hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09866.1
Complex Portal: CPX-11640
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MAFK | Transcription factor MafK (Erythroid transcription factor NF-E2 p18 subunit) | 5 | UniProt NCBI |
| MAFF | Transcription factor MafF (U-Maf) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog F) | 5 | UniProt NCBI |
| NFE2L3 | Nuclear factor erythroid 2-related factor 3 (NF-E2-related factor 3) (NFE2-related factor 3) (Nuclear factor, erythroid derived 2, like 3) | 5 | UniProt NCBI |
| BACH1 | Transcription regulator protein BACH1 (BTB and CNC homolog 1) (HA2303) | 5 | UniProt NCBI |
| NFE2L1 | Endoplasmic reticulum membrane sensor NFE2L1 (Locus control region-factor 1) (LCR-F1) (Nuclear factor erythroid 2-related factor 1) (NF-E2-related factor 1) (NFE2-related factor 1) (Nuclear factor, erythroid derived 2, like 1) (Protein NRF1, p120 form) (Transcription factor 11) (TCF-11) [Cleaved into: Transcription factor NRF1 (Protein NRF1, p110 form)] | 5 | UniProt NCBI |
| MAFG | Transcription factor MafG (V-maf musculoaponeurotic fibrosarcoma oncogene homolog G) (hMAF) | 5 | UniProt NCBI |
| MAFB | Transcription factor MafB (Maf-B) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog B) | 5 | UniProt NCBI |
| BACH2 | Transcription regulator protein BACH2 (BTB and CNC homolog 2) | 5 | UniProt NCBI |
| NFE2L2 | Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nrf-2) (HEBP1) (Nuclear factor, erythroid derived 2, like 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4269 | 4.23035314849e-10 | 0.444444444444 | MAFF MAFK NFE2L2 MAFG | Ethanol metabolism production of ROS by CYP2E1 |
| GO:0090575 | 5.81288913686e-10 | 0.888888888889 | MAFG MAFF BACH1 NFE2L3 MAFK BACH2 MAFB NFE2L2 | RNA polymerase II transcription regulator complex |
| GO:0005667 | 5.40657137812e-08 | 0.888888888889 | MAFG MAFF BACH1 NFE2L3 MAFK BACH2 MAFB NFE2L2 | transcription regulator complex |
| GO:0000978 | 1.39363925919e-07 | 1.0 | MAFG MAFF BACH1 NFE2L3 MAFB MAFK BACH2 NFE2L1 NFE2L2 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0000987 | 1.68106479583e-07 | 1.0 | MAFG MAFF BACH1 NFE2L3 MAFB MAFK BACH2 NFE2L1 NFE2L2 | cis-regulatory region sequence-specific DNA binding |
| REAC:R-HSA-9707587 | 3.82422324355e-07 | 0.333333333333 | BACH1 MAFK NFE2L2 | Regulation of HMOX1 expression and activity |
| GO:0000981 | 4.70442618489e-07 | 1.0 | MAFG MAFF BACH1 NFE2L3 MAFB MAFK BACH2 NFE2L1 NFE2L2 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0000977 | 6.07074025104e-07 | 1.0 | MAFG MAFF BACH1 NFE2L3 MAFB MAFK BACH2 NFE2L1 NFE2L2 | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| GO:0003700 | 8.2477271302e-07 | 1.0 | MAFG MAFF BACH1 NFE2L3 MAFB MAFK BACH2 NFE2L1 NFE2L2 | DNA-binding transcription factor activity |
| GO:0000976 | 1.3118326453e-06 | 1.0 | MAFG MAFF BACH1 NFE2L3 MAFB MAFK BACH2 NFE2L1 NFE2L2 | transcription cis-regulatory region binding |
| GO:0001067 | 1.32399175324e-06 | 1.0 | MAFG MAFF BACH1 NFE2L3 MAFB MAFK BACH2 NFE2L1 NFE2L2 | transcription regulatory region nucleic acid binding |
| GO:1990837 | 2.00399293797e-06 | 1.0 | MAFG MAFF BACH1 NFE2L3 MAFB MAFK BACH2 NFE2L1 NFE2L2 | sequence-specific double-stranded DNA binding |
| GO:0043565 | 3.82173749015e-06 | 1.0 | MAFG MAFF BACH1 NFE2L3 MAFB MAFK BACH2 NFE2L1 NFE2L2 | sequence-specific DNA binding |
| GO:0003690 | 3.91674881939e-06 | 1.0 | MAFG MAFF BACH1 NFE2L3 MAFB MAFK BACH2 NFE2L1 NFE2L2 | double-stranded DNA binding |
| WP:WP2435 | 5.34493407698e-06 | 0.333333333333 | MAFG MAFK NFE2L2 | Quercetin and Nf kB AP 1 induced apoptosis |
| REAC:R-HSA-9818027 | 2.1343196228e-05 | 0.333333333333 | BACH1 MAFK NFE2L2 | NFE2L2 regulating anti-oxidant/detoxification enzymes |
| REAC:R-HSA-9759194 | 2.19627733949e-05 | 0.444444444444 | BACH1 MAFK NFE2L2 MAFG | Nuclear events mediated by NFE2L2 |
| GO:0140110 | 2.26437494982e-05 | 1.0 | MAFG MAFF BACH1 NFE2L3 MAFB MAFK BACH2 NFE2L1 NFE2L2 | transcription regulator activity |
| GO:0003677 | 6.22072478432e-05 | 1.0 | MAFG MAFF BACH1 NFE2L3 MAFB MAFK BACH2 NFE2L1 NFE2L2 | DNA binding |
| REAC:R-HSA-9755511 | 7.02935009975e-05 | 0.444444444444 | BACH1 MAFK NFE2L2 MAFG | KEAP1-NFE2L2 pathway |
| GO:0000785 | 0.000157828922983 | 0.888888888889 | MAFF BACH1 NFE2L3 NFE2L1 MAFK BACH2 MAFB NFE2L2 | chromatin |
| GO:0006357 | 0.000211457594888 | 1.0 | MAFG MAFF BACH1 NFE2L3 MAFB MAFK BACH2 NFE2L1 NFE2L2 | regulation of transcription by RNA polymerase II |
| GO:0032993 | 0.000252339772546 | 0.888888888889 | MAFF BACH1 NFE2L3 NFE2L1 MAFK BACH2 MAFB NFE2L2 | protein-DNA complex |
| GO:0006366 | 0.000341817047822 | 1.0 | MAFG MAFF BACH1 NFE2L3 MAFB MAFK BACH2 NFE2L1 NFE2L2 | transcription by RNA polymerase II |
| REAC:R-HSA-9707616 | 0.000434042545956 | 0.333333333333 | BACH1 MAFK NFE2L2 | Heme signaling |
| GO:0140513 | 0.000441206708996 | 0.888888888889 | MAFG MAFF BACH1 NFE2L3 MAFK BACH2 MAFB NFE2L2 | nuclear protein-containing complex |
| REAC:R-HSA-9711123 | 0.000676305290122 | 0.444444444444 | BACH1 MAFK NFE2L2 MAFG | Cellular response to chemical stress |
| REAC:R-HSA-9707564 | 0.00122268984218 | 0.333333333333 | BACH1 MAFK NFE2L2 | Cytoprotection by HMOX1 |
| REAC:R-HSA-9818028 | 0.00223242997382 | 0.222222222222 | MAFG NFE2L2 | NFE2L2 regulates pentose phosphate pathway genes |
| GO:0005694 | 0.00281936555467 | 0.888888888889 | MAFF BACH1 NFE2L3 NFE2L1 MAFK BACH2 MAFB NFE2L2 | chromosome |
| GO:0006355 | 0.00303795876717 | 1.0 | MAFG MAFF BACH1 NFE2L3 MAFB MAFK BACH2 NFE2L1 NFE2L2 | regulation of DNA-templated transcription |
| GO:2001141 | 0.00320804197401 | 1.0 | MAFG MAFF BACH1 NFE2L3 MAFB MAFK BACH2 NFE2L1 NFE2L2 | regulation of RNA biosynthetic process |
| WP:WP2884 | 0.00324703837728 | 0.333333333333 | MAFF NFE2L2 MAFG | NRF2 pathway |
| REAC:R-HSA-9708530 | 0.00438093013445 | 0.222222222222 | BACH1 MAFK | Regulation of BACH1 activity |
| GO:0006351 | 0.00465537895398 | 1.0 | MAFG MAFF BACH1 NFE2L3 MAFB MAFK BACH2 NFE2L1 NFE2L2 | DNA-templated transcription |
| GO:0032774 | 0.00512577137556 | 1.0 | MAFG MAFF BACH1 NFE2L3 MAFB MAFK BACH2 NFE2L1 NFE2L2 | RNA biosynthetic process |
| GO:0051252 | 0.00831592797017 | 1.0 | MAFG MAFF BACH1 NFE2L3 MAFB MAFK BACH2 NFE2L1 NFE2L2 | regulation of RNA metabolic process |
| GO:0003676 | 0.0151133869702 | 1.0 | MAFG MAFF BACH1 NFE2L3 MAFB MAFK BACH2 NFE2L1 NFE2L2 | nucleic acid binding |
| GO:0034654 | 0.0158700258372 | 1.0 | MAFG MAFF BACH1 NFE2L3 MAFB MAFK BACH2 NFE2L1 NFE2L2 | nucleobase-containing compound biosynthetic process |
| GO:0018130 | 0.0187008801665 | 1.0 | MAFG MAFF BACH1 NFE2L3 MAFB MAFK BACH2 NFE2L1 NFE2L2 | heterocycle biosynthetic process |
