hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_09904.1

Confidence: Moderate High

Genename	Protein Name	Uniprot Annotation Score	Links
YME1L1	ATP-dependent zinc metalloprotease YME1L1 (EC 3.4.24.-) (ATP-dependent metalloprotease FtsH1) (Meg-4) (Presenilin-associated metalloprotease) (PAMP) (YME1-like protein 1)	5	UniProt NCBI
SLC25A19	Mitochondrial thiamine pyrophosphate carrier (Mitochondrial thiamine pyrophosphate transporter) (MTPPT) (Mitochondrial uncoupling protein 1) (Solute carrier family 25 member 19)	5	UniProt NCBI
TECR	Very-long-chain enoyl-CoA reductase (EC 1.3.1.93) (Synaptic glycoprotein SC2) (Trans-2,3-enoyl-CoA reductase) (TER)	5	UniProt NCBI
SLC35E1	Solute carrier family 35 member E1	3	UniProt NCBI
SPNS1	Protein spinster homolog 1 (HSpin1) (SPNS1) (Spinster-like protein 1)	5	UniProt NCBI
SLC7A11	Cystine/glutamate transporter (Amino acid transport system xc-) (Calcium channel blocker resistance protein CCBR1) (Solute carrier family 7 member 11) (xCT)	5	UniProt NCBI
SLC1A5	Neutral amino acid transporter B(0) (ATB(0)) (Baboon M7 virus receptor) (RD114/simian type D retrovirus receptor) (Sodium-dependent neutral amino acid transporter type 2) (Solute carrier family 1 member 5)	5	UniProt NCBI
HLA-DPA1	HLA class II histocompatibility antigen, DP alpha 1 chain (DP(W3)) (DP(W4)) (HLA-SB alpha chain) (MHC class II DP3-alpha) (MHC class II DPA1)	5	UniProt NCBI
SLC38A5	Sodium-coupled neutral amino acid transporter 5 (Solute carrier family 38 member 5) (System N transporter 2)	5	UniProt NCBI
HLA-B	HLA class I histocompatibility antigen, B alpha chain (Human leukocyte antigen B) (HLA-B)	5	UniProt NCBI
TAP1	Antigen peptide transporter 1 (APT1) (EC 7.4.2.14) (ATP-binding cassette sub-family B member 2) (Peptide supply factor 1) (Peptide transporter PSF1) (PSF-1) (Peptide transporter TAP1) (Peptide transporter involved in antigen processing 1) (Really interesting new gene 4 protein) (RING4)	5	UniProt NCBI
SLC39A7	Zinc transporter SLC39A7 (Histidine-rich membrane protein Ke4) (Really interesting new gene 5 protein) (Solute carrier family 39 member 7) (Zrt-, Irt-like protein 7) (ZIP7)	5	UniProt NCBI
MICOS13	MICOS complex subunit MIC13 (Protein P117)	5	UniProt NCBI
UQCC3	Ubiquinol-cytochrome-c reductase complex assembly factor 3 (Assembly factor CBP4 homolog)	5	UniProt NCBI
FAR1	Fatty acyl-CoA reductase 1 (EC 1.2.1.84) (Male sterility domain-containing protein 2)	5	UniProt NCBI
SLC25A6	ADP/ATP translocase 3 (ADP,ATP carrier protein 3) (ADP,ATP carrier protein, isoform T2) (ANT 2) (Adenine nucleotide translocator 3) (ANT 3) (Solute carrier family 25 member 6) [Cleaved into: ADP/ATP translocase 3, N-terminally processed]	5	UniProt NCBI
VKORC1	Vitamin K epoxide reductase complex subunit 1 (EC 1.17.4.4) (Vitamin K1 2,3-epoxide reductase subunit 1)	5	UniProt NCBI
KDELR2	ER lumen protein-retaining receptor 2 (ERD2-like protein 1) (ELP-1) (KDEL endoplasmic reticulum protein retention receptor 2) (KDEL receptor 2)	5	UniProt NCBI
NDUFA11	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (Complex I-B14.7) (CI-B14.7) (NADH-ubiquinone oxidoreductase subunit B14.7)	5	UniProt NCBI
SLC7A5	Large neutral amino acids transporter small subunit 1 (4F2 light chain) (4F2 LC) (4F2LC) (CD98 light chain) (Integral membrane protein E16) (E16) (L-type amino acid transporter 1) (hLAT1) (Solute carrier family 7 member 5) (y+ system cationic amino acid transporter)	5	UniProt NCBI
RHBDD2	Rhomboid domain-containing protein 2	5	UniProt NCBI
CISD1	CDGSH iron-sulfur domain-containing protein 1 (Cysteine transaminase CISD1) (EC 2.6.1.3) (MitoNEET)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-352230	4.40171259663e-06	0.210526315789	SLC7A11 SLC1A5 SLC7A5 SLC38A5	Amino acid transport across the plasma membrane
WP:WP3953	8.14339765439e-06	0.157894736842	SLC7A11 SLC1A5 SLC7A5	mRNA protein and metabolite inducation pathway by cyclosporin A
REAC:R-HSA-425393	0.000369350057721	0.210526315789	SLC7A11 SLC1A5 SLC7A5 SLC38A5	Transport of inorganic cations/anions and amino acids/oligopeptides
REAC:R-HSA-425407	0.000454293764354	0.263157894737	SLC7A11 SLC39A7 SLC1A5 SLC7A5 SLC38A5	SLC-mediated transmembrane transport
GO:0015297	0.000761518959677	0.263157894737	SLC38A5 SLC35E1 SLC1A5 SLC7A5 SLC7A11	antiporter activity
GO:0015175	0.00237304900771	0.210526315789	SLC7A11 SLC1A5 SLC7A5 SLC38A5	neutral L-amino acid transmembrane transporter activity
WP:WP5213	0.00300053589263	0.105263157895	SLC7A11 SLC1A5	Amino acid metabolism in triple negative breast cancer cells
GO:0015804	0.00358404425143	0.210526315789	SLC7A11 SLC1A5 SLC7A5 SLC38A5	neutral amino acid transport
GO:0031090	0.00384874652032	0.736842105263	HLA-B TECR YME1L1 RHBDD2 SLC25A19 VKORC1 CISD1 SLC39A7 MICOS13 FAR1 TAP1 SPNS1 NDUFA11 UQCC3	organelle membrane
HP:0004360	0.00661971825792	0.315789473684	YME1L1 UQCC3 HLA-B SLC25A19 NDUFA11 MICOS13	Abnormality of acid-base homeostasis
WP:WP4313	0.00688462413378	0.157894736842	SLC7A11 SLC1A5 CISD1	Ferroptosis
GO:1902475	0.00904889739717	0.210526315789	SLC7A11 SLC1A5 SLC7A5 SLC38A5	L-alpha-amino acid transmembrane transport
REAC:R-HSA-382551	0.0123831512814	0.315789473684	YME1L1 SLC38A5 SLC7A5 SLC1A5 SLC7A11 SLC39A7	Transport of small molecules
GO:0015179	0.0133971211549	0.210526315789	SLC7A11 SLC1A5 SLC7A5 SLC38A5	L-amino acid transmembrane transporter activity
GO:0015807	0.0133971211549	0.210526315789	SLC7A11 SLC1A5 SLC7A5 SLC38A5	L-amino acid transport
GO:0016020	0.0270015402397	0.947368421053	YME1L1 TECR SLC7A5 HLA-B RHBDD2 SLC25A19 VKORC1 FAR1 CISD1 SPNS1 SLC7A11 UQCC3 SLC39A7 TAP1 MICOS13 SLC1A5 NDUFA11 SLC38A5	membrane
GO:0003333	0.0309548317234	0.210526315789	SLC7A11 SLC1A5 SLC7A5 SLC38A5	amino acid transmembrane transport
GO:0015291	0.0435281027535	0.263157894737	SLC38A5 SLC35E1 SLC1A5 SLC7A5 SLC7A11	secondary active transmembrane transporter activity
GO:0022804	0.0454297962229	0.315789473684	SLC38A5 SLC35E1 SLC7A5 SLC7A11 TAP1 SLC1A5	active transmembrane transporter activity

Edges

Protein 1	Protein 2	Score	ProteomeHD
SLC35E1	SLC7A5	0.998	0.042
SLC35E1	MICOS13	0.997	0.028
SLC7A5	SLC1A5	0.993	0.61
SLC35E1	FAR1	0.993	0.036
SLC35E1	VKORC1	0.993
SPNS1	HLA-B	0.993	0.038
SLC35E1	TAP1	0.992	0.062
FAR1	HLA-B	0.992	0.09
SLC7A11	HLA-B	0.992	0.242
CISD1	NDUFA11	0.992	0.18
SLC35E1	NDUFA11	0.992	0.024
SLC35E1	SPNS1	0.991	0.05
MICOS13	CISD1	0.99	0.134
SLC35E1	HLA-B	0.989	0.048
SLC35E1	TECR	0.988	0.168
SLC35E1	SLC1A5	0.988	0.046
RHBDD2	HLA-B	0.987	0.088
SLC25A6	HLA-DPA1	0.986	0.29276
MICOS13	FAR1	0.985	0.02
MICOS13	SPNS1	0.985	0.028
NDUFA11	KDELR2	0.984	0.086
SLC7A11	FAR1	0.984	0.194
SLC25A19	FAR1	0.984	0.08
SLC7A11	SLC35E1	0.983	0.07
TECR	CISD1	0.983	0.048
SLC35E1	SLC38A5	0.982	0.022
MICOS13	SLC25A19	0.982	0.066
SLC7A5	MICOS13	0.978	0.032
SLC35E1	SLC39A7	0.978	0.116
