hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09851.1
Complex Portal: CPX-19593
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| KIF5B | Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC) | 5 | UniProt NCBI |
| KIF5C | Kinesin heavy chain isoform 5C (EC 3.6.4.-) (Kinesin heavy chain neuron-specific 2) (Kinesin-1) | 5 | UniProt NCBI |
| KLC4 | Kinesin light chain 4 (KLC 4) (Kinesin-like protein 8) | 5 | UniProt NCBI |
| SYNE4 | Nesprin-4 (KASH domain-containing protein 4) (KASH4) (Nuclear envelope spectrin repeat protein 4) | 5 | UniProt NCBI |
| KLC3 | Kinesin light chain 3 (KLC2-like) (kinesin light chain 2) | 5 | UniProt NCBI |
| MYCL | Protein L-Myc (Class E basic helix-loop-helix protein 38) (bHLHe38) (Protein L-Myc-1) (V-myc myelocytomatosis viral oncogene homolog) | 5 | UniProt NCBI |
| KIF5A | Kinesin heavy chain isoform 5A (Kinesin heavy chain neuron-specific 1) (Neuronal kinesin heavy chain) (NKHC) | 5 | UniProt NCBI |
| CTU2 | Cytoplasmic tRNA 2-thiolation protein 2 (Cytosolic thiouridylase subunit 2) | 5 | UniProt NCBI |
| KLC2 | Kinesin light chain 2 (KLC 2) | 5 | UniProt NCBI |
| KLC1 | Kinesin light chain 1 (KLC 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5625970 | 6.79535089809e-16 | 0.666666666667 | KLC2 KLC4 KLC3 KIF5B KIF5A KLC1 | RHO GTPases activate KTN1 |
| KEGG:04814 | 3.22512375816e-11 | 0.777777777778 | KIF5C KLC2 KLC4 KLC3 KIF5B KIF5A KLC1 | Motor proteins |
| REAC:R-HSA-983189 | 3.77011408522e-11 | 0.666666666667 | KLC2 KLC4 KLC3 KIF5B KIF5A KLC1 | Kinesins |
| KEGG:05132 | 3.20897930662e-10 | 0.777777777778 | KIF5C KLC2 KLC4 KLC3 KIF5B KIF5A KLC1 | Salmonella infection |
| KEGG:05012 | 4.9246149551e-10 | 0.777777777778 | KIF5C KLC2 KLC4 KLC3 KIF5B KIF5A KLC1 | Parkinson disease |
| KEGG:05020 | 6.04284948651e-10 | 0.777777777778 | KIF5C KLC2 KLC4 KLC3 KIF5B KIF5A KLC1 | Prion disease |
| WP:WP5124 | 7.19812182813e-10 | 0.777777777778 | KIF5C KLC2 KLC4 KLC3 KIF5B KIF5A KLC1 | Alzheimer 39 s disease |
| WP:WP2059 | 7.19812182813e-10 | 0.777777777778 | KIF5C KLC2 KLC4 KLC3 KIF5B KIF5A KLC1 | Alzheimer 39 s disease and miRNA effects |
| REAC:R-HSA-6811434 | 1.10504457702e-09 | 0.666666666667 | KLC2 KLC4 KLC3 KIF5B KIF5A KLC1 | COPI-dependent Golgi-to-ER retrograde traffic |
| KEGG:05016 | 1.23061974589e-09 | 0.777777777778 | KIF5C KLC2 KLC4 KLC3 KIF5B KIF5A KLC1 | Huntington disease |
| KEGG:05014 | 4.32449730251e-09 | 0.777777777778 | KIF5C KLC2 KLC4 KLC3 KIF5B KIF5A KLC1 | Amyotrophic lateral sclerosis |
| REAC:R-HSA-2132295 | 4.51492393218e-09 | 0.666666666667 | KLC2 KLC4 KLC3 KIF5B KIF5A KLC1 | MHC class II antigen presentation |
| KEGG:05010 | 6.06689477461e-09 | 0.777777777778 | KIF5C KLC2 KLC4 KLC3 KIF5B KIF5A KLC1 | Alzheimer disease |
| REAC:R-HSA-8856688 | 7.09851426377e-09 | 0.666666666667 | KLC2 KLC4 KLC3 KIF5B KIF5A KLC1 | Golgi-to-ER retrograde transport |
| KEGG:05022 | 2.41285648302e-08 | 0.777777777778 | KIF5C KLC2 KLC4 KLC3 KIF5B KIF5A KLC1 | Pathways of neurodegeneration - multiple diseases |
| REAC:R-HSA-983231 | 2.70669004563e-08 | 0.666666666667 | KLC2 KLC4 KLC3 KIF5B KIF5A KLC1 | Factors involved in megakaryocyte development and platelet production |
| REAC:R-HSA-6811442 | 9.45177747902e-08 | 0.666666666667 | KLC2 KLC4 KLC3 KIF5B KIF5A KLC1 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| GO:0005871 | 4.90947531423e-07 | 0.555555555556 | KLC2 KIF5B KIF5C KLC1 KIF5A | kinesin complex |
| GO:0007018 | 1.21708292868e-06 | 0.777777777778 | KIF5C KLC2 KLC4 KLC3 KIF5B KIF5A KLC1 | microtubule-based movement |
| REAC:R-HSA-195258 | 1.24128571501e-06 | 0.666666666667 | KLC2 KLC4 KLC3 KIF5B KIF5A KLC1 | RHO GTPase Effectors |