| GO:0019438 | 0.0188805671311 | 1.0 | MAFG MAFF BACH1 NFE2L3 MAFB MAFK BACH2 NFE2L1 NFE2L2 | aromatic compound biosynthetic process |
| GO:0019219 | 0.0189408029 | 1.0 | MAFG MAFF BACH1 NFE2L3 MAFB MAFK BACH2 NFE2L1 NFE2L2 | regulation of nucleobase-containing compound metabolic process |
| GO:0000122 | 0.0206219094099 | 0.666666666667 | MAFG MAFF BACH2 MAFK BACH1 MAFB | negative regulation of transcription by RNA polymerase II |
| REAC:R-HSA-983231 | 0.0230866683473 | 0.333333333333 | MAFF MAFK MAFG | Factors involved in megakaryocyte development and platelet production |
| GO:1901362 | 0.0245018387601 | 1.0 | MAFG MAFF BACH1 NFE2L3 MAFB MAFK BACH2 NFE2L1 NFE2L2 | organic cyclic compound biosynthetic process |
| WP:WP2882 | 0.0355353014643 | 0.333333333333 | MAFF NFE2L2 MAFG | Nuclear receptors meta pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| BACH1 | MAFK | 1.0 | 0.114 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| MAFF | NFE2L2 | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| BACH1 | MAFG | 0.999 | 0.062 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| MAFF | BACH2 | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| BACH1 | MAFF | 0.999 | 0.068 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| NFE2L3 | MAFF | 0.998 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MAFF | NFE2L1 | 0.998 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| NFE2L3 | MAFK | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| MAFB | BACH1 | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| NFE2L3 | MAFG | 0.991 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| BACH1 | BACH2 | 0.988 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| MAFK | MAFF | 0.985 | 0.206 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| MAFK | MAFG | 0.974 | 0.248 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| MAFK | BACH2 | 0.972 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| MAFF | MAFG | 0.956 | 0.208 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| MAFK | NFE2L2 | 0.955 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| NFE2L3 | NFE2L2 | 0.947 | bioplex_WMM bioplex3_WMM WMM_only | ||
| NFE2L1 | NFE2L2 | 0.939 | bioplex_WMM bioplex3_WMM WMM_only | ||
| MAFG | BACH2 | 0.913 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| BACH2 | NFE2L2 | 0.908 | bioplex_WMM bioplex3_WMM WMM_only | ||
| NFE2L3 | NFE2L1 | 0.908 | bioplex_WMM bioplex3_WMM WMM_only | ||
| NFE2L1 | BACH2 | 0.904 | bioplex_WMM bioplex3_WMM WMM_only | ||
| BACH1 | NFE2L2 | 0.888 | bioplex_WMM bioplex3_WMM WMM_only | ||
| NFE2L3 | BACH1 | 0.885 | bioplex_WMM bioplex3_WMM WMM_only | ||
| NFE2L3 | BACH2 | 0.884 | bioplex_WMM bioplex3_WMM WMM_only | ||
| BACH1 | NFE2L1 | 0.884 | bioplex_WMM bioplex3_WMM WMM_only | ||
| MAFK | NFE2L1 | 0.772 |
mutually_exclusive (Q9ULX9)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| MAFB | BACH2 | 0.463 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| MAFB | MAFK | 0.35 | bioplex_WMM bioplex3_WMM WMM_only | ||
| MAFB | MAFG | 0.303 | bioplex_WMM bioplex3_WMM WMM_only | ||
| MAFB | MAFF | 0.303 | bioplex_WMM bioplex3_WMM WMM_only | ||
| MAFG | NFE2L2 | 0.21 | bioplex3_WMM WMM_only | ||
| NFE2L1 | MAFG | 0.076 | bioplex3_WMM WMM_only |
Related Complexes