hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09927.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LRRC8A | Volume-regulated anion channel subunit LRRC8A (Leucine-rich repeat-containing protein 8A) (HsLRRC8A) (Swelling protein 1) | 5 | UniProt NCBI |
| NPEPPS | Puromycin-sensitive aminopeptidase (PSA) (EC 3.4.11.14) (Cytosol alanyl aminopeptidase) (AAP-S) | 5 | UniProt NCBI |
| TMEM179B | Transmembrane protein 179B | 5 | UniProt NCBI |
| LRRC8C | Volume-regulated anion channel subunit LRRC8C (Factor for adipocyte differentiation 158) (Leucine-rich repeat-containing protein 8C) | 5 | UniProt NCBI |
| LRRC8B | Volume-regulated anion channel subunit LRRC8B (Leucine-rich repeat-containing protein 8B) (T-cell activation leucine repeat-rich protein) (TA-LRRP) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6567 | 2.80175822576e-08 | 0.6 | LRRC8C LRRC8A LRRC8B | SWELL1-containing complex |
| REAC:R-HSA-5223345 | 3.55148388129e-06 | 0.6 | LRRC8C LRRC8A LRRC8B | Miscellaneous transport and binding events |
| CORUM:6581 | 1.36501667663e-05 | 0.4 | LRRC8C LRRC8A | LRRC8A-LRRC8C complex |
| GO:0005225 | 8.06911104389e-05 | 0.6 | LRRC8C LRRC8A LRRC8B | volume-sensitive anion channel activity |
| WP:WP5083 | 0.000264889191211 | 0.6 | LRRC8C LRRC8A LRRC8B | Neuroinflammation and glutamatergic signaling |
| GO:0098656 | 0.0135806930791 | 0.6 | LRRC8C LRRC8A LRRC8B | monoatomic anion transmembrane transport |
| GO:0005253 | 0.0264997162634 | 0.6 | LRRC8C LRRC8A LRRC8B | monoatomic anion channel activity |
| GO:0140361 | 0.0280843539964 | 0.4 | LRRC8C LRRC8A | cyclic-GMP-AMP transmembrane import across plasma membrane |
| GO:1903790 | 0.0280843539964 | 0.4 | LRRC8C LRRC8A | guanine nucleotide transmembrane transport |
| GO:0001408 | 0.0468008499735 | 0.4 | LRRC8C LRRC8A | guanine nucleotide transport |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| LRRC8A | LRRC8B | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| LRRC8C | LRRC8B | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NPEPPS | LRRC8B | 0.983 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NPEPPS | LRRC8A | 0.98 | 0.06 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| LRRC8B | TMEM179B | 0.978 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NPEPPS | LRRC8C | 0.855 | 0.03 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| LRRC8A | LRRC8C | 0.609 | 0.118 | bioplex_WMM bioplex3_WMM WMM_only |
| LRRC8A | TMEM179B | 0.405 | 0.142 | bioplex_WMM bioplex3_WMM WMM_only |
| LRRC8C | TMEM179B | 0.107 | 0.046 | bioplex_WMM bioplex3_WMM WMM_only |
| NPEPPS | TMEM179B | 0.02 | 0.118 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes