hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_09914.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| USP14 | Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.4.19.12) (Deubiquitinating enzyme 14) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14) | 5 | UniProt NCBI |
| PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3) | 5 | UniProt NCBI |
| GMPS | GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) (GMP synthetase) (Glutamine amidotransferase) | 5 | UniProt NCBI |
| BLVRB | Flavin reductase (NADPH) (FR) (EC 1.5.1.30) (Biliverdin reductase B) (BVR-B) (EC 1.3.1.24) (Biliverdin-IX beta-reductase) (Green heme-binding protein) (GHBP) (NADPH-dependent diaphorase) (NADPH-flavin reductase) (FLR) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:3183 | 0.0249718442456 | 0.333333333333 | PTPN11 | PDGFRA-SHP-2 complex, PDGF stimulated |
| REAC:R-HSA-166166 | 0.0290482612381 | 0.666666666667 | USP14 PTPN11 | MyD88-independent TLR4 cascade |
| REAC:R-HSA-937061 | 0.0290482612381 | 0.666666666667 | USP14 PTPN11 | TRIF(TICAM1)-mediated TLR4 signaling |
| WP:WP2253 | 0.0496447587094 | 0.333333333333 | PTPN11 | Pilocytic astrocytoma |
| CORUM:3186 | 0.0499402709677 | 0.333333333333 | PTPN11 | GRB2-SHP-2 complex, PDGF stimulated |
| CORUM:7441 | 0.0499402709677 | 0.333333333333 | PTPN11 | HOOK1-SHP2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PTPN11 | BLVRB | 0.989 | 0.074 | bioplex_WMM bioplex3_WMM fraction |
| PTPN11 | GMPS | 0.986 | 0.174 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction |
| USP14 | BLVRB | 0.957 | 0.068 | bioplex_WMM bioplex3_WMM WMM_only |
| GMPS | BLVRB | 0.953 | 0.012 | bioplex_WMM bioplex3_WMM fraction |
| PTPN11 | USP14 | 0.933 | 0.33 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction |
| GMPS | USP14 | 0.706 | 0.268 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction treiber_WMM |
Related Complexes