hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09920.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ERCC4 | DNA repair endonuclease XPF (EC 3.1.-.-) (DNA excision repair protein ERCC-4) (DNA repair protein complementing XP-F cells) (Xeroderma pigmentosum group F-complementing protein) | 5 | UniProt NCBI |
| SLX4 | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | 5 | UniProt NCBI |
| ERCC1 | DNA excision repair protein ERCC-1 | 5 | UniProt NCBI |
| XPA | DNA repair protein complementing XP-A cells (Xeroderma pigmentosum group A-complementing protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:531 | 7.01606139244e-10 | 0.75 | ERCC4 XPA ERCC1 | XPA-ERCC1-ERCC4 complex |
| GO:0000109 | 8.68316823302e-09 | 1.0 | ERCC4 XPA SLX4 ERCC1 | nucleotide-excision repair complex |
| WP:WP5114 | 2.60358699721e-08 | 1.0 | ERCC4 XPA SLX4 ERCC1 | Nucleotide excision repair in xeroderma pigmentosum |
| GO:0000110 | 3.84480164306e-07 | 0.75 | ERCC4 XPA ERCC1 | nucleotide-excision repair factor 1 complex |
| GO:0070522 | 3.84480164306e-07 | 0.75 | ERCC4 SLX4 ERCC1 | ERCC4-ERCC1 complex |
| WP:WP4753 | 4.30466180211e-06 | 0.75 | ERCC4 XPA ERCC1 | Nucleotide excision repair |
| CORUM:2220 | 5.12628525639e-06 | 0.5 | ERCC4 ERCC1 | RAD52-ERCC4-ERCC1 complex |
| KEGG:03460 | 6.30976562692e-06 | 0.75 | ERCC4 SLX4 ERCC1 | Fanconi anemia pathway |
| REAC:R-HSA-6783310 | 9.16893973468e-06 | 0.75 | ERCC4 SLX4 ERCC1 | Fanconi Anemia Pathway |
| KEGG:03420 | 1.0562525866e-05 | 0.75 | ERCC4 XPA ERCC1 | Nucleotide excision repair |
| HP:0001034 | 1.12899840805e-05 | 1.0 | ERCC4 XPA SLX4 ERCC1 | Hypermelanotic macule |
| REAC:R-HSA-5696400 | 1.49290675587e-05 | 0.75 | ERCC4 XPA ERCC1 | Dual Incision in GG-NER |
| CORUM:7295 | 1.53774525569e-05 | 0.5 | ERCC1 XPA | ERCC1-RPA1-XPA complex |
| CORUM:368 | 1.53774525569e-05 | 0.5 | ERCC4 ERCC1 | ERCC1-ERCC4-MSH2 complex |
| REAC:R-HSA-5696395 | 1.60766305396e-05 | 0.75 | ERCC4 XPA ERCC1 | Formation of Incision Complex in GG-NER |
| HP:0007400 | 2.02622764428e-05 | 1.0 | ERCC4 XPA SLX4 ERCC1 | Irregular hyperpigmentation |
| HP:0012733 | 2.15152901964e-05 | 1.0 | ERCC4 XPA SLX4 ERCC1 | Macule |
| REAC:R-HSA-73894 | 3.4398535169e-05 | 1.0 | ERCC4 XPA SLX4 ERCC1 | DNA Repair |
| GO:0006289 | 3.75329946872e-05 | 1.0 | ERCC4 XPA SLX4 ERCC1 | nucleotide-excision repair |
| REAC:R-HSA-6782135 | 5.82803880398e-05 | 0.75 | ERCC4 XPA ERCC1 | Dual incision in TC-NER |
| HP:0000953 | 6.48509655457e-05 | 1.0 | ERCC4 XPA SLX4 ERCC1 | Hyperpigmentation of the skin |
| WP:WP4946 | 8.13748974369e-05 | 0.75 | ERCC4 XPA ERCC1 | DNA repair pathways full network |
| REAC:R-HSA-6781827 | 0.000102255107087 | 0.75 | ERCC4 XPA ERCC1 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| REAC:R-HSA-5696399 | 0.000128399139144 | 0.75 | ERCC4 XPA ERCC1 | Global Genome Nucleotide Excision Repair (GG-NER) |
| HP:0002860 | 0.000156171646941 | 0.75 | ERCC4 SLX4 XPA | Squamous cell carcinoma |
| HP:0000135 | 0.000206124714055 | 1.0 | ERCC4 XPA SLX4 ERCC1 | Hypogonadism |
| REAC:R-HSA-5696398 | 0.000284930280132 | 0.75 | ERCC4 XPA ERCC1 | Nucleotide Excision Repair |
| HP:0001000 | 0.000408067124687 | 1.0 | ERCC4 XPA SLX4 ERCC1 | Abnormality of skin pigmentation |
| REAC:R-HSA-5693567 | 0.000422025999557 | 0.75 | ERCC4 SLX4 ERCC1 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| REAC:R-HSA-5693538 | 0.000487256563506 | 0.75 | ERCC4 SLX4 ERCC1 | Homology Directed Repair |
| HP:0006313 | 0.000501460556964 | 0.5 | ERCC4 ERCC1 | Widely spaced primary teeth |
| HP:0000509 | 0.000535321766521 | 0.75 | ERCC4 XPA ERCC1 | Conjunctivitis |
| HP:0000992 | 0.000591213991336 | 0.75 | ERCC4 XPA ERCC1 | Cutaneous photosensitivity |
| HP:0025337 | 0.000610673070958 | 0.75 | ERCC4 XPA ERCC1 | Red eye |
| HP:0006334 | 0.000701980712879 | 0.5 | ERCC4 ERCC1 | Hypoplasia of the primary teeth |
| REAC:R-HSA-5693532 | 0.000897810107574 | 0.75 | ERCC4 SLX4 ERCC1 | DNA Double-Strand Break Repair |
| HP:0001053 | 0.000903644973001 | 0.75 | ERCC4 SLX4 XPA | Hypopigmented skin patches |
| HP:0010649 | 0.000935888865729 | 0.5 | ERCC4 XPA | Flat nasal alae |
| HP:0008373 | 0.0010573228748 | 1.0 | ERCC4 XPA SLX4 ERCC1 | Puberty and gonadal disorders |
| HP:0000502 | 0.00207834768342 | 0.75 | ERCC4 XPA ERCC1 | Abnormal conjunctiva morphology |
| HP:0000028 | 0.00240969460314 | 1.0 | ERCC4 XPA SLX4 ERCC1 | Cryptorchidism |
| HP:0000080 | 0.00254478578394 | 1.0 | ERCC4 XPA SLX4 ERCC1 | Abnormality of reproductive system physiology |
| GO:0032205 | 0.00274053853655 | 0.75 | ERCC4 SLX4 ERCC1 | negative regulation of telomere maintenance |
| GO:0061819 | 0.0028092043205 | 0.5 | ERCC4 ERCC1 | telomeric DNA-containing double minutes formation |
| GO:1901255 | 0.0028092043205 | 0.5 | ERCC4 XPA | nucleotide-excision repair involved in interstrand cross-link repair |
| GO:1905764 | 0.0028092043205 | 0.5 | ERCC4 ERCC1 | regulation of protection from non-homologous end joining at telomere |
| GO:1990599 | 0.0028092043205 | 0.5 | ERCC4 ERCC1 | 3' overhang single-stranded DNA endodeoxyribonuclease activity |
| GO:1905765 | 0.0028092043205 | 0.5 | ERCC4 ERCC1 | negative regulation of protection from non-homologous end joining at telomere |
| HP:0010468 | 0.00287311393068 | 0.75 | ERCC4 SLX4 XPA | Aplasia/Hypoplasia of the testes |
| HP:0009755 | 0.00303997345979 | 0.5 | ERCC4 XPA | Ankyloblepharon |
| HP:0000518 | 0.0030892166281 | 1.0 | ERCC4 XPA SLX4 ERCC1 | Cataract |
| HP:0000517 | 0.00342066212746 | 1.0 | ERCC4 XPA SLX4 ERCC1 | Abnormal lens morphology |
| HP:0000674 | 0.00350734148159 | 0.5 | ERCC4 ERCC1 | Anodontia |
| HP:0003079 | 0.00350734148159 | 0.5 | ERCC4 XPA | Defective DNA repair after ultraviolet radiation damage |
| HP:0045058 | 0.00371547168799 | 0.75 | ERCC4 SLX4 XPA | Abnormality of the testis size |
| HP:0011355 | 0.00398837215065 | 1.0 | ERCC4 XPA SLX4 ERCC1 | Localized skin lesion |
| HP:0000680 | 0.00400802433742 | 0.5 | ERCC4 ERCC1 | Delayed eruption of primary teeth |
| HP:0100533 | 0.00405200286793 | 0.75 | ERCC4 XPA ERCC1 | Inflammatory abnormality of the eye |
| HP:0008069 | 0.00448184961512 | 0.75 | ERCC4 SLX4 XPA | Neoplasm of the skin |
| HP:0006739 | 0.00454201288615 | 0.5 | ERCC4 XPA | Squamous cell carcinoma of the skin |
| HP:0002818 | 0.00463159007288 | 0.75 | ERCC4 SLX4 ERCC1 | Abnormal morphology of the radius |
| HP:0001010 | 0.0047076910508 | 0.75 | ERCC4 SLX4 XPA | Hypopigmentation of the skin |
| HP:0000025 | 0.00551487774639 | 0.75 | ERCC4 SLX4 ERCC1 | Functional abnormality of male internal genitalia |
| HP:0003254 | 0.0057098705025 | 0.5 | ERCC4 XPA | Abnormality of DNA repair |
| HP:0040072 | 0.00577380592851 | 0.75 | ERCC4 SLX4 ERCC1 | Abnormal forearm bone morphology |
| HP:0002973 | 0.0058618765749 | 0.75 | ERCC4 SLX4 ERCC1 | Abnormal forearm morphology |
| HP:0000035 | 0.00600242249098 | 1.0 | ERCC4 XPA SLX4 ERCC1 | Abnormal testis morphology |
| KEGG:01524 | 0.00601982850302 | 0.5 | ERCC1 XPA | Platinum drug resistance |
| REAC:R-HSA-5685938 | 0.006081926491 | 0.5 | ERCC4 ERCC1 | HDR through Single Strand Annealing (SSA) |
| HP:0000524 | 0.00634372129255 | 0.5 | ERCC4 XPA | Conjunctival telangiectasia |
| HP:0000621 | 0.00634372129255 | 0.5 | ERCC4 XPA | Entropion |
| HP:0001029 | 0.00701084122037 | 0.5 | ERCC4 XPA | Poikiloderma |
| HP:0005522 | 0.00771122114953 | 0.5 | ERCC4 SLX4 | Pyridoxine-responsive sideroblastic anemia |
| HP:0004493 | 0.00771122114953 | 0.5 | ERCC4 XPA | Craniofacial hyperostosis |
| HP:0002827 | 0.00803184965878 | 0.75 | ERCC4 SLX4 ERCC1 | Hip dislocation |
| GO:1904506 | 0.00842684400117 | 0.5 | ERCC4 ERCC1 | negative regulation of telomere maintenance in response to DNA damage |
| HP:0010469 | 0.00844485194452 | 0.5 | ERCC4 SLX4 | Absent testis |
| HP:0000613 | 0.00847621018071 | 0.75 | ERCC4 XPA ERCC1 | Photophobia |
| HP:0008054 | 0.0092117244708 | 0.5 | ERCC4 XPA | Abnormal morphology of the conjunctival vasculature |
| GO:0003684 | 0.0100599149475 | 0.75 | ERCC4 XPA ERCC1 | damaged DNA binding |
| HP:0012874 | 0.0108105839895 | 0.75 | ERCC4 SLX4 ERCC1 | Abnormal male reproductive system physiology |
| HP:0000568 | 0.0110785663677 | 0.75 | ERCC4 SLX4 ERCC1 | Microphthalmia |
| HP:0000032 | 0.0112948770693 | 1.0 | ERCC4 XPA SLX4 ERCC1 | Abnormal male external genitalia morphology |
| HP:0010293 | 0.0117117011059 | 0.5 | ERCC4 SLX4 | Aplasia/Hypoplasia of the uvula |
| HP:0012848 | 0.0117117011059 | 0.5 | ERCC4 SLX4 | Small intestinal stenosis |
| HP:0100867 | 0.0117117011059 | 0.5 | ERCC4 SLX4 | Duodenal stenosis |
| HP:0000486 | 0.0119162519121 | 1.0 | ERCC4 XPA SLX4 ERCC1 | Strabismus |
| HP:0002245 | 0.0126114492305 | 0.5 | ERCC4 SLX4 | Meckel diverticulum |
| HP:0005328 | 0.0126114492305 | 0.5 | ERCC4 ERCC1 | Progeroid facial appearance |
| HP:0100760 | 0.0126114492305 | 0.5 | ERCC4 SLX4 | Clubbing of toes |
| HP:5200058 | 0.0127795152806 | 0.75 | ERCC4 XPA ERCC1 | Sensory hypersensitivity |
