hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09893.1
Complex Portal: CPX-11795
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DDOST | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit (DDOST 48 kDa subunit) (Oligosaccharyl transferase 48 kDa subunit) | 5 | UniProt NCBI |
| DAD1 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 (Oligosaccharyl transferase subunit DAD1) (Defender against cell death 1) (DAD-1) | 5 | UniProt NCBI |
| LMF2 | Lipase maturation factor 2 (Transmembrane protein 112B) (Transmembrane protein 153) | 4 | UniProt NCBI |
| STT3B | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B (Oligosaccharyl transferase subunit STT3B) (STT3-B) (EC 2.4.99.18) (Source of immunodominant MHC-associated peptides homolog) | 5 | UniProt NCBI |
| TUSC3 | Tumor suppressor candidate 3 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3) (Oligosaccharyl transferase subunit TUSC3) (Magnesium uptake/transporter TUSC3) (Protein N33) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1200 | 1.34226065824e-11 | 0.8 | STT3B TUSC3 DDOST DAD1 | Oligosaccharyltransferase complex (Stt3B variant) |
| KEGG:00513 | 1.16503464997e-08 | 0.8 | STT3B TUSC3 DDOST DAD1 | Various types of N-glycan biosynthesis |
| KEGG:00510 | 2.47940637774e-08 | 0.8 | STT3B TUSC3 DDOST DAD1 | N-Glycan biosynthesis |
| WP:WP5153 | 4.11972676234e-08 | 0.8 | STT3B TUSC3 DDOST DAD1 | N glycan biosynthesis |
| GO:0008250 | 4.33992010508e-08 | 0.8 | STT3B TUSC3 DDOST DAD1 | oligosaccharyltransferase complex |
| GO:0018279 | 9.61435992643e-07 | 0.8 | STT3B TUSC3 DDOST DAD1 | protein N-linked glycosylation via asparagine |
| KEGG:04141 | 3.00693972585e-06 | 0.8 | STT3B TUSC3 DDOST DAD1 | Protein processing in endoplasmic reticulum |
| REAC:R-HSA-9694548 | 2.03584684634e-05 | 0.6 | TUSC3 DDOST DAD1 | Maturation of spike protein |
| GO:0006487 | 6.39580887555e-05 | 0.8 | STT3B TUSC3 DDOST DAD1 | protein N-linked glycosylation |
| REAC:R-HSA-9694635 | 7.27326653199e-05 | 0.6 | TUSC3 DDOST DAD1 | Translation of Structural Proteins |
| REAC:R-HSA-9772573 | 0.000117314199984 | 0.6 | TUSC3 DDOST DAD1 | Late SARS-CoV-2 Infection Events |
| CORUM:1199 | 0.000204640425412 | 0.4 | DDOST DAD1 | Oligosaccharyltransferase complex (Stt3A variant) |
| GO:0140534 | 0.000625424261446 | 0.8 | STT3B TUSC3 DDOST DAD1 | endoplasmic reticulum protein-containing complex |
| GO:0006486 | 0.00309714791762 | 0.8 | STT3B TUSC3 DDOST DAD1 | protein glycosylation |
| GO:0043413 | 0.00309714791762 | 0.8 | STT3B TUSC3 DDOST DAD1 | macromolecule glycosylation |
| GO:0070085 | 0.00492038984684 | 0.8 | STT3B TUSC3 DDOST DAD1 | glycosylation |
| REAC:R-HSA-9694516 | 0.0101788028745 | 0.6 | TUSC3 DDOST DAD1 | SARS-CoV-2 Infection |
| REAC:R-HSA-446203 | 0.0113314618617 | 0.6 | TUSC3 DDOST DAD1 | Asparagine N-linked glycosylation |
| GO:0005789 | 0.0127016097142 | 1.0 | STT3B LMF2 TUSC3 DDOST DAD1 | endoplasmic reticulum membrane |
| GO:0098827 | 0.0137299443752 | 1.0 | STT3B LMF2 TUSC3 DDOST DAD1 | endoplasmic reticulum subcompartment |
| GO:0009101 | 0.0137548412893 | 0.8 | STT3B TUSC3 DDOST DAD1 | glycoprotein biosynthetic process |
| GO:0042175 | 0.0143182882786 | 1.0 | STT3B LMF2 TUSC3 DDOST DAD1 | nuclear outer membrane-endoplasmic reticulum membrane network |
| REAC:R-HSA-9679506 | 0.0263889851162 | 0.6 | TUSC3 DDOST DAD1 | SARS-CoV Infections |
| GO:0009100 | 0.0302165890257 | 0.8 | STT3B TUSC3 DDOST DAD1 | glycoprotein metabolic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| DDOST | STT3B | 0.998 | 0.906 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| DAD1 | STT3B | 0.977 | 0.83 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only |
| DAD1 | TUSC3 | 0.973 |
structurally_consistent (Q8TCJ2)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| STT3B | TUSC3 | 0.969 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| STT3B | LMF2 | 0.961 | 0.194 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| DDOST | TUSC3 | 0.661 |
structurally_consistent (Q8TCJ2)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| LMF2 | TUSC3 | 0.288 | bioplex_WMM bioplex3_WMM WMM_only | ||
| DDOST | DAD1 | 0.155 | 0.948 | bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only | |
| DDOST | LMF2 | 0.076 | 0.272 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| DAD1 | LMF2 | 0.037 | 0.196 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
Related Complexes