SPNS1	NDUFA11	0.978	0.024
SPNS1	KDELR2	0.976	0.098
SLC35E1	SLC25A19	0.976	0.078
SPNS1	FAR1	0.975	0.016
SLC35E1	CISD1	0.975	0.024
SLC7A11	SPNS1	0.974	0.072
SLC35E1	YME1L1	0.974	0.042
SLC35E1	RHBDD2	0.974	0.288
SLC25A19	SPNS1	0.974	0.014
SLC1A5	TECR	0.973	0.168
SLC25A19	CISD1	0.972	0.08
YME1L1	FAR1	0.969	0.054
SLC25A6	FAR1	0.969	0.028
HLA-DPA1	SLC35E1	0.968	0.076
SLC25A6	SLC7A11	0.966	0.146
SLC7A11	SLC7A5	0.965	0.194
FAR1	KDELR2	0.964	0.134
HLA-DPA1	HLA-B	0.963	0.4125625
SLC7A5	TAP1	0.961	0.094
SLC7A11	RHBDD2	0.961	0.098
MICOS13	NDUFA11	0.96	0.448
SPNS1	CISD1	0.959	0.03
SLC25A6	MICOS13	0.959	0.394
HLA-DPA1	FAR1	0.959	0.096
MICOS13	UQCC3	0.958	0.12
SLC7A5	VKORC1	0.958
SLC25A6	SLC25A19	0.956	0.158
SLC25A6	SLC35E1	0.956	0.124
SLC25A6	NDUFA11	0.953	0.33
TECR	SLC25A19	0.953	0.092
SLC39A7	TECR	0.952	0.106
SLC25A6	TECR	0.949	0.256
SLC38A5	SLC1A5	0.942	0.21
SLC1A5	CISD1	0.941	0.11
SLC25A6	CISD1	0.941	0.202666666667
SLC38A5	SPNS1	0.939	0.056
TECR	TAP1	0.937	0.1
SLC25A6	UQCC3	0.935	0.202
SLC39A7	TAP1	0.934	0.042
FAR1	CISD1	0.932	0.016
NDUFA11	RHBDD2	0.932	0.05
SPNS1	UQCC3	0.929	0.044
SLC25A19	KDELR2	0.928	0.158
MICOS13	KDELR2	0.925	0.118
SLC1A5	SLC25A19	0.924	0.12
CISD1	UQCC3	0.923	0.076
SLC38A5	HLA-B	0.92	0.104
SPNS1	RHBDD2	0.92	0.086
SLC35E1	UQCC3	0.919	0.036
SLC7A5	FAR1	0.918	0.074
SLC25A19	NDUFA11	0.915	0.038
YME1L1	SLC25A19	0.913	0.206
SLC35E1	KDELR2	0.911	0.11
HLA-DPA1	TECR	0.909	0.13
YME1L1	MICOS13	0.908	0.11
UQCC3	RHBDD2	0.907	0.054
SLC39A7	SLC7A5	0.907	0.04
FAR1	UQCC3	0.904	0.04
SLC7A11	MICOS13	0.899	0.032
MICOS13	RHBDD2	0.899	0.104
TAP1	VKORC1	0.897
SLC7A5	TECR	0.896	0.084
FAR1	RHBDD2	0.89	0.07
UQCC3	NDUFA11	0.886	0.128
UQCC3	KDELR2	0.88	0.072
SLC7A11	SLC25A19	0.879	0.032
SLC1A5	MICOS13	0.872	0.028
SLC39A7	VKORC1	0.862
SLC7A5	RHBDD2	0.86	0.06
HLA-DPA1	RHBDD2	0.848	0.116
SLC39A7	HLA-B	0.84	0.072
SLC39A7	SLC1A5	0.828	0.024
HLA-DPA1	SLC7A11	0.827	0.102
SLC1A5	NDUFA11	0.824	0.022
YME1L1	UQCC3	0.824	0.052
SLC25A6	KDELR2	0.824	0.116
SLC25A6	SLC38A5	0.824	0.026
SLC7A5	SPNS1	0.82	0.01
SLC7A11	CISD1	0.808	0.054
HLA-DPA1	SLC25A19	0.804	0.108
TECR	FAR1	0.8	0.04
KDELR2	RHBDD2	0.798	0.132
SLC25A6	SLC7A5	0.794	0.108
SPNS1	TAP1	0.784	0.048
SLC38A5	VKORC1	0.781
HLA-DPA1	KDELR2	0.775	0.166
SLC38A5	TAP1	0.766	0.096
SLC7A11	UQCC3	0.762	0.048
SLC25A19	UQCC3	0.758	0.056
SLC25A19	TAP1	0.757	0.02
SLC25A6	SPNS1	0.753	0.072
SLC7A11	NDUFA11	0.72	0.126
MICOS13	HLA-B	0.718	0.072
CISD1	KDELR2	0.703	0.058
SLC38A5	MICOS13	0.694	0.034
YME1L1	TECR	0.693	0.13
SLC38A5	SLC7A5	0.671	0.15
SLC38A5	YME1L1	0.656	0.098
SLC25A6	SLC1A5	0.636	0.148
FAR1	NDUFA11	0.622	0.03
SLC25A19	RHBDD2	0.617	0.06
HLA-DPA1	SLC7A5	0.579	0.13
SLC39A7	YME1L1	0.579	0.03
SLC1A5	TAP1	0.575	0.106
HLA-DPA1	YME1L1	0.562	0.108
TECR	NDUFA11	0.56	0.076
SLC7A5	KDELR2	0.557	0.1
MICOS13	TAP1	0.54	0.028
SLC7A5	SLC25A19	0.535	0.058
TECR	MICOS13	0.521	0.084
HLA-DPA1	SPNS1	0.491	0.062
SLC7A11	KDELR2	0.49	0.046
NDUFA11	HLA-B	0.483	0.04
SLC38A5	FAR1	0.473	0.146
SLC38A5	TECR	0.469	0.054
TAP1	FAR1	0.463	0.052
SLC7A11	TECR	0.463	0.128
SLC1A5	HLA-B	0.441	0.202
SLC25A6	YME1L1	0.439	0.126
YME1L1	SLC7A5	0.434	0.04
SLC7A5	HLA-B	0.421	0.164
SLC39A7	MICOS13	0.421	0.044
CISD1	RHBDD2	0.419	0.054
SLC7A11	YME1L1	0.409	0.034
SLC25A6	HLA-B	0.404	0.216
YME1L1	KDELR2	0.391	0.064
SLC7A11	SLC1A5	0.389	0.196
SLC38A5	KDELR2	0.374	0.084
SLC1A5	VKORC1	0.373
SLC7A5	CISD1	0.365	0.024
TECR	UQCC3	0.365	0.066
HLA-DPA1	MICOS13	0.35	0.074
YME1L1	NDUFA11	0.344	0.022
SLC38A5	RHBDD2	0.335	0.084
YME1L1	CISD1	0.335	0.042
SLC7A5	NDUFA11	0.33	0.012
SLC25A6	RHBDD2	0.323	0.11
SLC39A7	FAR1	0.319	0.034
CISD1	HLA-B	0.315	0.09
SLC25A19	HLA-B	0.302	0.04
YME1L1	SLC1A5	0.294	0.038
TAP1	RHBDD2	0.293	0.066
SLC38A5	SLC25A19	0.284	0.07
TECR	KDELR2	0.277	0.1
SLC1A5	KDELR2	0.249	0.154
SLC39A7	UQCC3	0.236	0.13
TAP1	CISD1	0.235	0.022
SLC39A7	SPNS1	0.233	0.036
HLA-DPA1	CISD1	0.229	0.1
SLC39A7	SLC38A5	0.229	0.078
TECR	HLA-B	0.227	0.136
SLC1A5	RHBDD2	0.214	0.076
TECR	RHBDD2	0.213	0.104
YME1L1	TAP1	0.212	0.054
SLC7A5	UQCC3	0.211	0.014
UQCC3	HLA-B	0.199	0.038
TAP1	UQCC3	0.198	0.048
SLC7A11	TAP1	0.197	0.144
YME1L1	HLA-B	0.195	0.086
TAP1	NDUFA11	0.182	0.048
TECR	SPNS1	0.18	0.05
VKORC1	HLA-B	0.177
TAP1	HLA-B	0.173	0.53
KDELR2	HLA-B	0.17	0.068
SLC39A7	NDUFA11	0.156	0.05
SLC39A7	SLC25A19	0.142	0.06
SLC38A5	NDUFA11	0.142	0.012
SLC1A5	UQCC3	0.137	0.034
SLC38A5	CISD1	0.13	0.044
YME1L1	SPNS1	0.129	0.012
YME1L1	VKORC1	0.126
SLC38A5	UQCC3	0.112	0.032
SLC39A7	KDELR2	0.108	0.372
VKORC1	RHBDD2	0.098
SLC7A11	VKORC1	0.098
SLC39A7	CISD1	0.094	0.05
SLC7A11	SLC39A7	0.089	0.038
SPNS1	VKORC1	0.081
