hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09896.1
Complex Portal: CPX-17740
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DNAJC17 | DnaJ homolog subfamily C member 17 | 2 | UniProt NCBI |
| CWC15 | Spliceosome-associated protein CWC15 homolog | 5 | UniProt NCBI |
| PRCC | Proline-rich protein PRCC (Papillary renal cell carcinoma translocation-associated gene protein) | 5 | UniProt NCBI |
| SENP6 | Sentrin-specific protease 6 (EC 3.4.22.-) (SUMO-1-specific protease 1) (Sentrin/SUMO-specific protease SENP6) | 5 | UniProt NCBI |
| YJU2B | Probable splicing factor YJU2B (Coiled-coil domain-containing protein 130) | 5 | UniProt NCBI |
| METTL23 | Histone-arginine methyltransferase METTL23 (EC 2.1.1.319) (Methyltransferase-like protein 23) | 5 | UniProt NCBI |
| PRPF19 | Pre-mRNA-processing factor 19 (EC 2.3.2.27) (Nuclear matrix protein 200) (PRP19/PSO4 homolog) (hPso4) (RING-type E3 ubiquitin transferase PRP19) (Senescence evasion factor) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1183 | 0.00510480575081 | 0.333333333333 | CWC15 PRPF19 | CDC5L complex |
| REAC:R-HSA-72163 | 0.00913908174037 | 0.5 | PRCC CWC15 PRPF19 | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 0.0101216651073 | 0.5 | PRCC CWC15 PRPF19 | mRNA Splicing |
| REAC:R-HSA-72203 | 0.0229811698012 | 0.5 | PRCC CWC15 PRPF19 | Processing of Capped Intron-Containing Pre-mRNA |
| CORUM:1181 | 0.0493179573456 | 0.333333333333 | CWC15 PRPF19 | C complex spliceosome |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PRPF19 | CWC15 | 0.997 | 0.548 | hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| SENP6 | PRPF19 | 0.994 | 0.296166666667 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM | |
| METTL23 | PRPF19 | 0.99 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| PRCC | CWC15 | 0.989 | 0.528 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM | |
| PRCC | PRPF19 | 0.985 | 0.284 | hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM | |
| YJU2B | PRPF19 | 0.962 | 0.186 |
structurally_consistent (dimer)
|
youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| CWC15 | DNAJC17 | 0.952 | 0.108 | bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| YJU2B | DNAJC17 | 0.899 | 0.092 | bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| YJU2B | METTL23 | 0.64 | bioplex3_WMM WMM_only | ||
| YJU2B | CWC15 | 0.565 | 0.273666666667 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | |
| SENP6 | METTL23 | 0.53 | bioplex_WMM bioplex3_WMM WMM_only | ||
| METTL23 | CWC15 | 0.315 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SENP6 | YJU2B | 0.139 | 0.16 | bioplex3_WMM youn_WMM WMM_only | |
| PRCC | DNAJC17 | 0.136 | 0.1 | bioplex3_WMM youn_WMM fraction | |
| SENP6 | CWC15 | 0.049 | 0.084 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| PRPF19 | DNAJC17 | 0.042 | 0.204 | bioplex3_HEK293 youn_WMM bioplex3_HCT116 WMM_only | |
| PRCC | YJU2B | 0.016 | 0.132 | youn_WMM WMM_only | |
| PRCC | SENP6 | 0.009 | 0.042 | youn_WMM gupta_WMM WMM_only | |
| SENP6 | DNAJC17 | 0.007 | 0.08 | youn_WMM WMM_only |
Related Complexes