hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_09863.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EIF4A1 | Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1) | 5 | UniProt NCBI |
| IBTK | Inhibitor of Bruton tyrosine kinase (IBtk) | 5 | UniProt NCBI |
| EIF4A2 | Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2) | 5 | UniProt NCBI |
| EIF4G3 | Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) | 5 | UniProt NCBI |
| IBA57 | Putative transferase CAF17, mitochondrial (EC 2.1.-.-) (Iron-sulfur cluster assembly factor homolog) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4566 | 1.28221943013e-05 | 0.6 | EIF4G3 EIF4A1 EIF4A2 | Translation inhibitors in chronically activated PDGFRA cells |
| WP:WP107 | 2.21427564884e-05 | 0.6 | EIF4G3 EIF4A1 EIF4A2 | Translation factors |
| REAC:R-HSA-1169408 | 0.000141884912451 | 0.6 | EIF4G3 EIF4A1 EIF4A2 | ISG15 antiviral mechanism |
| REAC:R-HSA-1169410 | 0.00018480745401 | 0.6 | EIF4G3 EIF4A1 EIF4A2 | Antiviral mechanism by IFN-stimulated genes |
| GO:0016281 | 0.000274621184043 | 0.6 | EIF4G3 EIF4A1 EIF4A2 | eukaryotic translation initiation factor 4F complex |
| GO:0034518 | 0.000537554131189 | 0.6 | EIF4G3 EIF4A1 EIF4A2 | RNA cap binding complex |
| REAC:R-HSA-913531 | 0.00269181495124 | 0.6 | EIF4G3 EIF4A1 EIF4A2 | Interferon Signaling |
| REAC:R-HSA-429947 | 0.00418294558639 | 0.4 | EIF4A1 EIF4A2 | Deadenylation of mRNA |
| GO:0003743 | 0.0126766174236 | 0.6 | EIF4G3 EIF4A1 EIF4A2 | translation initiation factor activity |
| REAC:R-HSA-429914 | 0.0224106525753 | 0.4 | EIF4A1 EIF4A2 | Deadenylation-dependent mRNA decay |
| REAC:R-HSA-72702 | 0.0258071378099 | 0.4 | EIF4A1 EIF4A2 | Ribosomal scanning and start codon recognition |
| REAC:R-HSA-72649 | 0.0258071378099 | 0.4 | EIF4A1 EIF4A2 | Translation initiation complex formation |
| REAC:R-HSA-72662 | 0.0266933781073 | 0.4 | EIF4A1 EIF4A2 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| EIF4A1 | EIF4A2 | 0.997 | 0.392 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction treiber_WMM |
| IBTK | EIF4A1 | 0.995 | 0.227272727273 | hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 fraction |
| EIF4A1 | EIF4G3 | 0.986 | 0.152 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| EIF4A1 | IBA57 | 0.974 | 0.038 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| IBTK | EIF4A2 | 0.792 | 0.046 | youn () bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| EIF4A2 | EIF4G3 | 0.773 | 0.068 | youn () bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| IBTK | EIF4G3 | 0.172 | 0.104 | youn () bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| IBTK | IBA57 | 0.146 | 0.10648 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| EIF4G3 | IBA57 | 0.119 | 0.024 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| EIF4A2 | IBA57 | 0.105 | 0.04 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes