hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_09916.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GABARAPL1 | Gamma-aminobutyric acid receptor-associated protein-like 1 (Early estrogen-regulated protein) (GABA(A) receptor-associated protein-like 1) (Glandular epithelial cell protein 1) (GEC-1) | 5 | UniProt NCBI |
| MAP1LC3B2 | Microtubule-associated proteins 1A/1B light chain 3 beta 2 (Microtubule-associated proteins 1A/1B light chain 3B-like) | 4 | UniProt NCBI |
| ATG3 | Ubiquitin-like-conjugating enzyme ATG3 (EC 2.3.2.-) (Autophagy-related protein 3) (APG3-like) (hApg3) (Protein PC3-96) | 5 | UniProt NCBI |
| GABARAPL2 | Gamma-aminobutyric acid receptor-associated protein-like 2 (GABA(A) receptor-associated protein-like 2) (Ganglioside expression factor 2) (GEF-2) (General protein transport factor p16) (Golgi-associated ATPase enhancer of 16 kDa) (GATE-16) (MAP1 light chain 3-related protein) | 5 | UniProt NCBI |
| GABARAP | Gamma-aminobutyric acid receptor-associated protein (GABA(A) receptor-associated protein) (MM46) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04136 | 3.49549082051e-09 | 0.8 | GABARAP ATG3 GABARAPL1 GABARAPL2 | Autophagy - other |
| KEGG:04140 | 6.3088166291e-09 | 1.0 | GABARAP MAP1LC3B2 GABARAPL2 GABARAPL1 ATG3 | Autophagy - animal |
| GO:0043562 | 9.20740386965e-09 | 0.8 | GABARAP MAP1LC3B2 GABARAPL1 GABARAPL2 | cellular response to nitrogen levels |
| GO:0006995 | 9.20740386965e-09 | 0.8 | GABARAP MAP1LC3B2 GABARAPL1 GABARAPL2 | cellular response to nitrogen starvation |
| GO:0000422 | 2.02936594367e-07 | 1.0 | GABARAP MAP1LC3B2 GABARAPL2 GABARAPL1 ATG3 | autophagy of mitochondrion |
| WP:WP5412 | 4.39047705433e-07 | 0.6 | GABARAPL2 GABARAPL1 GABARAP | 8q11 23 RB1CC1 copy number variation |
| KEGG:04137 | 4.59026184323e-07 | 0.8 | GABARAP MAP1LC3B2 GABARAPL1 GABARAPL2 | Mitophagy - animal |
| GO:0000045 | 5.50384964004e-07 | 1.0 | GABARAP MAP1LC3B2 GABARAPL2 GABARAPL1 ATG3 | autophagosome assembly |
| GO:1905037 | 6.77918257941e-07 | 1.0 | GABARAP MAP1LC3B2 GABARAPL2 GABARAPL1 ATG3 | autophagosome organization |
| KEGG:04621 | 2.3020533386e-06 | 0.8 | GABARAP MAP1LC3B2 GABARAPL1 GABARAPL2 | NOD-like receptor signaling pathway |
| REAC:R-HSA-1632852 | 4.24686934885e-06 | 0.8 | GABARAP ATG3 GABARAPL1 GABARAPL2 | Macroautophagy |
| GO:1903008 | 4.33118879937e-06 | 1.0 | GABARAP MAP1LC3B2 GABARAPL2 GABARAPL1 ATG3 | organelle disassembly |
| GO:0000421 | 5.37501604002e-06 | 0.8 | GABARAP MAP1LC3B2 GABARAPL1 GABARAPL2 | autophagosome membrane |
| REAC:R-HSA-9612973 | 6.68872511108e-06 | 0.8 | GABARAP ATG3 GABARAPL1 GABARAPL2 | Autophagy |
| GO:0007033 | 1.37870221294e-05 | 1.0 | GABARAP MAP1LC3B2 GABARAPL2 GABARAPL1 ATG3 | vacuole organization |
| KEGG:04727 | 4.44119474406e-05 | 0.6 | GABARAPL2 GABARAPL1 GABARAP | GABAergic synapse |
| GO:0016236 | 0.000109670539315 | 1.0 | GABARAP MAP1LC3B2 GABARAPL2 GABARAPL1 ATG3 | macroautophagy |
| GO:0050811 | 0.000115261178119 | 0.6 | GABARAPL2 GABARAPL1 GABARAP | GABA receptor binding |