| GO:0098971 | 3.22863876272e-05 | 0.333333333333 | KIF5B KIF5C KIF5A | anterograde dendritic transport of neurotransmitter receptor complex |
| REAC:R-HSA-109582 | 3.79190436273e-05 | 0.666666666667 | KLC2 KLC4 KLC3 KIF5B KIF5A KLC1 | Hemostasis |
| REAC:R-HSA-264876 | 5.0612044968e-05 | 0.333333333333 | KIF5B KIF5C KIF5A | Insulin processing |
| REAC:R-HSA-199991 | 6.36928786981e-05 | 0.666666666667 | KLC2 KLC4 KLC3 KIF5B KIF5A KLC1 | Membrane Trafficking |
| GO:0019894 | 7.82064017367e-05 | 0.444444444444 | KLC1 KLC3 KLC4 KLC2 | kinesin binding |
| REAC:R-HSA-5653656 | 8.78559968403e-05 | 0.666666666667 | KLC2 KLC4 KLC3 KIF5B KIF5A KLC1 | Vesicle-mediated transport |
| REAC:R-HSA-194315 | 0.000111617729477 | 0.666666666667 | KLC2 KLC4 KLC3 KIF5B KIF5A KLC1 | Signaling by Rho GTPases |
| REAC:R-HSA-9716542 | 0.00012709299758 | 0.666666666667 | KLC2 KLC4 KLC3 KIF5B KIF5A KLC1 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 |
| REAC:R-HSA-1280218 | 0.000152242058159 | 0.666666666667 | KLC2 KLC4 KLC3 KIF5B KIF5A KLC1 | Adaptive Immune System |
| GO:0098937 | 0.000161332517231 | 0.333333333333 | KIF5B KIF5C KIF5A | anterograde dendritic transport |
| GO:0098935 | 0.000161332517231 | 0.333333333333 | KIF5B KIF5C KIF5A | dendritic transport |
| GO:0005875 | 0.000238612317182 | 0.555555555556 | KLC2 KIF5B KIF5C KLC1 KIF5A | microtubule associated complex |
| KEGG:05223 | 0.000401022621003 | 0.333333333333 | KIF5B KIF5C KIF5A | Non-small cell lung cancer |
| GO:0099641 | 0.00045145282213 | 0.333333333333 | KIF5B KIF5C KIF5A | anterograde axonal protein transport |
| GO:0099640 | 0.00045145282213 | 0.333333333333 | KIF5B KIF5C KIF5A | axo-dendritic protein transport |
| GO:0007017 | 0.000875288134912 | 0.777777777778 | KIF5C KLC2 KLC4 KLC3 KIF5B KIF5A KLC1 | microtubule-based process |
| GO:1905383 | 0.000966803032193 | 0.333333333333 | KIF5B KIF5C KIF5A | protein localization to presynapse |
| GO:0099118 | 0.000966803032193 | 0.333333333333 | KIF5B KIF5C KIF5A | microtubule-based protein transport |
| GO:0098840 | 0.000966803032193 | 0.333333333333 | KIF5B KIF5C KIF5A | protein transport along microtubule |
| GO:0008092 | 0.00102535245841 | 0.777777777778 | KIF5C KLC2 KLC4 KLC3 KIF5B KIF5A KLC1 | cytoskeletal protein binding |
| KEGG:04728 | 0.0016587265878 | 0.333333333333 | KIF5B KIF5C KIF5A | Dopaminergic synapse |
| REAC:R-HSA-2980736 | 0.00171735643047 | 0.333333333333 | KIF5B KIF5C KIF5A | Peptide hormone metabolism |
| GO:0008574 | 0.00292902387419 | 0.333333333333 | KIF5B KIF5C KIF5A | plus-end-directed microtubule motor activity |
| GO:0003774 | 0.00790837187115 | 0.444444444444 | KLC1 KIF5B KIF5C KIF5A | cytoskeletal motor activity |
| KEGG:04144 | 0.0154277835769 | 0.333333333333 | KIF5B KIF5C KIF5A | Endocytosis |
| WP:WP4535 | 0.0213754193269 | 0.222222222222 | KIF5B SYNE4 | Envelope proteins and their potential roles in EDMD physiopathology |
| REAC:R-HSA-168256 | 0.0342353908338 | 0.666666666667 | KLC2 KLC4 KLC3 KIF5B KIF5A KLC1 | Immune System |
| GO:0048489 | 0.0396911574974 | 0.333333333333 | KIF5B KIF5C KIF5A | synaptic vesicle transport |
| GO:0097120 | 0.0396911574974 | 0.333333333333 | KIF5B KIF5C KIF5A | receptor localization to synapse |
| GO:0035418 | 0.0478559415828 | 0.333333333333 | KIF5B KIF5C KIF5A | protein localization to synapse |
| CORUM:5401 | 0.0499842271994 | 0.111111111111 | KIF5B | PLEKHM2-KIF5B complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| KLC4 | KLC3 | 1.0 | 0.206 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 boldt_WMM | |
