hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09877.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ALG8 | Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase (EC 2.4.1.265) (Asparagine-linked glycosylation protein 8 homolog) (Dol-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichyl alpha-1,3-glucosyltransferase) (Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase) | 5 | UniProt NCBI |
| ALG6 | Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase (EC 2.4.1.267) (Asparagine-linked glycosylation protein 6 homolog) (Dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase) (Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase) | 5 | UniProt NCBI |
| TAP2 | Antigen peptide transporter 2 (APT2) (EC 7.4.2.14) (ATP-binding cassette sub-family B member 3) (Peptide supply factor 2) (Peptide transporter PSF2) (PSF-2) (Peptide transporter TAP2) (Peptide transporter involved in antigen processing 2) (Really interesting new gene 11 protein) (RING11) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4521 | 0.000286309588192 | 0.666666666667 | ALG6 ALG8 | Glycosylation and related congenital defects |
| HP:0005543 | 0.000455401167586 | 0.666666666667 | ALG6 ALG8 | Reduced protein C activity |
| HP:0030780 | 0.000834787835662 | 0.666666666667 | ALG6 ALG8 | Abnormality of the protein C anticoagulant pathway |
| HP:0001929 | 0.000834787835662 | 0.666666666667 | ALG6 ALG8 | Reduced factor XI activity |
| KEGG:00510 | 0.00085927513712 | 0.666666666667 | ALG6 ALG8 | N-Glycan biosynthesis |
| HP:0001976 | 0.000986522412937 | 0.666666666667 | ALG6 ALG8 | Reduced antithrombin III activity |
| REAC:R-HSA-3781860 | 0.00129444299395 | 0.666666666667 | ALG6 ALG8 | Diseases associated with N-glycosylation of proteins |
| HP:0010988 | 0.00132788970801 | 0.666666666667 | ALG6 ALG8 | Abnormality of the extrinsic pathway |
| GO:0004583 | 0.00140460216025 | 0.666666666667 | ALG6 ALG8 | dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity |
| WP:WP5153 | 0.00144101964081 | 0.666666666667 | ALG6 ALG8 | N glycan biosynthesis |
| HP:0002243 | 0.00171977631115 | 0.666666666667 | ALG6 ALG8 | Protein-losing enteropathy |
| HP:0003642 | 0.00216216836724 | 0.666666666667 | ALG6 ALG8 | Type I transferrin isoform profile |
| HP:0010989 | 0.00587635932745 | 0.666666666667 | ALG6 ALG8 | Abnormality of the intrinsic pathway |
| HP:0003160 | 0.00985306624309 | 0.666666666667 | ALG6 ALG8 | Abnormal isoelectric focusing of serum transferrin |
| HP:0012347 | 0.0108752751697 | 0.666666666667 | ALG6 ALG8 | Abnormal protein N-linked glycosylation |
| HP:0012346 | 0.0114052550978 | 0.666666666667 | ALG6 ALG8 | Abnormal protein glycosylation |
| HP:0012345 | 0.0142438401108 | 0.666666666667 | ALG6 ALG8 | Abnormal glycosylation |
| REAC:R-HSA-446193 | 0.0178608636553 | 0.666666666667 | ALG6 ALG8 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| REAC:R-HSA-3781865 | 0.0421708333427 | 0.666666666667 | ALG6 ALG8 | Diseases of glycosylation |
| REAC:R-HSA-4724325 | 0.0498224659464 | 0.333333333333 | ALG8 | Defective ALG8 causes CDG-1h |
| REAC:R-HSA-4724289 | 0.0498224659464 | 0.333333333333 | ALG6 | Defective ALG6 causes CDG-1c |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ALG6 | ALG8 | 0.997 | 0.22 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| ALG8 | TAP2 | 0.96 | 0.038 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| ALG6 | TAP2 | 0.073 | 0.044 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| ALG8 | huMAP3_03497.1 huMAP3_07262.1 huMAP3_09877.1 huMAP3_15312.1 |
| ALG6 | huMAP3_00455.1 huMAP3_00859.1 huMAP3_03497.1 huMAP3_05559.1 huMAP3_07952.1 huMAP3_09877.1 |
| TAP2 | huMAP3_09877.1 |