| GO:0005776 | 0.000168126820122 | 0.8 | GABARAP MAP1LC3B2 GABARAPL1 GABARAPL2 | autophagosome |
| KEGG:04068 | 0.00021603679603 | 0.6 | GABARAPL2 GABARAPL1 GABARAP | FoxO signaling pathway |
| WP:WP5224 | 0.000224001431405 | 0.6 | GABARAPL2 GABARAPL1 GABARAP | 2q37 copy number variation syndrome |
| GO:0007005 | 0.000634690635486 | 1.0 | GABARAP MAP1LC3B2 GABARAPL2 GABARAPL1 ATG3 | mitochondrion organization |
| GO:0022411 | 0.000807544779987 | 1.0 | GABARAP MAP1LC3B2 GABARAPL2 GABARAPL1 ATG3 | cellular component disassembly |
| GO:0009267 | 0.00103813210542 | 0.8 | GABARAP MAP1LC3B2 GABARAPL1 GABARAPL2 | cellular response to starvation |
| GO:0061919 | 0.00130936938487 | 1.0 | GABARAP MAP1LC3B2 GABARAPL2 GABARAPL1 ATG3 | process utilizing autophagic mechanism |
| GO:0006914 | 0.00130936938487 | 1.0 | GABARAP MAP1LC3B2 GABARAPL2 GABARAPL1 ATG3 | autophagy |
| GO:0042594 | 0.00178074577644 | 0.8 | GABARAP MAP1LC3B2 GABARAPL1 GABARAPL2 | response to starvation |
| GO:0031669 | 0.0035170104576 | 0.8 | GABARAP MAP1LC3B2 GABARAPL1 GABARAPL2 | cellular response to nutrient levels |
| GO:0048487 | 0.00389166490199 | 0.6 | GABARAPL2 GABARAPL1 GABARAP | beta-tubulin binding |
| GO:0031668 | 0.00437843642246 | 0.8 | GABARAP MAP1LC3B2 GABARAPL1 GABARAPL2 | cellular response to extracellular stimulus |
| GO:0071496 | 0.00911621649963 | 0.8 | GABARAP MAP1LC3B2 GABARAPL1 GABARAPL2 | cellular response to external stimulus |
| REAC:R-HSA-8854214 | 0.0112072433688 | 0.4 | GABARAPL2 GABARAP | TBC/RABGAPs |
| GO:0031667 | 0.0121225590206 | 0.8 | GABARAP MAP1LC3B2 GABARAPL1 GABARAPL2 | response to nutrient levels |
| GO:0009991 | 0.0147584065712 | 0.8 | GABARAP MAP1LC3B2 GABARAPL1 GABARAPL2 | response to extracellular stimulus |
| GO:0070925 | 0.0156623135541 | 1.0 | GABARAP MAP1LC3B2 GABARAPL2 GABARAPL1 ATG3 | organelle assembly |
| GO:0031625 | 0.0202927466056 | 0.8 | GABARAP MAP1LC3B2 GABARAPL1 GABARAPL2 | ubiquitin protein ligase binding |
| GO:0044389 | 0.025656507175 | 0.8 | GABARAP MAP1LC3B2 GABARAPL1 GABARAPL2 | ubiquitin-like protein ligase binding |
| GO:0015631 | 0.0405744022835 | 0.8 | GABARAP MAP1LC3B2 GABARAPL1 GABARAPL2 | tubulin binding |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ATG3 | GABARAPL2 | 0.999 | 0.072 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| MAP1LC3B2 | ATG3 | 0.999 | 0.044 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ATG3 | GABARAP | 0.997 | 0.212 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| GABARAP | GABARAPL2 | 0.991 | 0.272 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| GABARAPL1 | GABARAP | 0.953 | 0.404 | bioplex_WMM bioplex3_WMM WMM_only |
| GABARAPL1 | GABARAPL2 | 0.949 | 0.25 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| MAP1LC3B2 | GABARAP | 0.907 | 0.212 | bioplex_WMM bioplex3_WMM WMM_only |
| MAP1LC3B2 | GABARAPL2 | 0.895 | 0.19 | bioplex_WMM bioplex3_WMM WMM_only |
| GABARAPL1 | ATG3 | 0.102 | 0.09 | bioplex3_WMM WMM_only |
| GABARAPL1 | MAP1LC3B2 | 0.078 | 0.132 | bioplex3_WMM WMM_only |
Related Complexes