hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09856.1
Complex Portal: CPX-11878
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ATG2B | Autophagy-related protein 2 homolog B | 5 | UniProt NCBI |
| WDR45 | WD repeat domain phosphoinositide-interacting protein 4 (WIPI-4) (WD repeat-containing protein 45) | 5 | UniProt NCBI |
| CARD8 | Caspase recruitment domain-containing protein 8 (EC 3.4.-.-) (CARD-inhibitor of NF-kappa-B-activating ligand) (CARDINAL) (Tumor up-regulated CARD-containing antagonist of CASP9) (TUCAN) [Cleaved into: Caspase recruitment domain-containing protein 8, C-terminus (CARD8-CT); Caspase recruitment domain-containing protein 8, N-terminus (CARD8-NT)] | 5 | UniProt NCBI |
| LHX6 | LIM/homeobox protein Lhx6 (LIM homeobox protein 6) (LIM/homeobox protein Lhx6.1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04140 | 0.0298999303213 | 0.5 | ATG2B WDR45 | Autophagy - animal |
| CORUM:6323 | 0.049938562206 | 0.25 | CARD8 | NLRP3 inflammasome |
| CORUM:6324 | 0.049938562206 | 0.25 | CARD8 | NLRP2 inflammasome |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| LHX6 | ATG2B | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| WDR45 | ATG2B | 0.994 | 0.15 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM |
| CARD8 | LHX6 | 0.989 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| WDR45 | LHX6 | 0.98 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| WDR45 | CARD8 | 0.188 | 0.088 | bioplex_WMM bioplex3_WMM WMM_only | |
| CARD8 | ATG2B | 0.188 | 0.096 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes