hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_09938.1

Complex Portal: CPX-23582

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
HLA-DRB5	HLA class II histocompatibility antigen, DR beta 5 chain (DR beta-5) (DR2-beta-2) (Dw2) (MHC class II antigen DRB5)	5	UniProt NCBI
HLA-DRB3	HLA class II histocompatibility antigen, DR beta 3 chain (MHC class II antigen DRB3)	5	UniProt NCBI
GLCE	D-glucuronyl C5-epimerase (EC 5.1.3.17) (Heparan sulfate C5-epimerase) (Hsepi) (Heparin/heparan sulfate:glucuronic acid C5-epimerase) (Heparosan-N-sulfate-glucuronate 5-epimerase)	5	UniProt NCBI
HLA-DPB1	HLA class II histocompatibility antigen, DP beta 1 chain (HLA class II histocompatibility antigen, DP(W4) beta chain) (MHC class II antigen DPB1)	5	UniProt NCBI
MPZL2	Myelin protein zero-like protein 2 (Epithelial V-like antigen 1)	5	UniProt NCBI
HLA-DRB1	HLA class II histocompatibility antigen, DRB1 beta chain (Human leukocyte antigen DRB1) (HLA-DRB1)	5	UniProt NCBI
CHST9	Carbohydrate sulfotransferase 9 (EC 2.8.2.-) (GalNAc-4-O-sulfotransferase 2) (GalNAc-4-ST2) (GalNAc4ST-2) (N-acetylgalactosamine-4-O-sulfotransferase 2)	5	UniProt NCBI
GABRQ	Gamma-aminobutyric acid receptor subunit theta (GABA(A) receptor subunit theta)	5	UniProt NCBI
HLA-DRA	HLA class II histocompatibility antigen, DR alpha chain (MHC class II antigen DRA)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:05310	4.3279366739e-09	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	Asthma
REAC:R-HSA-202430	5.59299191682e-09	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	Translocation of ZAP-70 to Immunological synapse
REAC:R-HSA-202427	1.86009193219e-08	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	Phosphorylation of CD3 and TCR zeta chains
REAC:R-HSA-389948	2.39102266359e-08	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	PD-1 signaling
KEGG:05330	3.18441013397e-08	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	Allograft rejection
KEGG:04672	3.71433059364e-08	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	Intestinal immune network for IgA production
KEGG:05332	5.70425142036e-08	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	Graft-versus-host disease
REAC:R-HSA-202433	8.29203003935e-08	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	Generation of second messenger molecules
KEGG:04940	9.48395608948e-08	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	Type I diabetes mellitus
KEGG:05320	1.65353041647e-07	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	Autoimmune thyroid disease
KEGG:05321	2.23140281561e-07	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	Inflammatory bowel disease
GO:0002503	3.86287613381e-07	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	peptide antigen assembly with MHC class II protein complex
GO:0002399	3.86287613381e-07	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	MHC class II protein complex assembly
KEGG:05150	4.51056884427e-07	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	Staphylococcus aureus infection
KEGG:05416	5.7044125919e-07	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	Viral myocarditis
GO:0042613	6.06890408176e-07	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	MHC class II protein complex
KEGG:04640	8.20037755687e-07	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	Hematopoietic cell lineage
KEGG:04612	9.39855940874e-07	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	Antigen processing and presentation
KEGG:05140	1.00445295319e-06	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	Leishmaniasis
GO:0002396	1.31435310045e-06	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	MHC protein complex assembly
GO:0002501	1.31435310045e-06	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	peptide antigen assembly with MHC protein complex
KEGG:05323	1.46444613894e-06	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	Rheumatoid arthritis
KEGG:04658	2.06635644055e-06	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	Th1 and Th2 cell differentiation
WP:WP2328	2.5408597542e-06	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	Allograft rejection
REAC:R-HSA-388841	3.06023336472e-06	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	Costimulation by the CD28 family
GO:0042611	3.34342729474e-06	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	MHC protein complex
KEGG:04659	4.57263525804e-06	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	Th17 cell differentiation
KEGG:05145	4.78181952093e-06	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	Toxoplasmosis
WP:WP4884	5.48226461236e-06	0.375	HLA-DRA HLA-DRB5 HLA-DRB1	Pathogenesis of SARS CoV 2 mediated by nsp9 nsp10 complex
KEGG:04514	8.20326109462e-06	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	Cell adhesion molecules
GO:0023026	8.89269760433e-06	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	MHC class II protein complex binding
KEGG:05322	9.55244968269e-06	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	Systemic lupus erythematosus
REAC:R-HSA-877300	9.89810058296e-06	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	Interferon gamma signaling
GO:0019886	1.09826893156e-05	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0098553	1.34203446702e-05	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	lumenal side of endoplasmic reticulum membrane
REAC:R-HSA-202424	1.87832841835e-05	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	Downstream TCR signaling
GO:0002495	1.94862705925e-05	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	antigen processing and presentation of peptide antigen via MHC class II
KEGG:04145	2.14237071886e-05	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	Phagosome
GO:0042605	2.31928556576e-05	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	peptide antigen binding
GO:0002504	2.31928556576e-05	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
WP:WP4217	2.3481565781e-05	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	Ebola virus infection in host
KEGG:05164	3.03789993158e-05	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	Influenza A
KEGG:05152	3.21066744491e-05	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	Tuberculosis
GO:0023023	3.21625423531e-05	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	MHC protein complex binding
GO:0002478	3.21625423531e-05	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	antigen processing and presentation of exogenous peptide antigen
REAC:R-HSA-202403	3.80734728157e-05	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	TCR signaling
GO:0098576	5.0190017663e-05	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	lumenal side of membrane
REAC:R-HSA-2132295	5.66828303964e-05	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	MHC class II antigen presentation
GO:0019884	5.76129393456e-05	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	antigen processing and presentation of exogenous antigen
KEGG:05169	7.4205437503e-05	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	Epstein-Barr virus infection
KEGG:05166	0.000108545420387	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	Human T-cell leukemia virus 1 infection
REAC:R-HSA-913531	0.00028497836115	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	Interferon Signaling
GO:0003823	0.000297812763465	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	antigen binding
GO:0012507	0.000354952818129	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	ER to Golgi transport vesicle membrane
GO:0048002	0.000455567453272	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	antigen processing and presentation of peptide antigen
GO:0030669	0.000887203135002	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	clathrin-coated endocytic vesicle membrane
KEGG:05168	0.00125152052582	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	Herpes simplex virus 1 infection
GO:0030134	0.00197464201845	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	COPII-coated ER to Golgi transport vesicle
GO:0045334	0.00197464201845	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	clathrin-coated endocytic vesicle
GO:0019882	0.002326053637	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	antigen processing and presentation
WP:WP5284	0.00250295506608	0.25	HLA-DRB1 HLA-DRA	Cell interactions of the pancreatic cancer microenvironment
GO:0031902	0.00272226199626	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	late endosome membrane
WP:WP530	0.00324014777067	0.25	HLA-DRB1 HLA-DRA	Cytokines and inflammatory response
GO:0032588	0.00482963771614	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	trans-Golgi network membrane
GO:0030665	0.00504805624577	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	clathrin-coated vesicle membrane
WP:WP5115	0.00770221928581	0.375	HLA-DRA HLA-DRB5 HLA-DRB1	Network map of SARS CoV 2 signaling pathway
GO:0030658	0.012426913615	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	transport vesicle membrane
GO:0002469	0.0131096201623	0.25	HLA-DRB1 HLA-DRA	myeloid dendritic cell antigen processing and presentation
GO:0002491	0.0131096201623	0.25	HLA-DRB1 HLA-DRA	antigen processing and presentation of endogenous peptide antigen via MHC class II
HP:0025439	0.0270195830756	0.25	HLA-DPB1 HLA-DRB1	Pharyngitis
GO:0030136	0.0306827893089	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	clathrin-coated vesicle
GO:0030666	0.0324277411936	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	endocytic vesicle membrane
GO:0030662	0.0333274601889	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	coated vesicle membrane
HP:0025389	0.0384712883781	0.25	HLA-DPB1 HLA-DRB1	Pulmonary interstitial high-resolution computed tomography abnormality
REAC:R-HSA-1280215	0.0388837771011	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	Cytokine Signaling in Immune system
GO:0050870	0.0391228062182	0.5	HLA-DRB1 HLA-DRA HLA-DRB5 HLA-DPB1	positive regulation of T cell activation
GO:0000139	0.0411720277791	0.625	HLA-DRB1 CHST9 HLA-DRB5 HLA-DRA HLA-DPB1	Golgi membrane

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
HLA-DRA	HLA-DRB1	1.0	0.21	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
HLA-DRB5	HLA-DRB1	0.999	0.31	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
HLA-DRA	HLA-DRB5	0.998	0.524	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
HLA-DPB1	HLA-DRB1	0.992	0.274		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
MPZL2	HLA-DRB1	0.99		structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
GABRQ	HLA-DRA	0.982			bioplex3_WMM bioplex3_HCT116 WMM_only
HLA-DRB3	HLA-DRB1	0.978	0.304	mutually_exclusive (P01903) structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
GLCE	HLA-DRB3	0.974	0.078	mutually_exclusive (P01903)	bioplex3_WMM bioplex3_HCT116 WMM_only
HLA-DRB3	HLA-DRA	0.973	0.481333333333	mutually_exclusive (P01911) structurally_consistent (dimer)	bioplex3_WMM bioplex3_HCT116 WMM_only
CHST9	HLA-DRA	0.969		structurally_consistent (dimer)	bioplex3_WMM bioplex3_HCT116 WMM_only
GLCE	HLA-DRA	0.968	0.048	structurally_consistent (dimer)	bioplex3_WMM bioplex3_HCT116 WMM_only
MPZL2	HLA-DRB3	0.963	0.094	structurally_consistent (P01911)	bioplex3_WMM bioplex3_HCT116 WMM_only
HLA-DPB1	HLA-DRA	0.934	0.394	structurally_consistent (dimer)	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
HLA-DPB1	HLA-DRB5	0.832	0.282		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
HLA-DPB1	HLA-DRB3	0.604	0.418		bioplex3_HEK293 bioplex3_WMM WMM_only
MPZL2	HLA-DRA	0.587	0.098		bioplex3_WMM WMM_only
GLCE	HLA-DRB1	0.39		mutually_exclusive (P01903)	bioplex3_WMM WMM_only
HLA-DRB3	GABRQ	0.384			bioplex3_WMM WMM_only
GLCE	GABRQ	0.356			bioplex3_WMM WMM_only
GLCE	HLA-DPB1	0.269	0.162	mutually_exclusive (P01903)	bioplex3_HEK293 bioplex3_WMM WMM_only
MPZL2	GLCE	0.205	0.154		bioplex3_WMM WMM_only
HLA-DRB3	HLA-DRB5	0.072	0.356		bioplex3_WMM WMM_only
GABRQ	HLA-DRB1	0.069			bioplex3_WMM WMM_only
GABRQ	HLA-DRB5	0.046			bioplex3_WMM WMM_only
MPZL2	HLA-DRB5	0.042	0.086	structurally_consistent (P01911)	bioplex3_WMM WMM_only
GLCE	HLA-DRB5	0.042	0.064	mutually_exclusive (P01903)	bioplex3_WMM WMM_only
HLA-DPB1	GABRQ	0.034			bioplex3_WMM WMM_only
MPZL2	HLA-DPB1	0.026	0.092		bioplex3_WMM WMM_only
CHST9	HLA-DRB1	0.019		mutually_exclusive (P01903)	bioplex3_HCT116 WMM_only

Related Complexes

Genename	Complexes
HLA-DRB5	huMAP3_03618.1 huMAP3_05213.1 huMAP3_06470.1 huMAP3_09938.1 huMAP3_10740.1
HLA-DRB3	huMAP3_00927.1 huMAP3_07774.1 huMAP3_09938.1
GLCE	huMAP3_00208.1 huMAP3_00927.1 huMAP3_01876.1 huMAP3_03744.1 huMAP3_05648.1 huMAP3_06470.1 huMAP3_07774.1 huMAP3_08424.1 huMAP3_09938.1 huMAP3_14761.1
HLA-DPB1	huMAP3_00587.1 huMAP3_03754.1 huMAP3_05213.1 huMAP3_05482.1 huMAP3_05974.1 huMAP3_06650.1 huMAP3_07234.1 huMAP3_08884.1 huMAP3_09938.1
MPZL2	huMAP3_00028.1 huMAP3_05213.1 huMAP3_05482.1 huMAP3_09938.1
HLA-DRB1	huMAP3_05213.1 huMAP3_05482.1 huMAP3_07806.1 huMAP3_09398.1 huMAP3_09938.1
CHST9	huMAP3_01876.1 huMAP3_02225.1 huMAP3_02969.1 huMAP3_06470.1 huMAP3_07774.1 huMAP3_09150.1 huMAP3_09926.1 huMAP3_09938.1 huMAP3_11790.1 huMAP3_13018.1 huMAP3_15203.1
GABRQ	huMAP3_01876.1 huMAP3_02680.1 huMAP3_06210.1 huMAP3_06470.1 huMAP3_07774.1 huMAP3_08016.1 huMAP3_09938.1 huMAP3_10252.1 huMAP3_10872.1 huMAP3_12192.1 huMAP3_13529.1 huMAP3_15203.1
HLA-DRA	huMAP3_01876.1 huMAP3_06470.1 huMAP3_07774.1 huMAP3_09938.1 huMAP3_15203.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_09938.1

Complex Portal: CPX-23582