hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09928.1
Complex Portal: CPX-13671
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ADGRG6 | Adhesion G-protein coupled receptor G6 (Developmentally regulated G-protein-coupled receptor) (G-protein coupled receptor 126) (Vascular inducible G protein-coupled receptor) [Cleaved into: ADGRG6 N-terminal fragment (ADGRG6-NTF); ADGRG6 C-terminal fragment (ADGRG6-CTF)] | 5 | UniProt NCBI |
| CLU | Clusterin (Aging-associated gene 4 protein) (Apolipoprotein J) (Apo-J) (Complement cytolysis inhibitor) (CLI) (Complement-associated protein SP-40,40) (Ku70-binding protein 1) (NA1/NA2) (Sulfated glycoprotein 2) (SGP-2) (Testosterone-repressed prostate message 2) (TRPM-2) [Cleaved into: Clusterin beta chain (ApoJalpha) (Complement cytolysis inhibitor a chain) (SP-40,40 beta-chain); Clusterin alpha chain (ApoJbeta) (Complement cytolysis inhibitor b chain) (SP-40,40 alpha-chain)] | 5 | UniProt NCBI |
| LMAN1 | Protein ERGIC-53 (ER-Golgi intermediate compartment 53 kDa protein) (Gp58) (Intracellular mannose-specific lectin MR60) (Lectin mannose-binding 1) | 5 | UniProt NCBI |
| GPAM | Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAT-1) (EC 2.3.1.15) | 5 | UniProt NCBI |
| MCFD2 | Multiple coagulation factor deficiency protein 2 (Neural stem cell-derived neuronal survival protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0030976 | 0.000100319571443 | 0.5 | LMAN1 MCFD2 | Abnormal factor VIII activity |
| HP:0003125 | 0.000100319571443 | 0.5 | LMAN1 MCFD2 | Reduced factor VIII activity |
| HP:0003225 | 0.000200620835246 | 0.5 | LMAN1 MCFD2 | Reduced coagulation factor V activity |
| HP:0011889 | 0.000200620835246 | 0.5 | LMAN1 MCFD2 | Bleeding with minor or no trauma |
| HP:0031899 | 0.000334337547576 | 0.5 | LMAN1 MCFD2 | Abnormal coagulation factor V activity |
| HP:0004846 | 0.00120317586686 | 0.5 | LMAN1 MCFD2 | Prolonged bleeding after surgery |
| HP:0030137 | 0.00120317586686 | 0.5 | LMAN1 MCFD2 | Prolonged bleeding following circumcision |
| HP:0005261 | 0.00220521848756 | 0.5 | LMAN1 MCFD2 | Joint hemorrhage |
| HP:0006298 | 0.00350734148159 | 0.5 | LMAN1 MCFD2 | Prolonged bleeding after dental extraction |
| REAC:R-HSA-5694530 | 0.00359044851421 | 0.5 | LMAN1 MCFD2 | Cargo concentration in the ER |
| HP:0000132 | 0.00701084122037 | 0.5 | LMAN1 MCFD2 | Menorrhagia |
| HP:0011890 | 0.00844485194452 | 0.5 | LMAN1 MCFD2 | Prolonged bleeding following procedure |
| HP:0002149 | 0.0092117244708 | 0.5 | LMAN1 MCFD2 | Hyperuricemia |
| HP:0003645 | 0.0145105245688 | 0.5 | LMAN1 MCFD2 | Prolonged partial thromboplastin time |
| HP:0010989 | 0.0155098335254 | 0.5 | LMAN1 MCFD2 | Abnormality of the intrinsic pathway |
| REAC:R-HSA-204005 | 0.0186613511621 | 0.5 | LMAN1 MCFD2 | COPII-mediated vesicle transport |
| HP:0008151 | 0.028689358225 | 0.5 | LMAN1 MCFD2 | Prolonged prothrombin time |
| HP:0010932 | 0.028689358225 | 0.5 | LMAN1 MCFD2 | Abnormal circulating nucleobase concentration |
| HP:0032199 | 0.0315158796726 | 0.5 | LMAN1 MCFD2 | Abnormal prothrombin time |
| HP:0012200 | 0.034474601612 | 0.5 | LMAN1 MCFD2 | Abnormality of prothrombin |
| HP:0000225 | 0.034474601612 | 0.5 | LMAN1 MCFD2 | Gingival bleeding |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| LMAN1 | MCFD2 | 0.991 | 0.254 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| GPAM | CLU | 0.988 | 0.228319327731 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| CLU | ADGRG6 | 0.96 | 0.138 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| LMAN1 | CLU | 0.951 | 0.036 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MCFD2 | CLU | 0.826 | 0.07 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| LMAN1 | ADGRG6 | 0.081 | 0.144 | bioplex3_WMM WMM_only | |
| MCFD2 | ADGRG6 | 0.009 | 0.078 | bioplex3_WMM WMM_only |
Related Complexes