hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09876.1
Complex Portal: CPX-16958
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TMEM164 | Transmembrane protein 164 | 3 | UniProt NCBI |
| ADCK2 | Uncharacterized aarF domain-containing protein kinase 2 (EC 2.7.11.-) | 5 | UniProt NCBI |
| LRRC8A | Volume-regulated anion channel subunit LRRC8A (Leucine-rich repeat-containing protein 8A) (HsLRRC8A) (Swelling protein 1) | 5 | UniProt NCBI |
| NPEPPS | Puromycin-sensitive aminopeptidase (PSA) (EC 3.4.11.14) (Cytosol alanyl aminopeptidase) (AAP-S) | 5 | UniProt NCBI |
| TMEM179B | Transmembrane protein 179B | 5 | UniProt NCBI |
| LRRC8D | Volume-regulated anion channel subunit LRRC8D (Leucine-rich repeat-containing protein 5) (Leucine-rich repeat-containing protein 8D) (HsLRRC8D) | 5 | UniProt NCBI |
| LRRC8C | Volume-regulated anion channel subunit LRRC8C (Factor for adipocyte differentiation 158) (Leucine-rich repeat-containing protein 8C) | 5 | UniProt NCBI |
| LRRC8B | Volume-regulated anion channel subunit LRRC8B (Leucine-rich repeat-containing protein 8B) (T-cell activation leucine repeat-rich protein) (TA-LRRP) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6567 | 1.68018318789e-11 | 0.5 | LRRC8A LRRC8B LRRC8C LRRC8D | SWELL1-containing complex |
| REAC:R-HSA-5223345 | 3.78412664014e-08 | 0.5 | LRRC8A LRRC8B LRRC8C LRRC8D | Miscellaneous transport and binding events |
| GO:0005225 | 2.31823352537e-07 | 0.5 | LRRC8A LRRC8B LRRC8C LRRC8D | volume-sensitive anion channel activity |
| WP:WP5083 | 1.96621938192e-05 | 0.5 | LRRC8A LRRC8B LRRC8C LRRC8D | Neuroinflammation and glutamatergic signaling |
| CORUM:6581 | 2.39226645298e-05 | 0.25 | LRRC8A LRRC8C | LRRC8A-LRRC8C complex |
| CORUM:6582 | 2.39226645298e-05 | 0.25 | LRRC8A LRRC8D | LRRC8A-LRRC8D complex |
| GO:0098656 | 0.000271975684832 | 0.5 | LRRC8A LRRC8B LRRC8C LRRC8D | monoatomic anion transmembrane transport |
| GO:0034214 | 0.00045145282213 | 0.375 | LRRC8A LRRC8C LRRC8D | protein hexamerization |
| GO:0005253 | 0.000668834683502 | 0.5 | LRRC8A LRRC8B LRRC8C LRRC8D | monoatomic anion channel activity |
| GO:0006820 | 0.00208702000495 | 0.5 | LRRC8A LRRC8B LRRC8C LRRC8D | monoatomic anion transport |
| GO:0008509 | 0.00301307308056 | 0.5 | LRRC8A LRRC8B LRRC8C LRRC8D | monoatomic anion transmembrane transporter activity |
| REAC:R-HSA-382551 | 0.0231753091084 | 0.5 | LRRC8A LRRC8B LRRC8C LRRC8D | Transport of small molecules |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| LRRC8A | LRRC8B | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| LRRC8C | LRRC8B | 0.995 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| TMEM164 | LRRC8B | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| LRRC8D | LRRC8B | 0.989 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| NPEPPS | LRRC8B | 0.983 |
structurally_consistent (Q8TDW0)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ADCK2 | LRRC8B | 0.982 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| NPEPPS | LRRC8A | 0.98 | 0.06 |
structurally_consistent (Q8TDW0)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| LRRC8B | TMEM179B | 0.978 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| NPEPPS | LRRC8D | 0.946 | 0.116 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| NPEPPS | LRRC8C | 0.855 | 0.03 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| LRRC8A | LRRC8C | 0.609 | 0.118 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM WMM_only |
| LRRC8A | TMEM179B | 0.405 | 0.142 | bioplex_WMM bioplex3_WMM WMM_only | |
| LRRC8D | LRRC8C | 0.396 | 0.05 | bioplex_WMM bioplex3_WMM WMM_only | |
| TMEM164 | LRRC8A | 0.358 | 0.062 | bioplex_WMM bioplex3_WMM WMM_only | |
| LRRC8D | LRRC8A | 0.353 | 0.082 | bioplex_WMM bioplex3_WMM WMM_only | |
| LRRC8D | TMEM179B | 0.244 | 0.074 | bioplex_WMM bioplex3_WMM WMM_only | |
| LRRC8D | ADCK2 | 0.165 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ADCK2 | LRRC8C | 0.151 | bioplex_WMM bioplex3_WMM WMM_only | ||
| TMEM164 | TMEM179B | 0.142 | 0.158 | bioplex_WMM bioplex3_WMM WMM_only | |
| ADCK2 | TMEM179B | 0.125 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ADCK2 | LRRC8A | 0.124 | bioplex_WMM bioplex3_WMM WMM_only | ||
| TMEM164 | LRRC8C | 0.124 | 0.042 | bioplex_WMM bioplex3_WMM WMM_only | |
| TMEM164 | ADCK2 | 0.11 | bioplex_WMM bioplex3_WMM WMM_only | ||
| LRRC8C | TMEM179B | 0.107 | 0.046 | bioplex_WMM bioplex3_WMM WMM_only | |
| NPEPPS | ADCK2 | 0.067 | bioplex_WMM bioplex3_WMM WMM_only | ||
| TMEM164 | LRRC8D | 0.051 | 0.078 | bioplex_WMM bioplex3_WMM WMM_only | |
| TMEM164 | NPEPPS | 0.033 | 0.092 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| NPEPPS | TMEM179B | 0.02 | 0.118 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes