hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_09887.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DHDDS | Dehydrodolichyl diphosphate synthase complex subunit DHDDS (EC 2.5.1.87) (Cis-isoprenyltransferase) (CIT) (Cis-IPTase) (Cis-prenyltransferase subunit hCIT) (Epididymis tissue protein Li 189m) | 5 | UniProt NCBI |
| IGFBP6 | Insulin-like growth factor-binding protein 6 (IBP-6) (IGF-binding protein 6) (IGFBP-6) | 5 | UniProt NCBI |
| NUS1 | Dehydrodolichyl diphosphate synthase complex subunit NUS1 (EC 2.5.1.87) (Cis-prenyltransferase subunit NgBR) (Nogo-B receptor) (NgBR) (Nuclear undecaprenyl pyrophosphate synthase 1 homolog) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6238 | 1.70876175213e-06 | 1.0 | DHDDS NUS1 | DHDDS-NUS1 complex |
| REAC:R-HSA-4755609 | 1.70876175213e-06 | 1.0 | DHDDS NUS1 | Defective DHDDS causes RP59 |
| REAC:R-HSA-446199 | 1.70876175213e-05 | 1.0 | DHDDS NUS1 | Synthesis of Dolichyl-phosphate |
| KEGG:00900 | 3.75535994234e-05 | 1.0 | DHDDS NUS1 | Terpenoid backbone biosynthesis |
| REAC:R-HSA-5609975 | 0.000133283416666 | 1.0 | DHDDS NUS1 | Diseases associated with glycosylation precursor biosynthesis |
| GO:0045547 | 0.000468200720083 | 1.0 | DHDDS NUS1 | dehydrodolichyl diphosphate synthase activity |
| GO:1904423 | 0.000468200720083 | 1.0 | DHDDS NUS1 | dehydrodolichyl diphosphate synthase complex |
| GO:0016094 | 0.000468200720083 | 1.0 | DHDDS NUS1 | polyprenol biosynthetic process |
| GO:0006489 | 0.0028092043205 | 1.0 | DHDDS NUS1 | dolichyl diphosphate biosynthetic process |
| GO:0046465 | 0.0028092043205 | 1.0 | DHDDS NUS1 | dolichyl diphosphate metabolic process |
| REAC:R-HSA-446219 | 0.00282458317627 | 1.0 | DHDDS NUS1 | Synthesis of substrates in N-glycan biosythesis |
| HP:0010844 | 0.00353713682691 | 1.0 | DHDDS NUS1 | EEG with multifocal slow activity |
| REAC:R-HSA-446193 | 0.00449062588459 | 1.0 | DHDDS NUS1 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| REAC:R-HSA-3781865 | 0.0106216630512 | 1.0 | DHDDS NUS1 | Diseases of glycosylation |
| HP:0011203 | 0.0113495955576 | 1.0 | DHDDS NUS1 | EEG with abnormally slow frequencies |
| HP:0200134 | 0.0143057533888 | 1.0 | DHDDS NUS1 | Epileptic encephalopathy |
| HP:0007843 | 0.0176036635704 | 1.0 | DHDDS NUS1 | Attenuation of retinal blood vessels |
| HP:0100710 | 0.0227948817734 | 1.0 | DHDDS NUS1 | Impulsivity |
| HP:0002123 | 0.0252247409849 | 1.0 | DHDDS NUS1 | Generalized myoclonic seizure |
| REAC:R-HSA-5668914 | 0.0297170756313 | 1.0 | DHDDS NUS1 | Diseases of metabolism |
| HP:0002509 | 0.0342128278011 | 1.0 | DHDDS NUS1 | Limb hypertonia |
| HP:0002121 | 0.0392194997349 | 1.0 | DHDDS NUS1 | Generalized non-motor (absence) seizure |
| HP:0002521 | 0.0413178591665 | 1.0 | DHDDS NUS1 | Hypsarrhythmia |
| HP:0002317 | 0.0456786191579 | 1.0 | DHDDS NUS1 | Unsteady gait |
| HP:0032677 | 0.0468029843908 | 1.0 | DHDDS NUS1 | Generalized-onset motor seizure |
| GO:0006488 | 0.0491610756088 | 1.0 | DHDDS NUS1 | dolichol-linked oligosaccharide biosynthetic process |
| HP:0033259 | 0.0496737041344 | 1.0 | DHDDS NUS1 | Non-motor seizure |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| DHDDS | NUS1 | 0.999 | 0.268 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| DHDDS | IGFBP6 | 0.97 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| NUS1 | IGFBP6 | 0.247 | bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| DHDDS | huMAP3_04340.1 huMAP3_09887.1 huMAP3_13395.1 huMAP3_13458.1 huMAP3_13747.1 |
| IGFBP6 | huMAP3_09887.1 huMAP3_13747.1 |
| NUS1 | huMAP3_04340.1 huMAP3_05569.1 huMAP3_07685.1 huMAP3_09887.1 huMAP3_13395.1 huMAP3_15113.1 |