hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09909.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ORC2 | Origin recognition complex subunit 2 | 5 | UniProt NCBI |
| CARTPT | Cocaine- and amphetamine-regulated transcript protein [Cleaved into: CART(1-39); CART(42-89)] | 5 | UniProt NCBI |
| LRWD1 | Leucine-rich repeat and WD repeat-containing protein 1 (Centromere protein 33) (CENP-33) (Origin recognition complex-associated protein) (ORC-associated protein) (ORCA) | 5 | UniProt NCBI |
| ORC5 | Origin recognition complex subunit 5 | 5 | UniProt NCBI |
| ORC3 | Origin recognition complex subunit 3 (Origin recognition complex subunit Latheo) | 5 | UniProt NCBI |
| ALKBH4 | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 (Alkylated DNA repair protein alkB homolog 4) (DNA N6-methyl adenine demethylase ALKBH4) (EC 1.14.11.51) (Lysine-specific demethylase ALKBH4) (EC 1.14.11.-) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1034 | 1.87066161015e-08 | 0.5 | ORC3 ORC2 ORC5 | ORC 2-5 complex (origin recognition 2-5 complex) |
| GO:0000808 | 2.76161616937e-08 | 0.666666666667 | ORC5 ORC3 ORC2 LRWD1 | origin recognition complex |
| GO:0005664 | 2.76161616937e-08 | 0.666666666667 | ORC5 ORC3 ORC2 LRWD1 | nuclear origin of replication recognition complex |
| CORUM:1038 | 4.675933868e-08 | 0.5 | ORC3 ORC2 ORC5 | ORC 1-5 complex (origin recognition 1-5 complex) |
| CORUM:1033 | 9.35042757897e-08 | 0.5 | ORC3 ORC2 ORC5 | ORC complex (origin recognition complex) |
| CORUM:1031 | 9.35042757897e-08 | 0.5 | ORC3 ORC2 ORC5 | ORC complex (origin recognition complex) |
| CORUM:389 | 9.35042757897e-08 | 0.5 | ORC3 ORC2 ORC5 | ORC complex (origin recognition complex) |
| REAC:R-HSA-68689 | 3.95483747683e-07 | 0.5 | ORC3 ORC2 ORC5 | CDC6 association with the ORC:origin complex |
| REAC:R-HSA-113507 | 5.93134254527e-07 | 0.5 | ORC3 ORC2 ORC5 | E2F-enabled inhibition of pre-replication complex formation |
| REAC:R-HSA-113510 | 1.08523688914e-05 | 0.5 | ORC3 ORC2 ORC5 | E2F mediated regulation of DNA replication |
| GO:0006270 | 1.41495482392e-05 | 0.666666666667 | ORC5 ORC3 ORC2 LRWD1 | DNA replication initiation |
| WP:WP466 | 3.14733202476e-05 | 0.5 | ORC3 ORC2 ORC5 | DNA replication |
| REAC:R-HSA-68962 | 3.83832488858e-05 | 0.5 | ORC3 ORC2 ORC5 | Activation of the pre-replicative complex |
| REAC:R-HSA-176187 | 5.02070457715e-05 | 0.5 | ORC3 ORC2 ORC5 | Activation of ATR in response to replication stress |
| CORUM:1032 | 5.12534978153e-05 | 0.333333333333 | ORC2 ORC3 | ORC 2-4 complex (origin recognition 2-4 complex) |
| CORUM:5251 | 0.000102488289015 | 0.333333333333 | ORC2 ORC3 | Ku-ORC complex |
| WP:WP45 | 0.000113837945426 | 0.5 | ORC3 ORC2 ORC5 | G1 to S cell cycle control |
| REAC:R-HSA-68616 | 0.000205084871777 | 0.5 | ORC3 ORC2 ORC5 | Assembly of the ORC complex at the origin of replication |
| REAC:R-HSA-68949 | 0.00038290615081 | 0.5 | ORC3 ORC2 ORC5 | Orc1 removal from chromatin |
| GO:0003688 | 0.00042234232358 | 0.5 | ORC3 ORC2 ORC5 | DNA replication origin binding |
| WP:WP179 | 0.000686980450846 | 0.5 | ORC3 ORC2 ORC5 | Cell cycle |
| REAC:R-HSA-69052 | 0.000819236589251 | 0.5 | ORC3 ORC2 ORC5 | Switching of origins to a post-replicative state |
| KEGG:04110 | 0.00109405575855 | 0.5 | ORC3 ORC2 ORC5 | Cell cycle |
| REAC:R-HSA-69239 | 0.00190090644588 | 0.5 | ORC3 ORC2 ORC5 | Synthesis of DNA |
| REAC:R-HSA-68867 | 0.00247941542207 | 0.5 | ORC3 ORC2 ORC5 | Assembly of the pre-replicative complex |
| REAC:R-HSA-69206 | 0.00247941542207 | 0.5 | ORC3 ORC2 ORC5 | G1/S Transition |
| REAC:R-HSA-69002 | 0.00358509487789 | 0.5 | ORC3 ORC2 ORC5 | DNA Replication Pre-Initiation |
| REAC:R-HSA-453279 | 0.00358509487789 | 0.5 | ORC3 ORC2 ORC5 | Mitotic G1 phase and G1/S transition |
| REAC:R-HSA-69481 | 0.00453532495717 | 0.5 | ORC3 ORC2 ORC5 | G2/M Checkpoints |
| REAC:R-HSA-69242 | 0.00453532495717 | 0.5 | ORC3 ORC2 ORC5 | S Phase |
| REAC:R-HSA-69306 | 0.0059397455674 | 0.5 | ORC3 ORC2 ORC5 | DNA Replication |
| GO:0006261 | 0.00613403369529 | 0.666666666667 | ORC5 ORC3 ORC2 LRWD1 | DNA-templated DNA replication |
| GO:0000781 | 0.00686543980196 | 0.666666666667 | ORC5 ORC3 ORC2 LRWD1 | chromosome, telomeric region |
| GO:0000228 | 0.0139633778176 | 0.666666666667 | ORC5 ORC3 ORC2 LRWD1 | nuclear chromosome |
| REAC:R-HSA-69620 | 0.0242482438447 | 0.5 | ORC3 ORC2 ORC5 | Cell Cycle Checkpoints |
| GO:0006260 | 0.0333826648412 | 0.666666666667 | ORC5 ORC3 ORC2 LRWD1 | DNA replication |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ORC2 | LRWD1 | 1.0 | 0.22 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () Malo gupta_WMM fraction |
| ALKBH4 | ORC3 | 0.999 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ALKBH4 | ORC2 | 0.999 | 0.02 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| ORC2 | ORC3 | 0.995 | bioplex_WMM bioplex3_WMM youn_WMM Malo gupta_WMM fraction | |
| ORC2 | ORC5 | 0.994 | 0.456 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| ALKBH4 | LRWD1 | 0.991 | 0.076 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| LRWD1 | ORC5 | 0.991 | 0.672 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| ORC2 | CARTPT | 0.958 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ORC3 | CARTPT | 0.95 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| LRWD1 | ORC3 | 0.858 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| LRWD1 | CARTPT | 0.755 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ORC3 | ORC5 | 0.692 | youn_WMM gupta_WMM fraction treiber_WMM |
Related Complexes