| KIF5A | KLC1 | 1.0 | 0.136 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| KLC4 | KLC1 | 1.0 | 0.274 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM | |
| KIF5B | KLC1 | 1.0 | 0.584 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| KIF5C | KLC1 | 1.0 | 0.102 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| KLC3 | KIF5A | 1.0 | 0.094 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 boldt_WMM WMM_only | |
| KIF5B | KLC3 | 1.0 | 0.18 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 boldt_WMM | |
| KLC3 | KLC2 | 1.0 | 0.138 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 boldt_WMM |
| KIF5B | KLC2 | 1.0 | 0.478 | hein_WMM bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () gupta_WMM fraction boldt_WMM treiber_WMM | |
| KLC2 | KLC1 | 1.0 | 0.682 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM | |
| MYCL | KLC4 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | ||
| MYCL | KLC3 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | ||
| KIF5C | KLC3 | 0.999 | 0.154 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 boldt_WMM WMM_only |
| KIF5C | SYNE4 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| KLC4 | KLC2 | 0.999 | 0.154 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM hein () gupta_WMM boldt_WMM treiber_WMM | |
| KLC3 | KLC1 | 0.999 | 0.1 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 boldt_WMM | |
| SYNE4 | KLC1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| SYNE4 | KLC3 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| KIF5C | KLC4 | 0.999 | 0.126 | bioplex_WMM Guru bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM | |
| KIF5B | KLC4 | 0.998 | 0.22 | hein_WMM bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () gupta_WMM fraction boldt_WMM treiber_WMM | |
| KLC4 | SYNE4 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| KIF5C | KLC2 | 0.998 | 0.154 |
mutually_exclusive (Q6P597)
|
bioplex_WMM Guru bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| KIF5B | SYNE4 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| SYNE4 | KLC2 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| KLC4 | KIF5A | 0.997 | 0.322 | bioplex_WMM Guru bioplex3_WMM boldt gupta_WMM fraction boldt_WMM | |
| MYCL | KIF5C | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| SYNE4 | KIF5A | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| MYCL | KIF5B | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | ||
| MYCL | KLC2 | 0.992 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | ||
| KIF5C | KIF5A | 0.99 | 0.186 | bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only | |
| KIF5B | KIF5A | 0.985 | 0.2028 | bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only | |
| KIF5A | KLC2 | 0.983 | 0.14 | bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only | |
| CTU2 | MYCL | 0.98 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| MYCL | KLC1 | 0.974 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | ||
| KIF5B | KIF5C | 0.97 | 0.374 | bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only | |
| MYCL | KIF5A | 0.951 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| CTU2 | KLC3 | 0.082 | 0.056 | bioplex_WMM bioplex3_WMM WMM_only | |
| CTU2 | KLC4 | 0.05 | 0.038 | bioplex_WMM bioplex3_WMM WMM_only | |
| CTU2 | KLC2 | 0.044 | 0.048 | bioplex_WMM bioplex3_WMM WMM_only | |
| CTU2 | KIF5C | 0.018 | 0.092 | bioplex_WMM bioplex3_WMM WMM_only | |
| CTU2 | KIF5A | 0.012 | 0.07 | bioplex_WMM bioplex3_WMM WMM_only | |
| CTU2 | KIF5B | 0.005 | 0.058 | bioplex_WMM bioplex3_WMM WMM_only | |
| CTU2 | KLC1 | 0.004 | 0.048 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes