hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_09902.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EPN3 | Epsin-3 (EPS-15-interacting protein 3) | 5 | UniProt NCBI |
| PHGDH | D-3-phosphoglycerate dehydrogenase (3-PGDH) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399) (Malate dehydrogenase) (EC 1.1.1.37) | 5 | UniProt NCBI |
| EPN2 | Epsin-2 (EPS-15-interacting protein 2) | 5 | UniProt NCBI |
| NUMBL | Numb-like protein (Numb-related protein) (Numb-R) | 5 | UniProt NCBI |
| CRTC2 | CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2) | 5 | UniProt NCBI |
| CRTC3 | CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3) | 5 | UniProt NCBI |
| EPN1 | Epsin-1 (EH domain-binding mitotic phosphoprotein) (EPS-15-interacting protein 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04144 | 0.00679381427833 | 0.428571428571 | EPN3 EPN1 EPN2 | Endocytosis |
| GO:0030125 | 0.0122273067778 | 0.428571428571 | EPN3 EPN1 EPN2 | clathrin vesicle coat |
| GO:0030118 | 0.0305188440994 | 0.428571428571 | EPN3 EPN1 EPN2 | clathrin coat |
| REAC:R-HSA-9707616 | 0.0325139680435 | 0.285714285714 | CRTC3 CRTC2 | Heme signaling |
| GO:0030276 | 0.0383127531327 | 0.428571428571 | EPN3 EPN1 EPN2 | clathrin binding |
| REAC:R-HSA-2151201 | 0.0425383740248 | 0.285714285714 | CRTC3 CRTC2 | Transcriptional activation of mitochondrial biogenesis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| EPN1 | EPN3 | 0.999 | 0.662 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| EPN2 | EPN3 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| EPN3 | PHGDH | 0.999 | 0.02 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| CRTC2 | CRTC3 | 0.994 | 0.086 | hein_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| EPN2 | PHGDH | 0.989 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| CRTC2 | EPN2 | 0.987 | hein_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| CRTC3 | EPN2 | 0.984 | hein_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| NUMBL | EPN2 | 0.981 | hein_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only | |
| EPN1 | PHGDH | 0.974 | 0.0660601503759 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| CRTC2 | NUMBL | 0.974 | 0.132 | hein_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only |
| EPN2 | EPN1 | 0.962 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| CRTC2 | EPN1 | 0.796 | 0.052 | hein_WMM WMM_only |
| NUMBL | EPN1 | 0.658 | 0.096 | hein_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| NUMBL | CRTC3 | 0.649 | 0.128 | hein_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only |
| CRTC3 | EPN1 | 0.545 | 0.072 | hein_WMM WMM_only |
| NUMBL | EPN3 | 0.165 | 0.042 | bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| CRTC2 | PHGDH | 0.032 | 0.154 | hein_WMM bioplex3_HEK293 bioplex () youn_WMM gupta_WMM |
| NUMBL | PHGDH | 0.006 | 0.0801823899371 | hein_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| CRTC3 | PHGDH | 0.006 | 0.134 | hein_WMM bioplex3_HEK293 youn_WMM gupta_WMM boldt_WMM WMM_only |
Related Complexes