hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09936.1
Complex Portal: CPX-16027
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MCM3AP | Germinal-center associated nuclear protein (GANP) (EC 2.3.1.48) (80 kDa MCM3-associated protein) (MCM3 acetylating protein) (MCM3AP) (EC 2.3.1.-) (MCM3 acetyltransferase) | 5 | UniProt NCBI |
| TRPM6 | Transient receptor potential cation channel subfamily M member 6 (EC 2.7.11.1) (Channel kinase 2) (Melastatin-related TRP cation channel 6) | 5 | UniProt NCBI |
| FLCN | Folliculin (BHD skin lesion fibrofolliculoma protein) (Birt-Hogg-Dube syndrome protein) | 5 | UniProt NCBI |
| WDFY3 | WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0001256 | 0.0210996257365 | 0.75 | FLCN MCM3AP WDFY3 | Intellectual disability, mild |
| CORUM:558 | 0.049938562206 | 0.25 | TRPM6 | Channel complex TRPM6-TRPM7 |
| CORUM:7430 | 0.049938562206 | 0.25 | FLCN | FLCN-FNIP2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TRPM6 | WDFY3 | 0.977 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| MCM3AP | WDFY3 | 0.958 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| WDFY3 | FLCN | 0.952 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| TRPM6 | FLCN | 0.303 | bioplex_WMM bioplex3_WMM WMM_only | ||
| MCM3AP | TRPM6 | 0.166 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | ||
| MCM3AP | FLCN | 0.013 | 0.046 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes