hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09858.1
Complex Portal: CPX-19042
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| XPC | DNA repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125) | 5 | UniProt NCBI |
| MACROH2A1 | Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (Histone H2A.y) (H2A/y) (Medulloblastoma antigen MU-MB-50.205) | 5 | UniProt NCBI |
| HLTF | Helicase-like transcription factor (EC 2.3.2.27) (EC 3.6.4.-) (DNA-binding protein/plasminogen activator inhibitor 1 regulator) (HIP116) (RING finger protein 80) (RING-type E3 ubiquitin transferase HLTF) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3) (Sucrose nonfermenting protein 2-like 3) | 5 | UniProt NCBI |
| PARP2 | Poly [ADP-ribose] polymerase 2 (PARP-2) (hPARP-2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 2) (ARTD2) (DNA ADP-ribosyltransferase PARP2) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 2) (ADPRT-2) (Poly[ADP-ribose] synthase 2) (pADPRT-2) (Protein poly-ADP-ribosyltransferase PARP2) (EC 2.4.2.-) | 5 | UniProt NCBI |
| RNF146 | E3 ubiquitin-protein ligase RNF146 (EC 2.3.2.27) (Dactylidin) (Iduna) (RING finger protein 146) (RING-type E3 ubiquitin transferase RNF146) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5696394 | 0.0106339701454 | 0.4 | XPC PARP2 | DNA Damage Recognition in GG-NER |
| REAC:R-HSA-5696395 | 0.0130168285242 | 0.4 | XPC PARP2 | Formation of Incision Complex in GG-NER |
| GO:0160004 | 0.0280843539964 | 0.4 | MACROH2A1 PARP2 | poly-ADP-D-ribose modification-dependent protein binding |
| WP:WP4946 | 0.0366585107731 | 0.4 | XPC PARP2 | DNA repair pathways full network |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| RNF146 | PARP2 | 0.999 | 0.088 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| XPC | PARP2 | 0.993 | 0.032 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| XPC | MACROH2A1 | 0.993 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM | ||
| XPC | RNF146 | 0.984 | 0.182 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| HLTF | XPC | 0.984 | 0.032 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| HLTF | RNF146 | 0.903 | 0.094 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| HLTF | PARP2 | 0.654 | 0.086 | bioplex_WMM bioplex3_WMM WMM_only | |
| MACROH2A1 | PARP2 | 0.622 | bioplex_WMM bioplex3_WMM WMM_only | ||
| HLTF | MACROH2A1 | 0.479 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only treiber_WMM | ||
| RNF146 | MACROH2A1 | 0.084 | bioplex3_HEK293 bioplex () bioplex_WMM |
Related Complexes