP3_13679.1
EXOC4	huMAP3_04054.1 huMAP3_06887.1 huMAP3_09839.1 huMAP3_12587.1 huMAP3_14032.1
EXOC5	huMAP3_04054.1 huMAP3_07009.1 huMAP3_09839.1 huMAP3_12587.1
IL1R2	huMAP3_01624.1 huMAP3_02199.1 huMAP3_07009.1 huMAP3_07634.1 huMAP3_08254.1 huMAP3_09839.1 huMAP3_12587.1 huMAP3_13679.1
EXOC3	huMAP3_04054.1 huMAP3_04817.1 huMAP3_07009.1 huMAP3_09487.1 huMAP3_09839.1 huMAP3_12587.1
EXOC6	huMAP3_04054.1 huMAP3_07009.1 huMAP3_09839.1 huMAP3_12587.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_09839.1

Complex Portal: CPX-17569