hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_09871.1

Complex Portal: CPX-20290

Confidence: Moderate High

Genename	Protein Name	Uniprot Annotation Score	Links
CLEC4G	C-type lectin domain family 4 member G (Liver and lymph node sinusoidal endothelial cell C-type lectin) (LSECtin)	5	UniProt NCBI
AP4S1	AP-4 complex subunit sigma-1 (AP-4 adaptor complex subunit sigma-1) (Adaptor-related protein complex 4 subunit sigma-1) (Sigma-1 subunit of AP-4) (Sigma-4-adaptin) (Sigma4-adaptin)	5	UniProt NCBI
TEPSIN	AP-4 complex accessory subunit Tepsin (ENTH domain-containing protein 2) (Epsin for AP-4) (Tetra-epsin)	5	UniProt NCBI
AP4M1	AP-4 complex subunit mu-1 (AP-4 adaptor complex mu subunit) (Adaptor-related protein complex 4 subunit mu-1) (Mu subunit of AP-4) (Mu-adaptin-related protein 2) (mu-ARP2) (Mu4-adaptin) (mu4)	5	UniProt NCBI
DISC1	Disrupted in schizophrenia 1 protein	5	UniProt NCBI
AP4E1	AP-4 complex subunit epsilon-1 (AP-4 adaptor complex subunit epsilon) (Adaptor-related protein complex 4 subunit epsilon-1) (Epsilon subunit of AP-4) (Epsilon-adaptin)	5	UniProt NCBI
AP4B1	AP-4 complex subunit beta-1 (AP-4 adaptor complex subunit beta) (Adaptor-related protein complex 4 subunit beta-1) (Beta subunit of AP-4) (Beta4-adaptin)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:67	1.92263483365e-12	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	AP4 adaptor complex
GO:0030124	9.2094208532e-10	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	AP-4 adaptor complex
HP:5200020	3.27469978519e-09	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Abnormal interest in others
HP:0100962	3.27469978519e-09	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Shyness
HP:0008807	7.54279269726e-08	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Acetabular dysplasia
HP:0002464	9.31603571786e-08	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Spastic dysarthria
HP:0010803	1.13843939746e-07	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Everted upper lip vermilion
REAC:R-HSA-432720	1.4537101986e-07	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Lysosome Vesicle Biogenesis
HP:0007020	3.18339843159e-07	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Progressive spastic paraplegia
HP:0002816	6.3569022244e-07	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Genu recurvatum
HP:0002761	1.02533089038e-06	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Generalized joint hypermobility
HP:0025502	1.02533089038e-06	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Overweight
HP:0010500	1.14576950689e-06	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Hyperextensibility of the knee
HP:0000297	1.9140162808e-06	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Facial hypotonia
REAC:R-HSA-199992	3.23754553505e-06	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	trans-Golgi Network Vesicle Budding
KEGG:04142	8.55799606515e-06	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Lysosome
GO:0032588	8.70757470934e-06	0.714285714286	AP4S1 AP4B1 AP4M1 AP4E1 TEPSIN	trans-Golgi network membrane
GO:0031904	1.37183898061e-05	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	endosome lumen
HP:0003170	1.97903117197e-05	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Abnormal acetabulum morphology
HP:0034670	2.08712710555e-05	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Abnormal knee physiology
GO:0030119	4.7975405982e-05	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	AP-type membrane coat adaptor complex
HP:0002307	5.32614804607e-05	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Drooling
HP:0000646	5.78468462937e-05	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Amblyopia
HP:0001258	6.52705278452e-05	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Spastic paraplegia
HP:0003781	7.33846660766e-05	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Excessive salivation
HP:0002515	7.91979887457e-05	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Waddling gait
HP:0002518	0.000163150863658	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Abnormal periventricular white matter morphology
HP:0010550	0.000163150863658	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Paraplegia
HP:0012433	0.000240770135857	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Abnormal social behavior
HP:0000341	0.00032558864022	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Narrow forehead