| HP:0200007 | 0.0127795152806 | 0.75 | ERCC4 SLX4 ERCC1 | Abnormal size of the palpebral fissures |
| HP:0000811 | 0.013341386737 | 1.0 | ERCC4 XPA SLX4 ERCC1 | Abnormal external genitalia |
| HP:0010461 | 0.0133945396722 | 1.0 | ERCC4 XPA SLX4 ERCC1 | Abnormality of the male genitalia |
| HP:0000549 | 0.0136087412238 | 1.0 | ERCC4 XPA SLX4 ERCC1 | Abnormal conjugate eye movement |
| HP:0001367 | 0.0137168003098 | 1.0 | ERCC4 XPA SLX4 ERCC1 | Abnormal joint morphology |
| HP:0100587 | 0.0145105245688 | 0.5 | ERCC4 SLX4 | Abnormal preputium morphology |
| HP:5200046 | 0.0146454020002 | 0.75 | ERCC4 XPA ERCC1 | Sensory behavioral abnormality |
| HP:0100887 | 0.0153053110125 | 0.75 | ERCC4 SLX4 ERCC1 | Abnormality of globe size |
| HP:0030311 | 0.0153053110125 | 0.75 | ERCC4 SLX4 ERCC1 | Lower extremity joint dislocation |
| HP:0001924 | 0.0165423111708 | 0.5 | ERCC4 SLX4 | Sideroblastic anemia |
| HP:0000026 | 0.0165423111708 | 0.5 | ERCC4 ERCC1 | Male hypogonadism |
| HP:0031826 | 0.0165711549475 | 1.0 | ERCC4 XPA SLX4 ERCC1 | Abnormal reflex |
| GO:1904431 | 0.0168521501606 | 0.5 | ERCC1 SLX4 | positive regulation of t-circle formation |
| HP:0007700 | 0.0172211022813 | 0.75 | ERCC4 SLX4 ERCC1 | Ocular anterior segment dysgenesis |
| HP:0006887 | 0.0198386649826 | 0.5 | ERCC4 XPA | Intellectual disability, progressive |
| HP:0004328 | 0.0202092954763 | 1.0 | ERCC4 XPA SLX4 ERCC1 | Abnormal anterior eye segment morphology |
| HP:0000504 | 0.0208694367619 | 1.0 | ERCC4 XPA SLX4 ERCC1 | Abnormality of vision |
| HP:0001059 | 0.021003726131 | 0.5 | ERCC4 XPA | Pterygium |
| HP:0002120 | 0.0210996257365 | 0.75 | ERCC4 XPA ERCC1 | Cerebral cortical atrophy |
| HP:0100579 | 0.0222019103471 | 0.5 | ERCC4 XPA | Mucosal telangiectasiae |
| HP:0001549 | 0.0222019103471 | 0.5 | ERCC4 SLX4 | Abnormal ileum morphology |
| HP:0040012 | 0.0222019103471 | 0.5 | ERCC4 SLX4 | Chromosome breakage |
| HP:0000818 | 0.0230269631822 | 1.0 | ERCC4 XPA SLX4 ERCC1 | Abnormality of the endocrine system |
| HP:0011821 | 0.0242493726833 | 1.0 | ERCC4 XPA SLX4 ERCC1 | Abnormal facial skeleton morphology |
| HP:0000252 | 0.0246674560744 | 1.0 | ERCC4 XPA SLX4 ERCC1 | Microcephaly |
| HP:0000554 | 0.0246976114972 | 0.5 | ERCC4 ERCC1 | Uveitis |
| HP:0004437 | 0.0246976114972 | 0.5 | ERCC4 XPA | Cranial hyperostosis |
| HP:0008047 | 0.0250503832174 | 0.75 | ERCC4 XPA ERCC1 | Abnormality of the vasculature of the eye |
| HP:0000492 | 0.0250909224346 | 1.0 | ERCC4 XPA SLX4 ERCC1 | Abnormal eyelid morphology |
| HP:0001384 | 0.0255174052948 | 0.75 | ERCC4 SLX4 ERCC1 | Abnormal hip joint morphology |
| HP:0040195 | 0.025606252379 | 1.0 | ERCC4 XPA SLX4 ERCC1 | Decreased head circumference |
| HP:0012243 | 0.0257797800958 | 1.0 | ERCC4 XPA SLX4 ERCC1 | Abnormal reproductive system morphology |
| GO:0034644 | 0.0258660780327 | 0.75 | ERCC4 XPA ERCC1 | cellular response to UV |
| HP:0004322 | 0.0263940803883 | 1.0 | ERCC4 XPA SLX4 ERCC1 | Short stature |
| HP:0001480 | 0.0273256954732 | 0.5 | ERCC4 XPA | Freckling |