SLC25A19	VKORC1	0.077
SLC7A11	SLC38A5	0.072	0.08
SLC1A5	SPNS1	0.07	0.028
VKORC1	KDELR2	0.066
HLA-DPA1	SLC39A7	0.06	0.06
HLA-DPA1	SLC1A5	0.059	0.218
SLC1A5	FAR1	0.056	0.138
SLC39A7	RHBDD2	0.049	0.11
VKORC1	CISD1	0.048
TAP1	KDELR2	0.041	0.18
MICOS13	VKORC1	0.038
YME1L1	RHBDD2	0.038	0.048
VKORC1	UQCC3	0.034
FAR1	VKORC1	0.028
HLA-DPA1	NDUFA11	0.025	0.126
TECR	VKORC1	0.024
HLA-DPA1	UQCC3	0.022	0.092
SLC25A6	TAP1	0.021	0.174
VKORC1	NDUFA11	0.018
HLA-DPA1	SLC38A5	0.013	0.1
SLC25A6	SLC39A7	0.012	0.098
SLC25A6	VKORC1	0.006

Related Complexes

Genename	Complexes
YME1L1	huMAP3_02214.1 huMAP3_08448.1 huMAP3_09904.1 huMAP3_15030.1
SLC25A19	huMAP3_05784.1 huMAP3_09904.1
TECR	huMAP3_03316.1 huMAP3_05784.1 huMAP3_07977.1 huMAP3_09691.1 huMAP3_09904.1 huMAP3_10473.1
SLC35E1	huMAP3_00678.1 huMAP3_05784.1 huMAP3_07365.1 huMAP3_08448.1 huMAP3_09904.1
SPNS1	huMAP3_05784.1 huMAP3_06999.1 huMAP3_09904.1
SLC7A11	huMAP3_00678.1 huMAP3_05784.1 huMAP3_07365.1 huMAP3_08448.1 huMAP3_09904.1
SLC1A5	huMAP3_03286.1 huMAP3_07245.1 huMAP3_09890.1 huMAP3_09904.1 huMAP3_10473.1
HLA-DPA1	huMAP3_00587.1 huMAP3_05974.1 huMAP3_06650.1 huMAP3_08884.1 huMAP3_09904.1 huMAP3_13699.1
SLC38A5	huMAP3_01649.1 huMAP3_02027.1 huMAP3_05783.1 huMAP3_05784.1 huMAP3_05797.1 huMAP3_08448.1 huMAP3_09904.1 huMAP3_10245.1 huMAP3_10473.1
HLA-B	huMAP3_09904.1
TAP1	huMAP3_05784.1 huMAP3_07254.1 huMAP3_09904.1
SLC39A7	huMAP3_00678.1 huMAP3_03704.1 huMAP3_05784.1 huMAP3_05797.1 huMAP3_07977.1 huMAP3_08448.1 huMAP3_09691.1 huMAP3_09904.1 huMAP3_10473.1 huMAP3_11421.1
MICOS13	huMAP3_05673.1 huMAP3_05784.1 huMAP3_09904.1
UQCC3	huMAP3_06206.1 huMAP3_09904.1
FAR1	huMAP3_05784.1 huMAP3_08448.1 huMAP3_09904.1
SLC25A6	huMAP3_00009.1 huMAP3_06760.1 huMAP3_09904.1 huMAP3_10256.1
VKORC1	huMAP3_05784.1 huMAP3_06124.1 huMAP3_07810.1 huMAP3_08403.1 huMAP3_09822.1 huMAP3_09904.1 huMAP3_10725.1
KDELR2	huMAP3_07365.1 huMAP3_08448.1 huMAP3_09904.1
NDUFA11	huMAP3_06885.1 huMAP3_07365.1 huMAP3_08448.1 huMAP3_09904.1
SLC7A5	huMAP3_02620.1 huMAP3_07568.1 huMAP3_07977.1 huMAP3_09691.1 huMAP3_09904.1 huMAP3_10473.1 huMAP3_10607.1
RHBDD2	huMAP3_08448.1 huMAP3_09904.1
CISD1	huMAP3_05784.1 huMAP3_05986.1 huMAP3_08318.1 huMAP3_09904.1 huMAP3_13301.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_09904.1