HP:0012472	0.000352162394999	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Eclabion
HP:0100755	0.000522210892215	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Abnormality of salivation
HP:0002465	0.000534555922747	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Poor speech
HP:0000414	0.000534555922747	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Bulbous nose
GO:0005802	0.000706434838609	0.714285714286	AP4S1 AP4B1 AP4M1 AP4E1 TEPSIN	trans-Golgi network
HP:0010551	0.00083031577872	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Paraplegia/paraparesis
HP:0000154	0.000865451784044	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Wide mouth
HP:0002061	0.00101719310257	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Lower limb spasticity
HP:0000280	0.00114339230548	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Coarse facial features
HP:0002352	0.00121069743747	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Leukoencephalopathy
GO:0098791	0.00158704183469	0.714285714286	AP4S1 AP4B1 AP4M1 AP4E1 TEPSIN	Golgi apparatus subcompartment
HP:0000322	0.0016494906913	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Short philtrum
GO:0048475	0.00202210317171	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	coated membrane
GO:0030117	0.00202210317171	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	membrane coat
HP:0000733	0.00205761005813	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Abnormal repetitive mannerisms
HP:0031432	0.00205761005813	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Restricted or repetitive behaviors or interests
HP:0031828	0.00261704338105	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Abnormal superficial reflex
HP:0003487	0.00261704338105	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Babinski sign
HP:0002355	0.00278364235165	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Difficulty walking
HP:0007370	0.00351193913333	0.714285714286	AP4S1 AP4B1 AP4M1 AP4E1 DISC1	Aplasia/Hypoplasia of the corpus callosum
HP:0031815	0.00368511957341	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Abnormal oral physiology
HP:0000301	0.00368511957341	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Abnormality of facial musculature
HP:0002538	0.00388394682689	0.714285714286	AP4S1 AP4B1 AP4M1 AP4E1 DISC1	Abnormal cerebral cortex morphology
HP:0002120	0.00524994434086	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Cerebral cortical atrophy
HP:0001763	0.00545788958387	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Pes planus
HP:0033725	0.00588607227615	0.714285714286	AP4S1 AP4B1 AP4M1 AP4E1 DISC1	Thin corpus callosum
HP:0010864	0.00635143461582	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Intellectual disability, severe
HP:0001384	0.00675412452899	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Abnormal hip joint morphology
HP:0000436	0.00726204381131	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Abnormal nasal tip morphology
HP:0034353	0.00855715073648	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Appendicular spasticity
HP:0001273	0.00857848314082	0.714285714286	AP4S1 AP4B1 AP4M1 AP4E1 DISC1	Abnormal corpus callosum morphology
HP:0002815	0.00895676768606	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Abnormality of the knee
HP:0001762	0.00905879972047	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Talipes equinovarus
HP:0011337	0.0112864591849	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Abnormality of mouth size
HP:0001317	0.0129343410886	0.714285714286	AP4S1 AP4B1 AP4M1 AP4E1 DISC1	Abnormal cerebellum morphology
HP:0007256	0.0129372325986	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Abnormal pyramidal sign
HP:0011282	0.0132236264343	0.714285714286	AP4S1 AP4B1 AP4M1 AP4E1 DISC1	Abnormal hindbrain morphology
HP:0011283	0.0132236264343	0.714285714286	AP4S1 AP4B1 AP4M1 AP4E1 DISC1	Abnormal metencephalon morphology
HP:0001272	0.0136175114425	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Cerebellar atrophy
REAC:R-HSA-199991	0.0144304646027	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Membrane Trafficking
HP:0011339	0.014908406472	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Abnormality of upper lip vermillion
HP:0004324	0.0159734802208	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Increased body weight
HP:0001883	0.0162878804703	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Talipes
HP:0005656	0.016930414323	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Positional foot deformity
HP:0002079	0.0174244995856	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Hypoplasia of the corpus callosum
REAC:R-HSA-5653656	0.0178473234243	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Vesicle-mediated transport
HP:0002500	0.0196649485966	0.714285714286	AP4S1 AP4B1 AP4M1 AP4E1 DISC1	Abnormal cerebral white matter morphology
HP:0004302	0.0196899667773	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Functional motor deficit
HP:0011799	0.0213813331773	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Abnormality of facial soft tissue
HP:0010549	0.0221665967647	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Weakness due to upper motor neuron dysfunction
HP:0001332	0.0255228404391	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Dystonia
HP:0100021	0.0281302035428	0.428571428571	AP4S1 AP4M1 AP4E1	Cerebral palsy
HP:0010993	0.0284983301401	0.714285714286	AP4S1 AP4B1 AP4M1 AP4E1 DISC1	Abnormal cerebral subcortex morphology
HP:0001382	0.030987905771	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Joint hypermobility
HP:0003272	0.0317596619846	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Abnormal hip bone morphology
HP:0007663	0.0341603212271	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Reduced visual acuity
HP:0001319	0.0405415169637	0.428571428571	AP4E1 AP4M1 AP4B1	Neonatal hypotonia
HP:0001260	0.0434648219475	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Dysarthria
HP:0002644	0.0492980006882	0.571428571429	AP4S1 AP4B1 AP4M1 AP4E1	Abnormal pelvic girdle bone morphology
CORUM:7235	0.0499958217778	0.142857142857	DISC1	DISC1-DRD2 complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
AP4E1	TEPSIN	1.0	0.138		hein_WMM bioplex3_HEK293 bioplex3_WMM hein () bioplex3_HCT116
AP4S1	AP4B1	1.0	0.172	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM
AP4E1	AP4B1	1.0	0.284	mutually_exclusive (Q9Y587)	hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM
AP4M1	AP4E1	1.0	0.17	mutually_exclusive (Q9Y587)	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM
AP4M1	TEPSIN	1.0	0.078		hein_WMM bioplex3_HEK293 bioplex3_WMM hein () bioplex3_HCT116
AP4M1	AP4B1	0.999	0.18	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only
AP4S1	AP4M1	0.999	0.112	mutually_exclusive (Q9Y6B7) structurally_consistent (dimer)	hein_WMM bioplex_WMM bioplex3_WMM hein () gupta_WMM
AP4S1	AP4E1	0.999	0.166342857143	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM
AP4B1	TEPSIN	0.998	0.172	mutually_exclusive (Q9Y587)	hein_WMM bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
AP4S1	TEPSIN	0.998	0.126	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
AP4S1	DISC1	0.994	0.066	structurally_consistent (O00189)	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
AP4E1	DISC1	0.993	0.154		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
CLEC4G	TEPSIN	0.986			bioplex3_HEK293 bioplex3_WMM WMM_only
AP4B1	DISC1	0.978	0.134		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
AP4M1	DISC1	0.925	0.122	structurally_consistent (dimer)	bioplex3_HEK293 bioplex3_WMM WMM_only
AP4B1	CLEC4G	0.415			bioplex3_WMM WMM_only
AP4M1	CLEC4G	0.278			bioplex3_WMM WMM_only
AP4E1	CLEC4G	0.278			bioplex3_WMM WMM_only
AP4S1	CLEC4G	0.274			bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
CLEC4G	huMAP3_03145.1 huMAP3_05011.1 huMAP3_05347.1 huMAP3_08005.1 huMAP3_09871.1 huMAP3_10461.1 huMAP3_11003.1 huMAP3_12731.1 huMAP3_12768.1 huMAP3_12927.1
AP4S1	huMAP3_01388.1 huMAP3_03145.1 huMAP3_05011.1 huMAP3_08618.1 huMAP3_09871.1 huMAP3_11003.1 huMAP3_12731.1 huMAP3_12768.1 huMAP3_12927.1
TEPSIN	huMAP3_03145.1 huMAP3_04613.1 huMAP3_05011.1 huMAP3_05347.1 huMAP3_06260.1 huMAP3_08005.1 huMAP3_09871.1 huMAP3_10461.1 huMAP3_10741.1 huMAP3_11003.1 huMAP3_12731.1 huMAP3_12768.1 huMAP3_12927.1
AP4M1	huMAP3_01388.1 huMAP3_03145.1 huMAP3_05011.1 huMAP3_08005.1 huMAP3_09871.1 huMAP3_11003.1 huMAP3_12731.1 huMAP3_12768.1 huMAP3_12927.1
DISC1	huMAP3_04928.1 huMAP3_08618.1 huMAP3_09108.1 huMAP3_09871.1 huMAP3_10973.1 huMAP3_11003.1 huMAP3_12731.1 huMAP3_12927.1
AP4E1	huMAP3_01388.1 huMAP3_03145.1 huMAP3_05011.1 huMAP3_08618.1 huMAP3_09871.1 huMAP3_11003.1 huMAP3_12731.1 huMAP3_12768.1 huMAP3_12927.1
AP4B1	huMAP3_01388.1 huMAP3_05011.1 huMAP3_08618.1 huMAP3_09871.1 huMAP3_11003.1 huMAP3_12731.1 huMAP3_12768.1 huMAP3_12864.1 huMAP3_12927.1 huMAP3_13753.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_09871.1

Complex Portal: CPX-20290