| HP:0001373 | 0.0289490607956 | 0.75 | ERCC4 SLX4 ERCC1 | Joint dislocation |
| HP:0100012 | 0.03008608933 | 0.5 | ERCC4 XPA | Neoplasm of the eye |
| HP:0005105 | 0.0305105137394 | 1.0 | ERCC4 XPA SLX4 ERCC1 | Abnormal nasal morphology |
| HP:0012740 | 0.0315158796726 | 0.5 | ERCC4 XPA | Papilloma |
| HP:0100774 | 0.0315158796726 | 0.5 | ERCC4 XPA | Hyperostosis |
| HP:0000813 | 0.0329787201379 | 0.5 | ERCC4 SLX4 | Bicornuate uterus |
| HP:0001172 | 0.0332300831153 | 0.75 | ERCC4 SLX4 ERCC1 | Abnormal thumb morphology |
| HP:0000498 | 0.034474601612 | 0.5 | ERCC4 XPA | Blepharitis |
| HP:0001760 | 0.0361997133303 | 1.0 | ERCC4 XPA SLX4 ERCC1 | Abnormal foot morphology |
| HP:0000002 | 0.0361997133303 | 1.0 | ERCC4 XPA SLX4 ERCC1 | Abnormality of body height |
| HP:0000365 | 0.0366506194199 | 1.0 | ERCC4 XPA SLX4 ERCC1 | Hearing impairment |
| HP:0007874 | 0.0375654511359 | 0.5 | ERCC4 SLX4 | Almond-shaped palpebral fissure |
| HP:0100026 | 0.0391604009626 | 0.5 | ERCC4 SLX4 | Arteriovenous malformation |
| HP:0000364 | 0.0392063646668 | 1.0 | ERCC4 XPA SLX4 ERCC1 | Hearing abnormality |
| HP:0004325 | 0.0404112373209 | 1.0 | ERCC4 XPA SLX4 ERCC1 | Decreased body weight |
| GO:2001251 | 0.0405772675542 | 0.75 | ERCC4 SLX4 ERCC1 | negative regulation of chromosome organization |
| HP:0003022 | 0.0424493051949 | 0.5 | ERCC4 SLX4 | Hypoplasia of the ulna |
| HP:0040070 | 0.0426776059203 | 0.75 | ERCC4 SLX4 ERCC1 | Abnormal upper limb bone morphology |
| HP:0030669 | 0.0434161697441 | 1.0 | ERCC4 XPA SLX4 ERCC1 | Abnormal ocular adnexa morphology |
| HP:0003220 | 0.0441432413831 | 0.5 | ERCC4 SLX4 | Abnormality of chromosome stability |
| GO:0071482 | 0.0449670283878 | 0.75 | ERCC4 XPA ERCC1 | cellular response to light stimulus |
| HP:0032039 | 0.0453774391785 | 1.0 | ERCC4 XPA SLX4 ERCC1 | Abnormality of the ocular adnexa |
| HP:0200005 | 0.0458701548093 | 0.5 | ERCC4 SLX4 | Abnormal shape of the palpebral fissure |
| HP:0009777 | 0.0458701548093 | 0.5 | ERCC4 SLX4 | Absent thumb |
| HP:0031704 | 0.0464502255589 | 1.0 | ERCC4 XPA SLX4 ERCC1 | Abnormal ear physiology |
| HP:0007364 | 0.0483732370923 | 1.0 | ERCC4 XPA SLX4 ERCC1 | Aplasia/Hypoplasia of the cerebrum |
| HP:0000315 | 0.0485128423941 | 1.0 | ERCC4 XPA SLX4 ERCC1 | Abnormality of the orbital region |
| HP:0006495 | 0.049422876951 | 0.5 | ERCC4 SLX4 | Aplasia/Hypoplasia of the ulna |
| HP:0008056 | 0.0499940694024 | 0.75 | ERCC4 SLX4 ERCC1 | Aplasia/Hypoplasia affecting the eye |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ERCC4 | ERCC1 | 0.999 | 0.24 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM Malo fraction |
| ERCC4 | XPA | 0.994 | 0.158 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| ERCC1 | XPA | 0.991 | 0.2 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| ERCC4 | SLX4 | 0.968 | 0.166 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| SLX4 | ERCC1 | 0.682 | 0.184 | bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes